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1. Full Text A Preliminary Study of DBH (Encoding Dopamine Beta-Hydroxylase) Genetic Variation and Neural Correlates of Emotional and Motivational Processing in Individuals with and without Pathological Gambling
by Yang, Bao-Zhu and Balodis, Iris M and Lacadie, Cheryl M and Xu, Jiansong and Potenza, Marc N
Journal of Behavioral Addictions, ISSN 2062-5871, 2016, Volume 5, Issue 2, pp. 282 - 292
Corticostriatal-limbic neurocircuitry, emotional and motivational processing, dopaminergic and noradrenergic systems and genetic factors have all been... 
Substance abuse and addiction | Neuropsychology | Cognitive Psychology | Clinical psychology | Psychoanalysis | Demography and human biology | Functional magnetic resonance imaging | Mood | Addiction | Cue responsivity | Dbh gene | BRAIN ACTIVITY | mood | GENOTYPE | PSYCHIATRY | addiction | cue responsivity | DISORDERS | POLYMORPHISM | IMPULSIVITY | URGES | PREFRONTAL CORTEX | DBH gene | DISULFIRAM | DECISION-MAKING | functional magnetic resonance imaging | United States | Humans | Male | Cocaine-Related Disorders - genetics | Cocaine-Related Disorders - physiopathology | Genotyping Techniques | European Continental Ancestry Group - psychology | Adult | Female | Emotions - physiology | European Continental Ancestry Group - genetics | Visual Perception - physiology | Cocaine-Related Disorders - psychology | Gambling - psychology | Brain - physiopathology | Neuropsychological Tests | Magnetic Resonance Imaging | Motivation - physiology | Dopamine beta-Hydroxylase - genetics | Brain Mapping | Video Recording | Heterozygote | Polymorphism, Single Nucleotide | Gambling - physiopathology | Gambling - genetics | Motivation - genetics | Psychological aspects | Genetic aspects | Gamblers | Compulsive gambling | Dopamine receptors
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2. Full Text Pharmacogenetic Randomized Trial for Cocaine Abuse: Disulfiram and Dopamine β-Hydroxylase
by Kosten, Thomas R and Wu, Guiying and Huang, Wen and Harding, Mark J and Hamon, Sara C and Lappalainen, Jaakko and Nielsen, David A
Biological Psychiatry, ISSN 0006-3223, 2013, Volume 73, Issue 3, pp. 219 - 224
Background Disulfiram has been an effective cocaine addiction pharmacotherapy, and one of its possible mechanisms of efficacy is through copper chelation and... 
Psychiatry | treatment | dependence | Cocaine | disulfiram | polymorphism | genes | DBH LOCUS | EMOTIONALLY-DISTURBED BOYS | PSYCHIATRY | CONDUCT DISORDER | MAJOR DEPRESSION | NEUROSCIENCES | GENOTYPE-CONTROLLED ANALYSIS | LINKAGE DISEQUILIBRIUM | HIV-INFECTION | POPULATION-STRUCTURE | METHADONE-MAINTENANCE PATIENTS | OPIOID ADDICTS | Opioid-Related Disorders - drug therapy | Humans | Middle Aged | Methadone - therapeutic use | Genotype | Male | Treatment Outcome | Cocaine-Related Disorders - genetics | Disulfiram - therapeutic use | Cocaine-Related Disorders - complications | Dopamine beta-Hydroxylase - genetics | Opioid-Related Disorders - genetics | Adult | Female | Cocaine-Related Disorders - drug therapy | Polymorphism, Single Nucleotide | Drug Therapy, Combination | Opioid-Related Disorders - complications | cocaine | Genes
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3. Full Text Dopamine beta-hydroxylase participate in the immunoendocrine responses of hypothermal stressed white shrimp, Litopenaeus vannamei
by Cheng, Winton and Ka, Ya-Wen and Chang, Chin-Chyuan
Fish and Shellfish Immunology, ISSN 1050-4648, 12/2016, Volume 59, pp. 166 - 178
Dopamine beta-hydroxylase (DBH) plays a critical role in catecholamine (CA) synthesis of neuroendocrine regulatory network, and is suggested to be involved in... 
