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Nature Cell Biology, ISSN 1465-7392, 05/2008, Volume 10, Issue 5, pp. 593 - 601
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 12/2007, Volume 35, Issue 12, pp. 2166 - 2176
Olmesartan, a novel angiotensin II AT1-receptor antagonist, is excreted into both bile and urine, with minimal metabolism. Because olmesartan is a hydrophilic... 
PHARMACOKINETICS | INVOLVEMENT | PHARMACOLOGY & PHARMACY | RESISTANCE-ASSOCIATED PROTEIN-4 | ORGANIC ANION TRANSPORTERS | EXCRETION | IDENTIFICATION | MEDOXOMIL | EXPRESSION | OATP1B1 | BLOCKER | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Membrane Transport Proteins - drug effects | Hepatocytes - metabolism | Imidazoles - pharmacokinetics | Neoplasm Proteins - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacokinetics | Sincalide - metabolism | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Prodrugs - metabolism | Tetrazoles - metabolism | Dose-Response Relationship, Drug | Kidney - metabolism | Protein Isoforms - metabolism | Transfection | Liver - drug effects | Membrane Transport Proteins - genetics | Organic Anion Transporters, Sodium-Independent - metabolism | Adenosine Triphosphate - metabolism | ATP-Binding Cassette Transporters - metabolism | Female | Membrane Transport Proteins - metabolism | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | Imidazoles - metabolism | Olmesartan Medoxomil | Cell Line | Liver - metabolism | Probenecid - pharmacology | Penicillin G - pharmacology | Mice, Knockout | p-Aminohippuric Acid - pharmacology | Animals | Estrone - analogs & derivatives | Multidrug Resistance-Associated Proteins - deficiency | Prodrugs - pharmacokinetics | Estrone - metabolism | Dogs | Protein Binding | ATP Binding Cassette Transporter, Sub-Family B | Mice | Kinetics | In Vitro Techniques | Solute Carrier Organic Anion Transporter Family Member 1b1 | Multidrug Resistance-Associated Proteins - metabolism | Tetrazoles - pharmacokinetics | Index Medicus
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0142176 - e0142176
The effects of indigestible carbohydrates, protein type, and protein level on large intestine health were examined in rats. For 21 days, 12 groups of six... 
BETA-GLUCURONIDASE ACTIVITY | YOUNG-PIGS | RED MEAT | RESISTANT STARCH | POTATO FIBER | DIETARY FIBER | BACTERIAL METABOLITES | MULTIDISCIPLINARY SCIENCES | CECAL FERMENTATION | ADULT DOGS | COLONIC DNA-DAMAGE | Propionates - metabolism | Body Weight | Pectins - metabolism | Rats, Wistar | Glucuronidase - metabolism | Starch - metabolism | Nutritional Physiological Phenomena | Dietary Carbohydrates - metabolism | Fatty Acids, Volatile - metabolism | Dietary Proteins - metabolism | Intestine, Large - metabolism | Phenol - metabolism | Dietary Proteins - pharmacology | Acetic Acid - metabolism | Biomarkers - metabolism | Starch - pharmacology | Ammonia - metabolism | Colon - pathology | Dietary Carbohydrates - pharmacology | Cecum - drug effects | Colon - metabolism | Cresols - metabolism | Cecum - pathology | Pectins - pharmacology | Animals | DNA Damage | Cellulose - pharmacology | Cellulose - metabolism | Hydrogen-Ion Concentration | Ammonia | Genetic aspects | Research | Casein | Potatoes | DNA damage | Cellulose | pH effects | Metabolites | Rodents | Bioindicators | Colon | Damage | Deoxyribonucleic acid--DNA | Carbohydrates | Nutrition | Starch | Propionic acid | Cecum | Rats | Pectin | Fermentation | Fatty acids | Diet | Large intestine | Weight reduction | Phenols | Biomarkers | Dietary fiber | Acetic acid | Index Medicus | Deoxyribonucleic acid | pH | DNA
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2008, Volume 14, Issue 1, pp. 79 - 89
Twist1 and Twist2 are major regulators of embryogenesis. Twist1 has been shown to favor the metastatic dissemination of cancer cells through its ability to... 
