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Cell, ISSN 0092-8674, 2007, Volume 129, Issue 7, pp. 1275 - 1286
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2018, Volume 115, Issue 28, pp. E6640 - E6649
Endosomes have emerged as a central hub and pathogenic driver of Alzheimer's disease (AD). The earliest brain cytopathology in neurodegeneration, occurring... 
Histone deacetylase | Trichostatin A | Amyloid beta | ApoE4 | exchanger | Na+/H+ exchanger | CHRISTIANSON SYNDROME | HUMAN BRAIN | trichostatin A | MULTIDISCIPLINARY SCIENCES | SPORADIC ALZHEIMERS-DISEASE | histone deacetylase | SYNAPTIC PLASTICITY | amyloid beta | APOLIPOPROTEIN-E | LYSOSOMAL DYSFUNCTION | DOWN-SYNDROME | A-BETA | GENE-EXPRESSION | PRECURSOR PROTEIN | Microcephaly - genetics | Epigenesis, Genetic | Humans | Astrocytes - pathology | Epilepsy - metabolism | Endosomes - metabolism | Alzheimer Disease - pathology | Intellectual Disability - metabolism | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Ataxia - drug therapy | Genetic Diseases, X-Linked - genetics | Ataxia - genetics | Ataxia - metabolism | Microcephaly - drug therapy | Ataxia - pathology | Ocular Motility Disorders - pathology | Tumor Suppressor Proteins - metabolism | Apolipoprotein E4 - metabolism | Endosomes - genetics | Histone Deacetylases - genetics | Ocular Motility Disorders - metabolism | Intellectual Disability - pathology | Alzheimer Disease - drug therapy | Receptors, LDL - metabolism | Mice, Knockout | Genetic Diseases, X-Linked - pathology | Epilepsy - drug therapy | Histone Deacetylase Inhibitors - pharmacology | Mice | Astrocytes - metabolism | Hydrogen-Ion Concentration | Apolipoprotein E4 - genetics | Ocular Motility Disorders - genetics | Intellectual Disability - genetics | Sodium-Hydrogen Exchangers - metabolism | Genetic Diseases, X-Linked - drug therapy | Microcephaly - pathology | Tumor Suppressor Proteins - genetics | Epilepsy - genetics | Sodium-Hydrogen Exchangers - genetics | Receptors, LDL - genetics | Microcephaly - metabolism | Histone Deacetylases - metabolism | Endosomes - pathology | Genetic Diseases, X-Linked - metabolism | Intellectual Disability - drug therapy | Ocular Motility Disorders - drug therapy | Animals | Alzheimer Disease - metabolism | Alzheimer Disease - genetics | Epilepsy - pathology | Physiological aspects | Epigenetic inheritance | Glycoproteins | Genetic aspects | Observations | Astrocytes | Protons | Brain | Membranes | Transcription | Gene regulation | Trafficking | Cognitive ability | Acidification | pH effects | Neuronal-glial interactions | Risk factors | Proteins | Apolipoprotein E | Neurodegeneration | Compartments | Down-regulation | Alzheimer's disease | Plaques | Translocation | Pathogens | Apolipoprotein E4 | Therapeutic applications | Na+/H+-exchanging ATPase | Risk analysis | Apolipoproteins | Nuclear transport | Alleles | Epigenetics | Cytopathology | Receptor density | Mutation | Alzheimers disease | Endosomes | Index Medicus | Biological Sciences | PNAS Plus | H+ exchanger | Na+
Journal Article
Molecular Cancer, ISSN 1476-4598, 02/2015, Volume 14, Issue 1, pp. 47 - 47
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2008, Volume 283, Issue 48, pp. 33394 - 33405
Micro-RNAs are similar to 21-25-nucleotide-long noncoding RNAs that regulate gene expression primarily at the post-transcriptional level in animals. Here, we... 