Disulfiram | Dopamine beta-hydroxylase | Hypothermal stress | Gene silencing | Catecholamines | TIGER SHRIMP | PHYSIOLOGICAL-RESPONSES | IMMUNOLOGY | ADRENERGIC-RECEPTORS | CHLAMYS-FARRERI | FISHERIES | HYPERGLYCEMIC RESPONSES | MARINE & FRESHWATER BIOLOGY | WATER GIANT PRAWN | BIOGENIC-AMINES | GENE-EXPRESSION | VETERINARY SCIENCES | CENTRAL-NERVOUS-SYSTEM | TRANSIENT MODULATION | Amino Acid Sequence | Penaeidae - genetics | RNA, Messenger - genetics | DNA, Complementary - genetics | Gene Expression Regulation | Arthropod Proteins - genetics | Phylogeny | Immunity, Innate | RNA, Messenger - metabolism | Dopamine beta-Hydroxylase - chemistry | Cold Temperature - adverse effects | Sequence Homology, Amino Acid | Arthropod Proteins - chemistry | Animals | Dopamine beta-Hydroxylase - genetics | Base Sequence | Cloning, Molecular | Dopamine beta-Hydroxylase - metabolism | Arthropod Proteins - metabolism | Penaeidae - metabolism | DNA, Complementary - metabolism | Disulfiram - pharmacology | Penaeidae - immunology | Copper compounds | Phenols | Genetic engineering | Dopamine
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4. Full Text Association of Dopamine Beta-Hydroxylase Polymorphisms with Alzheimer's Disease, Parkinson's Disease and Schizophrenia: Evidence Based on Currently Available Loci
by Tang, Siqi and Yao, Bin and Li, Na and Lin, Shuhuang and Lin, Shuhuang and Huang, Zunnan and Huang, Zunnan
Cellular Physiology and Biochemistry, ISSN 1015-8987, 2018, Volume 51, Issue 1, pp. 411 - 428
Background/Aims: The neuropathies Alzheimer's disease (AD), Parkinson's disease (PD), and schizophrenia (SCZ) have different pathological mechanisms but share... 
Dopamine beta-hydroxylase | Parkinson's disease | Alzheimer’s disease | Neurodegenerative diseases | Schizophrenia | Alzheimer's disease | Parkinson’s disease | Meta-analysis | Polymorphism | DIAGNOSIS | FUNCTIONAL POLYMORPHISM | PHYSIOLOGY | METAANALYSIS | INSERTION/DELETION POLYMORPHISM | DBH GENE | SUSCEPTIBILITY | SYMPTOMS | GENE POLYMORPHISM | CELL BIOLOGY | RISK-FACTOR | ONSET | European Continental Ancestry Group - genetics | Parkinson Disease - pathology | Humans | Risk | Schizophrenia - pathology | Genetic Loci | Parkinson Disease - genetics | Alzheimer Disease - pathology | Schizophrenia - genetics | Dopamine beta-Hydroxylase - genetics | Alleles | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Odds Ratio | Databases, Factual
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5. Full Text Involvement of dopamine beta-hydroxylase in the neuroendocrine-immune regulatory network of white shrimp, Litopenaeus vannamei
by Cheng, Winton and Ka, Ya-Wen and Chang, Chin-Chyuan
Fish and Shellfish Immunology, ISSN 1050-4648, 09/2017, Volume 68, pp. 92 - 101
In shrimp, the biosynthesis of catecholamines, including dopamine and norepinephrine, is required for physiological and immunological responses against stress.... 
Dopamine beta-hydroxylase | Gene silencing | Disulfiram | Catecholamines | Immunocompetence | Litopenaeus vannamei | Vibrio alginolyticus | MACROBRACHIUM-ROSENBERGII | PENAEUS-MONODON | TIGER SHRIMP | PHYSIOLOGICAL-RESPONSES | PROPHENOLOXIDASE SYSTEM | IMMUNOLOGY | CHLAMYS-FARRERI | FISHERIES | HYPERGLYCEMIC RESPONSES | MARINE & FRESHWATER BIOLOGY | WATER GIANT PRAWN | VETERINARY SCIENCES | VIBRIO-ALGINOLYTICUS INFECTION | TRANSIENT MODULATION | Vibrio alginolyticus - physiology | Penaeidae - genetics | Gene Silencing | Immunity, Innate - genetics | Neurosecretory Systems - immunology | Arthropod Proteins - genetics | Arthropod Proteins - immunology | Penaeidae - enzymology | Neurosecretory Systems - enzymology | Animals | Dopamine beta-Hydroxylase - genetics | Dopamine beta-Hydroxylase - metabolism | Arthropod Proteins - metabolism | Dopamine beta-Hydroxylase - immunology | Disulfiram - pharmacology | Penaeidae - immunology | Enzymes | Dopamine | Immunotherapy | Phenols | Disease susceptibility | Superoxide | Genetic engineering
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6. Full Text Analysis of dopamine beta hydroxylase gene polymorphisms in migraine
by Sezer, Saime and Kurt, Semiha and Ates, Omer
Clinical Neurology and Neurosurgery, ISSN 0303-8467, 2016, Volume 145, pp. 96 - 100
Highlights • Migraine is a genetic disease that affected by environmental factors. • Hypersensitivity of dopaminergic system can cause such as nausea and... 
