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Psychopharmacology, ISSN 0033-3158, 12/2012, Volume 224, Issue 3, pp. 363 - 376
Pupillometry can be used to characterize autonomic drug effects.This study was conducted to determine the autonomic effects of... 
Pupil | Neurosciences | Biomedicine | Serotonin | Pupillometry | Pupillary reflex | Norepinephrine | Pharmacology/Toxicology | Psychiatry | MDMA | YOHIMBINE | PSYCHIATRY | 3,4-METHYLENEDIOXYMETHAMPHETAMINE ECSTASY | PHARMACODYNAMICS | CLINICAL PHARMACOKINETICS | NEUROSCIENCES | ALPHA-ADRENOCEPTOR | FLUCTUATIONS | AGONIST CLONIDINE | PAROXETINE | PHARMACOLOGY & PHARMACY | MYDRIASIS | Doxazosin - pharmacology | Autonomic Agents - pharmacokinetics | Humans | Mydriasis - physiopathology | Mydriatics - blood | Miosis - physiopathology | Adrenergic Agonists - pharmacology | Autonomic Agents - pharmacology | Male | N-Methyl-3,4-methylenedioxyamphetamine - blood | Adrenergic alpha-2 Receptor Agonists - pharmacology | Recovery of Function | Mydriatics - pharmacology | Young Adult | N-Methyl-3,4-methylenedioxyamphetamine - pharmacology | Time Factors | Light | Reaction Time - drug effects | Adult | Body Temperature Regulation - drug effects | Clonidine - pharmacology | Female | Mydriatics - pharmacokinetics | Autonomic Agents - blood | Affect - drug effects | Reflex, Pupillary - drug effects | Dopamine Uptake Inhibitors - pharmacology | Miosis - prevention & control | Morpholines - pharmacology | Thiophenes - pharmacology | Randomized Controlled Trials as Topic | Cross-Over Studies | Mydriasis - chemically induced | Duloxetine Hydrochloride | Adrenergic Uptake Inhibitors - pharmacology | Hemodynamics - drug effects | Carbazoles - pharmacology | Propanolamines - pharmacology | Serotonin Uptake Inhibitors - pharmacology | N-Methyl-3,4-methylenedioxyamphetamine - pharmacokinetics | Side effects | Pharmacology | Eyes & eyesight | Index Medicus | Drug abuse | Sympathomimetics | Drug tolerance | clonidine | Duloxetine | Light effects | Parasympathetic nervous system | Reflexes | reboxetine
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2013, Volume 123, Issue 12, pp. 5119 - 5134
A systems pharmacological approach that capitalizes on the characterization of intracellular signaling networks can transform our understanding of human... 
MEDICINE, RESEARCH & EXPERIMENTAL | VISUAL CYCLE | PHAGOCYTOSIS | OPTICAL COHERENCE TOMOGRAPHY | ABCA4 | RHODOPSIN | MECHANISMS | MICE | DOXAZOSIN | LONG-TERM TREATMENT | CLINICAL-EXPERIENCE | Receptors, Adrenergic, alpha-2 - genetics | Guanabenz - therapeutic use | Reactive Oxygen Species | Receptor, Serotonin, 5-HT2A - genetics | Doxazosin - pharmacology | Humans | Photoreceptor Cells, Vertebrate - drug effects | Adrenergic alpha-Antagonists - therapeutic use | Macaca fascicularis | Adrenergic alpha-Antagonists - pharmacology | Molecular Targeted Therapy | Photoreceptor Cells, Vertebrate - physiology | Macular Degeneration - drug therapy | Adenylyl Cyclase Inhibitors | Adrenergic alpha-Agonists - therapeutic use | Alcohol Oxidoreductases - genetics | ATP-Binding Cassette Transporters - deficiency | Photoreceptor Cells, Vertebrate - radiation effects | ATP-Binding Cassette Transporters - genetics | Adenine - therapeutic use | Doxazosin - therapeutic use | Nerve Tissue Proteins - biosynthesis | Receptors, Adrenergic, alpha-2 - biosynthesis | Drug Evaluation, Preclinical | Disease Models, Animal | Macular Degeneration - prevention & control | Receptor, Serotonin, 5-HT2A - biosynthesis | Adenine - analogs & derivatives | Signal Transduction | Cell Survival | Light - adverse effects | Serotonin Antagonists - therapeutic use | Receptors, G-Protein-Coupled - biosynthesis | Adenine - pharmacology | Serotonin Antagonists - pharmacology | Nerve Tissue Proteins - genetics | Mice, Knockout | Guanabenz - pharmacology | Animals | Macular Degeneration - congenital | Macular Degeneration - genetics | Adrenergic alpha-Agonists - pharmacology | Mice | Mice, Inbred BALB C | Receptors, G-Protein-Coupled - genetics | Photoreceptor Cells, Vertebrate - pathology | Alcohol Oxidoreductases - deficiency | Macular degeneration | Retinal degeneration | Research | Studies | Pathology | Signal transduction | Disease | Genes | Retina | Photoreceptors | Pharmacology
Journal Article
Journal Article
Circulation Journal, ISSN 1346-9843, 2012, Volume 76, Issue 6, pp. 1423 - 1429
Journal Article
Journal Article
Journal Article
PHARMACEUTICAL BIOLOGY, ISSN 1388-0209, 04/2012, Volume 50, Issue 4, pp. 439 - 442
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2016, Volume 11, Issue 4, pp. e0154612 - e0154612
Glioblastoma is the most frequent and malignant brain tumor. Treatment includes chemotherapy with temozolomide concomitant with surgical resection and/or... 
