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Science (American Association for the Advancement of Science), ISSN 1095-9203, 2007, Volume 317, Issue 5843, pp. 1390 - 1393
... (SERT, NET, and DAT, respectively) in the presynaptic membrane. The drug-binding site and the mechanism of this inhibition are poorly understood... 
Molecules | Salts | Neurotransmitters | Antidepressants | Reuptake | Serotonin plasma membrane transport proteins | Neurotransmitter transport proteins | Reports | Pharmacology | Inhibitory concentration 50 | Crystal structure | SENSITIVE DOPAMINE TRANSPORTER | NOREPINEPHRINE TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | ION-BINDING | MONOAMINE TRANSPORTERS | SEROTONIN | INHIBITORS | Dopamine - chemistry | Antidepressive Agents, Tricyclic - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Bacterial Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Serotonin - chemistry | Dopamine Uptake Inhibitors - metabolism | Drosophila Proteins - metabolism | Antidepressive Agents, Tricyclic - chemistry | Neurotransmitter Uptake Inhibitors - metabolism | Desipramine - metabolism | Conserved Sequence | Binding Sites | Dopamine - metabolism | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Cell Line | Leucine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Models, Molecular | Serotonin Uptake Inhibitors - chemistry | Drosophila Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Leucine - chemistry | Sequence Homology, Amino Acid | Animals | Norepinephrine - metabolism | Desipramine - chemistry | Neurotransmitter Uptake Inhibitors - chemistry | Norepinephrine - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Protein Conformation | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Leucine | Structure | Desipramine | Health aspects | Antidepressants, Tricyclic | Inhibitor drugs | Psychiatry | Binding sites
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 532, Issue 7599, pp. 334 - 339
..., a group of G-protein-coupled receptors and ligand-gated ion channels that participate in both excitatory and inhibitory neurotransmission and modulate the release... 
HIGH-AFFINITY RECOGNITION | NEUROTRANSMITTER TRANSPORTERS | NOREPINEPHRINE TRANSPORTERS | N-LINKED GLYCOSYLATION | ALLOSTERIC BINDING | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVE RECOGNITION | MEMBRANE-PROTEINS | DOPAMINE TRANSPORTER | Citalopram - pharmacology | Humans | Protein Conformation - drug effects | Crystallography, X-Ray | Dopamine Plasma Membrane Transport Proteins - chemistry | Structure-Activity Relationship | Antidepressive Agents - metabolism | Citalopram - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Extracellular Space - metabolism | Antidepressive Agents - chemistry | Protein Binding - drug effects | Drug Design | Antidepressive Agents - pharmacology | Protein Stability | Allosteric Regulation - drug effects | Ions - chemistry | Serotonin Plasma Membrane Transport Proteins - immunology | Allosteric Site - drug effects | Models, Molecular | Ions - metabolism | Paroxetine - metabolism | Serotonin Plasma Membrane Transport Proteins - metabolism | Citalopram - chemistry | Intracellular Space - metabolism | Serotonin - metabolism | Ligands | Immunoglobulin Fab Fragments - immunology | Paroxetine - pharmacology | Paroxetine - chemistry | Drug metabolism | Paroxetine | Physiological research | Research | Serotonin | Binding sites (Biochemistry) | X rays | Mutation | Antidepressants | Binding sites | X-ray crystallography | Transporters in the nervous system | BASIC BIOLOGICAL SCIENCES | Membrane proteins
Journal Article
Psychopharmacology, ISSN 0033-3158, 1/2007, Volume 189, Issue 4, pp. 489 - 503
.... In rats, MDMA-mediated effects are attributed, in part, to selective high-affinity transport of MDMA into 5-HT neurons by the 5-HT transporter (SERT... 
Ecstasy | Biomedicine | Dopamine | Serotonin | Reuptake inhibitors | Transporters | Norepinephrine | Pharmacology/Toxicology | Trace amine receptors | Psychiatry | Monoamines | MDMA | norepinephrine | NONHUMAN-PRIMATES | SUBSTITUTED AMPHETAMINES | transporters | PSYCHIATRY | ecstasy | TRACE AMINES | MONOAMINE TRANSPORTERS | trace amine receptors | NEUROSCIENCES | serotonin | METHYLENEDIOXYMETHAMPHETAMINE MDMA | RAT-BRAIN SLICES | 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA | PARA-CHLOROAMPHETAMINE | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | reuptake inhibitors | dopamine | ABUSED DRUG MDMA | monoamines | Dopamine Plasma Membrane Transport Proteins - metabolism | Temperature | Dopamine Plasma Membrane Transport Proteins - drug effects | Stereoisomerism | Humans | Brain - metabolism | Dose-Response Relationship, Drug | Serotonin Agents - toxicity | Serotonin Plasma Membrane Transport Proteins - drug effects | Transfection | N-Methyl-3,4-methylenedioxyamphetamine - chemistry | Dopamine - metabolism | Binding, Competitive | Cell Line | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Serotonin Agents - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Brain - drug effects | N-Methyl-3,4-methylenedioxyamphetamine - metabolism | Neurotoxicity Syndromes - etiology | Serotonin Plasma Membrane Transport Proteins - metabolism | Norepinephrine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - drug effects | Serotonin Agents - chemistry | Serotonin - metabolism | Neurotoxicity Syndromes - metabolism | N-Methyl-3,4-methylenedioxyamphetamine - toxicity | Kinetics | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - drug effects | Primates | Brain | Neurotransmitters | Neurotoxicity | Neurons
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 02/2014, Volume 57, Issue 3, pp. 1000 - 1013
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 2011, Volume 108, Issue 29, pp. 12137 - 12142
Inhibitors of the serotonin transporter (SERT) and norepinephrine transporter (NET) are widely used in the treatment of major depressive disorder. Although... 
