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PloS one, ISSN 1932-6203, 2019, Volume 14, Issue 9, p. e0223252
.... In the current study, we treated HepG2/C3A and PLC/PRF/5 with the recombinant protein DKK1. Cytotoxicity was first determined by the WST-8 assay... 
Cyclin D1 - metabolism | RNA, Small Interfering - genetics | Proto-Oncogene Proteins c-mdm2 - genetics | Transforming Growth Factor beta1 - antagonists & inhibitors | Humans | Transforming Growth Factor beta1 - metabolism | Gene Expression Regulation, Neoplastic | Hepatocytes - pathology | Hepatocytes - metabolism | Tumor Suppressor Protein p53 - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Telomerase - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Telomerase - metabolism | Proto-Oncogene Proteins c-mdm2 - metabolism | Hepatocytes - drug effects | alpha-Fetoproteins - metabolism | alpha-Fetoproteins - genetics | Retinoblastoma Protein - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Tumor Suppressor Protein p53 - metabolism | Inflammation | Transforming Growth Factor beta1 - genetics | Proto-Oncogene Proteins c-myc - metabolism | Hep G2 Cells | Cell Movement - drug effects | Diffusion Chambers, Culture | Cyclin D1 - genetics | Wnt Signaling Pathway - genetics | Intercellular Signaling Peptides and Proteins - pharmacology | Retinoblastoma Protein - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-myc - genetics | RNA, Small Interfering - metabolism | CTNNB1 gene | Biotechnology | Phosphorylation | Boyden chamber | Telomerase reverse transcriptase | Wnt protein | Laboratories | Toxicity | Genomics | p53 Protein | Genes | Cytotoxicity | Hepatocellular carcinoma | mRNA | Biochemistry | Metastasis | Myc protein | Metastases | Proteins | Liver cancer | Signal transduction | Tumorigenesis | Enzyme-linked immunosorbent assay | MDM2 protein | Cytokines | Therapeutic applications | Breast cancer | Metabolism | Gene expression | Gelatinase B | Gelatinase A | Medicine | Serum levels | Medical prognosis | Kidney cancer | Tumor suppressor genes | β-Catenin | Mutation | Dkk1 protein | Cell migration | Tumors
Journal Article
Cell death & disease, ISSN 2041-4889, 2016, Volume 7, Issue 2, pp. e2119 - e2119
.... P38 mitogen-activated protein kinase (MAPK) activity is also dysregulated in advanced prostate cancer... 
MULTIPLE-MYELOMA | BREAST-CANCER | APOPTOSIS | ACTIVATED PROTEIN-KINASE | OSTEOBLAST DIFFERENTIATION | BONE METASTASES | PATHWAY | ANTAGONIST DKK1 | STRESS-RESPONSE | EXPRESSION | CELL BIOLOGY | Wnt3A Protein - metabolism | Mitogen-Activated Protein Kinase 14 - antagonists & inhibitors | Humans | Male | RNA, Messenger - metabolism | Mitogen-Activated Protein Kinase 12 - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Mitogen-Activated Protein Kinase 11 - metabolism | Prostatic Neoplasms | Antibodies, Neutralizing - immunology | Mitogen-Activated Protein Kinase 12 - metabolism | Mitogen-Activated Protein Kinase 14 - metabolism | RNA Interference | Cell Differentiation | p38 Mitogen-Activated Protein Kinases - metabolism | Pyrazoles - pharmacology | Mitogen-Activated Protein Kinase 11 - genetics | Mitogen-Activated Protein Kinase 12 - antagonists & inhibitors | Wnt3A Protein - genetics | Intercellular Signaling Peptides and Proteins - genetics | p38 Mitogen-Activated Protein Kinases - genetics | Imidazoles - pharmacology | Mitogen-Activated Protein Kinase 11 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 14 - genetics | Down-Regulation - drug effects | Naphthalenes - pharmacology | Signal Transduction - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Pyridines - pharmacology | RNA, Small Interfering | Intercellular Signaling Peptides and Proteins - immunology | Proteins | Metastasis | Cellular biology | Kinases | Prostate cancer | Original
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 2, p. e89525
...) and moderately elevated magnesium (1.4 mM) significantly reduced VSMC calcification and expression of the osteogenic transcription factors Cbfa-1 and osterix, and upregulated expression of the natural calcification inhibitors matrix Gla protein (MGP... 
