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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 29, pp. 13075 - 13080
Activation of the B-cell antigen receptor (BCR) signaling pathway contributes to the initiation and maintenance of B-cell malignancies and autoimmune diseases.... 
T lymphocytes | Animal models | Disease models | Gels | B lymphocytes | B cell lymphoma | Arthritis | Mice | Autoimmune diseases | Tumors | X-linked agammaglobulinemia | Lymphoma | COLLAGEN-INDUCED ARTHRITIS | THERAPY | RITUXIMAB | MULTIDISCIPLINARY SCIENCES | lymphoma | DOGS | FAMILY KINASES | BTK | RECEPTOR | DEPLETION | MICE | Arthritis, Experimental - drug therapy | Pyrazoles - therapeutic use | Humans | Benzofurans - administration & dosage | Benzofurans - pharmacology | Autoantibodies - biosynthesis | Pyrimidines - chemistry | Benzofurans - chemistry | Protein Kinase Inhibitors - chemistry | Pyrazoles - chemistry | Lymphoma, B-Cell - enzymology | Autoimmune Diseases - drug therapy | Disease Models, Animal | Lymphoma, B-Cell - drug therapy | Pyrazoles - pharmacology | B-Lymphocytes - enzymology | Benzofurans - therapeutic use | Autoimmune Diseases - enzymology | Administration, Oral | Pyrimidines - administration & dosage | Treatment Outcome | Pyrimidines - pharmacology | Receptors, Antigen, B-Cell - immunology | B-Lymphocytes - drug effects | Protein Kinase Inhibitors - administration & dosage | Pyrazoles - administration & dosage | Animals | B-Lymphocytes - immunology | Signal Transduction - drug effects | Lymphocyte Activation - drug effects | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Dogs | Protein Kinase Inhibitors - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Tyrosine | Cell receptors | Models | Lymphomas | Research | Properties | Biological Sciences
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e83144
Osteosarcoma is the most common primary bone tumour of both children and dogs. It is an aggressive tumour in both species with a rapid clinical course leading... 
BREAST-CANCER CELLS | MALIGNANT-TUMORS | CYCLOOXYGENASE-2 | SUBPOPULATION | PATHWAY | PROSPECTIVE IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | BONE-MARROW | GROWTH | MELOXICAM | GASTROINTESTINAL STROMAL TUMORS | Doxorubicin - therapeutic use | Neoplastic Stem Cells - drug effects | Humans | Spheroids, Cellular - pathology | Cell Survival - genetics | Spheroids, Cellular - enzymology | Bone Neoplasms - pathology | Dog Diseases - pathology | Osteosarcoma - veterinary | Cell Death - genetics | Neoplastic Stem Cells - metabolism | Cyclooxygenase 2 - genetics | Dog Diseases - enzymology | Neoplastic Stem Cells - pathology | Bone Neoplasms - genetics | Spheroids, Cellular - drug effects | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Bone Neoplasms - veterinary | Tumor Stem Cell Assay | Bone Neoplasms - enzymology | Osteosarcoma - enzymology | Cyclooxygenase 2 Inhibitors - pharmacology | Neoplasm Invasiveness | Carcinogenesis - genetics | Dog Diseases - genetics | Carcinogenesis - pathology | Drug Resistance, Neoplasm - genetics | Animals | Cyclooxygenase 2 - metabolism | Dogs | Osteosarcoma - genetics | Neoplastic Stem Cells - enzymology | Doxorubicin - pharmacology | Osteosarcoma - pathology | Drug Resistance, Neoplasm - drug effects | COX-2 inhibitors | Chemotherapy | Osteosarcoma | Analysis | Genes | Stem cells | Genetic research | Metastasis | Gene expression | Cancer | Adherent cells | Biotechnology | Bone tumors | Spheres | Kinases | Cancer therapies | Metastases | Skin cancer | Surgery | Population | Biocompatibility | Inhibition | Children | Meloxicam | Breast cancer | Studies | Bone cancer | DNA microarrays | Cell lines | Cyclooxygenase-2 | Tumors
Journal Article
Journal of the Neurological Sciences, ISSN 0022-510X, 2012, Volume 318, Issue 1, pp. 55 - 64
Abstract Canine degenerative myelopathy (DM) is an adult-onset, fatal neurodegenerative disease with many similarities to an upper-motor-neuron-onset form of... 