CELLBIO | HUMDISEASE | SIGNALING | BREAST-CANCER | TRANSFORMATION | DORSOVENTRAL PATTERN | ONCOGENIC RAS | ONCOLOGY | IN-VIVO | ZYGOTIC GENE | SUPPRESSION | EXPRESSION | TUMORIGENESIS | CELL IMMORTALIZATION | Neoplasms - metabolism | Up-Regulation | Fibroblasts - enzymology | Epithelial Cells - metabolism | Humans | Gene Expression Regulation, Neoplastic | ras Proteins - metabolism | Transplantation, Heterologous | Cell Transdifferentiation - genetics | Mammary Glands, Human - metabolism | Transfection | Neoplasms - genetics | RNA Interference | Cell Transformation, Neoplastic - genetics | Mice, Inbred DBA | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Fibroblasts - metabolism | Cell Line | Cellular Senescence - genetics | Neoplasm Invasiveness | Mice, Inbred C57BL | Retinoblastoma Protein - metabolism | Tumor Suppressor Protein p53 - metabolism | Neoplasms - enzymology | Repressor Proteins - genetics | Epithelial Cells - pathology | Mice, Transgenic | Nuclear Proteins - metabolism | Fibroblasts - pathology | Cell Transformation, Neoplastic - metabolism | Animals | Mice, Nude | Dogs | Epithelial Cells - enzymology | Twist-Related Protein 1 - genetics | Mice | Enzyme Activation | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Twist-Related Protein 1 - metabolism | Tumor proteins | Stem cells | Tumors | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e57847 - e57847
The aim of this experiment was to demonstrate the ability of feeding serotonin (5-HT; 5-hydroxytryptamine) precursors to increase 5-HT production during the... 
CONSCIOUS DOGS | ORGANIC NUTRIENT METABOLISM | ACTIVATION | HOMEOSTASIS | DISPOSAL | BOVINE | MULTIDISCIPLINARY SCIENCES | GLUT8 | INFUSION | INHIBITOR | INSULIN LEVELS | Glucose Transport Proteins, Facilitative - metabolism | Gene Expression Regulation, Enzymologic - drug effects | AMP-Activated Protein Kinases - metabolism | Liver - enzymology | Lactation - drug effects | 5-Hydroxytryptophan - pharmacology | Insulin - blood | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Mothers | Growth and Development - drug effects | Liver - drug effects | Lactation - blood | Female | Glucose Transport Proteins, Facilitative - genetics | Energy Metabolism - genetics | Mammary Glands, Animal - enzymology | Lactation - genetics | Biomarkers - metabolism | Liver - metabolism | RNA, Messenger - genetics | Rats | Mammary Glands, Animal - drug effects | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Pregnancy | Animals | Mammary Glands, Animal - metabolism | Milk - metabolism | Serotonin - metabolism | Lactation - metabolism | Tryptophan - pharmacology | Blood Glucose - metabolism | Energy Metabolism - drug effects | Enzymes | Serotonin | RNA | Pregnant women | Tryptophan | Phenols | Glucose | Protein kinases | Dextrose | Energy metabolism | Lactation | Liver | Genomics | Breasts | Glands | Homeostasis | Gestation | AMP-activated protein kinase | Experiments | Animal lactation | Proteins | Energy | Metabolites | Rodents | L-Tryptophan | Mammary gland | Milk | Dams | AMP | Mammary glands | Metabolism | Gene expression | Insulin | Endothelial cells | Feeding | Energy balance | Diet | Glycolysis | Index Medicus
Journal Article
Autophagy, ISSN 1554-8627, 11/2016, Volume 12, Issue 11, pp. 2145 - 2166
Ehrlichia chaffeensis is an obligatory intracellular bacterium that causes a potentially fatal emerging zoonosis, human monocytic ehrlichiosis. E. chaffeensis... 
