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1. Health risks from exposure to low levels of ionizing radiation : BEIR VII Phase 2
National Research Council (U.S.). Committee to Assess Health Risks from Exposure to Low Level of Ionizing Radiation
2006, ISBN 9780309091565, xvi, 406
Ionizing radiation | Toxicology | Radiation Injuries | Dose-response relationship | Dose-Response Relationship, Radiation | Physiological effect | Radiation, Ionizing
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2. Full Text Curvilinear dose-response relationship of carbohydrate (0-120 g·h-1) and performance
by Smith, Johneric W and Pascoe, David D and Passe, Dennis H and Ruby, Brent C and Stewart, Laura K and Baker, Lindsay B and Zachwieja, Jeffrey J
Medicine and Science in Sports and Exercise, ISSN 0195-9131, 02/2013, Volume 45, Issue 2, pp. 336 - 341
SMITH, J. W., D. D. PASCOE, D. H. PASSE, B. C. RUBY, L. K. STEWART, L. B. BAKER, and J. J. ZACHWIEJA. Curvilinear Dose-Response Relationship of Carbohydrate... 
carbohydrate ingestion rate | Cycling | time trial | TIME-TRIAL PERFORMANCE | OXIDATION | SPORT SCIENCES | CYCLING ENDURANCE PERFORMANCE | FLUID REPLACEMENT | PROLONGED EXERCISE | MUSCLE GLYCOGEN | TIME TRIAL | CARBOHYDRATE INGESTION RATE | INTENSE EXERCISE | INTESTINAL-ABSORPTION | INGESTION | GLUCOSE | CYCLING | Dietary Carbohydrates - administration & dosage | Lactates - blood | Humans | Male | Dose-Response Relationship, Drug | Swimming - physiology | Regression Analysis | Running - physiology | Bicycling - physiology | Adult | Beverages | Physical Endurance - drug effects | Athletic Performance - physiology | Usage | High-carbohydrate diet | Physiological aspects | Carbohydrate metabolism | Research | Cyclists | Health aspects
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3. Full Text Continuous dose-response relationship of the LDL-cholesterol-lowering effect of phytosterol intake
by Demonty, Isabelle and Ras, Rouyanne T and Van Der Knaap, Henk C.M and Duchateau, Guus S.M.J.E and Meijer, Linsie and Zock, Peter L and Geleijnse, Johanna M and Trautwein, Elke A
Journal of Nutrition, ISSN 0022-3166, 02/2009, Volume 139, Issue 2, pp. 271 - 284
Phytosterols (plant sterols and stanols) are well known for their LDL-cholesterol (LDL-C)-lowering effect. A meta-analysis of randomized controlled trials in... 
C-REACTIVE PROTEIN | SERUM TOTAL CHOLESTEROL | NUTRITION & DIETETICS | PLASMA-CHOLESTEROL | LOW-FAT YOGURT | BLOOD CHOLESTEROL | PLANT STANOL ESTERS | STEROL-ENRICHED SPREAD | SITOSTANOL-ESTER | DENSITY-LIPOPROTEIN-CHOLESTEROL | RANDOMIZED CONTROLLED-TRIAL | Dose-Response Relationship, Drug | Adult | Cholesterol, LDL - blood | Phytosterols - administration & dosage | Humans | Phytosterols - pharmacology | Dose-response relationship (Biochemistry) | Evaluation | Usage | Low density lipoproteins | Phytosterols | Dietary supplements | Management | Health aspects
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4. Full Text Leisure time physical activity and mortality: A detailed pooled analysis of the dose-response relationship
by Arem, Hannah and Moore, Steven C and Patel, Alpa and Hartge, Patricia and Berrington De Gonzalez, Amy and Visvanathan, Kala and Campbell, Peter T and Freedman, Michal and Weiderpass, Elisabete and Adami, Hans Olov and Linet, Martha S and Lee, I.-Min and Matthews, Charles E
JAMA Internal Medicine, ISSN 2168-6106, 06/2015, Volume 175, Issue 6, pp. 959 - 967
IMPORTANCE The 2008 Physical Activity Guidelines for Americans recommended a minimum of 75 vigorous-intensity or 150 moderate-intensity minutes per week (7.5... 
