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1. Full Text Four New ent-Kaurane Diterpene Glycosides from Isodon henryi
by Liu, Ya-Lin and Zhang, Ling-Xia and Wu, Hong and Chen, Sui-Qing and Li, Jun and Dai, Li-Ping and Wang, Zhi-Min
Molecules (Basel, Switzerland), ISSN 1420-3049, 08/2019, Volume 24, Issue 15, p. 2736
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Diterpenes, Kaurane - pharmacology | Isodon - chemistry | Models, Molecular | Antineoplastic Agents, Phytogenic - chemistry | Molecular Structure | Structure-Activity Relationship | Antineoplastic Agents, Phytogenic - pharmacology | Glycosides - pharmacology | Spectrum Analysis | Glycosides - chemistry | Diterpenes, Kaurane - chemistry | Index Medicus | Isodon henryi | ent-kaurane diterpene | cytotoxic activity
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2. Full Text Bioactive ent-kaurane diterpenoids from Isodon rubescens
by Zhang, Yuan-Yuan and Jiang, Hua-Yi and Liu, Miao and Hu, Kun and Wang, Wei-Guang and Du, Xue and Li, Xiao-Nian and Pu, Jian-Xin and Sun, Han-Dong
Phytochemistry (Oxford), ISSN 0031-9422, 11/2017, Volume 143, pp. 199 - 207
Cytotoxicity | 7,20-Epoxy-ent-kaurane diterpenoids | Lamiaceae | Anti-inflammatory | Isodon rubescens | Diterpenes, Kaurane - pharmacology | Isodon - chemistry | Nitric Oxide - biosynthesis | Diterpenes, Kaurane - isolation & purification | Plant Components, Aerial - chemistry | Humans | Drugs, Chinese Herbal - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Drugs, Chinese Herbal - chemistry | Lipopolysaccharides - pharmacology | HL-60 Cells | Macrophages - drug effects | Molecular Structure | Antineoplastic Agents, Phytogenic - pharmacology | Drugs, Chinese Herbal - isolation & purification | Antineoplastic Agents, Phytogenic - isolation & purification | Diterpenes, Kaurane - chemistry | Drug Screening Assays, Antitumor | Epoxy resins | Yuan (China) | Index Medicus
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3. Full Text Synthesis of ent‐Kaurane and Beyerane Diterpenoids by Controlled Fragmentations of Overbred Intermediates
by Cherney, Emily C and Green, Jason C and Baran, Phil S
Angewandte Chemie (International ed.), ISSN 1433-7851, 08/2013, Volume 52, Issue 34, pp. 9019 - 9022
ent‐kaurane | overbred intermediates | beyerane | diterpenes | total synthesis | ent-kaurane | Diterpenes, Kaurane - chemical synthesis | Diterpenes - chemical synthesis | Diterpenes - chemistry | Diterpenes, Kaurane - chemistry | Synthesis | Organic compounds | Index Medicus | Construction | Oxidation | Terpenes | Precursors | Fragmentation
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4. Full Text ent-Kaurane Diterpenoids with Neuroprotective Properties from Corn Silk (Zea mays)
by Qi, Xiao-Li and Zhang, Ying-Ying and Zhao, Peng and Zhou, Le and Wang, Xiao-Bo and Huang, Xiao-Xiao and Lin, Bin and Song, Shao-Jiang
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 05/2018, Volume 81, Issue 5, pp. 1225 - 1234
Crystallography, X-Ray - methods | Diterpenes, Kaurane - pharmacology | Zea mays - chemistry | Cell Line | Neuroprotective Agents - chemistry | Neuroprotective Agents - pharmacology | Apoptosis - drug effects | Humans | Hydrogen Peroxide - pharmacology | Diterpenes, Kaurane - chemistry
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5. Full Text Oridonin, a promising ent-kaurane diterpenoid lead compound
by Li, Dahong and Han, Tong and Liao, Jie and Hu, Xu and Xu, Shengtao and Tian, Kangtao and Gu, Xiaoke and Cheng, Keguang and Li, Zhanlin and Hua, Huiming and Xu, Jinyi
International journal of molecular sciences, ISSN 1661-6596, 09/2016, Volume 17, Issue 9, pp. 1395 - 1395
Structural modification | Medicinal chemistry | Ent-kaurane | Biological activity | Oridonin | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Diterpenes, Kaurane - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Antineoplastic Agents - chemistry | Diterpenes, Kaurane - chemistry | Index Medicus | oridonin | biological activity | ent-kaurane | medicinal chemistry | structural modification
