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Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 11/2012, Volume 109, Issue 47, pp. 19408 - 19413
Bromodomain and extra terminal domain (BET) proteins function as epigenetic signaling factors that associate with acetylated histones and facilitate... 
Betting | Cell growth | Messenger RNA | Genes | Cell lines | Cell cycle | Histones | Small interfering RNA | Down regulation | Lung neoplasms | Drug development | Chromatin | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Humans | Lung Neoplasms - pathology | Molecular Targeted Therapy | Gene Knockdown Techniques | Adenocarcinoma - genetics | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Triazoles - therapeutic use | Lung Neoplasms - genetics | Proto-Oncogene Proteins c-fos - metabolism | Nuclear Proteins - metabolism | Signal Transduction - genetics | Down-Regulation - drug effects | Adenocarcinoma - drug therapy | Proto-Oncogene Proteins c-myc - metabolism | Down-Regulation - genetics | Azepines - therapeutic use | Azepines - pharmacology | Transcription Factors - metabolism | Triazoles - pharmacology | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Proto-Oncogene Proteins c-fos - genetics | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-myc - genetics | Drug Screening Assays, Antitumor | Adenocarcinoma | Epigenetic inheritance | Lung cancer | Physiological aspects | Development and progression | Genetic aspects | Research | Health aspects | Cancer | Proteins | Genotype & phenotype | Epigenetics | Cytotoxicity | Oncology | Blood diseases | Gene expression | Index Medicus | drug development | chromatin | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 08/2015, Volume 112, Issue 32, pp. 10038 - 10043
Colorectal cancer risk is associated with diets high in red meat. Heme, the pigment of red meat, induces cytotoxicity of colonic contents and elicits... 
Immunohistochemistry | Up-Regulation | Body Weight | Cell Proliferation | Biological Markers | Male | Mucus | Colony Count, Microbial | Journal Article | Antioxidants | Sulfides | Anti-Bacterial Agents | Microbiota | Ki-67 Antigen | Cell Death | Heme | Colon | Feces | Intestinal Mucosa | Down-Regulation | Mice, Inbred C57BL | Epithelial Cells | Animals | Cell Cycle | Diet | Models, Biological | Research Support, Non-U.S. Gov't | Mucolysis | (Tri)sulfides | Red meat | Mucus barrier | Colorectal cancer | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Cycle - genetics | Epithelial Cells - metabolism | Epithelial Cells - drug effects | Colon - drug effects | Microbiota - drug effects | Body Weight - drug effects | Ki-67 Antigen - metabolism | Mucus - drug effects | Intestinal Mucosa - drug effects | Feces - microbiology | Heme - pharmacology | Mucus - metabolism | Sulfides - metabolism | Cell Death - drug effects | Biomarkers - metabolism | Colon - pathology | Epithelial Cells - pathology | Up-Regulation - genetics | Antioxidants - pharmacology | Intestinal Mucosa - microbiology | Down-Regulation - drug effects | Down-Regulation - genetics | Up-Regulation - drug effects | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Colon - microbiology | Cell Cycle - drug effects | Intestinal Mucosa - pathology | Cell proliferation | Colon cancer | Epithelial cells | Physiological aspects | Observations | Health aspects | Bacteria | Microorganisms | Rodents | Genes | Index Medicus | Biological Sciences | colorectal cancer | mucus barrier | (tri)sulfides | mucolysis | red meat | susceptibility | expression | bacterial | inhibitor | mucin | fat | colorectal-cancer | mice | cytotoxicity
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 08/2007, Volume 179, Issue 3, pp. 1634 - 1647
1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) can modulate immune responses, but whether it directly affects B cell function is unknown. Patients with systemic... 
Immunologic Factors - deficiency | Apoptosis - drug effects | Humans | Middle Aged | Calcitriol - physiology | Apoptosis - genetics | Male | Receptors, Calcitriol - genetics | Plasma Cells - pathology | Receptors, Calcitriol - biosynthesis | Plasma Cells - drug effects | Cell Differentiation - genetics | Calcitriol - deficiency | Lupus Erythematosus, Systemic - drug therapy | Lupus Erythematosus, Systemic - immunology | Adult | Female | Growth Inhibitors - genetics | Steroid Hydroxylases - genetics | B-Lymphocytes - cytology | B-Lymphocytes - enzymology | Immunologic Factors - physiology | Cells, Cultured | Vitamin D3 24-Hydroxylase | Down-Regulation - drug effects | Down-Regulation - genetics | Vitamin D - blood | Gene Expression Regulation - drug effects | B-Lymphocytes - drug effects | Cell Differentiation - immunology | Apoptosis - immunology | B-Lymphocytes - immunology | Vitamin D - antagonists & inhibitors | Cell Differentiation - drug effects | Down-Regulation - immunology | Lymphocyte Activation - drug effects | ADP-ribosyl Cyclase 1 - biosynthesis | Calcitriol - pharmacology | Adolescent | Growth Inhibitors - physiology | Vitamin D - analogs & derivatives | Aged | Lupus Erythematosus, Systemic - pathology | Steroid Hydroxylases - biosynthesis | Immunologic Factors - pharmacology | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
BMC plant biology, ISSN 1471-2229, 2014, Volume 14, Issue 1, pp. 116 - 116
Background: Brown algae are sessile macro-organisms of great ecological relevance in coastal ecosystems. They evolved independently from land plants and other... 
