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Nature, ISSN 0028-0836, 05/2001, Volume 411, Issue 6835, pp. 321 - 325
Wnt glycoproteins have been implicated in diverse processes during embryonic patterning in metazoa. They signal through frizzled-type... 
SIGNAL-TRANSDUCTION | CERBERUS | ACTIVATION | XENOPUS | ANTAGONIST | HEAD INDUCTION | MULTIDISCIPLINARY SCIENCES | SECRETED PROTEINS | WNT | EXPRESSION | SPEMANN ORGANIZER | Receptors, Immunologic - chemistry | Cytoskeletal Proteins - genetics | Humans | Embryo, Nonmammalian - metabolism | Substrate Specificity | Embryo, Nonmammalian - embryology | Wnt Proteins | RNA, Messenger - metabolism | Receptors, LDL - chemistry | Recombinant Fusion Proteins - metabolism | Receptors, Immunologic - antagonists & inhibitors | Recombinant Fusion Proteins - antagonists & inhibitors | Cytoskeletal Proteins - metabolism | Low Density Lipoprotein Receptor-Related Protein-1 | Head - embryology | Binding Sites | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Cell Line | Proto-Oncogene Proteins - antagonists & inhibitors | Receptors, LDL - genetics | Xenopus laevis - embryology | Low Density Lipoprotein Receptor-Related Protein-6 | Signal Transduction | beta Catenin | Intercellular Signaling Peptides and Proteins | RNA, Messenger - genetics | Receptors, LDL - antagonists & inhibitors | Trans-Activators | Zebrafish Proteins | Receptors, Cell Surface - metabolism | Receptors, LDL - metabolism | Embryonic Induction | Proto-Oncogene Proteins - genetics | Xenopus Proteins | Precipitin Tests | Proteins - genetics | Animals | Proteins - metabolism | Protein Binding | Proteins - chemistry | Receptors, Immunologic - genetics | Proteins - antagonists & inhibitors | Receptors, Immunologic - metabolism | Receptors, Cell Surface - genetics | Sequence Deletion - genetics | Proteins | Cellular biology | Embryos | Genes | Patterning | Receptors | Inhibitors | Modulation | Signalling | Inducers | Dkk2 protein | b-catenin | LDL-receptor-related protein 6 | Wnt protein | LRP6 protein | Dkk1 protein | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 12/2016, Volume 134, Issue 24, pp. 1991 - 2007
BACKGROUND:Myocardial infarction is one of the leading causes of morbidity and mortality worldwide, triggering irreversible myocardial cell damage and heart... 
beta-catenin | insulin-like growth factor binding protein 4 | Dkk1 protein, mouse | low-density lipoprotein receptor-related proteins 5 and 6 | myocardial infarction | ischemia | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | HEART-FAILURE | DNA-DAMAGE | DOWN-REGULATION | RECEPTOR | LRP6 | SIGNAL-TRANSDUCTION | mouse | PATHWAY | PERIPHERAL VASCULAR DISEASE | Dkk1 protein | PROTEINS | Recombinant Proteins - therapeutic use | Myocardial Ischemia - metabolism | Low Density Lipoprotein Receptor-Related Protein-5 - genetics | Insulin-Like Growth Factor Binding Protein 4 - pharmacology | Male | Recombinant Proteins - biosynthesis | Wnt Proteins - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 - genetics | RNA Interference | Low Density Lipoprotein Receptor-Related Protein-5 - antagonists & inhibitors | Disease Models, Animal | DNA Damage - drug effects | Hydrogen Peroxide - toxicity | Myocytes, Cardiac - cytology | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Myocardial Ischemia - prevention & control | Recombinant Proteins - pharmacology | Down-Regulation - drug effects | Low Density Lipoprotein Receptor-Related Protein-6 - antagonists & inhibitors | Insulin-Like Growth Factor Binding Protein 4 - genetics | beta Catenin - metabolism | beta Catenin - genetics | Mice, Knockout | Myocardial Ischemia - pathology | Low Density Lipoprotein Receptor-Related Protein-6 - metabolism | Animals | Wnt Signaling Pathway - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | beta Catenin - antagonists & inhibitors | Low Density Lipoprotein Receptor-Related Protein-5 - metabolism | Myocytes, Cardiac - metabolism | Intercellular Signaling Peptides and Proteins - therapeutic use | Mice | Histones - metabolism | Wnt Proteins - antagonists & inhibitors | Insulin-Like Growth Factor Binding Protein 4 - therapeutic use | RNA, Small Interfering - metabolism | Heart failure | Catenanes | Care and treatment | Research | Index Medicus | Abridged Index Medicus
Journal Article
Cell Death and Disease, ISSN 2041-4889, 2016, Volume 7, Issue 2, pp. e2119 - e2119
The Wnt inhibitor Dickkopf-1 (DKK-1) has been associated with the occurrence of bone metastases in osteotropic prostate cancer by inhibiting... 