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6. Full Text Bioactive ent-kaurane diterpenoids from Isodon serra
by Wan, Jun and Liu, Miao and Jiang, Hua-Yi and Yang, Jin and Du, Xue and Li, Xiao-Nian and Wang, Wei-Guang and Li, Yan and Pu, Jian-Xin and Sun, Han-Dong
Phytochemistry (Oxford), ISSN 0031-9422, 10/2016, Volume 130, pp. 244 - 251
7,20-Epoxy-ent-kaurane diterpenoids | Isodon serra | Lamiaceae | Anti-inflammatory | Cytotoxic activity | Diterpenes, Kaurane - pharmacology | Isodon - chemistry | Nitric Oxide - biosynthesis | Diterpenes, Kaurane - isolation & purification | Plant Components, Aerial - chemistry | Humans | Antineoplastic Agents, Phytogenic - chemistry | Animals | Lipopolysaccharides - pharmacology | HL-60 Cells | Macrophages - drug effects | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Diterpenes, Kaurane - chemistry | Drug Screening Assays, Antitumor | Epoxy resins | Analysis | Index Medicus
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7. Full Text Cytotoxic ent-Kaurane Diterpenoids from Isodon wikstroemioides
by Wu, Hai-Yan and Zhan, Rui and Wang, Wei-Guang and Jiang, Hua-Yi and Du, Xue and Li, Xiao-Nian and Li, Yan and Pu, Jian-Xin and Sun, Han-Dong
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 04/2014, Volume 77, Issue 4, pp. 931 - 941
Diterpenes, Kaurane - pharmacology | Isodon - chemistry | Nitric Oxide - biosynthesis | Diterpenes, Kaurane - isolation & purification | Humans | Drugs, Chinese Herbal - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Animals | Drugs, Chinese Herbal - chemistry | Lipopolysaccharides - pharmacology | HL-60 Cells | Nuclear Magnetic Resonance, Biomolecular | Macrophages - drug effects | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Drugs, Chinese Herbal - isolation & purification | Antineoplastic Agents, Phytogenic - isolation & purification | Diterpenes, Kaurane - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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8. Full Text Bioactive Enmein-Type ent-Kaurane Diterpenoids from Isodon phyllostachys
by Yang, Jin and Wang, Wei-Guang and Wu, Hai-Yan and Du, Xue and Li, Xiao-Nian and Li, Yan and Pu, Jian-Xin and Sun, Han-Dong
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 01/2016, Volume 79, Issue 1, pp. 132 - 140
Diterpenes, Kaurane - pharmacology | Isodon - chemistry | Nitric Oxide - biosynthesis | Diterpenes, Kaurane - isolation & purification | Plant Components, Aerial - chemistry | Humans | Molecular Conformation | Drugs, Chinese Herbal - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Animals | Drugs, Chinese Herbal - chemistry | Lipopolysaccharides - pharmacology | Diterpenes | HL-60 Cells | Inhibitory Concentration 50 | Mice | Molecular Structure | Antineoplastic Agents, Phytogenic - pharmacology | Drugs, Chinese Herbal - isolation & purification | Antineoplastic Agents, Phytogenic - isolation & purification | Diterpenes, Kaurane - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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9. Full Text Geopyxins A–E, ent-Kaurane Diterpenoids from Endolichenic Fungal Strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: Structure–Activity Relationships of Geopyxins and Their Analogues
by Wijeratne, E. M. Kithsiri and Bashyal, Bharat P and Liu, Manping X and Rocha, Danilo D and Gunaherath, G. M. Kamal B and U’Ren, Jana M and Gunatilaka, Malkanthi K and Arnold, A. Elizabeth and Whitesell, Luke and Gunatilaka, A. A. Leslie
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 03/2012, Volume 75, Issue 3, pp. 361 - 369