SEVELAMER | HOMEOSTASIS | CORONARY-ARTERY CALCIFICATION | BINDER | MULTIDISCIPLINARY SCIENCES | CALCIUM | HEMODIALYSIS-PATIENTS | PARATHYROID-HORMONE | OSTEOPROTEGERIN | PHOSPHATE-INDUCED CALCIFICATION | MODULATION | Muscle, Smooth, Vascular - metabolism | Humans | Protein-Serine-Threonine Kinases | Wnt Proteins - metabolism | Vascular Calcification - metabolism | Wnt Proteins - genetics | Osteoprotegerin - genetics | Real-Time Polymerase Chain Reaction | Extracellular Matrix Proteins - metabolism | Muscle, Smooth, Vascular - drug effects | Calcium-Binding Proteins - metabolism | Boron Compounds - pharmacology | Extracellular Matrix Proteins - genetics | Osteogenesis - drug effects | RNA, Messenger - genetics | Cells, Cultured | Vascular Calcification - drug therapy | Magnesium - pharmacology | Muscle, Smooth, Vascular - cytology | Reverse Transcriptase Polymerase Chain Reaction | beta Catenin - metabolism | beta Catenin - genetics | TRPM Cation Channels - antagonists & inhibitors | Signal Transduction - drug effects | beta Catenin - antagonists & inhibitors | TRPM Cation Channels - genetics | TRPM Cation Channels - metabolism | Osteoprotegerin - metabolism | Wnt Proteins - antagonists & inhibitors | Calcium-Binding Proteins - genetics | Calcification (ectopic) | Phosphates | Transformation | Transcription factors | Wnt protein | Calcium | Frizzled protein | Homeostasis | Calcium content | Smooth muscle | Activation | Kinases | Osteoprotegerin | Proteins | Transient receptor potential proteins | Signal transduction | Biomedical materials | Biocompatibility | Magnesium | Inhibition | Translocation | Cbfa-1 protein | Muscles | siRNA | Gene expression | Studies | Signaling | Lymphocytes B | Calcification | β-Catenin | Transport | Dkk1 protein | Apoptosis
Journal Article
PloS one, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e21397
Journal Article
Expert opinion on therapeutic targets, ISSN 1744-7631, 2009, Volume 13, Issue 4, pp. 485 - 496
... increase bone mass, lower adiposity and reduce fracture risk. Neutralizing antibodies to Dickkopf 1, secreted Frizzled-related protein 1 and sclerostin produce similar outcomes in animal models... 
Osteoporosis | Sfrp1 | Sclerostin | GSK-3 | SOST | Dkk1 | OSTEOBLAST | LRP5 | DISTINCT ROLES | BETA-CATENIN | NEGATIVE REGULATOR | DKK1-MEDIATED INHIBITION | HIP OSTEOARTHRITIS | INCREASES MARKERS | PARATHYROID-HORMONE | PHARMACOLOGY & PHARMACY | FRIZZLED-RELATED PROTEIN-1 | Bone Morphogenetic Proteins - antagonists & inhibitors | Bone Morphogenetic Proteins - physiology | Humans | Glycogen Synthase Kinase 3 beta | Osteoporosis - drug therapy | LDL-Receptor Related Proteins - genetics | Intercellular Signaling Peptides and Proteins - physiology | beta Catenin - biosynthesis | Membrane Proteins - deficiency | Bone Diseases - drug therapy | Membrane Proteins - physiology | LDL-Receptor Related Proteins - deficiency | Intercellular Signaling Peptides and Proteins - deficiency | Drug Evaluation, Preclinical | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Low Density Lipoprotein Receptor-Related Protein-5 | Membrane Proteins - genetics | Osteoblasts - drug effects | Osteoblasts - physiology | Osteogenesis - drug effects | Bone Resorption - drug therapy | Intercellular Signaling Peptides and Proteins - genetics | Bone Diseases - physiopathology | Organ Specificity | Regeneration - physiology | LDL-Receptor Related Proteins - physiology | beta Catenin - genetics | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Genetic Markers - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Wnt Proteins - physiology | Wnt Proteins - antagonists & inhibitors | Fractures, Bone - drug therapy
Journal Article
Immunology, ISSN 0019-2805, 2017, Volume 152, Issue 2, pp. 265 - 275
...‐1 expression was dependent on de novo protein synthesis... 