ALL-CAUSE MORTALITY | VIGOROUS EXERCISE | BREAST-CANCER | MEDICINE, GENERAL & INTERNAL | LIFE-STYLE | CARDIOVASCULAR-DISEASE | COHORT | RANDOMIZED CONTROLLED-TRIAL | CORONARY-HEART-DISEASE | PRIMARY PREVENTION | WOMENS HEALTH | United States | Humans | Middle Aged | Mortality | Male | Young Adult | Exercise | Recreation | Aged, 80 and over | Adult | Female | Aged | Cohort Studies | Dose-response relationship (Biochemistry) | Analysis | Longevity | Health aspects
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5. Medical effects of ionizing radiation
by Mettler, Fred A., 1945 and Upton, Arthur C., 1923
2008, 3rd ed., New ed., ISBN 9780721602004, xvii, 564
Radiation carcinogenesis | Ionizing radiation | Toxicology | Dose-response relationship | Radiation injuries | Radiation Effects | Dose-Response Relationship, Radiation | Radiation, Ionizing
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6. The dose-response relation in pharmacology
by Tallarida, Ronald J and Jacob, Leonard S
1979, ISBN 3540904158, xiii, 207
Drugs | Dose-response relationship, Drug | Dose-response relationship | Drug receptors
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7. Full Text Dose–response relationship between alcohol consumption before and during pregnancy and the risks of low birthweight, preterm birth and small for gestational age (SGA)—a systematic review and meta‐analyses
by Patra, J and Bakker, R and Irving, H and Jaddoe, VWV and Malini, S and Rehm, J
BJOG: An International Journal of Obstetrics & Gynaecology, ISSN 1470-0328, 11/2011, Volume 118, Issue 12, pp. 1411 - 1421
Please cite this paper as: Patra J, Bakker R, Irving H, Jaddoe V, Malini S, Rehm J. Dose–response relationship between alcohol consumption before and during... 
preterm birth | Alcohol | meta‐analysis | small for gestational age | low birthweight | neonatal development | meta-analysis | MATERNAL DRINKING | FETAL-GROWTH | NATIONAL SAMPLE | BINGE-DRINKING | HEALTH-COMPROMISING BEHAVIORS | DELIVERY | OBSTETRICS & GYNECOLOGY | WOMEN | CIGARETTE-SMOKING | PRENATAL ALCOHOL | EXPOSURE | Infant, Low Birth Weight | Humans | Risk Factors | Risk | Premature Birth - epidemiology | Alcohol Drinking - adverse effects | Dose-Response Relationship, Drug | Pregnancy | Regression Analysis | Alcohol Drinking - epidemiology | Female | Infant, Small for Gestational Age | Infant, Newborn | Fetal alcohol syndrome | Pregnant women | Infants (Premature) | Effect of alcohol on | Fetus | Drinking of alcoholic beverages | Beverages | Public health
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8. Full Text Design, synthesis and structure–activity relationship of 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[ b]furan derivatives as a novel class of inhibitors of tubulin polymerization
by Romagnoli, Romeo and Baraldi, Pier Giovanni and Carrion, Maria Dora and Cara, Carlota Lopez and Cruz-Lopez, Olga and Tolomeo, Manlio and Grimaudo, Stefania and Cristina, Antonietta Di and Pipitone, Maria Rosaria and Balzarini, Jan and Zonta, Nicola and Brancale, Andrea and Hamel, Ernest
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2009, Volume 17, Issue 19, pp. 6862 - 6871
The biological importance of microtubules in mitosis and cell division makes them an interesting target for the development of anticancer agents. Small... 