Neurology | Neurosurgery | Dopamin beta hydroxylase gene | Genetic susceptibility | Migraine | Polymorphism | SURGERY | DBH LOCUS | LINKAGE DISEQUILIBRIUM | SUSCEPTIBILITY | ASSOCIATION | CLINICAL NEUROLOGY | Genetic Predisposition to Disease | Turkey | Migraine Disorders - genetics | Dopamine beta-Hydroxylase - genetics | Humans | Middle Aged | Adult | Female | Male | Polymorphism, Genetic | Genetic research | Genetic aspects | Genes | Analysis | Genetic polymorphisms | Nervous system diseases | Anopheles | Disease susceptibility | Studies | Confidence intervals | Enzymes | Statistical analysis | Dopamine | Headaches | Age | Data bases | Deoxyribonucleic acid--DNA
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7. Full Text Associations between the DBH gene, plasma dopamine β-hydroxylase activity and cognitive measures in Han Chinese patients with schizophrenia
by Sun, Zuoli and Ma, Yun and Li, Wenbiao and He, Jing and Li, Jun and Yang, Xue and Mao, Peixian and Cubells, Joseph F and Tang, Yilang
Schizophrenia Research, ISSN 0920-9964, 2017, Volume 193, pp. 58 - 63
Abstract The dopamine (DA) and norepinephrine (NE) systems modulate cognitive function. Dopamine β-hydroxylase (DβH) converts DA to NE, and its activity is... 
Psychiatry | Schizophrenia | Cognitive function | Genetic polymorphism | Dopamine β-hydroxylase | ATTENTION | BP INSERTION/DELETION POLYMORPHISM | PSYCHIATRY | ALZHEIMERS-DISEASE | PERFORMANCE | LOCUS | CHILDREN | Dopamine beta-hydroxylase | LINKAGE DISEQUILIBRIUM | DISORDER | SINGLE NUCLEOTIDE POLYMORPHISM | HAPLOTYPE | China - ethnology | Genetic Association Studies | Schizophrenia - blood | Cognition Disorders - blood | Gene Frequency | Humans | Genotype | Male | Schizophrenia - complications | Schizophrenic Psychology | Neuropsychological Tests | Young Adult | Cognition Disorders - diagnosis | Schizophrenia - genetics | Dopamine beta-Hydroxylase - genetics | Cognition Disorders - etiology | Adolescent | Dopamine beta-Hydroxylase - blood | Polymorphism, Single Nucleotide - genetics | Adult | Female
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8. Full Text Association of Dopamine Beta-Hydroxylase (DBH) Polymorphisms with Susceptibility to Parkinson's Disease
by Shao, P and Yu, YX and Bao, JX
MEDICAL SCIENCE MONITOR, ISSN 1643-3750, 05/2016, Volume 22, pp. 1617 - 1622
Background: The purpose of this study was to explore the association between 2 single-nucleotide polymorphisms (SNPs) in the dopamine beta-hydroxylase (DBH)... 
MEDICINE, RESEARCH & EXPERIMENTAL | FUNCTIONAL POLYMORPHISM | SCHIZOPHRENIA | RISK | Dopamine beta-Hydroxylase | LOCUS | DEFICIENCY | Polymorphism, Genetic | CELL-DEATH | Parkinson Disease | GENE | LINKAGE | BRAIN | AGE | Genetic Predisposition to Disease | Gene Frequency | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Male | Parkinson Disease - genetics | Case-Control Studies | Dopamine beta-Hydroxylase - genetics | China | Parkinson Disease - enzymology | Alleles | Dopamine beta-Hydroxylase - metabolism | Female | Aged | Polymorphism, Single Nucleotide
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9. Full Text Dopamine beta-hydroxylase gene modulates individuals' empathic ability
by Gong, Pingyuan and Liu, Jinting and Li, She and Zhou, Xiaolin
Social Cognitive and Affective Neuroscience, ISSN 1749-5016, 04/2013, Volume 9, Issue 9, pp. 1341 - 1345
Dopamine beta-hydroxylase (DBH), an enzyme that converts dopamine to norepinephrine, has broad influences on social functions. In this study, we examined to... 