Diterpenes, Kaurane - pharmacology | Diterpenes, Kaurane - isolation & purification | Humans | Ascomycota - chemistry | Male | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Animals | Antineoplastic Agents - isolation & purification | Nuclear Magnetic Resonance, Biomolecular | Female | Porifera - microbiology | Antineoplastic Agents - pharmacology | Molecular Structure | Diterpenes, Kaurane - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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10. Full Text Anti-neuroinflammatory ent-kaurane diterpenoids from Pteris multifida roots
by Kim, Jung Wha and Seo, Ji Yeon and Oh, Won Keun and Sung, Sang Hyun
Molecules (Basel, Switzerland), ISSN 1420-3049, 01/2017, Volume 22, Issue 1, pp. 27 - 27
BV-2 microglia | Ent-kaurane diterpenoids | Pteris multifida | Anti-neuroinflammation | Nitric oxide (NO) | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Plant Extracts - chemistry | Interleukin-6 - antagonists & inhibitors | Diterpenes, Kaurane - isolation & purification | Dinoprostone - biosynthesis | Solvents - chemistry | Tumor Necrosis Factor-alpha - genetics | Interleukin-1beta - genetics | Lipopolysaccharides - antagonists & inhibitors | Microglia - immunology | Neuroprotective Agents - pharmacology | Cyclooxygenase 2 - genetics | Tumor Necrosis Factor-alpha - immunology | Anti-Inflammatory Agents - isolation & purification | Methanol - chemistry | Cyclooxygenase 2 - immunology | Diterpenes, Kaurane - chemistry | Interleukin-1beta - antagonists & inhibitors | Diterpenes, Kaurane - pharmacology | Microglia - cytology | Cell Line | Nitric Oxide - biosynthesis | Neuroprotective Agents - chemistry | Interleukin-6 - genetics | Microglia - drug effects | Anti-Inflammatory Agents - pharmacology | Nitric Oxide - antagonists & inhibitors | Gene Expression Regulation | Interleukin-1beta - immunology | Inflammation | Animals | Anti-Inflammatory Agents - chemistry | Pteris - chemistry | Neuroprotective Agents - isolation & purification | Plant Roots - chemistry | Interleukin-6 - immunology | Lipopolysaccharides - pharmacology | Mice | Dinoprostone - antagonists & inhibitors | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Nuclear magnetic resonance--NMR | Neurodegenerative diseases | Roots | Prostaglandin E2 | Data processing | Microglia | Lipopolysaccharides | Interleukin 6 | Tumor necrosis factor | Diterpenes | Tumor necrosis factor-TNF | Cyclooxygenase-2 | Methanol | Index Medicus | nitric oxide (NO) | ent-kaurane diterpenoids | anti-neuroinflammation
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11. Full Text Ent-Kaurane diterpenes from the stem bark of Annona vepretorum (Annonaceae) and cytotoxic evaluation
by Dutra, Lívia M and Bomfim, Larissa M and Rocha, Suellen L.A and Nepel, Angelita and Soares, Milena B.P and Barison, Andersson and Costa, Emmanoel V and Bezerra, Daniel P
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 08/2014, Volume 24, Issue 15, pp. 3315 - 3320
Cytotoxicity | Annonaceae | ent-Kaurane diterpenes | Annona vepretorum | Diterpenes, Kaurane - pharmacology | Leukocytes, Mononuclear - drug effects | Diterpenes, Kaurane - isolation & purification | Humans | Antineoplastic Agents, Phytogenic - chemistry | Structure-Activity Relationship | Annonaceae - chemistry | Plant Bark - chemistry | Hep G2 Cells | Dose-Response Relationship, Drug | Animals | K562 Cells | Cell Line, Tumor | HL-60 Cells | Cell Proliferation - drug effects | Mice | Molecular Structure | Plant Stems - chemistry | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Diterpenes, Kaurane - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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12. Full Text Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives
by Batista, Ronan and García, Pablo A and Castro, María Angeles and Miguel Del Corral, José M and Speziali, Nivaldo L and De P. Varotti, Fernando and De Paula, Renata C and García-Fernández, Luis F and Francesch, Andrés and San Feliciano, Arturo and De Oliveira, Alaíde B