type IV secretion effector | BECN1 | endosome | infection | autophagy | RAB5 | Ehrlichia chaffeensis | Etf-1 | class III PtdIns3K | LC3 | ATG5 | PUROMYCIN-SENSITIVE AMINOPEPTIDASE | RAT-LIVER | POLYGLUTAMINE SEQUENCES | EARLY ENDOSOME | ENDOCYTIC TRAFFICKING | HUMAN MONOCYTES | MAMMALIAN-CELLS | CELL BIOLOGY | CHAFFEENSIS INFECTION | PROTEIN-DEGRADATION | ANAPLASMA-PHAGOCYTOPHILUM | Ehrlichiosis - pathology | Humans | Glutamine - metabolism | Guanosine Triphosphate - metabolism | Host-Pathogen Interactions - drug effects | rab5 GTP-Binding Proteins - metabolism | Autophagy - drug effects | Autophagosomes - drug effects | Ubiquitination - drug effects | Ehrlichia chaffeensis - drug effects | Protein Binding - drug effects | HEK293 Cells | Cell Membrane - metabolism | Inclusion Bodies - metabolism | Cell Membrane - drug effects | Ehrlichiosis - microbiology | Adenine - analogs & derivatives | Huntingtin Protein - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Mutant Proteins - metabolism | Adenine - pharmacology | Cell Membrane - ultrastructure | Autophagosomes - metabolism | Enzyme Activation - drug effects | Sirolimus - pharmacology | Autophagosomes - ultrastructure | Animals | Signal Transduction - drug effects | Dogs | Autophagy-Related Protein 5 - metabolism | Ehrlichia chaffeensis - growth & development | Bacterial Proteins - metabolism | Cell Proliferation - drug effects | Glutamic Acid - metabolism | Ehrlichia chaffeensis - metabolism | Beclin-1 - metabolism | Index Medicus
Journal Article
Veterinary Pathology, ISSN 0300-9858, 5/2010, Volume 47, Issue 3, pp. 446 - 454
Several markers of malignancy have been proposed for canine mammary tumors on the mRNA and protein levels. However, their association with tumor malignancy... 
BMP2 | Derlin-1 | DERL1 | LTBP4 | Breast cancer | Mammary tumor | Metastasis | Dog | Canine | CELLS | TGF-BETA | ANGIOGENESIS | BONE MORPHOGENETIC PROTEIN-2 | ADENOCARCINOMAS | breast cancer | canine | PATHOLOGY | BREAST-CANCER | IN-VITRO | GENE | metastasis | GROWTH | VETERINARY SCIENCES | mammary tumor | dog | CARCINOMA | Osteopontin - genetics | Receptors, Estrogen - metabolism | Dog Diseases - metabolism | Mammary Neoplasms, Animal - diagnosis | Proto-Oncogene Proteins p21(ras) - genetics | Glycoproteins - metabolism | Osteopontin - metabolism | Receptors, Progesterone - genetics | Tumor Suppressor Protein p53 - genetics | Receptors, Progesterone - metabolism | Bone Morphogenetic Proteins - metabolism | Proliferating Cell Nuclear Antigen - genetics | Telomerase - genetics | BRCA1 Protein - metabolism | Bone Morphogenetic Protein 2 - metabolism | Antigens, Surface - metabolism | Biomarkers, Tumor - metabolism | Female | Telomerase - metabolism | Membrane Proteins - metabolism | Dog Diseases - diagnosis | Bone Morphogenetic Proteins - genetics | Latent TGF-beta Binding Proteins - metabolism | Mammary Neoplasms, Animal - genetics | Proto-Oncogene Proteins p21(ras) - metabolism | Glycoproteins - genetics | Rad51 Recombinase - metabolism | Gene Expression | Receptors, Estrogen - genetics | Serpins - genetics | Rad51 Recombinase - genetics | Serpins - metabolism | Tumor Suppressor Protein p53 - metabolism | Dog Diseases - genetics | BRCA1 Protein - genetics | Animals | Mammary Neoplasms, Animal - metabolism | Dogs | Biomarkers, Tumor - genetics | Proliferating Cell Nuclear Antigen - metabolism | Index Medicus
Journal Article