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1. Full Text Evidence against dopamine D1/D2 receptor heteromers
by Frederick, A.L and Yano, H and Trifilieff, P and Vishwasrao, H.D and Biezonski, D and Mészáros, J and Urizar, E and Sibley, D.R and Kellendonk, C and Sonntag, K.C and Graham, D.L and Colbran, R.J and Stanwood, G.D and Javitch, J.A
Molecular Psychiatry, ISSN 1359-4184, 11/2015, Volume 20, Issue 11, pp. 1373 - 1385
Hetero-oligomers of G-protein-coupled receptors have become the subject of intense investigation, because their purported potential to manifest signaling and... 
RAT STRIATUM | PSYCHIATRY | BASAL GANGLIA | COMPARTMENTAL ORGANIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPASE-C | BAC TRANSGENIC MICE | NEUROSCIENCES | NUCLEUS-ACCUMBENS | GENE-EXPRESSION | MEDIUM SPINY NEURONS | PHOSPHOINOSITIDE HYDROLYSIS | ADENYLATE-CYCLASE | Humans | Nucleus Accumbens - metabolism | Motor Activity - drug effects | Male | Receptors, Dopamine D2 - metabolism | Corpus Striatum - metabolism | Receptors, Dopamine D1 - metabolism | Protein Multimerization - physiology | HEK293 Cells | Phosphorylation - drug effects | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Protein Structure, Tertiary | Dopamine Agonists - pharmacology | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Mice, Inbred C57BL | Grooming - drug effects | Models, Molecular | 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - analogs & derivatives | Receptors, Dopamine D2 - genetics | Mice, Knockout | Motor Activity - genetics | Animals | Dopamine Antagonists - pharmacology | 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology | Corpus Striatum - drug effects | Luminescent Proteins - genetics | Mice | Nucleus Accumbens - drug effects | Protein Multimerization - drug effects | Luminescent Proteins - metabolism | Receptors, Dopamine D1 - genetics | Oligomers | Depression, Mental | Schizophrenia | Physiological aspects | Research | Risk factors | Dopamine receptors | BRET | striatum | Gαq | hetero-oligomer | proximity ligation assay | biased agonism | dopamine
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2. Full Text Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers
by Navarro, Gemma and Moreno, Estefania and Bonaventura, Jordi and Brugarolas, Marc and Farré, Daniel and Aguinaga, David and Mallol, Josefa and Cortés, Antoni and Casadó, Vicent and Lluís, Carmen and Ferre, Sergi and Franco, Rafael and Canela, Enric and McCormick, Peter J
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e61245
Under normal conditions the brain maintains a delicate balance between inputs of reward seeking controlled by neurons containing the D1-like family of dopamine... 
Cocaine - metabolism | Cricetinae | Corpus Striatum - physiopathology | Cricetulus | Humans | Protein Multimerization | Male | Receptors, sigma - physiology | Cocaine-Related Disorders - physiopathology | Corpus Striatum - metabolism | Mice, Knockout | Cocaine - pharmacology | Animals | Receptors, Dopamine D1 - physiology | HEK293 Cells | Receptors, Dopamine D2 - physiology | Mice | Dopamine D2 Receptor Antagonists | CHO Cells | Brain | Dopamine | Neurons | Dopamine D3 receptors | Biochemistry | Gene expression | Addictions | Dopamine D4 receptors | Oligomers | Signal transduction | Signaling | Receptors | Dopamine D1 receptors | Rodents | Aversion | Neostriatum | Reinforcement | Ligands | Cocaine | Receptor mechanisms | Molecular biology | Dopamine D2 receptors | Dopamine receptors | Cell receptors | Cocaïna | Dopamina | Receptors cel·lulars
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3. Full Text Novel Resolvin D2 receptor axis in infectious inflammation
by Nan, Chiang and De La Rosa, Xavier and Libreros, Stephania and Serhan, Charles N
Journal of Immunology, ISSN 0022-1767, 01/2017, Volume 198, Issue 2, pp. 842 - 851
Resolution of acute inflammation is an active process governed by specialized proresolving mediators, including resolvin (Rv)D2, that activates a cell surface... 
