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Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2016, Volume 26, Issue 10, pp. 2422 - 2427
Journal Article
Science, ISSN 0036-8075, 9/2007, Volume 317, Issue 5843, pp. 1390 - 1393
Tricyclic antidepressants exert their pharmacological effect--inhibiting the reuptake of serotonin, norepinephrine, and dopamine--by directly blocking... 
Molecules | Salts | Neurotransmitters | Antidepressants | Reuptake | Serotonin plasma membrane transport proteins | Neurotransmitter transport proteins | Reports | Pharmacology | Inhibitory concentration 50 | Crystal structure | SENSITIVE DOPAMINE TRANSPORTER | NOREPINEPHRINE TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | ION-BINDING | MONOAMINE TRANSPORTERS | SEROTONIN | INHIBITORS | Dopamine - chemistry | Antidepressive Agents, Tricyclic - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Bacterial Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Serotonin - chemistry | Dopamine Uptake Inhibitors - metabolism | Drosophila Proteins - metabolism | Antidepressive Agents, Tricyclic - chemistry | Neurotransmitter Uptake Inhibitors - metabolism | Desipramine - metabolism | Conserved Sequence | Binding Sites | Dopamine - metabolism | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Cell Line | Leucine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Models, Molecular | Serotonin Uptake Inhibitors - chemistry | Drosophila Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Leucine - chemistry | Sequence Homology, Amino Acid | Animals | Norepinephrine - metabolism | Desipramine - chemistry | Neurotransmitter Uptake Inhibitors - chemistry | Norepinephrine - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Protein Conformation | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Leucine | Structure | Desipramine | Health aspects | Antidepressants, Tricyclic | Inhibitor drugs | Psychiatry | Binding sites
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2009, Volume 52, Issue 21, pp. 6768 - 6781
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 18, pp. 5559 - 5566
Two new series of monoamine triple reuptake inhibitors (TRIs) have been discovered through scaffold homologation of our recently reported series of... 
Triple reuptake inhibitor | Dopamine | Serotonin | Monoamine reuptake inhibitors | Depression | Norepinephrine | Noradrenalin | Major depressive disorder | CHEMISTRY, MEDICINAL | SSRIS | CHEMISTRY, ORGANIC | NEXT-GENERATION | Serotonin Uptake Inhibitors - pharmacokinetics | Neurotransmitter Uptake Inhibitors - pharmacokinetics | Antidepressive Agents, Tricyclic - pharmacokinetics | Humans | Neurotransmitter Uptake Inhibitors - pharmacology | Dopamine Uptake Inhibitors - pharmacokinetics | Serotonin Uptake Inhibitors - chemical synthesis | Antidepressive Agents, Tricyclic - chemistry | Pyrrolidines - pharmacology | Depression - drug therapy | Pain - drug therapy | Drug Design | Dopamine Uptake Inhibitors - chemical synthesis | Dopamine - metabolism | Caco-2 Cells | Neurotransmitter Uptake Inhibitors - chemical synthesis | Dopamine Uptake Inhibitors - pharmacology | Pyrrolidines - pharmacokinetics | Rats | Serotonin Uptake Inhibitors - chemistry | Pyrrolidines - chemistry | Animals | Norepinephrine - metabolism | Antidepressive Agents, Tricyclic - chemical synthesis | Pyrrolidines - chemical synthesis | Antidepressive Agents, Tricyclic - pharmacology | Neurotransmitter Uptake Inhibitors - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Serotonin Uptake Inhibitors - pharmacology | Analysis | Depression, Mental | Electric utilities | Health aspects | Noradrenaline | Atmospheric carbon dioxide | Brain
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2013, Volume 23, Issue 20, pp. 5515 - 5518
The design, synthesis and in vitro assay evaluation of a novel series of 3,4-diarylpyrrolidin-2-one is described as a triple reuptake inhibitor. Most of... 
Antidepressant | Dopamine | Triple reuptake inhibitors | Serotonin | Lactam | Monoamine | Reuptake | Depression | Norepinephrine | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | MAJOR DEPRESSION | POTENT | PROFILE | AGENTS | PHARMACOLOGICAL EVALUATION | Dopamine Plasma Membrane Transport Proteins - metabolism | Humans | Lactams - chemical synthesis | Dopamine Uptake Inhibitors - metabolism | Antidepressive Agents - metabolism | Serotonin Uptake Inhibitors - chemical synthesis | Serotonin Plasma Membrane Transport Proteins - chemistry | Adrenergic Uptake Inhibitors - chemistry | Antidepressive Agents - chemistry | Pyrrolidinones - metabolism | Dopamine Uptake Inhibitors - chemical synthesis | Adrenergic Uptake Inhibitors - chemical synthesis | Serotonin Uptake Inhibitors - metabolism | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Serotonin Uptake Inhibitors - chemistry | Pyrrolidinones - chemistry | Lactams - metabolism | Dopamine Plasma Membrane Transport Proteins - antagonists & inhibitors | Serotonin Plasma Membrane Transport Proteins - metabolism | Pyrrolidinones - chemical synthesis | Adrenergic Uptake Inhibitors - metabolism | Dopamine Uptake Inhibitors - chemistry | Antidepressive Agents - chemical synthesis | Protein Binding | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Lactams - chemistry | Analysis | Resveratrol | Antidepressants
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2010, Volume 53, Issue 12, pp. 4731 - 4748
To create potentially superior aids to smoking cessation and/or antidepressants and to elucidate bupropion’s possible mechanisms of action(s), 23 analogues... 
SYSTEM | NICOTINIC RECEPTORS | METABOLITES | CHEMISTRY, MEDICINAL | DRUG-INTERACTIONS | TRANSPORTERS | NEURONS | TARGETS | ALPHA 6 | BRAIN | BUPROPION HYDROXYLATION | Analgesics - pharmacology | Body Temperature - drug effects | Stereoisomerism | Humans | Bupropion - analogs & derivatives | Motor Activity - drug effects | Male | Nicotinic Antagonists - pharmacology | Structure-Activity Relationship | Serotonin Uptake Inhibitors - chemical synthesis | Nicotine - pharmacology | Adrenergic Uptake Inhibitors - chemistry | Nicotinic Antagonists - chemical synthesis | Analgesics - chemical synthesis | Dopamine Uptake Inhibitors - chemical synthesis | Adrenergic Uptake Inhibitors - chemical synthesis | Nicotinic Agonists - pharmacology | Cell Line | Dopamine Uptake Inhibitors - pharmacology | Bupropion - chemical synthesis | Serotonin Uptake Inhibitors - chemistry | Mice, Inbred ICR | Animals | Bupropion - chemistry | Nicotinic Antagonists - chemistry | Receptors, Nicotinic - physiology | Analgesics - chemistry | Dopamine Uptake Inhibitors - chemistry | Adrenergic Uptake Inhibitors - pharmacology | Bupropion - pharmacology | Mice | Serotonin Uptake Inhibitors - pharmacology | Smoking Cessation | hydroxybupropion | antinociception | hypothermia | nAChR antagonism | norepinephrine uptake | locomotor activity | structure activity relationship | dopamine uptake | bupropion | Nicotine
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 11, pp. 3451 - 3461
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2012, Volume 22, Issue 23, pp. 7219 - 7222
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2014, Volume 24, Issue 11, pp. 2429 - 2432