FEBS Letters, ISSN 0014-5793, 07/2013, Volume 587, Issue 14, pp. 2214 - 2218
Cytochrome oxygen reductase from has three hemes, , and . We found that the enzyme, as-prepared or in turnover with O , rapidly decomposes H O with formation...
Oxidative stress | Reactive oxygen species | Respiratory chain | Hemeprotein | Bacteria–host interaction | Microbial metabolism | N-ethylmaleimide | dithiothreitol | DTT | NEM | ROS | reactive oxygen species | 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone | Bacteria-host interaction | AEROBIC RESPIRATORY-CHAIN | OXYGEN-REDUCING SITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DI-HEME | HIGH-AFFINITY | TERMINAL OXIDASE | CELL BIOLOGY | BIOPHYSICS | QUINOL OXIDASE | CARBON-MONOXIDE | NITRIC-OXIDE | HYDROGEN-PEROXIDE | C-OXIDASE | Oxidoreductases - antagonists & inhibitors | Cytochromes - chemistry | Oxidative Stress | Hydroquinones - chemistry | Sodium Cyanide - chemistry | Oxidoreductases - chemistry | Hydrogen Peroxide - chemistry | NAD - chemistry | Cattle | Enzyme Inhibitors - chemistry | Oxygen - chemistry | Electron Transport Chain Complex Proteins - antagonists & inhibitors | Dithiothreitol - chemistry | Escherichia coli Proteins - antagonists & inhibitors | Reducing Agents - chemistry | NAD(P)H Dehydrogenase (Quinone) - chemistry | Cytochromes - antagonists & inhibitors | Escherichia coli - enzymology | Oxidants - chemistry | Rats | Electron Transport Chain Complex Proteins - chemistry | Animals | Kinetics | Escherichia coli Proteins - chemistry | Catalase - chemistry | Proteins | Oxidases | Denaturation | Nitric oxide | Escherichia coli | Oxygen | Enzyme Inhibitors | Hydrogen Peroxide | Biochemistry, Molecular Biology | Sodium Cyanide | Reducing Agents | NAD(P)H Dehydrogenase (Quinone) | NAD | Life Sciences | Hydroquinones | Escherichia coli Proteins | Catalase | Oxidants | Cytochromes | Oxidoreductases | Dithiothreitol | Electron Transport Chain Complex Proteins
Oxidative stress | Reactive oxygen species | Respiratory chain | Hemeprotein | Bacteria–host interaction | Microbial metabolism | N-ethylmaleimide | dithiothreitol | DTT | NEM | ROS | reactive oxygen species | 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-1,4-benzoquinone | Bacteria-host interaction | AEROBIC RESPIRATORY-CHAIN | OXYGEN-REDUCING SITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DI-HEME | HIGH-AFFINITY | TERMINAL OXIDASE | CELL BIOLOGY | BIOPHYSICS | QUINOL OXIDASE | CARBON-MONOXIDE | NITRIC-OXIDE | HYDROGEN-PEROXIDE | C-OXIDASE | Oxidoreductases - antagonists & inhibitors | Cytochromes - chemistry | Oxidative Stress | Hydroquinones - chemistry | Sodium Cyanide - chemistry | Oxidoreductases - chemistry | Hydrogen Peroxide - chemistry | NAD - chemistry | Cattle | Enzyme Inhibitors - chemistry | Oxygen - chemistry | Electron Transport Chain Complex Proteins - antagonists & inhibitors | Dithiothreitol - chemistry | Escherichia coli Proteins - antagonists & inhibitors | Reducing Agents - chemistry | NAD(P)H Dehydrogenase (Quinone) - chemistry | Cytochromes - antagonists & inhibitors | Escherichia coli - enzymology | Oxidants - chemistry | Rats | Electron Transport Chain Complex Proteins - chemistry | Animals | Kinetics | Escherichia coli Proteins - chemistry | Catalase - chemistry | Proteins | Oxidases | Denaturation | Nitric oxide | Escherichia coli | Oxygen | Enzyme Inhibitors | Hydrogen Peroxide | Biochemistry, Molecular Biology | Sodium Cyanide | Reducing Agents | NAD(P)H Dehydrogenase (Quinone) | NAD | Life Sciences | Hydroquinones | Escherichia coli Proteins | Catalase | Oxidants | Cytochromes | Oxidoreductases | Dithiothreitol | Electron Transport Chain Complex Proteins
Journal Article
Biomacromolecules, ISSN 1525-7797, 04/2017, Volume 18, Issue 4, pp. 1356 - 1364
Multifunctional and multiresponsive hydrogels have presented a promising platform to design and fabricate smart devices for application in a wide variety of...