CIRCUITS | ACTIVATION | RESOLUTION | SIGNALS | LIPID MEDIATORS | SEPSIS | MODEL | IMMUNOLOGY | IDENTIFICATION | TRANSGENIC MICE | Sepsis - immunology | Receptors, G-Protein-Coupled - metabolism | Phagocytosis - immunology | Male | Inflammation - immunology | Mice, Knockout | Receptors, G-Protein-Coupled - immunology | Docosahexaenoic Acids - immunology | Tandem Mass Spectrometry | Inflammation - metabolism | Animals | Sepsis - metabolism | Chromatography, Liquid | Mice | Macrophages - immunology | Disease Models, Animal | Docosahexaenoic Acids - metabolism | Protein kinase A | Phosphorylation | Downstream effects | Intracellular signalling | Kinases | Macrophages | Cell surface | Pathways | E coli | Rodents | Bacteria | Dopamine D2 receptors | Cecum | Stat3 protein | Extracellular signal-regulated kinase | Mass spectroscopy | Inflammation | Cyclic AMP response element-binding protein | Survival | Exudates | Cytometry | Infectious diseases | Leukotriene B4 | Sepsis | Exudation | Intracellular | Mass spectrometry | Phagocytosis | Hypothermia | eicosanoids | phagocytes | resolution of infection | pro-resolving mediators | innate response
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4. Full Text Targeting the dopamine D2 receptor in schizophrenia
by Seeman, Philip
Expert Opinion on Therapeutic Targets, ISSN 1472-8222, 08/2006, Volume 10, Issue 4, pp. 515 - 531
After a 12-year search for the antipsychotic receptor, the binding site was discovered and labelled by [ 3 H]haloperidol in 1975. Of the various... 
brain imaging | supersensitivity | domperidone | antipsychotic | schizophrenia | dopamine receptor | psychosis | Psychosis | Brain imaging | Domperidone | Dopamine receptor | Schizophrenia | Supersensitivity | Antipsychotic | Schizophrenia - metabolism | Antipsychotic Agents - therapeutic use | Humans | Antipsychotic Agents - pharmacology | Schizophrenia - drug therapy | Receptors, Dopamine D2 - metabolism | Receptors, Dopamine D1 - metabolism
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5. Full Text Distinct Dopamine Dâ‚‚ Receptor Antagonists Differentially Impact Dâ‚‚ Receptor Oligomerization
by Wouters, Elise and Marín, Adrián Ricarte and Dalton, James Andrew Rupert and Giraldo, Jesús and Stove, Christophe
International journal of molecular sciences, ISSN 1422-0067, 04/2019, Volume 20, Issue 7, p. 1686
Dopamine Dâ‚‚ receptors (Dâ‚‚R) are known to form transient homodimer complexes, of which the increased formation has already been associated with development of... 
G protein-coupled receptor (GPCR) | dimerization | protein complementation assay | NanoLuc binary technology (NanoBiT) | oligomerization | dopamine D2 receptor
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6. Full Text Allosteric interactions between agonists and antagonists within the adenosine A2A receptordopamine D2 receptor heterotetramer
by Bonaventura, Jordi and Navarro, Gemma and Casadó-Anguera, Verònica and Azdad, Karima and Rea, William and Moreno, Estefanía and Brugarolas, Marc and Mallol, Josefa and Canela, Enric I and Lluís, Carme and Cortés, Antoni and Volkowd, Nora D and Schiffmann, Serge N and Ferré, Sergi and Casadó, Vicent
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2015, Volume 112, Issue 27, pp. E3609 - E3618
GPCR heteromers | Dopamine D | receptor | Adenosine A | Caffeine
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7. Full Text Treadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson's disease
by Fisher, Beth E and Li, Quanzheng and Nacca, Angelo and Salem, George J and Song, Jooeun and Yip, Jeanine and Hui, Jennifer S and Jakowec, Michael W and Petzinger, Giselle M
NeuroReport, ISSN 0959-4965, 07/2013, Volume 24, Issue 10, pp. 509 - 514
We have previously demonstrated changes in dopaminergic neurotransmission after intensive exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned... 
experience-dependent plasticity | running | fallypride | rehabilitation | basal ganglia | PET imaging | motor behavior | neuroplasticity | 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-LESIONED MOUSE MODEL | RADIOLIGAND | RISK | RELEASE | SYNAPTIC PLASTICITY | NEUROSCIENCES | PROJECTION | RECOVERY | PEOPLE | PET | Parkinson Disease - therapy | Neostriatum - pathology | Parkinson Disease - diagnostic imaging | Humans | Middle Aged | Male | Positron-Emission Tomography | Receptors, Dopamine D2 - metabolism | Gait - physiology | Psychomotor Performance - physiology | Exercise Therapy | Magnetic Resonance Imaging | Biomechanical Phenomena | Pilot Projects | Neuronal Plasticity - physiology | Posture - physiology | Brain - pathology | Pyrrolidines | Female | Neostriatum - metabolism | Neostriatum - diagnostic imaging | Parkinson Disease - metabolism | Benzamides | Radiopharmaceuticals
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8. Full Text Estimating dopamine D2 receptor occupancy for doses of 8 antipsychotics : a meta-analysis
by Lako, IM and Heuvel, van den, ER Edwin and Knegtering, H and Bruggeman, R Roy and Taxis, K
Journal of Clinical Psychopharmacology, ISSN 0271-0749, 2013, Volume 33, Issue 5, pp. 675 - 681
Dose equivalents based on dopamine Dâ‚‚ receptor occupancy can be used to compare antipsychotics on Dâ‚‚ receptor-mediated (adverse) effects such as extrapyramidal... 
