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British Journal of Pharmacology, ISSN 0007-1188, 10/2007, Volume 152, Issue 4, pp. 471 - 480
Background and purpose: Licofelone is a dual inhibitor of the cyclooxygenase and 5- lipoxygenase ( 5- LO) pathway, and has been developed for the treatment of... 
arachidonic acid | polymorphonuclear leukocytes | 5‐lipoxygenase‐activating protein | inflammation | leukotriene | 5‐lipoxygenase | Leukotriene | Polymorphonuclear leukocytes | 5-lipoxygenase-activating protein | Inflammation | 5-lipoxygenase | Arachidonic acid | TRANSLOCATION | PROTEIN | MONO-MAC-6 CELLS | PHOSPHORYLATION | ARACHIDONIC-ACID | CYCLOOXYGENASE | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | POTENT | LEUKOTRIENE SYNTHESIS INHIBITORS | PHARMACOLOGICAL PROFILE | PHARMACOLOGY & PHARMACY | Arsenites - pharmacology | Neutrophils - cytology | Arachidonate 5-Lipoxygenase - genetics | Humans | Acetates - chemistry | Quinolines - pharmacology | Dose-Response Relationship, Drug | Leukotrienes - chemistry | Transfection | Leukotriene Antagonists - pharmacology | Indoles - pharmacology | Molecular Structure | Neutrophils - metabolism | Dithiothreitol - pharmacology | Calcium - pharmacology | Arachidonate 5-Lipoxygenase - metabolism | Bridged Bicyclo Compounds - pharmacology | Carrier Proteins - biosynthesis | Neutrophils - drug effects | Carrier Proteins - antagonists & inhibitors | Cells, Cultured | Leukotrienes - biosynthesis | Sodium Compounds - pharmacology | Calcimycin - pharmacology | Nuclear Envelope - metabolism | Membrane Proteins - biosynthesis | Nuclear Envelope - drug effects | Pyrroles - pharmacology | Cell-Free System | Membrane Proteins - antagonists & inhibitors | 5-Lipoxygenase-Activating Proteins | Arachidonic Acid - chemistry | Arachidonic Acid - pharmacology | Pyrroles - chemistry | Acetates - pharmacology | HeLa Cells | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Research Papers
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 14, pp. 9101 - 9112
Aldose reductase (AR) catalyzes the reduction of several aldehydes ranging from lipid peroxidation products to glucose. The activity of AR is increased in the... 
S-NITROSYLATION | MOUSE HEART | LATE-PHASE | PEROXYNITRITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | MYOCARDIAL-CONTRACTILITY | SMOOTH-MUSCLE-CELLS | RAT-HEART | AKT | PROTEIN-SULFENIC ACIDS | Imidazolidines - pharmacology | Male | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Metalloporphyrins - pharmacology | Myocardial Reperfusion Injury - enzymology | Myocardial Reperfusion Injury - pathology | Nitric Oxide Synthase Type II - antagonists & inhibitors | Nitric Oxide Synthase Type I - antagonists & inhibitors | Lipid Peroxidation - drug effects | Aldehyde Reductase - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Bradykinin - pharmacology | Dithiothreitol - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Insulin - pharmacology | Aldehyde Reductase - antagonists & inhibitors | Vasodilator Agents - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Ferric Compounds - pharmacology | Myocardium - pathology | Enzyme Activation - drug effects | Hypoglycemic Agents - pharmacology | Naphthalenes - pharmacology | Myocardium - enzymology | Animals | Signal Transduction - drug effects | Nitric Oxide Synthase Type I - metabolism | Peroxynitrous Acid - metabolism | Glucose - metabolism | Hesperidin - pharmacology | Nitric Oxide - metabolism | Sorbitol - pharmacology | Nitric Oxide Synthase Type II - metabolism | Index Medicus | Enzyme Catalysis and Regulation
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2009, Volume 53, Issue 9, pp. 3675 - 3682
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2014, Volume 445, Issue 1, pp. 30 - 35
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 2007, Volume 165, Issue 2, pp. 127 - 137
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 05/1994, Volume 14, Issue 5, pp. 2924 - 2932
Formation of reactive oxygen species and disfunction of the excitatory amino acid (EAA) system are thought to be key events in the development of neuronal... 
antioxidants | disulfide-reducing agents | glutamate uptake | protein thiol groups | astrocytes | excitotoxicity | redox modulation | oxygen free radicals | TISSUE-INJURY | NMDA RECEPTOR | ANTIOXIDANTS | PROTEIN THIOL GROUPS | LIPID-PEROXIDATION | INVITRO ANOXIA | NEURONAL INJURY | BRAIN SYNAPTOSOMES | GLUTAMATE UPTAKE | ASTROCYTES | NEUROSCIENCES | EXCITOTOXICITY | AMINO-ACIDS | CENTRAL-NERVOUS-SYSTEM | OXYGEN FREE RADICALS | RETINAL GLIAL-CELLS | DISULFIDE-REDUCING AGENTS | REDOX MODULATION | METHYL-D-ASPARTATE | Catalase - pharmacology | 2-Amino-5-phosphonovalerate - pharmacology | Free Radical Scavengers | Glutamates - metabolism | Xanthines - pharmacology | Cerebral Cortex - metabolism | Quinoxalines - pharmacology | Glutathione - pharmacology | Time Factors | Dithionitrobenzoic Acid - pharmacology | L-Lactate Dehydrogenase - analysis | Ethylmaleimide - pharmacology | Biological Transport - drug effects | Dithiothreitol - pharmacology | Animals, Newborn | 6-Cyano-7-nitroquinoxaline-2,3-dione | Astrocytes - drug effects | Superoxide Dismutase - pharmacology | Xanthine Oxidase - pharmacology | Cells, Cultured | Hydrogen Peroxide - pharmacology | Rats | Antioxidants - pharmacology | Xanthine | Glutamic Acid | Animals | p-Chloromercuribenzoic Acid | Free Radicals - pharmacology | Kinetics | Chloromercuribenzoates - pharmacology | Astrocytes - metabolism
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 03/2012, Volume 679, Issue 1-3, pp. 40 - 50
We previously reported that both nitric oxide (NO) generated from NO synthase by bombesin and NO generated from SIN-1 (NO donor) activate the brain... 