POLYMER NETWORK | ACIDIC PH | POLYMER SCIENCE | GELS | DRUG-DELIVERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | STIMULI | CHEMISTRY, ORGANIC | RELEASE | BIOMEDICAL APPLICATIONS | GLUCOSE-RESPONSIVE HYDROGELS | COPOLYMER | COMPLEXATION | Dopamine - chemistry | Cross-Linking Reagents - chemistry | Oxidation-Reduction | Acrylic Resins - chemical synthesis | Catechols - chemistry | Boronic Acids - chemistry | Hydrogels - chemical synthesis | Acrylic Resins - chemistry | Phase Transition | Dopamine - chemical synthesis | Dopamine - analogs & derivatives | Cystamine - analogs & derivatives | Cystamine - chemistry | Cystamine - chemical synthesis | Disulfides - chemistry | Surface Properties | Glucose - chemistry | Dithiothreitol - chemistry | Boronic Acids - chemical synthesis | Hydrogels - chemistry
POLYMER NETWORK | ACIDIC PH | POLYMER SCIENCE | GELS | DRUG-DELIVERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | STIMULI | CHEMISTRY, ORGANIC | RELEASE | BIOMEDICAL APPLICATIONS | GLUCOSE-RESPONSIVE HYDROGELS | COPOLYMER | COMPLEXATION | Dopamine - chemistry | Cross-Linking Reagents - chemistry | Oxidation-Reduction | Acrylic Resins - chemical synthesis | Catechols - chemistry | Boronic Acids - chemistry | Hydrogels - chemical synthesis | Acrylic Resins - chemistry | Phase Transition | Dopamine - chemical synthesis | Dopamine - analogs & derivatives | Cystamine - analogs & derivatives | Cystamine - chemistry | Cystamine - chemical synthesis | Disulfides - chemistry | Surface Properties | Glucose - chemistry | Dithiothreitol - chemistry | Boronic Acids - chemical synthesis | Hydrogels - chemistry
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Journal of Biological Chemistry, ISSN 0021-9258, 12/2014, Volume 289, Issue 51, pp. 35570 - 35581
Nitroxyl (HNO), the protonated one-electron reduction product of NO, remains an enigmatic reactive nitrogen species. Its chemical reactivity and biological...
Peroxynitrite | Nitroxyl | Oxidative Stress | Cardiovascular | BIOCHEMISTRY & MOLECULAR BIOLOGY | Boronate Probes | NITROSYL HYDRIDE | Angeli's Salt | Nitric Oxide | Vascular | ARYLBORONIC ACID | ANGELIS SALT | AQUEOUS-SOLUTION | NITRONYL NITROXIDES | Cardioprotection | Ischemia | SODIUM TRIOXODINITRATE | HYDROGEN-PEROXIDE | NITRIC-OXIDE NO | SUPEROXIDE-DISMUTASE | FLUORESCENT-PROBE | Boron Compounds - chemistry | Models, Chemical | Oxidation-Reduction | Captopril - chemistry | Humans | Hydrogen Sulfide - chemistry | Nitrogen Oxides - chemistry | Coumarins - chemistry | Boronic Acids - chemistry | Chromatography, High Pressure Liquid | Cysteine - chemistry | Algorithms | Animals | Acetylcysteine - chemistry | Cattle | Mass Spectrometry | Oxygen - chemistry | Sulfhydryl Compounds - chemistry | Dithiothreitol - chemistry | Kinetics | Peroxynitrous Acid - chemistry | Serum Albumin - chemistry | Spectrophotometry | Hydrogen-Ion Concentration | Molecular Biophysics
Peroxynitrite | Nitroxyl | Oxidative Stress | Cardiovascular | BIOCHEMISTRY & MOLECULAR BIOLOGY | Boronate Probes | NITROSYL HYDRIDE | Angeli's Salt | Nitric Oxide | Vascular | ARYLBORONIC ACID | ANGELIS SALT | AQUEOUS-SOLUTION | NITRONYL NITROXIDES | Cardioprotection | Ischemia | SODIUM TRIOXODINITRATE | HYDROGEN-PEROXIDE | NITRIC-OXIDE NO | SUPEROXIDE-DISMUTASE | FLUORESCENT-PROBE | Boron Compounds - chemistry | Models, Chemical | Oxidation-Reduction | Captopril - chemistry | Humans | Hydrogen Sulfide - chemistry | Nitrogen Oxides - chemistry | Coumarins - chemistry | Boronic Acids - chemistry | Chromatography, High Pressure Liquid | Cysteine - chemistry | Algorithms | Animals | Acetylcysteine - chemistry | Cattle | Mass Spectrometry | Oxygen - chemistry | Sulfhydryl Compounds - chemistry | Dithiothreitol - chemistry | Kinetics | Peroxynitrous Acid - chemistry | Serum Albumin - chemistry | Spectrophotometry | Hydrogen-Ion Concentration | Molecular Biophysics
Journal Article
Biomacromolecules, ISSN 1525-7797, 07/2012, Volume 13, Issue 7, pp. 2003 - 2012
Thiol–ene photoclick hydrogels have been used for a variety of tissue engineering and controlled release applications. In this step-growth photopolymerization...
