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International Journal of Molecular Sciences, ISSN 1422-0067, 09/2019, Volume 20, Issue 18, p. 4555
In order to search for novel antipsychotics acting through the D2 receptor, it is necessary to know the structure−activity relationships for dopamine D2... 
3D-QSAR | dopamine D2 receptor antagonists | CoMFA model | dopamine D2 receptor
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 04/2019, Volume 20, Issue 7, p. 1686
Dopamine D₂ receptors (D₂R) are known to form transient homodimer complexes, of which the increased formation has already been associated with development of... 
G protein-coupled receptor (GPCR) | dimerization | protein complementation assay | NanoLuc binary technology (NanoBiT) | oligomerization | dopamine D2 receptor
Journal Article
by Liu, Z and Jiang, XB and Gao, L and Liu, X and Li, JL and Huang, X and Zeng, T
WORLD NEUROSURGERY, ISSN 1878-8750, 08/2019, Volume 128, pp. E468 - E477
OBJECTIVE: The current standard treatment of malignant glioma is maximal resection followed by chemotherapy and radiotherapy. Temozolomide (TMZ) has been the... 
SURGERY | HUMAN BRAIN | Glioblastoma | PROLIFERATION | AUTOPHAGY | IDENTIFICATION | CLINICAL NEUROLOGY | CANCER STEM-CELLS | ADJUVANT TEMOZOLOMIDE | Dopamine D2 receptor | ANTITUMOR IMIDAZOTETRAZINES | PHARMACOKINETICS | DNA | DRUGS | Synergy | Temozolomide | Proteins | Chemotherapy | Dopamine | Growth | DNA damage | Stem cells | Phenols | Glioblastoma multiforme | Dopamine receptors | Cancer
Journal Article
Frontiers in Neuroscience, ISSN 1662-4548, 2013, Volume 7, Issue 7, p. 76
Repeated exposure to the psychostimulant amphetamine has been shown to disrupt goal-directed instrumental actions and promote the early and abnormal... 
Goal-directed | and D | Sensitization | Amphetamine | receptor subtypes | Habits | Dopamine | Lithium chloride | Extinction | Experiments | Dopamine D1 receptors | Aversion | Amphetamines | Reinforcement | Physiology | Behavior | Flupenthixol | Dopamine D2 receptors | Drug dosages | Dopamine receptors | goal-directed | habits | D1 and D2 receptor subtypes | sensitization
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2018, Volume 175, Issue 21, pp. 4121 - 4136
Target binding kinetics influence the time course of the drug effect (pharmacodynamics) both (i) directly, by affecting the time course of target occupancy,... 
Phenols | Analysis | Binding | Pharmacodynamics | Fluctuations | Dopamine | Computer simulation | Variations | Cyclic AMP | Pharmacology | Signal transduction | Signaling | Side effects | Negative feedback | Feedback | Transduction | Kinetics | Pharmacokinetics | Dopamine D2 receptors | Dopamine receptors
Journal Article
Journal Article
Medicinal Chemistry Research, ISSN 1054-2523, 4/2018, Volume 27, Issue 4, pp. 1149 - 1166
The dopaminergic hypothesis of schizophrenia is the main concept explaining the direct reasons of schizophrenia and the effectiveness of current... 
Biochemistry, general | Biomedicine | Dopamine D 2 receptor antagonists | QSAR | Molecular modeling | Non-basic compounds | Pharmacology/Toxicology | Dopamine D 2 receptor | Cell Biology | CoMFA | receptor | receptor antagonists | Dopamine D | Dopamine D2 receptor antagonists | Dopamine D2 receptor | Original Research
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 04/2017, Volume 45, Issue 7, pp. 912 - 921
Group II metabotropic glutamate receptor agonists have been suggested as potential anti‐psychotics, at least in part, based on the observation that the agonist... 