Tricyclic antidepressive agents | Antidepressants | Norepinephrine plasma membrane transport proteins | Reuptake | Serotonin plasma membrane transport proteins | Norepinephrine | Enantiomers | Experimental procedures | Binding sites | Chemicals | Monoamine | Neurotransmitter | SLC6 transporter | HIGH-AFFINITY RECOGNITION | NEUROTRANSMITTER TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | CITALOPRAM | MONOAMINE TRANSPORTERS | monoamine | BACTERIAL HOMOLOG | SUBSTRATE | DOPAMINE | BINDING-SITE | LEUT | neurotransmitter | STRUCTURAL DOMAINS | Humans | Cercopithecus aethiops | Molecular Sequence Data | Structure-Activity Relationship | Antidepressive Agents - metabolism | Citalopram - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | DNA Mutational Analysis | Norepinephrine Plasma Membrane Transport Proteins - genetics | Base Sequence | Radioligand Assay | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Crystallization | Models, Molecular | Binding Sites - genetics | Genetic Vectors - genetics | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Propylamines - metabolism | COS Cells | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Benzofurans - metabolism | Biological Sciences
Journal Article
Physical chemistry chemical physics : PCCP, ISSN 1463-9084, 2018, Volume 20, Issue 9, pp. 6606 - 6616
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2007, Volume 104, Issue 31, pp. 12761 - 12766
Journal Article
Molecular psychiatry, ISSN 1476-5578, 2014, Volume 19, Issue 6, pp. 688 - 698
Pharmacologic blockade of monoamine oxidase A (MAOA) or serotonin transporter (5-HTT) has antidepressant and anxiolytic efficacy in adulthood. Yet, genetically... 
anxiety | development | serotonin | aggression | depression | dopamine | BRAIN-SEROTONIN | RHESUS-MONKEYS | PSYCHIATRY | ENVIRONMENT INTERACTIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEFICIENT MICE | NEUROSCIENCES | GENE | SOMATOSENSORY CORTEX | MONOAMINE-OXIDASE-A | TRANSPORTER KNOCKOUT MICE | DORSAL RAPHE NUCLEUS | Aggression - physiology | Dopamine Plasma Membrane Transport Proteins - metabolism | Depression - physiopathology | Male | Brain - growth & development | Mice, 129 Strain | Brain - physiology | Dopaminergic Neurons - drug effects | Dopaminergic Neurons - physiology | Female | Dopamine - metabolism | Affect - drug effects | 3,4-Dihydroxyphenylacetic Acid - metabolism | Affect - physiology | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Amphetamine - pharmacology | Anxiety - physiopathology | Brain - drug effects | Dopamine Plasma Membrane Transport Proteins - antagonists & inhibitors | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Serotonin - metabolism | Central Nervous System Agents - pharmacology | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Aggression - drug effects | Monoamine Oxidase - metabolism | Passive-aggressive personality | Dopamine | Genetic susceptibility | Serotonin | Genetic research | Genetic aspects | Research | Properties | Mouse | Aggression | Development | Depression | Anxiety
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 569, Issue 7754, pp. 141 - 145
.... The transport activities of NSSs can be inhibited or modulated by cocaine and amphetamines(2,3), and genetic variants of NSSs are associated with several neuropsychiatric... 
FACING STATE | SITE | MOLECULAR-DYNAMICS | NEUROTRANSMITTER TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | VALIDATION | GENERAL FORCE-FIELD | X-RAY STRUCTURES | LEUT | BINDING | SOFTWARE NEWS | Binding, Competitive | Hallucinogens - pharmacology | Humans | Protein Conformation - drug effects | Hallucinogens - chemistry | Models, Molecular | Serotonin Plasma Membrane Transport Proteins - ultrastructure | Serotonin Uptake Inhibitors - chemistry | Ibogaine - pharmacology | Structure-Activity Relationship | Cryoelectron Microscopy | Serotonin Plasma Membrane Transport Proteins - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | Ibogaine - chemistry | Serotonin - metabolism | Biological Transport - drug effects | Serotonin Uptake Inhibitors - pharmacology | Binding Sites - drug effects | Serotonin | Physiological aspects | Membrane proteins | Competition | Drug abuse | Mental disorders | Disorders | Homeostasis | Homology | Serotonin uptake inhibitors | Helices | Mental depression | Experiments | Ion diffusion | Proteins | Dopamine transporter | Anxiety | Noradrenaline | Dopamine | Narcotics | Attention deficit hyperactivity disorder | Unwinding | Substrate inhibition | Ibogaine | Electron microscopy | Substrates | Genetic variance | Autism | Serotonin transporter | Microscopy | Sodium | Natural products | Cocaine | Norepinephrine | Transport | Transporter | Binding sites | Cytoplasm
Journal Article