MULTIPLE-MYELOMA | BREAST-CANCER | APOPTOSIS | ACTIVATED PROTEIN-KINASE | OSTEOBLAST DIFFERENTIATION | BONE METASTASES | PATHWAY | ANTAGONIST DKK1 | STRESS-RESPONSE | EXPRESSION | CELL BIOLOGY | Wnt3A Protein - metabolism | Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors | Humans | Male | RNA, Messenger - metabolism | Mitogen-Activated Protein Kinase 12 - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Mitogen-Activated Protein Kinase 11 - metabolism | Prostatic Neoplasms | Antibodies, Neutralizing - immunology | Mitogen-Activated Protein Kinase 12 - metabolism | Mitogen-Activated Protein Kinase 14 - metabolism | RNA Interference | Cell Differentiation | p38 Mitogen-Activated Protein Kinases - metabolism | Pyrazoles - pharmacology | Mitogen-Activated Protein Kinase 11 - genetics | Mitogen-Activated Protein Kinase 12 - antagonists & inhibitors | Wnt3A Protein - genetics | Intercellular Signaling Peptides and Proteins - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | Mitogen-Activated Protein Kinase 11 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 14 - genetics | Down-Regulation - drug effects | Naphthalenes - pharmacology | Signal Transduction - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Pyridines - pharmacology | RNA, Small Interfering | Intercellular Signaling Peptides and Proteins - immunology | Proteins | Metastasis | Cellular biology | Kinases | Prostate cancer | Index Medicus | Original
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 2, pp. e89525 - e89525
Magnesium reduces vascular smooth muscle cell (VSMC) calcification in vitro but the mechanism has not been revealed so far. This work used only slightly... 
SEVELAMER | HOMEOSTASIS | CORONARY-ARTERY CALCIFICATION | BINDER | MULTIDISCIPLINARY SCIENCES | CALCIUM | HEMODIALYSIS-PATIENTS | PARATHYROID-HORMONE | PHOSPHATE-INDUCED CALCIFICATION | CHRONIC KIDNEY-DISEASE | MODULATION | Muscle, Smooth, Vascular - metabolism | Humans | Protein-Serine-Threonine Kinases | Wnt Proteins - metabolism | Vascular Calcification - metabolism | Wnt Proteins - genetics | Osteoprotegerin - genetics | Real-Time Polymerase Chain Reaction | Extracellular Matrix Proteins - metabolism | Muscle, Smooth, Vascular - drug effects | Calcium-Binding Proteins - metabolism | Boron Compounds - pharmacology | Extracellular Matrix Proteins - genetics | Osteogenesis - drug effects | RNA, Messenger - genetics | Cells, Cultured | Vascular Calcification - drug therapy | Magnesium - pharmacology | Muscle, Smooth, Vascular - cytology | Reverse Transcriptase Polymerase Chain Reaction | beta Catenin - metabolism | beta Catenin - genetics | TRPM Cation Channels - antagonists & inhibitors | Signal Transduction - drug effects | beta Catenin - antagonists & inhibitors | TRPM Cation Channels - genetics | TRPM Cation Channels - metabolism | Osteoprotegerin - metabolism | Wnt Proteins - antagonists & inhibitors | Calcium-Binding Proteins - genetics | Calcification (ectopic) | Phosphates | Transformation | Transcription factors | Wnt protein | Calcium | Frizzled protein | Homeostasis | Smooth muscle | Activation | Kinases | Osteoprotegerin | Proteins | Transient receptor potential proteins | β-catenin | Signal transduction | Biomedical materials | Biocompatibility | Magnesium | Inhibition | Translocation | Cbfa-1 protein | Muscles | siRNA | Gene expression | Studies | Signaling | Lymphocytes B | Calcification | Transport | Dkk1 protein | Apoptosis | Index Medicus
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 09/2017, Volume 19, Issue 10, pp. 1274 - 1285
Metastatic cancer is a systemic disease, and metastasis determinants might elicit completely different effects in various target organs. Here we show that... 