SURVIVAL | C/EBP-ALPHA | MICRORNA FUNCTION | THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | TUMOR-SUPPRESSOR | TARGETS | DEGRADATION | HUMAN HEPATOCELLULAR CARCINOMAS | EXPRESSION | Lung Neoplasms - drug therapy | Histone Deacetylases - biosynthesis | Antibiotics, Antineoplastic - pharmacology | Caspase 7 - biosynthesis | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Apoptosis - genetics | MicroRNAs - metabolism | Proto-Oncogene Proteins - biosynthesis | RNA, Neoplasm - metabolism | Receptors, Growth Factor - genetics | Caspase 3 - genetics | Caspase 3 - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Lung Neoplasms - genetics | Forkhead Transcription Factors - biosynthesis | Histone Deacetylases - genetics | Caspase 7 - genetics | Cell Survival | Proto-Oncogene Proteins c-met | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Poly(ADP-ribose) Polymerases - biosynthesis | Down-Regulation - drug effects | Forkhead Transcription Factors - genetics | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Down-Regulation - genetics | Animals | Poly(ADP-ribose) Polymerases - genetics | Repressor Proteins - biosynthesis | Mice, Nude | Myeloid Cell Leukemia Sequence 1 Protein | Receptors, Growth Factor - biosynthesis | Cell Line, Tumor | Proto-Oncogene Proteins c-pim-1 - genetics | RNA, Neoplasm - genetics | Mice | MicroRNAs - genetics | Poly (ADP-Ribose) Polymerase-1 | Proto-Oncogene Proteins c-bcl-2 - genetics | Proto-Oncogene Proteins c-pim-1 - biosynthesis | Doxorubicin - pharmacology | Cell Movement | Index Medicus | RNA-Mediated Regulation and Noncoding Rnas
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2010, Volume 285, Issue 35, pp. 27487 - 27498
The S100B-p53 protein complex was discovered in C8146A malignant melanoma, but the consequences of this interaction required further study. When S100B... 
WILD-TYPE P53 | UV-RADIATION | CANCER-CELLS | P53-MEDIATED APOPTOSIS | P53-INDUCED APOPTOSIS | CARCINOMA-CELLS | MDM2 GENE | DIFFERENTIAL EXPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PROTEIN | PIFITHRIN-ALPHA | RNA, Small Interfering - genetics | Caspase 9 - genetics | Caspase 9 - metabolism | Inhibitor of Apoptosis Proteins - genetics | Membrane Potential, Mitochondrial - radiation effects | Humans | Caspase 3 - metabolism | Cell Survival - genetics | Multiprotein Complexes - genetics | Nerve Growth Factors - metabolism | fas Receptor - metabolism | Death Domain Receptor Signaling Adaptor Proteins | Multiprotein Complexes - metabolism | RNA, Messenger - biosynthesis | Phosphorylation - genetics | S100 Proteins - genetics | Ultraviolet Rays | Caspase 3 - genetics | fas Receptor - genetics | Biomarkers, Tumor - metabolism | Membrane Potential, Mitochondrial - genetics | Inhibitor of Apoptosis Proteins - metabolism | S100 Calcium Binding Protein beta Subunit | Down-Regulation | S100 Proteins - metabolism | Melanoma - pathology | Enzyme Activation - radiation effects | Phosphorylation - radiation effects | RNA, Neoplasm - biosynthesis | Nerve Growth Factors - genetics | Cell Line, Tumor | RNA, Neoplasm - genetics | Biomarkers, Tumor - genetics | Mutation | Transcription, Genetic - genetics | Enzyme Activation - genetics | Caspase 8 - metabolism | Gene Expression Regulation, Neoplastic | Transcription, Genetic - radiation effects | Cytochromes c - genetics | Tumor Suppressor Protein p53 - genetics | Caspase 8 - genetics | Melanoma - genetics | Melanoma - metabolism | Cytochromes c - metabolism | RNA, Messenger - genetics | Tumor Suppressor Protein p53 - metabolism | Cell Survival - radiation effects | Carrier Proteins - genetics | Carrier Proteins - metabolism | Apoptosis | Index Medicus | Molecular Bases of Disease | S100 Proteins | Calcium-binding Proteins | S100B | Cell Biology | p53 | Protein-Protein Interactions | Tumor Suppressor
Journal Article
Cell, ISSN 0092-8674, 2005, Volume 123, Issue 4, pp. 593 - 605
The yeast histone deacetylase Rpd3 can be recruited to promoters to repress transcription initiation. Biochemical, genetic, and gene-expression analyses show... 