Antiproliferative agents | Colchicine | Combretastatin-A4 | Benzo[ b]furan derivatives | Antitubulin agents | Benzo[b]furan derivatives | CHEMISTRY, MEDICINAL | COMBRETASTATIN-A-4 | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIMITOTIC AGENTS | ANTINEOPLASTIC AGENTS | CHEMISTRY, ORGANIC | CANCER | DISCOVERY | PHOSPHATE | GROWTH | BIOLOGICAL EVALUATION | Tubulin Modulators - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Protein Multimerization | Benzofurans - chemical synthesis | Benzofurans - pharmacology | Structure-Activity Relationship | Dose-Response Relationship, Drug | Tubulin Modulators - chemical synthesis | Drug Design | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Cell Cycle - drug effects | Binding Sites | Polymerization | Thiophene | Tubulins | Heterocyclic aromatic compounds
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9. Full Text Structure–Activity Relationship for the 4(3H)‑Quinazolinone Antibacterials
by Bouley, Renee and Ding, Derong and Peng, Zhihong and Bastian, Maria and Lastochkin, Elena and Song, Wei and Suckow, Mark A and Schroeder, Valerie A and Wolter, William R and Mobashery, Shahriar and Chang, Mayland
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 10, pp. 5011 - 5021
We recently reported on the discovery of a novel antibacterial (2) with a 4­(3H)-quinazolinone core. This discovery was made by in silico screening of 1.2... 
BETA-LACTAM RESISTANCE | IN-VITRO | CHEMISTRY, MEDICINAL | BACTERIAL-INFECTIONS | BAD BUGS | BROAD-SPECTRUM CEPHALOSPORIN | NO ESKAPE | INFECTIOUS-DISEASES-SOCIETY | RESISTANT STAPHYLOCOCCUS-AUREUS | BINDING PROTEIN 2A | ANTIMICROBIAL RESISTANCE | Gram-Positive Bacteria - drug effects | Humans | Quinazolinones - administration & dosage | Structure-Activity Relationship | Mice, Inbred ICR | Hep G2 Cells | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Anti-Bacterial Agents - therapeutic use | Peritonitis - microbiology | Animals | Anti-Bacterial Agents - chemistry | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Mice | Molecular Structure | Quinazolinones - chemistry | Peritonitis - drug therapy | Quinazolinones - therapeutic use | Anti-Bacterial Agents - administration & dosage | Quinazolinones - pharmacology | Disease Models, Animal | Index Medicus
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10. Uncertainty modeling in dose response
: bench testing environmental toxicity
by Cooke, Roger M., 1946
2009, Statistics in practice, ISBN 0470447508, xiii, 230
A valuable guide to understanding the problem of quantifying uncertainty in dose response relations for toxic substances In today's scientific research, there... 
Environmental toxicology | Toxicology | Mathematical models | Dose-response relationship | Uncertainty
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11. Full Text Structure–Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori α‑Carbonic Anhydrase
by Modak, Joyanta K and Liu, Yu C and Supuran, Claudiu T and Roujeinikova, Anna
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2016, Volume 59, Issue 24, pp. 11098 - 11109
α-Carbonic anhydrase of Helicobacter pylori (HpαCA) plays an important role in the acclimation of this oncobacterium to the acidic pH of the stomach.... 