POLYMER SCIENCE | STATISTICAL KINETIC-MODEL | CLICK CHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | B-PLA HYDROGEL | CONTROLLED-RELEASE | CHEMISTRY, ORGANIC | MECHANICAL-PROPERTIES | ACRYLATE PHOTOPOLYMERS | POLY(ETHYLENE GLYCOL) HYDROGELS | BULK DEGRADATION | PROTEIN DELIVERY | CONJUGATE ADDITION | Cross-Linking Reagents - chemistry | Molecular Weight | Models, Chemical | Norbornanes - chemistry | Click Chemistry | Polymerization | Polyethylene Glycols - chemistry | Hydrogels - chemical synthesis | Photochemical Processes | Hydrolysis | Algorithms | Proteolysis | Chymotrypsin - chemistry | Sulfhydryl Compounds - chemistry | Dithiothreitol - chemistry | Kinetics | Oligopeptides - chemistry | Hydrogels - chemistry | Hydrogen-Ion Concentration
POLYMER SCIENCE | STATISTICAL KINETIC-MODEL | CLICK CHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | B-PLA HYDROGEL | CONTROLLED-RELEASE | CHEMISTRY, ORGANIC | MECHANICAL-PROPERTIES | ACRYLATE PHOTOPOLYMERS | POLY(ETHYLENE GLYCOL) HYDROGELS | BULK DEGRADATION | PROTEIN DELIVERY | CONJUGATE ADDITION | Cross-Linking Reagents - chemistry | Molecular Weight | Models, Chemical | Norbornanes - chemistry | Click Chemistry | Polymerization | Polyethylene Glycols - chemistry | Hydrogels - chemical synthesis | Photochemical Processes | Hydrolysis | Algorithms | Proteolysis | Chymotrypsin - chemistry | Sulfhydryl Compounds - chemistry | Dithiothreitol - chemistry | Kinetics | Oligopeptides - chemistry | Hydrogels - chemistry | Hydrogen-Ion Concentration
Journal Article
ChemBioChem, ISSN 1439-4227, 07/2016, Volume 17, Issue 13, pp. 1263 - 1281
Small glutamate‐containing peptides bearing coumarin derivatives as fluorescent leaving groups attached to the γ‐carboxylic acid group of the Glu residue were...
inhibitors | transferases | reactive peptides | solid-phase synthesis | enzyme assays | CHEMISTRY, MEDICINAL | ASSAY | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELIAC-DISEASE | DIRECT LINEAR PLOT | FLUORESCENCE | PIG LIVER TRANSGLUTAMINASE | SUBSTRATE | TISSUE TRANSGLUTAMINASE | HUNTINGTONS-DISEASE | CELL | Amines - chemistry | Fluorescent Dyes - chemical synthesis | Antioxidants - chemistry | Humans | Coumarins - chemistry | Piperazines - chemistry | Aminoacetonitrile - chemistry | Glutamates - chemistry | Biotin - chemistry | Phosphines - chemistry | Dithiothreitol - chemistry | Oligopeptides - chemistry | Transglutaminases - chemistry | Fluorescent Dyes - chemistry | Lysine - analogs & derivatives | Oligopeptides - chemical synthesis | Guinea Pigs | GTP-Binding Proteins - chemistry | Enzyme Assays - methods | Animals | Glutamates - chemical synthesis | Coumarins - chemical synthesis | Kinetics | Lysine - chemistry | Biotin - analogs & derivatives | Iodoacetamide - chemistry | Hydrolysis | Enzymes | Enzyme inhibitors | Peptides | Coumarins | Glutamate | Derivatives (Financial instruments)
inhibitors | transferases | reactive peptides | solid-phase synthesis | enzyme assays | CHEMISTRY, MEDICINAL | ASSAY | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELIAC-DISEASE | DIRECT LINEAR PLOT | FLUORESCENCE | PIG LIVER TRANSGLUTAMINASE | SUBSTRATE | TISSUE TRANSGLUTAMINASE | HUNTINGTONS-DISEASE | CELL | Amines - chemistry | Fluorescent Dyes - chemical synthesis | Antioxidants - chemistry | Humans | Coumarins - chemistry | Piperazines - chemistry | Aminoacetonitrile - chemistry | Glutamates - chemistry | Biotin - chemistry | Phosphines - chemistry | Dithiothreitol - chemistry | Oligopeptides - chemistry | Transglutaminases - chemistry | Fluorescent Dyes - chemistry | Lysine - analogs & derivatives | Oligopeptides - chemical synthesis | Guinea Pigs | GTP-Binding Proteins - chemistry | Enzyme Assays - methods | Animals | Glutamates - chemical synthesis | Coumarins - chemical synthesis | Kinetics | Lysine - chemistry | Biotin - analogs & derivatives | Iodoacetamide - chemistry | Hydrolysis | Enzymes | Enzyme inhibitors | Peptides | Coumarins | Glutamate | Derivatives (Financial instruments)
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 10/2016, Volume 27, Issue 10, pp. 2400 - 2406
Water-soluble trialkylphosphines such as tris(carboxyethyl)phosphine (TCEP) and trishydroxypropyl phosphine (THPP) are effective agents for reducing...