European journal of medicinal chemistry, ISSN 0223-5234, 04/2013, Volume 62, pp. 168 - 176
Antineoplastic activity | Plasmodium falciparum | ent-Kaurane derivatives | In vitro antimalarial activity | Wedelia paludosa D.C | Diterpenes, Kaurane - pharmacology | Parasitic Sensitivity Tests | Antineoplastic Agents - chemical synthesis | Models, Molecular | Structure-Activity Relationship | Plasmodium falciparum - drug effects | Antineoplastic Agents - chemistry | Antimalarials - pharmacology | Dose-Response Relationship, Drug | Diterpenes, Kaurane - chemical synthesis | Antimalarials - chemistry | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Cell Death - drug effects | Antimalarials - chemical synthesis | Diterpenes, Kaurane - chemistry | Drug Screening Assays, Antitumor | Malaria | Antimalarials | Derivatives (Financial instruments) | Index Medicus
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13. Full Text An ent‐Kaurane Diterpenoid Isolated from Rabdosia excisa Suppresses Bcr‐Abl Protein Expression in Vitro and in Vivo and Induces Apoptosis of CML Cells
by Xia, Yan and Feng, Miao and Wang, Erkang and Chen, Li and Wang, Jin and Hou, Ruibin and Zhao, Yinping
Chemistry & biodiversity, ISSN 1612-1872, 10/2019, Volume 16, Issue 10, pp. e1900443 - n/a
Bcr-Abl | CML | diterpenoid | kamebakaurin | TKIs | cytotoxicity | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Apoptosis - drug effects | Humans | Molecular Conformation | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Male | Structure-Activity Relationship | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Diterpenes - chemistry | Diterpenes - pharmacology | Cell Survival - drug effects | Isodon - chemistry | Diterpenes - isolation & purification | Cells, Cultured | Antineoplastic Agents, Phytogenic - chemistry | Animals | Mice, Nude | Fusion Proteins, bcr-abl - antagonists & inhibitors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Neoplasms, Experimental - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Neoplasms, Experimental - drug therapy | Fusion Proteins, bcr-abl - metabolism | Antineoplastic Agents, Phytogenic - isolation & purification | Drug Screening Assays, Antitumor | Stem cells | Apoptosis | Cell proliferation | BCR protein | Tyrosine | Myeloid leukemia | Leukemia | Organs | Abl protein | Chronic myeloid leukemia | Kinases | Hematopoietic stem cells | Anticancer properties | Proteins | Side effects | Chemotherapy | Reagents | Mutation | Protein-tyrosine kinase | Index Medicus
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14. Full Text Three new cytotoxic ent-kaurane diterpenes from isodon excisoides
by Dai, Li-Ping and Li, Chun and Yang, Han-Ze and Lu, Yan-Qing and Yu, Hong-Yan and Gao, Hui-Min and Wang, Zhi-Min
Molecules (Basel, Switzerland), ISSN 1420-3049, 09/2015, Volume 20, Issue 9, pp. 17544 - 17556
Isodon excisoides | Ent-kaurane diterpene | Structure-activity relationship | Cytotoxic activity | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Diterpenes - pharmacology | Isodon - chemistry | Drug Screening Assays, Antitumor - methods | Plant Components, Aerial - chemistry | Diterpenes - isolation & purification | HCT116 Cells | Humans | Antineoplastic Agents, Phytogenic - chemistry | Structure-Activity Relationship | Hep G2 Cells | Cell Line, Tumor | Cell Proliferation - drug effects | Molecular Structure | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Diterpenes - chemistry | Index Medicus | cytotoxic activity | structure-activity relationship | ent-kaurane diterpene
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15. Full Text Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei
by Zheng, Heng and Chen, Qiong and Zhang, Mengke and Lai, Yongji and Lei, Liang and Shu, Penghua and Zhang, Jinwen and Xue, Yongbo and Luo, Zengwei and Li, Yan and Yao, Guangmin and Zhang, Yonghui
