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Molecular Cell, ISSN 1097-2765, 03/2009, Volume 33, Issue 5, pp. 627 - 638
Mutations in cause autosomal recessive Parkinson's disease. PINK1 is a mitochondrial kinase of unknown function. We investigated calcium homeostasis and... 
CELLBIO | CELLCYCLE | PERMEABILITY TRANSITION PORE | NADPH OXIDASE | OXIDATIVE STRESS | PINK1 | INTACT-CELLS | HUMAN BRAIN | PROTECTS NEURONS | COMPLEX-I | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOPAMINERGIC-NEURONS | HEART-MITOCHONDRIA | CELL BIOLOGY | Glucose Transport Proteins, Facilitative - metabolism | Protein Kinases - metabolism | Mitochondria - enzymology | Neurons - pathology | Fetal Stem Cells - pathology | Protein Kinases - genetics | Reactive Oxygen Species - metabolism | Oxidative Stress | Apoptosis - drug effects | Apoptosis - radiation effects | Calcium - metabolism | Humans | NADPH Oxidases - metabolism | Homeostasis | Ultraviolet Rays | RNA Interference | Time Factors | Sodium-Calcium Exchanger - metabolism | Membrane Potential, Mitochondrial | Mitochondria - radiation effects | Parkinsonian Disorders - genetics | Protein Kinases - deficiency | Fetal Stem Cells - enzymology | Fetal Stem Cells - radiation effects | Neurons - drug effects | Mitochondrial Membrane Transport Proteins - metabolism | Oxidation-Reduction | Mesencephalon - enzymology | Cells, Cultured | Parkinsonian Disorders - enzymology | Mitochondria - drug effects | Mitochondria - pathology | Mice, Knockout | Animals | Mesencephalon - embryology | Energy Metabolism | Fetal Stem Cells - drug effects | Parkinsonian Disorders - pathology | Neurons - enzymology | Cell Line, Tumor | Cytosol - metabolism | Mice | Neurons - radiation effects | RNA, Small Interfering - metabolism | Oxidases | Neurosciences | Parkinson's disease | Neurons | Cell death | Biochemistry | Mitochondrial DNA | Disease susceptibility | Glucose | Permeability | Dextrose
Journal Article
Journal Article
Journal Article
Journal Article
Journal Article
Brain, ISSN 0006-8950, 2012, Volume 135, Issue 11, pp. 3355 - 3370
Axonal degeneration is one of the earliest features of Parkinson's disease pathology, which is followed by neuronal death in the substantia nigra and other... 
axonal degeneration | Parkinson's disease | rho kinase | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | dopaminergic cell death | CONTROLLED-TRIAL | SIGNALING PATHWAYS | REGENERATION | SUBSTANTIA-NIGRA | NEUROSCIENCES | CLINICAL NEUROLOGY | CELL-DEATH | COENZYME Q | IN-VITRO | 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP | NEURITE OUTGROWTH | DOUBLE-BLIND | Neuroprotective Agents - therapeutic use | Rats, Wistar | Dopaminergic Neurons - pathology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Male | Corpus Striatum - metabolism | Nerve Degeneration - chemically induced | Neuroprotective Agents - metabolism | rho-Associated Kinases - antagonists & inhibitors | Parkinson Disease, Secondary - pathology | Neuroprotective Agents - pharmacology | Parkinson Disease, Secondary - drug therapy | Dopaminergic Neurons - physiology | Behavior, Animal - drug effects | Parkinson Disease, Secondary - chemically induced | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - physiology | Dopamine - metabolism | Disease Models, Animal | Substantia Nigra - enzymology | Cell Survival - drug effects | rho-Associated Kinases - physiology | Nerve Degeneration - enzymology | Mice, Inbred C57BL | Cells, Cultured | Axons - drug effects | Rats | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - therapeutic use | Behavior, Animal - physiology | MPTP Poisoning - drug therapy | MPTP Poisoning - enzymology | Parkinson Disease, Secondary - enzymology | Neurites - pathology | Dopaminergic Neurons - enzymology | Substantia Nigra - drug effects | Animals | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Axons - pathology | 1-Methyl-4-phenylpyridinium - toxicity | Mice | Nerve Degeneration - drug therapy | Proto-Oncogene Proteins c-akt - drug effects | Cell culture | Neuroprotection | Animal models | Cell survival | Dopamine | Neurodegenerative diseases | Substantia nigra | Central nervous system | AKT protein | Motor task performance | Rho-associated kinase | Axons | Regeneration | Metabolites | Neurodegeneration | Neostriatum | Axon guidance | Movement disorders
Journal Article
Annals of Neurology, ISSN 0364-5134, 2014, Volume 76, Issue 1, pp. 95 - 107
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 07/2012, Volume 21, Issue 14, pp. 3215 - 3225
Human DJ-1 is a genetic cause of early-onset Parkinsons disease (PD), although its biochemical function is unknown. We report here that human DJ-1 and its... 
OXIDATIVE STRESS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | MITOCHONDRIAL-FUNCTION | 3-DEOXYGLUCOSONE | GENETICS & HEREDITY | GLYCATION | ALPHA-SYNUCLEIN | DOPAMINERGIC-NEURONS | METHYLGLYOXAL | PROTEIN DJ-1 | Caenorhabditis elegans - chemistry | Oncogene Proteins - genetics | Glyoxal - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Neurons - cytology | Intracellular Signaling Peptides and Proteins - metabolism | Pyruvaldehyde - metabolism | Aldehyde Oxidoreductases - chemistry | Neurons - metabolism | Parkinson Disease - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Amino Acid Sequence | Cell Line | Oncogene Proteins - chemistry | Caenorhabditis elegans - genetics | Mice, Inbred C57BL | Oncogene Proteins - metabolism | Rats | Aldehyde Oxidoreductases - genetics | Parkinson Disease - genetics | Aldehyde Oxidoreductases - metabolism | Mice, Knockout | Peroxiredoxins | Protein Deglycase DJ-1 | Sequence Alignment | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Neurons - enzymology | Parkinson Disease - enzymology | Mice | Kinetics | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Apoptosis | Glutamic acid | Cysteine | Dopamine | Parkinson's disease | Neurodegenerative diseases | Neurons | carbonyls | Embryo fibroblasts | PARK7 protein | Intestine | Neurodegeneration | Lactic acid | Pyruvaldehyde | Age | Movement disorders | Glutathione
Journal Article