TRIS(2-CARBOXYETHYL)PHOSPHINE TCEP | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | REDUCTANTS | CHEMISTRY, MULTIDISCIPLINARY | REDUCTION | BIOCHEMISTRY | PHOSPHINES | CHEMISTRY | MALEIMIDE | DITHIOTHREITOL | LIPOSOMES | PEGYLATION | Water | Phosphines - chemistry | Magnetic Resonance Spectroscopy | Disulfides - chemistry | Sulfones - chemistry | Solubility | Polysaccharides - chemistry | Proteins - chemistry | Maleimides - chemistry | Sulfhydryl Reagents - chemistry | Alkylating Agents - chemistry
TRIS(2-CARBOXYETHYL)PHOSPHINE TCEP | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | REDUCTANTS | CHEMISTRY, MULTIDISCIPLINARY | REDUCTION | BIOCHEMISTRY | PHOSPHINES | CHEMISTRY | MALEIMIDE | DITHIOTHREITOL | LIPOSOMES | PEGYLATION | Water | Phosphines - chemistry | Magnetic Resonance Spectroscopy | Disulfides - chemistry | Sulfones - chemistry | Solubility | Polysaccharides - chemistry | Proteins - chemistry | Maleimides - chemistry | Sulfhydryl Reagents - chemistry | Alkylating Agents - chemistry
Journal Article
7.
Full Text
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
Nature, ISSN 0028-0836, 02/2007, Volume 445, Issue 7127, pp. 541 - 545
The nervous system senses peripheral damage through nociceptive neurons that transmit a pain signal(1,2). TRPA1 is a member of the Transient Receptor Potential...
S-NITROSYLATION | PROTEIN | CLICK CHEMISTRY | MULTIDISCIPLINARY SCIENCES | REACTIVITY | KEAP1 | ELECTROPHILE | SENSATION | COLD | INDUCERS | NOCICEPTION | Disulfides - metabolism | Acrolein - analogs & derivatives | Noxae - metabolism | Humans | Electric Conductivity | Pain - chemically induced | Acrolein - metabolism | Disulfides - chemistry | Noxae - pharmacology | Cysteine - metabolism | Transient Receptor Potential Channels - metabolism | Noxae - chemistry | Dithiothreitol - pharmacology | Acrolein - pharmacology | Plant Oils - pharmacology | Transient Receptor Potential Channels - chemistry | Ethyl Methanesulfonate - chemistry | Ethyl Methanesulfonate - metabolism | Cysteine - chemistry | Transient Receptor Potential Channels - agonists | Ethyl Methanesulfonate - analogs & derivatives | Mustard Plant - chemistry | Animals | Pain - physiopathology | Ethyl Methanesulfonate - pharmacology | Plant Oils - metabolism | Mice | Acrolein - chemistry | Mustard Plant - metabolism | Plant Oils - chemistry | Ion Channel Gating - drug effects | Neurology | Chemistry | Rodents | Spectrum analysis | Ions | Chemical reactions | Binding sites
S-NITROSYLATION | PROTEIN | CLICK CHEMISTRY | MULTIDISCIPLINARY SCIENCES | REACTIVITY | KEAP1 | ELECTROPHILE | SENSATION | COLD | INDUCERS | NOCICEPTION | Disulfides - metabolism | Acrolein - analogs & derivatives | Noxae - metabolism | Humans | Electric Conductivity | Pain - chemically induced | Acrolein - metabolism | Disulfides - chemistry | Noxae - pharmacology | Cysteine - metabolism | Transient Receptor Potential Channels - metabolism | Noxae - chemistry | Dithiothreitol - pharmacology | Acrolein - pharmacology | Plant Oils - pharmacology | Transient Receptor Potential Channels - chemistry | Ethyl Methanesulfonate - chemistry | Ethyl Methanesulfonate - metabolism | Cysteine - chemistry | Transient Receptor Potential Channels - agonists | Ethyl Methanesulfonate - analogs & derivatives | Mustard Plant - chemistry | Animals | Pain - physiopathology | Ethyl Methanesulfonate - pharmacology | Plant Oils - metabolism | Mice | Acrolein - chemistry | Mustard Plant - metabolism | Plant Oils - chemistry | Ion Channel Gating - drug effects | Neurology | Chemistry | Rodents | Spectrum analysis | Ions | Chemical reactions | Binding sites
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 11/2018, Volume 29, Issue 11, pp. 3866 - 3876
Thiol(-click) chemistry has been extensively investigated to conjugate (bio)molecules to polymers. Handling of cysteine-containing molecules may however be...