regulatory T cells | Dickkopf‐1 | autoimmune colitis | Dickkopf-1 | THERAPY | RECEPTOR | WNT ANTAGONIST DICKKOPF-1 | IMMUNOLOGY | EXPRESSION | DKK1 | MASTER REGULATOR | Autoimmunity | Forkhead Transcription Factors - immunology | T-Lymphocytes, Regulatory - metabolism | Cell Proliferation | Cricetulus | Colitis - genetics | Colitis - pathology | Colon - immunology | Adoptive Transfer | DNA-Binding Proteins - deficiency | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | Intercellular Signaling Peptides and Proteins - metabolism | Transfection | Time Factors | Forkhead Transcription Factors - metabolism | Cell Membrane - metabolism | Intercellular Signaling Peptides and Proteins - deficiency | Colitis - immunology | Autoimmune Diseases - metabolism | Autoimmune Diseases - pathology | CHO Cells | Disease Models, Animal | Genetic Predisposition to Disease | Signal Transduction | Colon - pathology | Lymphocyte Activation | Mice, Inbred C57BL | Autoimmune Diseases - immunology | Intercellular Signaling Peptides and Proteins - genetics | Self Tolerance | DNA-Binding Proteins - genetics | Forkhead Transcription Factors - genetics | Colon - metabolism | Mice, Knockout | Phenotype | Animals | Colitis - metabolism | Cell Membrane - immunology | T-Lymphocytes, Regulatory - transplantation | Intercellular Signaling Peptides and Proteins - immunology | Mitogen-Activated Protein Kinases - metabolism | Analysis | Monoclonal antibodies | Protein biosynthesis | Colitis | T cells | Mitogens | Protein kinases | Cell proliferation | Wnt protein | Homeostasis | Effector cells | Lymphocytes T | In vitro testing | Kinases | Thymus | T-cell receptor | Immunology | Lymphocytes | Rodents | Foxp3 protein | Immunoregulation | MAP kinase | T cell receptors | Immunological tolerance | CD4 antigen | Inflammatory bowel disease | Protein synthesis | Protein kinase | Dkk1 protein | Original
Journal Article
PloS one, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, p. e0161682
Wnt/beta-catenin signaling is relatively understudied in immunity and autoimmunity. beta-catenin blocks inflammatory mediators and favors tolerogenic dendritic... 
ADHESION | DENDRITIC CELLS | GENE | PATHWAY | COLORECTAL-CANCER | MULTIDISCIPLINARY SCIENCES | MICE | E-CADHERIN | MUTATIONS | WNT | NF-KAPPA-B | Leukocytes - pathology | Spleen - immunology | Axin Protein - genetics | Dendritic Cells - immunology | Humans | Dendritic Cells - pathology | Male | Wnt Proteins - metabolism | Axin Protein - metabolism | Intercellular Signaling Peptides and Proteins - blood | Leukocytes - immunology | beta Catenin - immunology | Wnt Proteins - genetics | Axin Protein - immunology | Gene Deletion | Lupus Erythematosus, Systemic - immunology | Female | Spleen - pathology | Macrophages - immunology | Wnt Signaling Pathway | Disease Models, Animal | Follistatin-Related Proteins - genetics | Follistatin-Related Proteins - metabolism | Macrophages - pathology | Mice, Inbred C57BL | beta Catenin - deficiency | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Mice, Transgenic | beta Catenin - genetics | Wnt Proteins - immunology | Animals | Follistatin-Related Proteins - immunology | Lupus Erythematosus, Systemic - genetics | Mice | Lupus Erythematosus, Systemic - pathology | Intercellular Signaling Peptides and Proteins - immunology | Autoimmunity | Care and treatment | Systemic lupus erythematosus | Dendritic cells | Analysis | Hepatoma | Diagnosis | Research | Macrophages | Wnt protein | Disease | Leukocytes | Immunity | Cell adhesion & migration | β-catenin | Engineering | Immunology | Clonal deletion | Rodents | Biomedical engineering | Lupus | Myeloid cells | Kidneys | Internal medicine | Rheumatic diseases | Inflammation | Preempting | Patients | Human subjects | White blood cells | Medicine | Serum levels | Signaling | Chronic conditions | Insects | Mutation | Autoimmune diseases | Dkk1 protein
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2003, Volume 425, Issue 6958, pp. 633 - 637
Journal Article