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Journal of Biological Chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 14, pp. 9101 - 9112
Aldose reductase (AR) catalyzes the reduction of several aldehydes ranging from lipid peroxidation products to glucose. The activity of AR is increased in the... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Imidazolidines - pharmacology | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Metalloporphyrins - pharmacology | Myocardial Reperfusion Injury - enzymology | Myocardial Reperfusion Injury - pathology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Nitric Oxide Synthase Type I - antagonists & inhibitors | Lipid Peroxidation - drug effects | Aldehyde Reductase - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Bradykinin - pharmacology | Dithiothreitol - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Insulin - pharmacology | Aldehyde Reductase - antagonists & inhibitors | Vasodilator Agents - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Ferric Compounds - pharmacology | Myocardium - pathology | Enzyme Activation - drug effects | Hypoglycemic Agents - pharmacology | Naphthalenes - pharmacology | Myocardium - enzymology | Animals | Signal Transduction - drug effects | Nitric Oxide Synthase Type I - metabolism | Peroxynitrous Acid - metabolism | Glucose - metabolism | Hesperidin - pharmacology | Nitric Oxide - metabolism | Sorbitol - pharmacology | Nitric Oxide Synthase Type II - metabolism | Index Medicus | Enzyme Catalysis and Regulation
Journal Article
Journal Article
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 06/2007, Volume 321, Issue 3, pp. 830 - 838
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 12/2003, Volume 285, Issue 6, pp. 2316 - 2326
Journal Article
The EMBO journal, ISSN 0261-4189, 10/1996, Volume 15, Issue 19, pp. 5256 - 5267
Journal Article
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 12/2007, Volume 293, Issue 6, pp. 3720 - 3725
Journal Article
Journal Article
Biochemical journal, ISSN 0264-6021, 06/2006, Volume 396, Issue 3, pp. 537 - 545
P-glycoprotein (P-gp; ABCB1) actively transports a broad range of structurally unrelated compounds out of the cell. An important step in the transport cycle is... 
Cysteine-scanning mutagenesis | P-glycoprotein | Drug transport | Drug-binding pocket | Transmembrane segment 1 (TM1) | Protein modification | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Fluoresceins - pharmacology | Colchicine - pharmacology | Cyclosporine - pharmacology | Humans | Verapamil - analogs & derivatives | Binding Sites - physiology | Disulfides - analysis | Flupenthixol - pharmacology | Binding Sites - drug effects | Dithiothreitol - pharmacology | Amino Acid Sequence | Cell Line | Cricetinae | Demecolcine - pharmacology | Adenosine Triphosphatases - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - physiology | Verapamil - pharmacology | Point Mutation | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Mesylates - pharmacology | Vinblastine - pharmacology | Verapamil - metabolism | Amino Acid Substitution | Protein Structure, Tertiary - physiology | Index Medicus | P-gp, P-glycoprotein | cysteine-scanning mutagenesis | drug transport | protein modification | TMD, TM domain | TBS, Tris-buffered saline | DTT, dithiothreitol | NBD, nucleotide-binding domain | drug-binding pocket | M11M, 3,6,9-trioxaundecane-1,11-diyl bismethanethiosulphonate | calcein-AM, calcein acetoxymethyl ester | TMD2, C-terminal TMD containing TM7–TM12 | PXR, pregnane X receptor | M4M, 1,4-butanediyl bismethanethiosulphonate | ABC transporter, ATP-binding-cassette transporter | M8M, 3,6-dioxaoctane-1,8-diyl bismethanethiosulphonate | BHK cell, baby hamster kidney cell | TM, transmembrane | TMD1, N-terminal TMD containing TM1–TM6 | HEK-293 cell, human embryonic kidney 293 cell | TM1 (etc.), TM segment 1 (etc.) | transmembrane segment 1 (TM1) | M17M, 3,6,9,12,15-pentaoxaheptadecane-1,17-diyl bismethanethiosulphonate | MTS, methanethiosulphonate
Journal Article
Journal of pharmacological sciences, ISSN 1347-8613, 05/2019, Volume 140, Issue 1, pp. 43 - 47
This study investigated the effects of thiol and heme oxidants on responsiveness to cGMP generators in isolated rat aorta and pulmonary artery using an organ... 
Heme oxidation | Thiol oxidation | Vasorelaxation | Nitric oxide | Soluble guanylate cyclase | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Oxidants - pharmacology | Vasodilator Agents - pharmacology | Oxidative Stress | Rats, Wistar | Soluble Guanylyl Cyclase - metabolism |