RNA-POLYMERASE-II | CHROMATIN REMODELING COMPLEX | TRANSCRIPTION ELONGATION-FACTORS | REGULATES H3 METHYLATION | TARGETED RECRUITMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GENE-EXPRESSION | DEACETYLASE COMPLEX | SACCHAROMYCES-CEREVISIAE | H2A VARIANT HTZ1 | CELL BIOLOGY | Acetyltransferases - metabolism | Oligonucleotide Array Sequence Analysis | Saccharomyces cerevisiae - genetics | Methyltransferases - metabolism | Methyltransferases - genetics | Molecular Sequence Data | RNA Polymerase II - metabolism | Acetyltransferases - genetics | Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics | Saccharomyces cerevisiae - metabolism | Sirtuin 2 | Gene Deletion | Lysine - metabolism | Acetylation | Cyclin-Dependent Kinases - genetics | Sirtuins - genetics | Repressor Proteins - metabolism | Gene Expression Regulation, Fungal | Amino Acid Sequence | Histone Deacetylases - genetics | Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | Mutation - genetics | Down-Regulation - genetics | Sequence Homology, Amino Acid | Transcription Factors - metabolism | Epistasis, Genetic | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Histones - metabolism | Methylation | Sirtuins - metabolism | Cluster Analysis | Suppression, Genetic | Medical colleges | Methyltransferases | RNA | Lysine | Medical genetics | Histones | Nucleosomes | Index Medicus
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 03/2010, Volume 8, Issue 3, pp. 433 - 443
Journal Article
Molecular Cancer, ISSN 1476-4598, 07/2017, Volume 16, Issue 1, pp. 125 - 125
Background: Despite accumulating evidence that long noncoding RNAs (lncRNAs) are associated with cancer development in multiple types of cancer, the biological... 
ARHGAP11A | LncRNA | MiR19a | HOXD-AS1 | Human hepatocellular carcinoma | ACTIVATION | lncRNA | CANCER CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | MECHANISMS | NETWORKS | MICRORNAS | IDENTIFICATION | miR19a | ONCOLOGY | RECURRENCE | EXPRESSION | PROGRESSION | RGS Proteins - genetics | Liver Neoplasms - genetics | Humans | RNA, Messenger - genetics | Apoptosis - genetics | Up-Regulation - genetics | RNA, Long Noncoding - genetics | Signal Transduction - genetics | Cell Movement - genetics | Down-Regulation - genetics | Neoplasm Metastasis - genetics | Animals | MAP Kinase Signaling System - genetics | Mice, Nude | Neoplasm Metastasis - pathology | Carcinoma, Hepatocellular - genetics | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Liver Neoplasms - pathology | Biomarkers, Tumor - genetics | Mice | MicroRNAs - genetics | GTPase-Activating Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | DNA microarrays | MicroRNA | Oncology, Experimental | Antisense RNA | Genetic aspects | Hepatoma | Research | Comparative analysis | Gene expression | Apoptosis | Cancer | Motility | Hepatocellular carcinoma | In vitro testing | Metastasis | Kinases | Tissues | Metastases | Cell adhesion & migration | Proteins | Liver cancer | Cell growth | Rodents | Surgery | Cell cycle | Growth factors | MiRNA | Extracellular signal-regulated kinase | Ribonucleic acids | MicroRNAs | In vivo methods and tests | Guanosinetriphosphatase | Index Medicus
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 2014, Volume 19, Issue 7, pp. 774 - 783
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 113, Issue 25, pp. 6411 - 6418
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 609 - 621
is involved in chromosomal rearrangements that generate fusion proteins with deregulated transcriptional activity. The mechanisms of MLL fusion... 
CELLCYCLE | DNA | HUMDISEASE | RNA-POLYMERASE-II | CHROMOSOMAL TRANSLOCATIONS | TARGET GENES | STEM-CELLS | HISTONE H2B | ONCOLOGY | H3 METHYLATION | TUMOR-SUPPRESSOR PROTEIN | LEUKEMIA | EXPRESSION | TRANSCRIPTIONAL ELONGATION | CELL BIOLOGY | Myeloid Cells - cytology | Myeloid-Lymphoid Leukemia Protein - metabolism | Oncogene Proteins, Fusion - metabolism | Transcriptional Activation - genetics | Protein Interaction Domains and Motifs - physiology | Humans | Leukemia - metabolism | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Transfection | RNA Interference | Cell Transformation, Neoplastic - genetics | Tumor Suppressor Proteins - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Leukemia - genetics | Recombinant Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Sequence Deletion - physiology | Mice, Inbred C57BL | Gene Expression Regulation | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | DNA - metabolism | Phosphoproteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Down-Regulation - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Transcription, Genetic - physiology | Animals | Carrier Proteins - metabolism | Models, Biological | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | HL-60 Cells | Myeloid Cells - metabolism | Mice | HeLa Cells | Myeloid Ecotropic Viral Integration Site 1 Protein | Cell Transformation, Neoplastic - pathology | Protein Binding - physiology | Proteins | RNA | Gene expression | Index Medicus
Journal Article