COILED-COIL INTERACTIONS | TRIS(2-CARBOXYETHYL)PHOSPHINE TCEP | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEXTRAN | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | CHEMISTRY, MULTIDISCIPLINARY | IMMOBILIZATION | BIOCONJUGATION | REDUCTION | SURFACE | MALEIMIDE | PROTEINS | LIPOSOMES | Oxidation-Reduction | Peptides - chemistry | Polymers - chemical synthesis | Click Chemistry - methods | Sulfhydryl Compounds - chemical synthesis | Alkylation | Reducing Agents - chemical synthesis | Peptides - chemical synthesis | Sulfones - chemistry | Maleimides - chemical synthesis | Polymers - chemistry | Sulfhydryl Compounds - chemistry | Maleimides - chemistry | Reducing Agents - chemistry | Sulfones - chemical synthesis | Analytical chemistry | Phosphates | Coils | Conjugates | Peptides | Phosphine | Alkylating agents | Chemical reactions | Reducing agents | Vinyl sulfone | Molecules | Organic chemistry | Buffers (chemistry) | Oxidation | Conjugation | Polymers | Chemical synthesis | Dithiothreitol
COILED-COIL INTERACTIONS | TRIS(2-CARBOXYETHYL)PHOSPHINE TCEP | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEXTRAN | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | CHEMISTRY, MULTIDISCIPLINARY | IMMOBILIZATION | BIOCONJUGATION | REDUCTION | SURFACE | MALEIMIDE | PROTEINS | LIPOSOMES | Oxidation-Reduction | Peptides - chemistry | Polymers - chemical synthesis | Click Chemistry - methods | Sulfhydryl Compounds - chemical synthesis | Alkylation | Reducing Agents - chemical synthesis | Peptides - chemical synthesis | Sulfones - chemistry | Maleimides - chemical synthesis | Polymers - chemistry | Sulfhydryl Compounds - chemistry | Maleimides - chemistry | Reducing Agents - chemistry | Sulfones - chemical synthesis | Analytical chemistry | Phosphates | Coils | Conjugates | Peptides | Phosphine | Alkylating agents | Chemical reactions | Reducing agents | Vinyl sulfone | Molecules | Organic chemistry | Buffers (chemistry) | Oxidation | Conjugation | Polymers | Chemical synthesis | Dithiothreitol
Journal Article
Journal of Inorganic Biochemistry, ISSN 0162-0134, 01/2013, Volume 118, pp. 140 - 147
Nitroxyl (HNO) has gained interest as a potential treatment of congestive heart failure through the ability of the HNO donor, Angeli's salt (AS), to evoke...
Thiol protein | Nitroxyl | Esterase | Dehydroalanine | Nitric oxide | Heme proteins | ORGANIC-SYNTHESIS | ALDEHYDE DEHYDROGENASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DECOMPOSITION | CYSTEINE | ANGELIS SALT | GUANYLATE-CYCLASE | CHEMISTRY, INORGANIC & NUCLEAR | SODIUM TRIOXODINITRATE | NITRIC-OXIDE | CHEMISTRY | Fungal Proteins - chemistry | Oxidation-Reduction | Solvents - chemistry | Nitrogen Oxides - chemistry | Solubility | Myoglobin - chemistry | Fungal Proteins - antagonists & inhibitors | Chromatography, Gas | Aldehyde Dehydrogenase - chemistry | Metmyoglobin - chemistry | Nitrous Oxide - chemistry | Hydrolysis | Nitroso Compounds - chemical synthesis | Nitroso Compounds - chemistry | Heme - chemistry | Enzyme Inhibitors - chemistry | Nitrogen Dioxide - chemistry | Water - chemistry | Sulfhydryl Compounds - chemistry | Dithiothreitol - chemistry | Kinetics | Nitrogen oxide | Proteins | Thiols | Nitroso compounds | Heme | Hemoproteins | nitroxyl | nitric oxide | esterase | heme proteins | thiol protein | dehydroalanine
Thiol protein | Nitroxyl | Esterase | Dehydroalanine | Nitric oxide | Heme proteins | ORGANIC-SYNTHESIS | ALDEHYDE DEHYDROGENASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DECOMPOSITION | CYSTEINE | ANGELIS SALT | GUANYLATE-CYCLASE | CHEMISTRY, INORGANIC & NUCLEAR | SODIUM TRIOXODINITRATE | NITRIC-OXIDE | CHEMISTRY | Fungal Proteins - chemistry | Oxidation-Reduction | Solvents - chemistry | Nitrogen Oxides - chemistry | Solubility | Myoglobin - chemistry | Fungal Proteins - antagonists & inhibitors | Chromatography, Gas | Aldehyde Dehydrogenase - chemistry | Metmyoglobin - chemistry | Nitrous Oxide - chemistry | Hydrolysis | Nitroso Compounds - chemical synthesis | Nitroso Compounds - chemistry | Heme - chemistry | Enzyme Inhibitors - chemistry | Nitrogen Dioxide - chemistry | Water - chemistry | Sulfhydryl Compounds - chemistry | Dithiothreitol - chemistry | Kinetics | Nitrogen oxide | Proteins | Thiols | Nitroso compounds | Heme | Hemoproteins | nitroxyl | nitric oxide | esterase | heme proteins | thiol protein | dehydroalanine
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 11/2008, Volume 130, Issue 44, pp. 14418 - 14419
A new redox-responsive hybrid nanogated ensemble has been developed by introducing the disulfide-linked polymeric network at the outlet of mesoporous silica....