CHEMISTRY, MEDICINAL | INFECTION | CLONING | BINDING | EPIDEMIOLOGY | Sulfonamides - chemistry | Carbonic Anhydrase Inhibitors - chemistry | Models, Molecular | Crystallography, X-Ray | Helicobacter pylori - drug effects | Carbonic Anhydrase Inhibitors - chemical synthesis | Structure-Activity Relationship | Carbonic Anhydrase Inhibitors - pharmacology | Sulfonamides - pharmacology | Carbonic Anhydrases - metabolism | Anti-Bacterial Agents - chemical synthesis | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Sulfonamides - chemical synthesis | Helicobacter pylori - metabolism | Helicobacter pylori - enzymology | Anti-Bacterial Agents - chemistry | Anti-Bacterial Agents - pharmacology | Molecular Structure
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12. Full Text Isatin Derived Spirocyclic Analogues with α‑Methylene-γ-butyrolactone as Anticancer Agents: A Structure–Activity Relationship Study
by Rana, Sandeep and Blowers, Elizabeth C and Tebbe, Calvin and Contreras, Jacob I and Radhakrishnan, Prakash and Kizhake, Smitha and Zhou, Tian and Rajule, Rajkumar N and Arnst, Jamie L and Munkarah, Adnan R and Rattan, Ramandeep and Natarajan, Amarnath
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2016, Volume 59, Issue 10, pp. 5121 - 5127
Design, synthesis, and evaluation of α-methylene-γ-butyrolactone analogues and their evaluation as anticancer agents is described. SAR identified a spirocyclic... 
CHEMISTRY, MEDICINAL | QUINOXALINE UREA ANALOG | MELAMPOMAGNOLIDE-B | NATURAL-PRODUCTS | BIOLOGICAL EVALUATION | COVALENT DRUGS | TUMOR-CELLS | OVARIAN-CANCER | SESQUITERPENE LACTONE PARTHENOLIDE | NF-KAPPA-B | AMINO-DERIVATIVES | Tumor Necrosis Factor-alpha - metabolism | NF-kappa B - antagonists & inhibitors | Antineoplastic Agents - chemical synthesis | Humans | Isatin - pharmacology | NF-kappa B - metabolism | Structure-Activity Relationship | Isatin - chemistry | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Spiro Compounds - chemical synthesis | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Spiro Compounds - chemistry | Spiro Compounds - pharmacology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Drug Screening Assays, Antitumor
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13. Full Text Design, synthesis and structure–activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents
by Sajith, Ayyiliath M and Abdul Khader, K.K and Joshi, Nithin and Reddy, Manchala Nageswar and Syed Ali Padusha, M and Nagaswarupa, H.P and Nibin Joy, M and Bodke, Yadav D and Karuvalam, Ranjith P and Banerjee, Rinti and Muralidharan, A and Rajendra, P
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 89, pp. 21 - 31
Drug resistance to chemotherapeutic agents paved the way to develop novel synthetic molecules which are active on MDR cancer cell lines. Regio-isomeric... 
Suzuki coupling | Chemotherapy | Cytotoxic studies | Imidazo[4,5-b]pyridine analogues | CHEMISTRY, MEDICINAL | PRIVILEGED STRUCTURES | MECHANISM | ISOXAZOLINE | ANTICANCER AGENTS | NUCLEOSIDES | BOND-FORMING REACTIONS | BIOISOSTERISM | EXPLORATION | INHIBITORS | DERIVATIVES | Purines - chemical synthesis | Cell Survival - drug effects | Purines - pharmacology | Pyridines - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Pyridines - chemical synthesis | Imidazoles - pharmacology | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Purines - chemistry | Drug Design | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Pyridines - pharmacology | Imidazoles - chemical synthesis | Drug Screening Assays, Antitumor | Alkaloids | Pyridine | Drug resistance | Cancer
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14. Full Text Structure−Activity Relationship Studies and in Vivo Activity of Guanidine-Based Sphingosine Kinase Inhibitors: Discovery of SphK1- and SphK2-Selective Inhibitors
by Patwardhan, Neeraj N and Morris, Emily A and Kharel, Yugesh and Raje, Mithun R and Gao, Ming and Tomsig, Jose L and Lynch, Kevin R and Santos, Webster L
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2015, Volume 58, Issue 4, pp. 1879 - 1899
Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that acts as a ligand for five G-protein coupled receptors (S1P1–5) whose downstream effects... 
