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Allergologia et Immunopathologia, ISSN 0301-0546, 11/2014, Volume 42, Issue 6, pp. 616 - 619
Because of the widespread use of botanicals, it has become crucial for health professionals to improve their knowledge about safety problems. Several herbal... 
Allergy | Rosemary | Allergic contact dermatitis | Contact dermatitis | Rosmarinus officinalis | CARNOSIC ACID | ANTIOXIDANT | IMMUNOLOGY | Cross Reactions | Dermatitis, Contact - immunology | Diterpenes, Abietane - immunology | Animals | Allergens - immunology | Humans | Thymus Plant - immunology | Antigens, Plant - immunology | Rosmarinus - immunology
Journal Article
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 07/2016, Volume 188, pp. 193 - 199
var. roots are used as the Chinese traditional medicine Danshen for the treatment of cardiovascular diseases in local clinical practice. Tanshinones are the... 
Pro-inflammatory cytokines | Anti-inflammatory activity | Tanshinones | Bioactivity evaluation | Atherosclerosis | IIA | SYSTEM | CELLS | CHEMISTRY, MEDICINAL | PLANT SCIENCES | INHIBITION | DITERPENOIDS | INTEGRATIVE & COMPLEMENTARY MEDICINE | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | TNF-ALPHA | EXPRESSION | TLR4 | Tumor Necrosis Factor-alpha - metabolism | Interleukin-8 - genetics | Plant Extracts - chemistry | Plant Extracts - toxicity | Plant Extracts - pharmacology | Humans | Tumor Necrosis Factor-alpha - genetics | Diterpenes, Abietane - isolation & purification | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Proton Magnetic Resonance Spectroscopy | Interleukin-1beta - metabolism | Carbon-13 Magnetic Resonance Spectroscopy | Inflammation Mediators - metabolism | Anti-Inflammatory Agents - isolation & purification | Molecular Structure | Interleukin-8 - metabolism | Phytotherapy | Real-Time Polymerase Chain Reaction | Macrophages - immunology | Diterpenes, Abietane - toxicity | Enzyme-Linked Immunosorbent Assay | Anti-Inflammatory Agents - pharmacology | Anti-Inflammatory Agents - toxicity | Down-Regulation | RNA, Messenger - genetics | Diterpenes, Abietane - chemistry | Plant Extracts - isolation & purification | Diterpenes, Abietane - pharmacology | Macrophages - metabolism | Salvia miltiorrhiza - chemistry | Anti-Inflammatory Agents - chemistry | Plant Roots - chemistry | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Plants, Medicinal | Anti-inflammatory drugs | Macrophages | Analysis
Journal Article
Biomaterials, ISSN 0142-9612, 2012, Volume 34, Issue 3, pp. 817 - 830
Abstract Tanshinone IIA is a good candidate for treating cerebral ischemia, but its short half-life and poor permeability across the blood–brain-barrier (BBB)... 
Advanced Basic Science | Dentistry | Tanshinone IIA | Neuroprotection | Cerebral ischemia | PEGylated nanoparticles | Cationic bovine serum albumin | MATERIALS SCIENCE, BIOMATERIALS | ARTERY OCCLUSION | PLA NANOPARTICLES | ENGINEERING, BIOMEDICAL | COPOLYMER NANOPARTICLES | REPERFUSION INJURY | STROKE | TRAUMATIC BRAIN-INJURY | INFLAMMATION | THERAPEUTIC TARGET | PPAR-GAMMA | MOLECULAR-MECHANISMS | Nanoparticles - chemistry | Immunosuppressive Agents - pharmacokinetics | Immunosuppressive Agents - therapeutic use | Brain Ischemia - genetics | Polyethylene Glycols - chemistry | Brain Ischemia - immunology | Diterpenes, Abietane - administration & dosage | Diterpenes, Abietane - pharmacokinetics | Drug Carriers - chemistry | Brain - metabolism | Cattle | Tumor Necrosis Factor-alpha - immunology | Serum Albumin, Bovine - chemistry | Immunosuppressive Agents - administration & dosage | PPAR gamma - genetics | Diterpenes, Abietane - therapeutic use | Nanoparticles - ultrastructure | Interleukin-1beta - immunology | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Rats, Sprague-Dawley | Brain - drug effects | Gene Expression Regulation - drug effects | Animals | Brain Ischemia - drug therapy | Brain Ischemia - pathology | Interleukin-6 - immunology | Brain - pathology | Brain - immunology | Nanoparticles | Biological products | Messenger RNA | Permeability | Neurons
Journal Article
International Immunopharmacology, ISSN 1567-5769, 05/2015, Volume 26, Issue 1, pp. 4 - 12
Journal Article
Cell death & disease, ISSN 2041-4889, 08/2017, Volume 8, Issue 8, pp. e3004 - e3004
Tanshinones belong to a group of lipophilic constituents of Salvia miltiorrhiza Bunge (Danshen), which is widely used in traditional Chinese medicine. A deluge... 