CELLS | INVASION | WNT/BETA-CATENIN | PATHWAY | GENES | DICKKOPF-1 | INDUCTION | BETA-CATENIN | CARCINOMA | FAMILY | CELL BIOLOGY | Humans | Lung Neoplasms - metabolism | Transforming Growth Factor beta1 - metabolism | Bone Neoplasms - secondary | JNK Mitogen-Activated Protein Kinases - metabolism | NF-kappa B - metabolism | Molecular Targeted Therapy | Neutrophil Infiltration | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Transfection | Lung Neoplasms - secondary | RNA Interference | Time Factors | Female | Antineoplastic Agents - pharmacology | Bone Neoplasms - genetics | Neuropeptides - genetics | Neutrophils - metabolism | Calcium Signaling | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Latent TGF-beta Binding Proteins - metabolism | Neutrophils - pathology | Lung Neoplasms - genetics | Macrophages - pathology | Mice, Inbred C57BL | Intercellular Signaling Peptides and Proteins - genetics | Neuropeptides - metabolism | Mice, SCID | Breast Neoplasms - drug therapy | Cell Movement - drug effects | Osteoblasts - pathology | Macrophages - metabolism | Animals | Breast Neoplasms - genetics | Wnt Signaling Pathway - drug effects | Lung Neoplasms - prevention & control | Bone Neoplasms - prevention & control | Breast Neoplasms - pathology | Cyclooxygenase 2 - metabolism | Mice, Inbred NOD | Mice, Inbred BALB C | HeLa Cells | Osteoblasts - metabolism | rac1 GTP-Binding Protein - metabolism | rac1 GTP-Binding Protein - genetics | Wnt protein | Lung | Lung cancer | Metastasis | Macrophages | Osteoblasts | Metastases | Recruitment | Calcium signalling | Biomedical materials | Biocompatibility | Secretion | Organs | Rac1 protein | JNK protein | Breast cancer | Bone cancer | Lungs | Breast | Bone | Dkk1 protein | Organotropism | Cancer | Tumors | Ca2+/calmodulin-dependent protein kinase II | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, pp. e0161682 - e0161682
Wnt/beta-catenin signaling is relatively understudied in immunity and autoimmunity. beta-catenin blocks inflammatory mediators and favors tolerogenic dendritic... 
ADHESION | DENDRITIC CELLS | GENE | PATHWAY | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | MICE | E-CADHERIN | MUTATIONS | WNT | NF-KAPPA-B | Leukocytes - pathology | Spleen - immunology | Axin Protein - genetics | Dendritic Cells - immunology | Humans | Dendritic Cells - pathology | Male | Wnt Proteins - metabolism | Axin Protein - metabolism | Intercellular Signaling Peptides and Proteins - blood | Leukocytes - immunology | beta Catenin - immunology | Wnt Proteins - genetics | Axin Protein - immunology | Gene Deletion | Lupus Erythematosus, Systemic - immunology | Female | Spleen - pathology | Macrophages - immunology | Wnt Signaling Pathway | Disease Models, Animal | Follistatin-Related Proteins - genetics | Follistatin-Related Proteins - metabolism | Macrophages - pathology | Mice, Inbred C57BL | beta Catenin - deficiency | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | beta Catenin - genetics | Wnt Proteins - immunology | Animals | Follistatin-Related Proteins - immunology | Lupus Erythematosus, Systemic - genetics | Mice | Lupus Erythematosus, Systemic - pathology | Intercellular Signaling Peptides and Proteins - immunology | Autoimmunity | Care and treatment | Systemic lupus erythematosus | Dendritic cells | Analysis | Hepatoma | Diagnosis | Research | Macrophages | Wnt protein | Disease | Leukocytes | Immunity | Cell adhesion & migration | β-catenin | Engineering | Immunology | Clonal deletion | Rodents | Deletion | Biomedical engineering | Lupus | Myeloid cells | Kidneys | Internal medicine | Rheumatic diseases | Inflammation | Preempting | Patients | Human subjects | White blood cells | Medicine | Serum levels | Signaling | Chronic conditions | Insects | Mutation | Autoimmune diseases | Dkk1 protein | Index Medicus
Journal Article
Immunology, ISSN 0019-2805, 10/2017, Volume 152, Issue 2, pp. 265 - 275
Induction of tolerance is a key mechanism to maintain or to restore immunological homeostasis. Here we show that Foxp3 + regulatory T (Treg) cells use... 