CORE | NANOPARTICLES | DRUG-DELIVERY | PH-DRIVEN | GUEST MOLECULES | CONTROLLED-RELEASE | BLOCK-COPOLYMER MICELLES | MESOPOROUS SILICA | CROSS-LINKED MICELLES | SUPRAMOLECULAR NANOVALVE | CHEMISTRY, MULTIDISCIPLINARY | Cystamine - chemistry | Oxidation-Reduction | Disulfides - chemistry | X-Ray Diffraction | Silicon Dioxide - chemistry | Nanostructures - chemistry | Dithiothreitol - chemistry | Rhodamines - chemistry | Spectroscopy, Fourier Transform Infrared | Acrylic Resins - chemistry | Succinimides - chemistry | Antioxidants | Oxidation-reduction reaction | Chemical properties | Structure | Silica | Analysis
CORE | NANOPARTICLES | DRUG-DELIVERY | PH-DRIVEN | GUEST MOLECULES | CONTROLLED-RELEASE | BLOCK-COPOLYMER MICELLES | MESOPOROUS SILICA | CROSS-LINKED MICELLES | SUPRAMOLECULAR NANOVALVE | CHEMISTRY, MULTIDISCIPLINARY | Cystamine - chemistry | Oxidation-Reduction | Disulfides - chemistry | X-Ray Diffraction | Silicon Dioxide - chemistry | Nanostructures - chemistry | Dithiothreitol - chemistry | Rhodamines - chemistry | Spectroscopy, Fourier Transform Infrared | Acrylic Resins - chemistry | Succinimides - chemistry | Antioxidants | Oxidation-reduction reaction | Chemical properties | Structure | Silica | Analysis
Journal Article
Biochemistry, ISSN 0006-2960, 07/2009, Volume 48, Issue 26, pp. 6213 - 6223
Mammalian thioredoxin reductase (TR) contains a rare selenocysteine (Sec) residue in a conserved redox-active tetrapeptide of sequence Gly-Cys1-Sec2-Gly. The...
GLUTATHIONE-REDUCTASE | AMINO-ACID | HUMAN PLACENTA | MECHANISM | SELENOENZYME | DROSOPHILA-MELANOGASTER | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | DISULFIDE INTERCHANGE | GLUTAREDOXIN SYSTEMS | Models, Chemical | Thioredoxin-Disulfide Reductase - genetics | Substrate Specificity | Dinitrobenzenes - chemistry | Organoselenium Compounds - chemistry | Cystine - chemistry | Enzyme Inhibitors - chemistry | Gene Deletion | Dithiothreitol - chemistry | Cystine - analogs & derivatives | Thioctic Acid - chemistry | Thioredoxin-Disulfide Reductase - chemistry | Selenium - chemistry | Recombinant Proteins - antagonists & inhibitors | Auranofin - chemistry | Biocatalysis | Selenocysteine - chemistry | Recombinant Proteins - chemistry | Thioredoxin Reductase 2 - antagonists & inhibitors | Thioredoxin Reductase 2 - genetics | Animals | Selenocysteine - genetics | Aurothioglucose - chemistry | Drosophila melanogaster - enzymology | Sodium Selenite - chemistry | Thioredoxin Reductase 2 - chemistry | Glutathione - chemistry | Mice | Thioredoxin-Disulfide Reductase - antagonists & inhibitors | Kinetics | Caenorhabditis elegans - enzymology | Amino Acid Substitution | Hydrogen-Ion Concentration | Selenium compounds | Cysteine | Research | Chemical properties | Structure | Thioredoxin
GLUTATHIONE-REDUCTASE | AMINO-ACID | HUMAN PLACENTA | MECHANISM | SELENOENZYME | DROSOPHILA-MELANOGASTER | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | DISULFIDE INTERCHANGE | GLUTAREDOXIN SYSTEMS | Models, Chemical | Thioredoxin-Disulfide Reductase - genetics | Substrate Specificity | Dinitrobenzenes - chemistry | Organoselenium Compounds - chemistry | Cystine - chemistry | Enzyme Inhibitors - chemistry | Gene Deletion | Dithiothreitol - chemistry | Cystine - analogs & derivatives | Thioctic Acid - chemistry | Thioredoxin-Disulfide Reductase - chemistry | Selenium - chemistry | Recombinant Proteins - antagonists & inhibitors | Auranofin - chemistry | Biocatalysis | Selenocysteine - chemistry | Recombinant Proteins - chemistry | Thioredoxin Reductase 2 - antagonists & inhibitors | Thioredoxin Reductase 2 - genetics | Animals | Selenocysteine - genetics | Aurothioglucose - chemistry | Drosophila melanogaster - enzymology | Sodium Selenite - chemistry | Thioredoxin Reductase 2 - chemistry | Glutathione - chemistry | Mice | Thioredoxin-Disulfide Reductase - antagonists & inhibitors | Kinetics | Caenorhabditis elegans - enzymology | Amino Acid Substitution | Hydrogen-Ion Concentration | Selenium compounds | Cysteine | Research | Chemical properties | Structure | Thioredoxin
Journal Article
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, ISSN 0273-2289, 05/2017, Volume 182, Issue 1, pp. 181 - 196
Plant proteases are capable of performing several functions in biological systems, and their use is attractive for biotechnological process due to their...
STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | Aguama | PROTEINASES | Characterization | PLANT PROTEASES | PEPTIDES | Enzyme stability | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ENZYMES | UNRIPE FRUITS | PURIFICATION | Proteolytic activity | SERINE-PROTEASE | PAPAIN | Bromelia pinguin | LATEX | Plant Extracts - chemistry | Polysorbates - chemistry | Solvents - chemistry | Fruit - enzymology | Cysteine Proteases - isolation & purification | Aspartic Acid Proteases - chemistry | Bromelia - enzymology | Plant Proteins - chemistry | Proteolysis | Plant Proteins - antagonists & inhibitors | Serine Proteases - chemistry | Dithiothreitol - chemistry | Bromelia - chemistry | Cysteine Proteases - chemistry | Plant Proteins - isolation & purification | Fruit - chemistry | Protease Inhibitors - chemistry | Enzyme Assays | Aspartic Acid Proteases - isolation & purification | Mercaptoethanol - chemistry | Sodium Dodecyl Sulfate - chemistry | Serine Proteases - isolation & purification | Aspartic Acid Proteases - antagonists & inhibitors | Kinetics | Hydrogen-Ion Concentration | Usage | Detergents, Synthetic | Cysteine | Protease inhibitors | Fruit | Proteases | Analysis | Digital television | Solvents | Enzymes | Ethanol | Organic solvents | Serine | Proteinase inhibitors | Brewing | Reducing agents | Propanol | Surfactants | pH effects | Fruits | Plant extracts | Hydrogen ions | Pollutants | Breweries | Dithiothreitol | Acetone | Methanol
STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | Aguama | PROTEINASES | Characterization | PLANT PROTEASES | PEPTIDES | Enzyme stability | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ENZYMES | UNRIPE FRUITS | PURIFICATION | Proteolytic activity | SERINE-PROTEASE | PAPAIN | Bromelia pinguin | LATEX | Plant Extracts - chemistry | Polysorbates - chemistry | Solvents - chemistry | Fruit - enzymology | Cysteine Proteases - isolation & purification | Aspartic Acid Proteases - chemistry | Bromelia - enzymology | Plant Proteins - chemistry | Proteolysis | Plant Proteins - antagonists & inhibitors | Serine Proteases - chemistry | Dithiothreitol - chemistry | Bromelia - chemistry | Cysteine Proteases - chemistry | Plant Proteins - isolation & purification | Fruit - chemistry | Protease Inhibitors - chemistry | Enzyme Assays | Aspartic Acid Proteases - isolation & purification | Mercaptoethanol - chemistry | Sodium Dodecyl Sulfate - chemistry | Serine Proteases - isolation & purification | Aspartic Acid Proteases - antagonists & inhibitors | Kinetics | Hydrogen-Ion Concentration | Usage | Detergents, Synthetic | Cysteine | Protease inhibitors | Fruit | Proteases | Analysis | Digital television | Solvents | Enzymes | Ethanol | Organic solvents | Serine | Proteinase inhibitors | Brewing | Reducing agents | Propanol | Surfactants | pH effects | Fruits | Plant extracts | Hydrogen ions | Pollutants | Breweries | Dithiothreitol | Acetone | Methanol
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 09/2012, Volume 53, Issue 6, pp. 1308 - 1316
Singlet oxygen ( O ) is a reactive oxygen species generated during photo-oxidation, inflammation, and via peroxidase-catalyzed reactions (e.g., myeloperoxidase...
Glutathione peroxidase | Photo-oxidation | Singlet oxygen | Dehydroalanine | Selenium | Thioredoxin reductase | Rose Bengal | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEDIATED PROTEIN OXIDATION | DAMAGE | SINGLET MOLECULAR-OXYGEN | SIDE-CHAIN PEROXIDES | AMINO-ACIDS | RATE CONSTANTS | ENDOCRINOLOGY & METABOLISM | CHEMISTRY | HYDROPEROXIDES | PHOTOOXIDATION | Cell Line | Protein Carbonylation - radiation effects | Oxidation-Reduction | Free Radical Scavengers - chemistry | Rats | Cell Extracts - chemistry | Enzyme Stability - drug effects | Protein Carbonylation - drug effects | Hydrogen Peroxide - chemistry | Oxidants, Photochemical - chemistry | Rose Bengal - chemistry | Animals | Borohydrides - chemistry | Glutathione Peroxidase - chemistry | Photolysis | Singlet Oxygen - chemistry | Cattle | Methionine - chemistry | Glutathione - chemistry | Mice | Dithiothreitol - chemistry | Enzyme Stability - radiation effects | Reducing Agents - chemistry | Thioredoxin-Disulfide Reductase - chemistry | Antioxidants | Heavy water | Thiols | Peptides | Active oxygen | Peroxidase | Thioredoxin
Glutathione peroxidase | Photo-oxidation | Singlet oxygen | Dehydroalanine | Selenium | Thioredoxin reductase | Rose Bengal | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEDIATED PROTEIN OXIDATION | DAMAGE | SINGLET MOLECULAR-OXYGEN | SIDE-CHAIN PEROXIDES | AMINO-ACIDS | RATE CONSTANTS | ENDOCRINOLOGY & METABOLISM | CHEMISTRY | HYDROPEROXIDES | PHOTOOXIDATION | Cell Line | Protein Carbonylation - radiation effects | Oxidation-Reduction | Free Radical Scavengers - chemistry | Rats | Cell Extracts - chemistry | Enzyme Stability - drug effects | Protein Carbonylation - drug effects | Hydrogen Peroxide - chemistry | Oxidants, Photochemical - chemistry | Rose Bengal - chemistry | Animals | Borohydrides - chemistry | Glutathione Peroxidase - chemistry | Photolysis | Singlet Oxygen - chemistry | Cattle | Methionine - chemistry | Glutathione - chemistry | Mice | Dithiothreitol - chemistry | Enzyme Stability - radiation effects | Reducing Agents - chemistry | Thioredoxin-Disulfide Reductase - chemistry | Antioxidants | Heavy water | Thiols | Peptides | Active oxygen | Peroxidase | Thioredoxin
Journal Article
ACS Nano, ISSN 1936-0851, 05/2014, Volume 8, Issue 5, pp. 4790 - 4798
Rheumatoid arthritis (RA) is a chronic inflammatory immune disease causing the inflammation of synovial membrane and the articular cartilage destruction. In...