RESPONSES | ACTIVATION | INHIBITION | INFLAMMATION | MACROPHAGES | TOLL-LIKE RECEPTORS | DOWN-REGULATION | MUTATIONS | SUPPRESSION | NF-KAPPA-B | CELL BIOLOGY | Edema - genetics | Transcription Factor AP-1 - genetics | Humans | Protein Multimerization | Tumor Necrosis Factor-alpha - genetics | Transcription Factor AP-1 - immunology | NF-KappaB Inhibitor alpha - genetics | Diterpenes, Abietane - isolation & purification | Interleukin-1beta - genetics | Transcription Factor RelA - genetics | Sepsis - drug therapy | Nitric Oxide Synthase Type II - immunology | Cyclooxygenase 2 - genetics | Myeloid Differentiation Factor 88 - immunology | Tumor Necrosis Factor-alpha - immunology | Transcription Factor RelA - immunology | Anti-Inflammatory Agents - isolation & purification | Mitogen-Activated Protein Kinases - immunology | Toll-Like Receptor 4 - antagonists & inhibitors | Cyclooxygenase 2 - immunology | Sepsis - immunology | Edema - immunology | Interleukin-6 - genetics | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Gene Expression Regulation | Myeloid Differentiation Factor 88 - genetics | THP-1 Cells | Interleukin-1beta - immunology | Toll-Like Receptor 4 - genetics | Edema - drug therapy | Toll-Like Receptor 4 - immunology | NF-KappaB Inhibitor alpha - immunology | Sepsis - genetics | Diterpenes, Abietane - pharmacology | Salvia miltiorrhiza - chemistry | Animals | Sepsis - chemically induced | Nitric Oxide Synthase Type II - genetics | Ear | Interleukin-6 - immunology | Lipopolysaccharides - pharmacology | Mitogen-Activated Protein Kinases - genetics | RAW 264.7 Cells | Mice | Edema - chemically induced | Phosphorylation | Transcription factors | Transcription | Syngeneic grafts | Macrophages | Inflammatory diseases | Lipopolysaccharides | Prostaglandin endoperoxide synthase | Interleukin 6 | Lipophilic | Chinese medicine | Rodents | Bone marrow | Toll-like receptors | Dimerization | Edema | Kidneys | Secretion | TAK1 protein | Extracellular signal-regulated kinase | MAP kinase | JNK protein | Tanshinones | Nuclear transport | Nitric-oxide synthase | Phytochemicals | Cellular biology | Nitric oxide | MyD88 protein | Cyclooxygenase-2 | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2012, Volume 7, Issue 6, p. e40165
Background: Ischemia/reperfusion (I/R) injury is associated with systemic inflammatory response. Macrophage migration inhibitory factor (MIF) has been... 
ACTIVATION | ARTERY OCCLUSION | BRAIN-INJURY | INFLAMMATION | DISEASE | BIOLOGY | ISCHEMIA | EXPERIMENTAL STROKE | MODEL | NF-KAPPA-B | EXPRESSION | Neuroprotective Agents - therapeutic use | Water | Cerebral Infarction - drug therapy | Macrophage Migration-Inhibitory Factors - antagonists & inhibitors | Antigens, Nuclear - metabolism | Reperfusion Injury - drug therapy | Intramolecular Oxidoreductases - antagonists & inhibitors | Macrophage Migration-Inhibitory Factors - metabolism | Male | Protein Transport - drug effects | Glial Fibrillary Acidic Protein - metabolism | Cerebral Infarction - complications | Cerebral Infarction - enzymology | Brain Ischemia - enzymology | Neuroprotective Agents - pharmacology | Time Factors | Inflammation Mediators - metabolism | Reperfusion Injury - complications | Intramolecular Oxidoreductases - metabolism | Neutrophil Infiltration - drug effects | Cerebral Infarction - pathology | Brain Ischemia - complications | Neuroprotective Agents - chemistry | Reperfusion Injury - pathology | Diterpenes, Abietane - therapeutic use | Reperfusion Injury - enzymology | Diterpenes, Abietane - chemistry | Rats | Rats, Sprague-Dawley | Nerve Tissue Proteins - metabolism | Diterpenes, Abietane - pharmacology | Animals | Transcription Factor RelA - metabolism | Brain Ischemia - drug therapy | Brain Ischemia - pathology | Peroxidase - metabolism | Brain | Research | Macrophages | Neurons | Enzyme-linked immunosorbent assay | Occlusion | Neuroprotection | Cerebral cortex | Traumatic brain injury | Leukocyte migration | Migration | Inflammatory response | Alcohol | Interleukin 6 | Reperfusion | Ischemia | Moisture content | Cerebral blood flow | Rodents | Water content | Tumor necrosis factor-TNF | Peroxidase | Inhibition | Injuries | Injury analysis | Edema | Cerebral infarction | NF-κB protein | Stroke | Cytokines | Astrocytes | Neutrophils | Cortex | Inflammation | Tumor necrosis factor-α | Neurological diseases | Macrophage migration inhibitory factor | Studies | Pathology | Neurological complications | Migration inhibitory factor | Infarction | Infiltration | Immunofluorescence | Apoptosis
Journal Article
Experimental Parasitology, ISSN 0014-4894, 10/2015, Volume 157, pp. 128 - 137
Journal Article