regulatory T cells | Dickkopf‐1 | autoimmune colitis | Dickkopf-1 | THERAPY | RECEPTOR | WNT ANTAGONIST DICKKOPF-1 | IMMUNOLOGY | EXPRESSION | DKK1 | MASTER REGULATOR | Autoimmunity | Forkhead Transcription Factors - immunology | T-Lymphocytes, Regulatory - metabolism | Cell Proliferation | Cricetulus | Colitis - genetics | Colitis - pathology | Colon - immunology | Adoptive Transfer | DNA-Binding Proteins - deficiency | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Transfection | Time Factors | Forkhead Transcription Factors - metabolism | Cell Membrane - metabolism | Intercellular Signaling Peptides and Proteins - deficiency | Colitis - immunology | Autoimmune Diseases - metabolism | Autoimmune Diseases - pathology | CHO Cells | Disease Models, Animal | Genetic Predisposition to Disease | Signal Transduction | Colon - pathology | Lymphocyte Activation | Mice, Inbred C57BL | Autoimmune Diseases - immunology | Intercellular Signaling Peptides and Proteins - genetics | Self Tolerance | DNA-Binding Proteins - genetics | Forkhead Transcription Factors - genetics | Colon - metabolism | Mice, Knockout | Phenotype | Animals | Colitis - metabolism | Cell Membrane - immunology | T-Lymphocytes, Regulatory - transplantation | Intercellular Signaling Peptides and Proteins - immunology | Mitogen-Activated Protein Kinases - metabolism | Analysis | Monoclonal antibodies | Protein biosynthesis | Colitis | T cells | Mitogens | Protein kinases | Cell proliferation | Wnt protein | Homeostasis | Effector cells | Lymphocytes T | In vitro testing | Kinases | Thymus | T-cell receptor | Immunology | Lymphocytes | Rodents | Foxp3 protein | Immunoregulation | MAP kinase | T cell receptors | Immunological tolerance | CD4 antigen | Inflammatory bowel disease | Protein synthesis | Protein kinase | Dkk1 protein | Index Medicus | Original
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, pp. e21397 - e21397
Recent studies have demonstrated the importance of cellular extrinsic factors in the aging of adult stem cells. However, the effects of an aged cell-extrinsic... 
NICHES | MAINTENANCE | ACTIVATION | REJUVENATION | MULTIDISCIPLINARY SCIENCES | STROMAL CELLS | P16(INK4A) | CELLULAR SENESCENCE | EXPRESSION | PROGRESSION | BETA | Cell Proliferation | Reactive Oxygen Species - metabolism | Cell Survival | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Cellular Senescence - physiology | Rats | Wnt Proteins - metabolism | Rats, Sprague-Dawley | beta Catenin - metabolism | Tumor Suppressor Protein p53 - genetics | beta Catenin - genetics | Mesenchymal Stromal Cells - cytology | Animals | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Wnt Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Signal Transduction - physiology | Apoptosis - physiology | DNA Damage | Mesenchymal Stromal Cells - physiology | Cell proliferation | Senescence | Wnt protein | Mesenchyme | p53 Protein | DNA damage | INK4a protein | c-Myc protein | Galactosidase | Stem cell transplantation | Staining | Myc protein | Kinases | β-catenin | Signal transduction | Allografts | Rodents | Aging | Damage | Deoxyribonucleic acid--DNA | Cell survival | p16 Protein | Aging (artificial) | siRNA | Gene expression | Survival | Studies | Signaling | Cyclin-dependent kinase inhibitor p21 | Stem cells | Dkk1 protein | Immunofluorescence | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
International Journal of Cancer, ISSN 0020-7136, 04/2011, Volume 128, Issue 8, pp. 1793 - 1803
The functional significance of Wnt antagonist DKK1 has not been investigated in renal cell carcinoma (RCC). Therefore, we hypothesized that DKK1 may be a tumor... 
Immunohistochemistry | Western blot | cell cycle | TCF/LEF reporter assay | apoptosis | FACS | invasion assay | DKK1 | real‐time RT‐PCR | RCC | ChIP assay | methylation | in vivo | real-time RT-PCR | CANCER-CELLS | DNA METHYLATION | BETA-CATENIN/TCF | REGULATOR | DICKKOPF FAMILY | ONCOLOGY | SIGNALING PATHWAY | EPIGENETIC INACTIVATION | COLORECTAL-CANCER | EXPRESSION | PROGRESSION | Kidney Neoplasms - genetics | Cell Proliferation | Epigenesis, Genetic | Humans | Caspase 3 - metabolism | Carcinoma, Renal Cell - genetics | Male | Kidney Neoplasms - metabolism | Promoter Regions, Genetic - genetics | Immunoenzyme Techniques | Tumor Suppressor Protein p53 - genetics | Intercellular Signaling Peptides and Proteins - physiology | DNA Methylation | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Chromatin Immunoprecipitation | Caspase 3 - genetics | Apoptosis Regulatory Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Antimetabolites, Antineoplastic - pharmacology | Female | Tumor Cells, Cultured | Genes, Tumor Suppressor | Hydroxamic Acids - pharmacology | Proto-Oncogene Proteins - metabolism | Carcinoma, Renal Cell - pathology | RNA, Messenger - genetics | Tumor Suppressor Protein p53 - metabolism | Azacitidine - analogs & derivatives | Proto-Oncogene Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Azacitidine - pharmacology | Carcinoma, Renal Cell - metabolism | Kidney Neoplasms - pathology | Wnt Proteins - antagonists & inhibitors | Apoptosis | Index Medicus
Journal Article