Dopamine beta-hydroxylase | Empathy | 1021C/T | DBH | Polymorphism | empathy | AUTISM | NOREPINEPHRINE | EMOTIONAL EMPATHY | ADULTS | SCHIZOPHRENIA | polymorphism | dopamine beta-hydroxylase | ASPERGER-SYNDROME | NEUROSCIENCES | PSYCHOLOGY, EXPERIMENTAL | PSYCHOLOGY | MIND | Empathy - genetics | Humans | Asian Continental Ancestry Group - genetics | Genotype | Male | Asian Continental Ancestry Group - ethnology | Young Adult | Analysis of Variance | Dopamine beta-Hydroxylase - genetics | Individuality | Female | Polymorphism, Genetic - genetics | Psychological Tests | 1021C | Original
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10. Full Text Generation of two noradrenergic-specific dopamine-beta-hydroxylase-FLPo knock-in mice using CRISPR/Cas9-Mediated targeting in embryonic stem cells
by Sun, Jenny J and Ray, Russell
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, p. e0159474
CRISPR/Cas9 mediated DNA double strand cutting is emerging as a powerful approach to increase rates of homologous recombination of large targeting vectors, but... 
CONSOLIDATION | NOREPINEPHRINE | MEMORY | ALZHEIMERS-DISEASE | ZYGOTES | MULTIDISCIPLINARY SCIENCES | DBH GENE | NEURONS | POLYMORPHISM | NORADRENALINE | LOCUS | Embryonic Stem Cells - metabolism | Gene Targeting - methods | Catecholamines - metabolism | RNA, Guide - metabolism | Brain Stem - metabolism | Mice, Transgenic | CRISPR-Cas Systems - genetics | Homozygote | Animals | Dopamine beta-Hydroxylase - genetics | DNA Nucleotidyltransferases - metabolism | Heterozygote | Inbreeding | Mice | Gene Knock-In Techniques - methods | Genetic engineering | Research | Embryonic stem cells | Dopamine receptors | Attention deficit disorder | Neurosciences | Brain stem | Homologous recombination | Embryo cells | Stem cell transplantation | Homology | Alcohol | Nervous system | Recombinase | Optimization | DBH gene | Efficiency | Rodents | Physiology | Deoxyribonucleic acid--DNA | CRISPR | Translation | Dopamine | Neurons | Hydroxylase | Migraine | Cloning | Stop codon | Injection | Loci | Medicine | Stem cells | Norepinephrine | Alzheimers disease | Deoxyribonucleic acid | DNA
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11. Full Text Deep sequencing identifies novel regulatory variants in the distal promoter region of the dopamine-β-hydroxylase gene
by Punchaichira, Toyanji J and Prasad, Suman and Deshpande, Smita N and Thelma, B.K
Pharmacogenetics and Genomics, ISSN 1744-6872, 07/2016, Volume 26, Issue 7, pp. 311 - 323
OBJECTIVEDopamine-β-hydroxylase (DBH), an enzyme that converts dopamine into norepinephrine, is a drug target in cardiovascular and neuropsychiatric disorders.... 
DBH activity | NEPICASTAT RS-25560-197 | SCHIZOPHRENIC-PATIENTS | DBH quantity | quantitative trait | ALZHEIMERS-DISEASE | DBH GENE | SUSCEPTIBILITY LOCI | targeted resequencing | BLOOD-PRESSURE | PLASMA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | PERSONAL GENOMES | PHARMACOLOGY & PHARMACY | regulatory SNPs | CONGESTIVE-HEART-FAILURE | ASSOCIATION | Genetic Predisposition to Disease | Humans | Genotype | Male | Promoter Regions, Genetic - genetics | Linkage Disequilibrium | Gene Expression Regulation, Enzymologic | Haplotypes - genetics | Phenotype | Dopamine beta-Hydroxylase - genetics | Polymorphism, Single Nucleotide - genetics | Adult | Female | High-Throughput Nucleotide Sequencing - methods | Regulatory Elements, Transcriptional - genetics | Cohort Studies
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12. Full Text Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease
by Mustapic, Maja and Presecki, Paola and Pivac, Nela and Mimica, Ninoslav and Hof, Patrick R and Simic, Goran and Folnegovic-Smalc, Vera and Muck-Seler, Dorotea
Progress in Neuropsychopharmacology & Biological Psychiatry, ISSN 0278-5846, 07/2013, Volume 44, pp. 94 - 99
The noradrenergic system is involved in the etiology and progression of Alzheimer's disease (AD) but its role is still unclear. Dopamine beta-hydroxylase (DBH)... 