Neurology | Axonopathy | Animal model | Axons | Schwann cells | Amyotrophic lateral sclerosis | Neuropathy | Dog | Canine | TRIALS | NERVE PATHOLOGY | INVOLVEMENT | MUSCULAR-DYSTROPHY | ALS | AMYOTROPHIC-LATERAL-SCLEROSIS | RADICULOMYELOPATHY | NEUROSCIENCES | CLINICAL NEUROLOGY | DIABETES-MELLITUS | MOTOR | GERMAN SHEPHERD DOG | Heredodegenerative Disorders, Nervous System - genetics | Genetic Predisposition to Disease - genetics | Superoxide Dismutase - genetics | Heredodegenerative Disorders, Nervous System - pathology | Heredodegenerative Disorders, Nervous System - enzymology | Peripheral Nervous System Diseases - enzymology | Dog Diseases - genetics | Superoxide Dismutase - deficiency | Disease Progression | Mutation, Missense - genetics | Spinal Cord Diseases - genetics | Homozygote | Animals | Spinal Cord Diseases - enzymology | Dog Diseases - enzymology | Dogs | Peripheral Nervous System Diseases - pathology | Spinal Cord Diseases - pathology | Superoxide Dismutase-1 | Peripheral Nervous System Diseases - genetics | Disease Models, Animal | Nervous system diseases | Analysis | Genes | Genetic research | Superoxide | Genetic aspects | Euthanasia | Motor neurons | Animal models | Spinal cord | Neurodegenerative diseases | Proprioception | Peripheral nerves | Central nervous system diseases | Muscles | Superoxide dismutase | Pelvis | Peripheral neuropathy | Atrophy | spastic paraparesis | Missense mutation | Demyelination | Ataxia | Paralysis | Denervation
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, p. e0151641
Context An increase in enzyme lactate dehydrogenase (LDH) in serum is a negative prognostic factor for survival in cats affected by lymphoma. Measuring LDH at... 
FELINE | DIAGNOSIS | CATS | LACTATE-DEHYDROGENASE ACTIVITY | CELL LYMPHOMA | MULTIDISCIPLINARY SCIENCES | BIOPSY | DOGS | CLASSIFICATION | MUSCULARIS PROPRIA | GASTROINTESTINAL INFLAMMATION | Digestive System Neoplasms - veterinary | Prospective Studies | Age Factors | Humans | Inflammatory Bowel Diseases - diagnosis | Male | Cat Diseases - blood | Cat Diseases - enzymology | Lymphoma - blood | Lymphoma - veterinary | Inflammatory Bowel Diseases - enzymology | Sensitivity and Specificity | Lymphoma - enzymology | Female | Inflammatory Bowel Diseases - veterinary | Cats | Diagnosis, Differential | Lymphoma - diagnosis | Digestive System Neoplasms - diagnosis | Cat Diseases - diagnosis | Digestive System Neoplasms - blood | Inflammatory Bowel Diseases - blood | Animals | L-Lactate Dehydrogenase - blood | Sex Factors | Digestive System Neoplasms - enzymology | Lactate dehydrogenase | Inflammatory bowel diseases | Non-Hodgkin's lymphomas | Diagnosis | Research | Health aspects | Dehydrogenases | Control methods | Veterinary services | Standardization | Males | Veterinary medicine | Ethics | Intestine | Differential diagnosis | Endoscopy | Age | Gastrointestinal symptoms | Enzymes | Cytokines | Inflammation | Lymphoma | L-Lactate dehydrogenase | Abdomen | Inflammatory bowel disease | Biopsy | Medical prognosis | Dogs | Lymphomas | Diagnostic systems | Lactic acid | Laboratory animals | Cancer | Tumors
Journal Article
Neuron, ISSN 0896-6273, 06/2007, Volume 54, Issue 5, pp. 721 - 737
Journal Article
PLoS Genetics, ISSN 1553-7390, 03/2017, Volume 13, Issue 3, p. e1006651
Journal Article
Journal Article
Journal of Veterinary Internal Medicine, ISSN 0891-6640, 11/2014, Volume 28, Issue 6, pp. 1684 - 1691
Journal Article