Brain - diagnostic imaging | Schizophrenia - metabolism | Antipsychotic Agents - adverse effects | Humans | Tomography, Emission-Computed, Single-Photon | Male | Positron-Emission Tomography | Receptors, Dopamine D2 - metabolism | Dopamine Antagonists - administration & dosage | Emotions - drug effects | Brain - metabolism | Dose-Response Relationship, Drug | Young Adult | Dopamine Antagonists - metabolism | Adult | Female | Basal Ganglia Diseases - chemically induced | Treatment Outcome | Schizophrenia - diagnostic imaging | Antipsychotic Agents - administration & dosage | Brain - drug effects | Dopamine Antagonists - adverse effects | Protein Binding | Antipsychotic Agents - metabolism | Schizophrenia - drug therapy | Nonlinear Dynamics | Dopamine D2 Receptor Antagonists
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9. Full Text Human cognitive flexibility depends on dopamine D2 receptor signaling
by Holstein, M.G.A. van and Aarts, E and Schaaf, M.E. van der and Geurts, D.E.M and Verkes, R.J and Franke, B and Schouwenburg, M.R. van and Cools, R
Psychopharmacologia, ISSN 0033-3158, 2011, Volume 218, Issue 3, pp. 567 - 578
RATIONALE: Accumulating evidence indicates that the cognitive effects of dopamine depend on the subtype of dopamine receptor that is activated. In particular,... 
Striatum | Neurosciences | Biomedicine | Cognitive flexibility | DAT1 | Bromocriptine | Pharmacology/Toxicology | Psychiatry | Sulpiride | SLC6A3 | Set switching | SYSTEMIC SULPIRIDE | PSYCHIATRY | BASAL GANGLIA | COMPONENT PROCESSES | NEUROSCIENCES | PREFRONTAL CORTEX | NUCLEUS-ACCUMBENS | TRANSPORTER AVAILABILITY | HUMAN STRIATUM | SPATIAL WORKING-MEMORY | HUMAN-BRAIN | PHARMACOLOGY & PHARMACY | PARKINSONS-DISEASE | Dopamine Agonists - pharmacology | Sulpiride - pharmacology | Double-Blind Method | Humans | Male | Bromocriptine - pharmacology | Tandem Repeat Sequences | Cognition - drug effects | Receptors, Dopamine D2 - metabolism | Dopamine Plasma Membrane Transport Proteins - genetics | Polymorphism, Genetic | Cross-Over Studies | Young Adult | Signal Transduction - drug effects | Dopamine Antagonists - pharmacology | Adolescent | Receptors, Dopamine D2 - drug effects | Cognition - physiology | Adult | Female | Phenols | Cognition & reasoning | Psychopharmacology | Dopamine | 3' Untranslated regions | Cognitive ability | Dopamine transporter | Dopamine D2 receptors | Gene polymorphism | sulpiride | Original Investigation
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10. Full Text Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
by Kupchik, Yonatan M and Brown, Robyn M and Heinsbroek, Jasper A and Lobo, Mary Kay and Schwartz, Danielle J and Kalivas, Peter W
Nature Neuroscience, ISSN 1097-6256, 08/2015, Volume 18, Issue 9, pp. 1230 - 1232
It is widely accepted that D1 dopamine receptor-expressing striatal neurons convey their information directly to the output nuclei of the basal ganglia,... 
DOPAMINE NEURONS | VENTRAL PALLIDAL NEURONS | CONNECTIVITY | BASAL GANGLIA | COCAINE | TEGMENTAL AREA | DISTINCT ROLES | STRIATAL NEURONS | D-2 RECEPTOR | NEUROSCIENCES | NUCLEUS-ACCUMBENS | Nucleus Accumbens - chemistry | Optogenetics - methods | Receptors, Dopamine D2 - analysis | Mice, Inbred C57BL | Nucleus Accumbens - metabolism | Basal Forebrain - metabolism | Male | Mice, Transgenic | Receptors, Dopamine D2 - biosynthesis | Receptors, Dopamine D2 - genetics | Receptors, Dopamine D1 - analysis | Animals | Neural Pathways - metabolism | Receptors, Dopamine D1 - biosynthesis | Female | Mice | Basal Forebrain - chemistry | Neural Pathways - chemistry | Receptors, Dopamine D1 - genetics | Physiological aspects | Visual cortex | Genetic aspects | Research | Dopamine receptors
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11. Full Text Dopamine D2 receptor occupancy and clinical effects: A systematic review and pooled analysis
by Uchida, Hiroyuki and Takeuchi, Hiroyoshi and Graff-Guerrero, Ariel and Suzuki, Takefumi and Watanabe, Koichiro and Mamo, David C
Journal of Clinical Psychopharmacology, ISSN 0271-0749, 08/2011, Volume 31, Issue 4, pp. 497 - 502
Positron emission tomography (PET) studies proposed a therapeutic window of D2 receptor occupancy (65%-80%) of antipsychotics for the treatment of... 