S-Nitrosylation | Brain | Adrenomedullary outflow | Bombesin | Cyclooxygenase-1 | Nitric oxide | POTASSIUM CHANNELS | NITRIC-OXIDE SYNTHASE | SYMPATHETIC PREGANGLIONIC NEURONS | THORACIC SPINAL-CORD | DORSAL VAGAL COMPLEX | PARAVENTRICULAR NUCLEUS | PLASMA NORADRENALINE | PHARMACOLOGY & PHARMACY | GASTRIC-ACID SECRETION | CENTRAL-NERVOUS-SYSTEM | THROMBOXANE A | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - administration & dosage | Cysteine - analogs & derivatives | Oxadiazoles - administration & dosage | Rats, Wistar | Injections, Intraventricular | Imidazoles - administration & dosage | Male | Molsidomine - analogs & derivatives | Molsidomine - administration & dosage | S-Nitrosothiols - metabolism | Bombesin - administration & dosage | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Bombesin - pharmacology | Oxadiazoles - pharmacology | Dithiothreitol - administration & dosage | Sulfhydryl Reagents - administration & dosage | Ethylmaleimide - pharmacology | Adrenal Medulla - drug effects | Cysteine - metabolism | Nitric Oxide Donors - pharmacology | Dithiothreitol - pharmacology | Quinoxalines - administration & dosage | Rats | Imidazoles - pharmacology | Catecholamines - blood | Benzoates - administration & dosage | Brain - drug effects | Nitric Oxide Donors - administration & dosage | Paraventricular Hypothalamic Nucleus - drug effects | Adrenal Medulla - secretion | Animals | Bombesin - antagonists & inhibitors | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Molsidomine - pharmacology | Paraventricular Hypothalamic Nucleus - metabolism | Benzoates - pharmacology | Molsidomine - antagonists & inhibitors | Sulfhydryl Reagents - pharmacology | Ethylmaleimide - administration & dosage | Nitrogen oxide | Cysteine | Catecholamines | Neuropeptides | Cells | Thromboxanes | Thiols | Neurons | Adrenal medulla | Thromboxane A2 | Hypothalamus | Paraventricular nucleus | Guanylate cyclase | Nitric-oxide synthase | Dithiothreitol | N-Ethylmaleimide
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2010, Volume 49, Issue 12, pp. 1969 - 1977
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2007, Volume 321, Issue 3, pp. 830 - 838
Transient receptor potential vanilloid 1 (TRPV1) is a calcium-selective ion channel expressed in human lung cells. We show that activation of the intracellular... 
UNFOLDED PROTEIN RESPONSE | EPITHELIAL-CELLS | ER STRESS | INFLAMMATION | PHARMACOLOGY & PHARMACY | INITIATION-FACTOR 2 | HYDROGEN-SULFIDE | TRPV1 | RECEPTOR POTENTIAL VANILLOID-1 | PEPPER-SPRAY | CAPSAICIN | Transcription Factor CHOP - genetics | Epithelial Cells - metabolism | Gene Expression - drug effects | Calcium - metabolism | Capsaicin - pharmacology | Epithelial Cells - drug effects | Humans | Cyclins - genetics | Endoplasmic Reticulum - metabolism | Thiourea - pharmacology | Lung - cytology | Transfection | TRPV Cation Channels - antagonists & inhibitors | Endoplasmic Reticulum - drug effects | Eukaryotic Initiation Factor-2 - metabolism | Lung - metabolism | Phosphorylation - drug effects | Epithelial Cells - cytology | Endocannabinoids | Activating Transcription Factor 3 - genetics | Dithiothreitol - pharmacology | Diterpenes - pharmacology | Cell Line | Cell Survival - drug effects | Cyclin G2 | TRPV Cation Channels - agonists | Cells, Cultured | Enzyme Inhibitors - pharmacology | Capsaicin - analogs & derivatives | Cinnamates - pharmacology | Arachidonic Acids - pharmacology | TRPV Cation Channels - genetics | Cyclin D1 - genetics | Eukaryotic Initiation Factor-2 - genetics | Polyunsaturated Alkamides - pharmacology | Cell Line, Tumor | Thapsigargin - pharmacology | Transcription Factor CHOP - metabolism | Thiourea - analogs & derivatives
Journal Article