tocilizumab | drug delivery | gold nanoparticle | rheumatoid arthritis | hyaluronic acid | COLLAGEN-INDUCED ARTHRITIS | ACID | RECEPTOR INHIBITION | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | NANOPARTICLES | THERAPY | DISEASE | Gold - chemistry | Human Umbilical Vein Endothelial Cells | Inflammation - pathology | Microscopy, Electron, Transmission | Enzyme-Linked Immunosorbent Assay | Magnetic Resonance Spectroscopy | Nanotechnology - methods | Humans | Interleukin-6 - chemistry | Metal Nanoparticles - chemistry | Hyaluronic Acid - chemistry | Collagen - chemistry | Synovial Membrane - drug effects | Spectrophotometry, Ultraviolet | Cartilage, Articular - pathology | Animals | Antibodies, Monoclonal, Humanized - administration & dosage | Arthritis, Rheumatoid - drug therapy | Light | Cartilage - chemistry | Mice, Inbred DBA | Mice | Dithiothreitol - chemistry | Immunosuppressive Agents - chemistry
tocilizumab | drug delivery | gold nanoparticle | rheumatoid arthritis | hyaluronic acid | COLLAGEN-INDUCED ARTHRITIS | ACID | RECEPTOR INHIBITION | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | NANOPARTICLES | THERAPY | DISEASE | Gold - chemistry | Human Umbilical Vein Endothelial Cells | Inflammation - pathology | Microscopy, Electron, Transmission | Enzyme-Linked Immunosorbent Assay | Magnetic Resonance Spectroscopy | Nanotechnology - methods | Humans | Interleukin-6 - chemistry | Metal Nanoparticles - chemistry | Hyaluronic Acid - chemistry | Collagen - chemistry | Synovial Membrane - drug effects | Spectrophotometry, Ultraviolet | Cartilage, Articular - pathology | Animals | Antibodies, Monoclonal, Humanized - administration & dosage | Arthritis, Rheumatoid - drug therapy | Light | Cartilage - chemistry | Mice, Inbred DBA | Mice | Dithiothreitol - chemistry | Immunosuppressive Agents - chemistry
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2003, Volume 125, Issue 15, pp. 4451 - 4459
An MCM-41 type mesoporous silica nanosphere-based (MSN) controlled-release delivery system has been synthesized and characterized using surface-derivatized...
IN-VITRO RELEASE | ANTIBIOTICS | SIEVES | VANCOMYCIN | SURFACE | SOL-GEL | CULTURED ASTROCYTES | MCM-41 | ENZYME IMMOBILIZATION | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | Silicon Dioxide - administration & dosage | Adenosine Triphosphate - administration & dosage | Biocompatible Materials - chemistry | Sulfides - chemistry | Sulfides - administration & dosage | Drug Carriers | Vancomycin - chemistry | Dithiothreitol - administration & dosage | Dithiothreitol - chemistry | Astrocytes - drug effects | Cadmium Compounds - administration & dosage | Vancomycin - administration & dosage | Cadmium Compounds - chemistry | Silicon Dioxide - chemical synthesis | Silicon Dioxide - chemistry | Cells, Cultured | Rats | Mercaptoethanol - administration & dosage | Particle Size | Neurotransmitter Agents - chemistry | Animals | Mercaptoethanol - chemistry | Biocompatible Materials - administration & dosage | Neurotransmitter Agents - administration & dosage | Adenosine Triphosphate - chemistry | Delayed-Action Preparations | Astrocytes - metabolism | Chemical bonds | Drug delivery systems | Product development | Observations
IN-VITRO RELEASE | ANTIBIOTICS | SIEVES | VANCOMYCIN | SURFACE | SOL-GEL | CULTURED ASTROCYTES | MCM-41 | ENZYME IMMOBILIZATION | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | Silicon Dioxide - administration & dosage | Adenosine Triphosphate - administration & dosage | Biocompatible Materials - chemistry | Sulfides - chemistry | Sulfides - administration & dosage | Drug Carriers | Vancomycin - chemistry | Dithiothreitol - administration & dosage | Dithiothreitol - chemistry | Astrocytes - drug effects | Cadmium Compounds - administration & dosage | Vancomycin - administration & dosage | Cadmium Compounds - chemistry | Silicon Dioxide - chemical synthesis | Silicon Dioxide - chemistry | Cells, Cultured | Rats | Mercaptoethanol - administration & dosage | Particle Size | Neurotransmitter Agents - chemistry | Animals | Mercaptoethanol - chemistry | Biocompatible Materials - administration & dosage | Neurotransmitter Agents - administration & dosage | Adenosine Triphosphate - chemistry | Delayed-Action Preparations | Astrocytes - metabolism | Chemical bonds | Drug delivery systems | Product development | Observations
Journal Article