antipsychotic | receptor | schizophrenia | dopamine D | positron emission tomography | dopamine | Brain - diagnostic imaging | Schizophrenia - metabolism | Humans | Treatment Outcome | Positron-Emission Tomography - methods | Receptors, Dopamine D2 - metabolism | Schizophrenia - diagnostic imaging | Brain - metabolism | Animals | Antipsychotic Agents - therapeutic use | Antipsychotic Agents - metabolism | Receptors, Dopamine D2 - physiology | Clinical Trials as Topic - methods | Schizophrenia - drug therapy
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12. Full Text Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
by Johnson, Paul M and Kenny, Paul J
Nature Neuroscience, ISSN 1097-6256, 05/2010, Volume 13, Issue 5, pp. 635 - 641
We found that development of obesity was coupled with emergence of a progressively worsening deficit in neural reward responses. Similar changes in reward... 
LEPTIN | LATERAL HYPOTHALAMUS | DIET | SELF-STIMULATION | DRUG-ADDICTION | SENSITIVITY | NEUROSCIENCES | BRAIN | CONSUMPTION | DARK SIDE | FOOD | Rats, Wistar | Diet - adverse effects | Food Preferences - physiology | Conditioning, Operant - physiology | Behavior, Addictive - etiology | Male | Phosphopyruvate Hydratase - metabolism | Weight Gain - physiology | Green Fluorescent Proteins - genetics | Compulsive Behavior - etiology | Glial Fibrillary Acidic Protein - metabolism | Receptors, Dopamine D2 - metabolism | Behavior, Addictive - metabolism | Behavior, Animal | Energy Intake - physiology | Compulsive Behavior - metabolism | RNA, Small Nuclear - genetics | Obesity - etiology | Electric Stimulation - methods | Disease Models, Animal | Hypothalamus - physiology | Obesity - complications | Rats | Feeding Behavior - physiology | Receptors, Dopamine D2 - genetics | Obesity - metabolism | Down-Regulation - physiology | Animals | Corpus Striatum - physiology | RNA, Small Nuclear - metabolism | Reward | Animal experimentation | Obesity | Usage | Dopamine | Compulsive eating | Physiological aspects | Research
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13. Full Text Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation
by Trifilieff, P and Feng, B and Urizar, E and Winiger, V and Ward, R.D and Taylor, K.M and Martinez, D and Moore, H and Balsam, P.D and Simpson, E.H and Javitch, J.A
Molecular Psychiatry, ISSN 1359-4184, 09/2013, Volume 18, Issue 9, pp. 1025 - 1033
A decrease in dopamine D2 receptor (D2R) binding in the striatum is one of the most common findings in disorders that involve a dysregulation of motivation,... 
reward | D2 receptor | nucleus accumbens | viral vector | dopamine | motivation | MICE LACKING DOPAMINE-D-2 | NEGATIVE SYMPTOMS | PSYCHIATRY | BASAL GANGLIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | INCENTIVE MOTIVATION | NEUROSCIENCES | STRIATAL DOPAMINE | DECISION-MAKING | COCAINE DEPENDENCE | SEEKING BEHAVIOR | DORSAL STRIATUM | ANIMAL-MODEL | Green Fluorescent Proteins - metabolism | Microtubule-Associated Proteins - metabolism | Mice, Inbred C57BL | Nucleus Accumbens - metabolism | Gene Expression Regulation - physiology | Green Fluorescent Proteins - genetics | Receptors, Dopamine D2 - metabolism | Mice, Knockout | Animals | Motivation - physiology | Tritium - metabolism | Analysis of Variance | Conditioning, Classical | Conditioning, Operant | Genetic Vectors - physiology | Mice | Reward | Psychological aspects | Nucleus accumbens | Molecular neurobiology | Motivation (Psychology) | Dopamine | Physiological aspects | Reward (Psychology) | Research | Neuropsychology | Dopamine receptors | D2 Receptor | Nucleus Accumbens | incentive salience
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