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Chemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 7, pp. 727 - 730
A diversity-oriented synthetic strategy was developed for the total synthesis of kainoid amino acids, which led to the enantioselective synthesis of (-)-kainic... 
CATALYZED CYCLOISOMERIZATIONS | HUNTINGTONS-CHOREA | NEUROEXCITATORY AMINO-ACIDS | ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS | (-)-ALPHA-KAINIC ACID | ACROMELIC ACID | KAINIC ACID | (+)-ALPHA-ALLOKAINIC ACID | CHEMISTRY, MULTIDISCIPLINARY | CLITOCYBE-ACROMELALGA | DOMOIC ACID | Amino acids | Amides | Chemical synthesis | Vinyl acetate | Isomerization
Journal Article
Chemical communications (Cambridge, England), ISSN 1359-7345, 01/2018, Volume 54, Issue 7, pp. 727 - 730
A diversity-oriented synthetic strategy was developed for the total synthesis of kainoid amino acids, which led to the enantioselective synthesis of (-)-kainic... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2017, Volume 114, Issue 2, pp. 239 - 244
Journal Article
Marine Drugs, ISSN 1660-3397, 2014, Volume 12, Issue 3, pp. 1185 - 1207
Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was... 
Rat | Aggression | Olfactory | Piriform cortex | Epilepsy | Seizure | Amnesic shellfish poison | Domoic acid | Sea lion | epilepsy | AGGRESSIVE-BEHAVIOR | CHEMISTRY, MEDICINAL | seizure | rat | TEMPORAL-LOBE EPILEPSY | piriform cortex | CALIFORNIA SEA LIONS | KAINIC ACID | aggression | ANTERIOR OLFACTORY NUCLEUS | domoic acid | sea lion | ZALOPHUS-CALIFORNIANUS | olfactory | amnesic shellfish poison | EXPOSURE | BRAIN | Recurrence | Food Contamination | Humans | Middle Aged | Kainic Acid - analogs & derivatives | Shellfish Poisoning - diagnosis | Marine Toxins - poisoning | Epilepsy, Temporal Lobe - physiopathology | Male | Seizures - chemically induced | Neuromuscular Depolarizing Agents - poisoning | Olfactory Pathways - physiopathology | Amnesia - chemically induced | Bivalvia | Neurotoxins - poisoning | Aged, 80 and over | Behavior, Animal - drug effects | Female | Seizures - veterinary | Kainic Acid - poisoning | Amnesia - psychology | Epilepsy, Temporal Lobe - chemically induced | Rats | Seizures - diagnosis | Animal Diseases - diagnosis | Animal Diseases - chemically induced | Epilepsy - diagnosis | Animals | Aging - physiology | Epilepsy - chemically induced | Sea Lions - physiology | Epilepsy - veterinary | Shellfish Poisoning - veterinary | Aged | Animal Diseases - physiopathology | Hippocampus - physiopathology | Shellfish Poisoning - physiopathology
Journal Article
Harmful Algae, ISSN 1568-9883, 02/2014, Volume 32, pp. 49 - 63
A new toxin-producing marine diatom, sp. nov., isolated from the Bizerte Lagoon (Tunisia, Southwest Mediterranean Sea) is, based on studies on eight different... 
Toxin | LSU rDNA | ITS rDNA | Diatom | SSU rDNA | Phylogeny | Domoic acid | Nitzschia bizertensis sp. nov | NAVIS-VARINGICA | BACILLARIACEAE | Nitzschia bizertensis sp nov | MULTISERIES | IDENTIFICATION | PSEUDO-NITZSCHIA | AMINO-ACID | MARINE & FRESHWATER BIOLOGY | RDNA SEQUENCES | SHELLFISH | BACILLARIOPHYCEAE | Environmental Sciences
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 09/2013, Volume 271, Issue 2, pp. 127 - 136
Our previous findings suggest that mitochondrial dysfunction is the mechanism underlying cognitive deficits induced by domoic acid (DA). Ursolic acid (UA), a... 
Ursolic acid | FoxO1 knockdown | Mitochondrial dysfunction | Domoic acid | Cognitive deficits | MOUSE-BRAIN | ACTIVATION | PROTEIN-KINASE | INDUCTION | MEDIATED INFLAMMATORY PATHWAYS | ESTROGEN-RECEPTOR | FOXO1 | D-GALACTOSE | TROXERUTIN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | INDUCED NEUROTOXICITY | Cognition Disorders - chemically induced | Neuromuscular Depolarizing Agents - adverse effects | Triterpenes - therapeutic use | Kainic Acid - analogs & derivatives | Male | Phosphatidylinositol 3-Kinases - metabolism | Hippocampus - drug effects | Cognition Disorders - prevention & control | Forkhead Transcription Factors - metabolism | Mitochondrial Diseases - chemically induced | Kainic Acid - toxicity | Oncogene Protein v-akt - metabolism | Cognition Disorders - psychology | Mitochondrial Diseases - prevention & control | Animals, Genetically Modified | Psychomotor Performance - drug effects | Dependovirus | Maze Learning - drug effects | Mice, Inbred ICR | Hippocampus - metabolism | Animals | Signal Transduction - drug effects | Fluorescent Antibody Technique | Neuromuscular Depolarizing Agents - toxicity | Forkhead Box Protein O1 | Mice | Oxidative Stress - drug effects | Genetic Vectors | Kainic Acid - antagonists & inhibitors | Cyclooxygenase Inhibitors - therapeutic use | Index Medicus | HIPPOCAMPUS | BIOLOGICAL FUNCTIONS | FLUORESCENCE | HEME | ELECTRONS | PHOSPHORYLATION | MITOCHONDRIA | MICE | PROTEINS | 60 APPLIED LIFE SCIENCES | ATP
Journal Article
Toxicon, ISSN 0041-0101, 09/2019, Volume 167, pp. 101 - 105
Domoic acid (DA) or Amnesic Shellfish Poisoning (ASP) produced by the genus diatom was investigated in two seasonal periods in fishing areas of in the South... 
Harmful algal blooms | Brazilian coast/environment | Pseudo-nitzschia spp | Skipjack tuna | Domoic acid | MORTALITY | COMPLEX BACILLARIOPHYCEAE | PSEUDODELICATISSIMA | BLOOMS | PUNGENS | PSEUDO-NITZSCHIA | VARIABILITY | PHARMACOLOGY & PHARMACY | SHELLFISH | TOXICOLOGY | DIATOM | DE-FUCA EDDY | Case studies | Ocean | Air pollution | Fishing | Index Medicus
Journal Article