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 12/2013, Volume 76, Issue 12, pp. 2253 - 2262
Diterpenes, Kaurane - pharmacology | Diterpenes, Kaurane - isolation & purification | Humans | Molecular Conformation | Drugs, Chinese Herbal - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Cisplatin - pharmacology | Salvia - chemistry | MCF-7 Cells | Drugs, Chinese Herbal - chemistry | HL-60 Cells | Nuclear Magnetic Resonance, Biomolecular | Female | Molecular Structure | Antineoplastic Agents, Phytogenic - pharmacology | Circular Dichroism | Drugs, Chinese Herbal - isolation & purification | Antineoplastic Agents, Phytogenic - isolation & purification | Diterpenes, Kaurane - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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16. Full Text Fimbrialtols K–M, highly functionalized ent-kaurane diterpenoids from traditional Chinese plant Flickingeria fimbriata (B1.) Hawkes
by Ding, Gang and Wang, Jing and Fei, Jiao-Dong and Li, Rong-Tao and Jia, Hong-Mei and Zhang, Tao and Yu, Chang-Yuan and Zou, Zhong-Mei
Chinese chemical letters, ISSN 1001-8417, 03/2017, Volume 28, Issue 3, pp. 593 - 596
NMR | Flickingeria fimbriata (B1.) Hawkes | ent-Kaurane diterpenoids | Fimbrialtols | Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Orchids | Diterpenes | Usage | Nuclear magnetic resonance | Chemical properties | Chemical research
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17. Full Text Bioactive ent-Kaurane Diterpenoids from Isodon rosthornii
by Zhan, Rui and Li, Xiao-Nian and Du, Xue and Wang, Wei-Guang and Dong, Ke and Su, Jia and Li, Yan and Pu, Jian-Xin and Sun, Han-Dong
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 07/2013, Volume 76, Issue 7, pp. 1267 - 1277
Diterpenes, Kaurane - pharmacology | Isodon - chemistry | Diterpenes, Kaurane - isolation & purification | Humans | Molecular Conformation | Drugs, Chinese Herbal - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Nitric Oxide - analysis | Animals | Drugs, Chinese Herbal - chemistry | Lipopolysaccharides - pharmacology | Nuclear Magnetic Resonance, Biomolecular | Macrophages - drug effects | Mice | Molecular Structure | Antineoplastic Agents, Phytogenic - pharmacology | Drugs, Chinese Herbal - isolation & purification | Antineoplastic Agents, Phytogenic - isolation & purification | Diterpenes, Kaurane - chemistry | Drug Screening Assays, Antitumor | Index Medicus
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18. Full Text A novel ent-kaurane diterpenoid executes antitumor function in colorectal cancer cells by inhibiting Wnt/β-catenin signaling
by Ye, Qi and Yao, Guangmin and Zhang, Mengke and Guo, Guoli and Hu, Yufeng and Jiang, Jue and Cheng, Ling and Shi, Jianguo and Li, Hua and Zhang, Yonghui and Liu, Hudan
Carcinogenesis (New York), ISSN 0143-3334, 07/2014, Volume 36, Issue 3, pp. 318 - 326
Life Sciences & Biomedicine | Oncology | Science & Technology | Apoptosis - drug effects | Colorectal Neoplasms - genetics | Humans | HCT116 Cells - drug effects | Molecular Targeted Therapy | Colorectal Neoplasms - drug therapy | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Colorectal Neoplasms - metabolism | Diterpenes, Kaurane - chemistry | Diterpenes, Kaurane - pharmacology | Transcription Factor 4 | beta Catenin - metabolism | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Wnt Signaling Pathway - drug effects | beta Catenin - antagonists & inhibitors | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Cell Proliferation - drug effects | Mice, Inbred BALB C | Molecular Docking Simulation | Antineoplastic Agents, Phytogenic - pharmacology | Colorectal Neoplasms - pathology | Drug Screening Assays, Antitumor | Index Medicus
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