AMPA | Gria1 | schizophrenia | habituation | TASK | NMDA RECEPTORS | DOPAMINERGIC SYSTEM | SHORT-TERM-MEMORY | SYNAPTIC PLASTICITY | T-MAZE | NEUROSCIENCES | A-DEFICIENT MICE | EXPRESSION | SUBUNIT | Bridged Bicyclo Compounds - pharmacology | Excitatory Amino Acid Agonists - therapeutic use | Mice, Inbred C57BL | Haloperidol - therapeutic use | Dopamine Antagonists - therapeutic use | Male | Memory, Short-Term - drug effects | Excitatory Amino Acid Agonists - pharmacology | Hyperkinesis - physiopathology | Hyperkinesis - metabolism | Hyperkinesis - drug therapy | Animals | Dopamine Antagonists - pharmacology | Bridged Bicyclo Compounds - therapeutic use | Female | Mice | Haloperidol - pharmacology | Receptors, AMPA - genetics | Receptors, AMPA - metabolism | Locomotion - drug effects | Receptors, AMPA - antagonists & inhibitors | Methyl aspartate | Analysis | Genomics | Short-term memory | Schizophrenia | Aspartate | Haloperidol | Glutamate | Animal models | Dopamine | Mental disorders | Hyperactivity | Animal memory | Spatial discrimination | Cognitive ability | N-Methyl-D-aspartic acid receptors | Genomes | Pharmacology | Glutamic acid receptors | α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid | Rodents | Glutamatergic transmission | Short term memory | Dopamine D2 receptors | Glutamic acid receptors (metabotropic) | Spatial memory | Behavioural Neuroscience
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 01/2017, Volume 8, Issue 1, pp. 165 - 177
Journal Article
中国药理学报:英文版, ISSN 1671-4083, 2017, Volume 38, Issue 9, pp. 1282 - 1296
Recent evidence shows that dopamine D2-1ike receptor (D2DR) antagonists, such as trifluoperazine and thioridazine, are effective for cancer therapy and... 
转移性 | 多巴胺受体 | 舒必利 | 乳腺癌 | 地塞米松 | 联合治疗 | 受体拮抗剂 | 耐药 | dexamethasone | 7-OH-DPAT | metastasis | combination therapy | drug-resistance | Breast cancer | cancer stem cells | dopamine-D2 receptor | sulpiride | STEM-CELLS | ESTROGEN SULFOTRANSFERASE | breast cancer | INDUCTION | CHEMISTRY, MULTIDISCIPLINARY | LUNG-CANCER | TUMOR-METASTASIS | GROWTH | PHARMACOLOGY & PHARMACY | SUPPRESSES | TUMORIGENESIS | EXPRESSION | CARCINOMA | Dexamethasone - chemistry | Sulpiride - pharmacology | Antineoplastic Agents, Hormonal - pharmacology | Humans | Structure-Activity Relationship | Breast Neoplasms - drug therapy | Dopamine D2 Receptor Antagonists - chemistry | Dose-Response Relationship, Drug | Animals | Dexamethasone - pharmacology | MCF-7 Cells | Breast Neoplasms - pathology | Mice, Nude | Mammary Neoplasms, Experimental - pathology | Dopamine D2 Receptor Antagonists - pharmacology | Female | Cell Proliferation - drug effects | Mice | Tumor Cells, Cultured | Antineoplastic Agents, Hormonal - chemistry | Sulpiride - chemistry | Drug Resistance, Neoplasm - drug effects | Drug Screening Assays, Antitumor | Mammary Neoplasms, Experimental - drug therapy | Therapy | Neuroleptics | Trifluoperazine | Leukocyte migration | Toxicity | 7-Hydroxy-2-(di-n-propylamino)tetralin | Metastasis | Drug resistance | Tissues | Sulpiride | E-cadherin | Metastases | Anticancer properties | Xenografts | Biocompatibility | Bioindicators | Inhibition | Dopamine D2 receptors | Dexamethasone | Dopamine | Oral administration | Gelatinase A | Thioridazine | Lungs | Biomarkers | Breast | In vitro methods and tests | Cell migration | Tumors | Cancer | Index Medicus | Original
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