Primary metabolism | Copper stress response | Brown algae | ABC transporters | Heavy metal | Oxylipins | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Metabolomics | Gas Chromatography-Mass Spectrometry | Humans | Gene Expression Profiling | Chromatography, High Pressure Liquid | Phylogeny | Phaeophyta - genetics | Phaeophyta - physiology | Amino Acids - metabolism | Photosynthesis - genetics | Stress, Physiological - drug effects | Copper - toxicity | Fatty Acids - metabolism | Stress, Physiological - genetics | Oxidative Stress - genetics | Up-Regulation - genetics | Signal Transduction - genetics | Transcriptome - drug effects | Down-Regulation - drug effects | Down-Regulation - genetics | Metabolome - genetics | Discriminant Analysis | Up-Regulation - drug effects | Oxylipins - metabolism | Metabolic Networks and Pathways - genetics | Metabolome - drug effects | Signal Transduction - drug effects | Photosynthesis - drug effects | Least-Squares Analysis | Acclimatization - genetics | Metabolic Networks and Pathways - drug effects | Oxidative Stress - drug effects | Acclimatization - drug effects | Algal Proteins - metabolism | Phaeophyta - drug effects | Cluster Analysis | Physiological aspects | Evolution | Plants | Analysis | Oxidative stress | Discriminant analysis | Ecosystems | Algae | Genomics | Biology | Genomes | Metabolism | Gene expression | Ecosystem biology | Proteins | Studies | Signal transduction | Metabolites | Flowers & plants | Stress response | Photosynthesis | Copper | Index Medicus | Up-Regulation | Fatty Acids | Oxidative Stress | Stress, Physiological | Transcriptome | Life Sciences | Signal Transduction | Down-Regulation | Metabolome | Acclimatization | Algal Proteins | Amino Acids | Metabolic Networks and Pathways | Phaeophyta
Journal Article
PloS one, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e49036 - e49036
We have previously shown that the eye is a mineralocorticoid-sensitive organ and we now question the role of mineralocorticoid receptor (MR) in ocular... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Microglia - metabolism | Receptors, Mineralocorticoid - genetics | Ciliary Body - pathology | Intravitreal Injections | Spironolactone - administration & dosage | Receptors, Mineralocorticoid - metabolism | Humans | Endotoxins | Rats, Inbred Lew | Receptors, Glucocorticoid - metabolism | Anti-Inflammatory Agents - metabolism | Aldosterone - administration & dosage | Lipopolysaccharides | Aqueous Humor - metabolism | Spironolactone - pharmacology | Inflammation Mediators - metabolism | Iris - drug effects | Iris - enzymology | Anti-Inflammatory Agents - therapeutic use | Microglia - pathology | Female | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics | Uveitis - metabolism | Microglia - drug effects | Anti-Inflammatory Agents - pharmacology | Ciliary Body - enzymology | Uveitis - drug therapy | Rats | Aldosterone - pharmacology | Down-Regulation - drug effects | Iris - pathology | Down-Regulation - genetics | Animals | Signal Transduction - drug effects | 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism | Receptors, Glucocorticoid - genetics | Chemokines - metabolism | Aqueous Humor - drug effects | Uveitis - chemically induced | Uveitis - pathology | Enzymes | Anti-inflammatory drugs | Corticosterone | Analysis | Uveitis | Inflammation | Aldosterone | Mitogens | Steroids | Glucocorticoids | Mortality | Adipocytes | Injection | Tumor necrosis factor-α | Macrophages | Gene expression | Microglia | Cell adhesion & migration | Eye | Iris | Rodents | Nitric oxide | γ-Interferon | Down-regulation | Structural damage | Tumor necrosis factor-TNF | Interferon | Diabetes | Index Medicus
Journal Article
Journal Article