Cognitive decline | Plasma DBH activity | Dopamine beta-hydroxylase | DBH gene polymorphisms | Alzheimer's disease | MINI-MENTAL-STATE | NOREPINEPHRINE | IMMUNOREACTIVITY | PSYCHIATRY | DBH GENE | POLYMORPHISM | CEREBROSPINAL-FLUID | LOCUS-CERULEUS | NEUROSCIENCES | CLINICAL NEUROLOGY | CHOLINERGIC NEURONS | NORADRENERGIC NERVOUS-SYSTEM | PHARMACOLOGY & PHARMACY | PARKINSONS-DISEASE | Genetic Predisposition to Disease - genetics | Humans | Middle Aged | Genotype | Male | Case-Control Studies | Psychiatric Status Rating Scales | Analysis of Variance | Dopamine beta-Hydroxylase - genetics | Dopamine beta-Hydroxylase - blood | Aged, 80 and over | Polymorphism, Single Nucleotide - genetics | Female | Aged | Alzheimer Disease - genetics | Odds Ratio | Alzheimer Disease - blood | Dopamine | Analysis | Amyloid beta-protein | Phenols | Development and progression | Genetic aspects | Noradrenaline
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13. Full Text The dopamine beta-hydroxylase gene polymorphism rs1611114 is associated with schizophrenia in the Chinese Zhuang but not Chinese Han population
by Long, Jianxiong and Huang, Guifeng and Liang, Baoyun and Ling, Weijun and Guo, Xiaojing and Jiang, Juan and Su, Li
Molecular Genetics and Genomics, ISSN 1617-4615, 10/2016, Volume 291, Issue 5, pp. 1813 - 1821
Schizophrenia (SCZ) is a devastating neurodevelopmental disorder. However, the mechanism underlying this highly heritable disorder remains unclear. The... 
Life Sciences | Biochemistry, general | Microbial Genetics and Genomics | Schizophrenia | Association study | Dopamine beta-hydroxylase gene | Cell Biology | Plant Genetics & Genomics | Animal Genetics and Genomics | mRNA expression | Polymorphism | LOCALIZATION | DBH LOCUS | VARIANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY | PREVALENCE | GENETICS & HEREDITY | HUMAN-BRAIN | LINKAGE ANALYSIS | HAPLOTYPE | EXPRESSION | GENOME-WIDE ASSOCIATION | China - ethnology | Genetic Predisposition to Disease | Genetic Association Studies | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Male | Case-Control Studies | Asian Continental Ancestry Group - ethnology | Young Adult | Schizophrenia - ethnology | Schizophrenia - genetics | Dopamine beta-Hydroxylase - genetics | Adult | Female | Polymorphism, Single Nucleotide
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14. Full Text Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure
by Chen, Yuqing and Wen, Gen and Rao, Fangwen and Zhang, Kuixing and Wang, Lei and Rodriguez-Flores, Juan L and Sanchez, Amber P and Mahata, Manjula and Taupenot, Laurent and Sun, Ping and Mahata, Sushil K and Tayo, Bamidele and Schork, Nicholas J and Ziegler, Michael G and Hamilton, Bruce A and OʼConnor, Daniel T
Journal of Hypertension, ISSN 0263-6352, 01/2010, Volume 28, Issue 1, pp. 76 - 86
RATIONALEDopamine beta-hydroxylase (DBH) plays an essential role in catecholamine synthesis by converting dopamine into norepinephrine. Here we systematically... 
Hypertension | Dopamine beta-hydroxylase | Polymorphism | TRANSCRIPTION FACTORS | NERVOUS-SYSTEM | polymorphism | dopamine beta-hydroxylase | CEREBROSPINAL-FLUID | CARDIOVASCULAR REACTIVITY | LINKAGE DISEQUILIBRIUM | GENETIC RISK | INHIBITORY PEPTIDE CATESTATIN | DISEASE | PERIPHERAL VASCULAR DISEASE | hypertension | ASSOCIATION | United States - epidemiology | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Blood Pressure - genetics | Heart Rate - genetics | Humans | Middle Aged | Autonomic Nervous System - physiology | Male | Hypertension - physiopathology | Genetic Variation | Young Adult | Dopamine beta-Hydroxylase - genetics | Adolescent | Nigeria - epidemiology | Aged, 80 and over | Adult | Female | Aged | Blood Pressure - physiology | Polymorphism, Single Nucleotide | African Continental Ancestry Group - genetics | Hypertension - epidemiology | Hypertension - genetics | Index Medicus
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