CHEMISTRY, MEDICINAL | PHOSPHORYLATION | HUMAN LEUKEMIA | SPHINGOSINE-1-PHOSPHATE | BIOLOGICAL EVALUATION | SPHK INHIBITORS | MICE | CANCER | TYPE-2 | IMMUNOMODULATORY DRUG FTY720 | 1-PHOSPHATE | Dose-Response Relationship, Drug | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Protein Kinase Inhibitors - chemical synthesis | Protein Kinase Inhibitors - chemistry | Guanidine - chemical synthesis | Guanidine - chemistry | Guanidine - pharmacology | Molecular Structure | Protein Kinase Inhibitors - pharmacology | Structure-Activity Relationship | Drug Discovery | Phosphotransferases (Alcohol Group Acceptor) - metabolism
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15. Full Text Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy—a [123I]CNS-1261 SPET study
by Stone, James M and Stone, James M and Erlandsson, Kjell and Erlandsson, Kjell and Arstad, Erik and Arstad, Erik and Squassante, Lisa and Squassante, Lisa and Teneggi, Vincenzo and Teneggi, Vincenzo and Bressan, Rodrigo A and Bressan, Rodrigo A and Krystal, John H and Krystal, John H and Ell, Peter J and Ell, Peter J and Pilowsky, Lyn S and Pilowsky, Lyn S
Psychopharmacology, ISSN 0033-3158, 4/2008, Volume 197, Issue 3, pp. 401 - 408
Ketamine induces effects resembling both positive and negative psychotic symptoms of schizophrenia. These are thought to arise through its action as an... 
Psychosis | Negative symptoms | Biomedicine | Ketamine | NMDA | Schizophrenia | Pharmacology/Toxicology | Glutamate | Psychiatry | SPECT | SCHIZOPHRENIC-PATIENTS | PSYCHIATRY | HUMANS | MODEL | BLOOD-FLOW | NEUROSCIENCES | psychosis | GLUTAMATERGIC DRUGS | PREFRONTAL CORTEX | STRIATAL DOPAMINE | ketamine | negative symptoms | IN-VIVO | C-11 RACLOPRIDE | PHARMACOLOGY & PHARMACY | glutamate | PET | Single-Blind Method | Schizophrenia - chemically induced | Receptors, N-Methyl-D-Aspartate - drug effects | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Tomography, Emission-Computed, Single-Photon | Male | Iodine Radioisotopes - pharmacokinetics | Schizophrenia - diagnostic imaging | Ketamine - administration & dosage | Dose-Response Relationship, Drug | Brief Psychiatric Rating Scale | Ketamine - toxicity | Psychoses, Substance-Induced - diagnostic imaging | Prefrontal Cortex - drug effects | Psychoses, Substance-Induced - physiopathology | Ketamine - pharmacokinetics | Adult | Guanidines - pharmacokinetics | Infusions, Intravenous | Prefrontal Cortex - diagnostic imaging | Psychotropic drugs | Neurotransmitters | Pharmacology | Brain research | Binding sites | Index Medicus
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16. Full Text The Structure–Activity Relationship of a Tetrahydroisoquinoline Class of N‑Methyl‑d‑Aspartate Receptor Modulators that Potentiates GluN2B-Containing N‑Methyl‑d‑Aspartate Receptors
by Strong, Katie L and Epplin, Matthew P and Bacsa, John and Butch, Christopher J and Burger, Pieter B and Menaldino, David S and Traynelis, Stephen F and Liotta, Dennis C
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2017, Volume 60, Issue 13, pp. 5556 - 5585
We have identified a series of positive allosteric NMDA receptor (NMDAR) modulators derived from a known class of GluN2C/D-selective tetrahydroisoquinoline... 
Allosteric Regulation - drug effects | Tetrahydroisoquinolines - pharmacology | Administration, Oral | Humans | Microsomes, Liver - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Models, Molecular | Crystallography, X-Ray | Structure-Activity Relationship | Tetrahydroisoquinolines - administration & dosage | Microsomes, Liver - chemistry | Dose-Response Relationship, Drug | Tetrahydroisoquinolines - chemistry | Molecular Structure
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