GLIOMA-CELLS | CANCER-CELLS | PROSTATE | APOPTOSIS | ANTAGONIST DOXAZOSIN | IN-VITRO | O-6-METHYLGUANINE DNA-METHYLTRANSFERASE | MULTIDISCIPLINARY SCIENCES | GROWTH | KINASE INHIBITORS | TEMOZOLOMIDE | Tumor Suppressor Protein p53 - biosynthesis | Doxazosin - pharmacology | Rats, Wistar | Apoptosis - drug effects | Glycogen Synthase Kinase 3 beta - biosynthesis | Humans | Caspase 3 - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Hippocampus - drug effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Lapatinib | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Astrocytes - drug effects | Doxazosin - toxicity | Morpholines - pharmacology | Rats | Brain Neoplasms - drug therapy | Enzyme Activation - drug effects | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | G1 Phase Cell Cycle Checkpoints - drug effects | Glioblastoma - drug therapy | Quinazolines - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Chemotherapy | Usage | Doxazosin | Dosage and administration | Research | Glioblastoma multiforme | Cancer | Brain | Cell culture | p53 Protein | Brain cancer | AKT protein | Metastasis | Confocal | Drug development | Caspase-3 | Cancer therapies | Proteins | Cell activation | Surgery | Tumorigenesis | Inhibition | Protein-tyrosine kinase | Tyrosine | Medical research | Astrocytes | Mortality | Cultures | 1-Phosphatidylinositol 3-kinase | Inhibitors | Irradiation | Temozolomide | Hippocampus | Cell proliferation | Drugs | Flow cytometry | Brain tumors | Glioblastoma | Confocal microscopy | Kinases | Neurotoxicity | Cell cycle | G1 phase | Tumor cells | Caspase | Pharmacology | Chemical compounds | Cytometry | Brain research | Microscopy | Cell death | Medical prognosis | Glioblastoma cells | Laboratory animals | Prostate cancer | Tumors | Apoptosis | Index Medicus
Journal Article
International Journal of Impotence Research, ISSN 0955-9930, 11/2012, Volume 24, Issue 6, pp. 221 - 227
Journal Article
Journal Article
AMERICAN JOURNAL OF CARDIOLOGY, ISSN 0002-9149, 12/2005, Volume 96, Issue 12B, pp. 42M - 46M
Currently, 3 phosphodiesterase 5 (PDE5) inhibitor agents are available worldwide for the, treatment of erectile dysfunction (ED): sildenafil, vardenafil, and... 
VARDENAFIL | CARDIAC & CARDIOVASCULAR SYSTEMS | SAFETY | MEN | CARDIOVASCULAR-DISEASE | SILDENAFIL-CITRATE | TAMSULOSIN | TADALAFIL | DOXAZOSIN | ERECTILE DYSFUNCTION
Journal Article
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 12/2011, Volume 89, Issue 12, pp. 883 - 890
(–)Doxazosin, one of (±)doxazosin enantiomers, was speculated to have a pharmacological enantioselectivity between the cardiovascular system and the urinary... 
contractile response | obstruction des voies urinaires | rat | bladder outlet obstruction | réponse relaxante | mesenteric artery | réponse contractile | énantiomère de la doxazosine | artère mésentérique | doxazosin enantiomer | détrusor | detrusor | relaxant response | Relaxant response | Mesenteric artery | Detrusor | Rat | Contractile response | Doxazosin enantiomer | Bladder outlet obstruction | PHYSIOLOGY | PURINERGIC VASOCONSTRICTION | RABBIT URINARY-BLADDER | BENIGN PROSTATIC HYPERPLASIA | SMOOTH-MUSCLE | POTENTIATION | PHARMACOLOGY & PHARMACY | RECEPTORS | ARTERY | EXPRESSION | Norepinephrine - pharmacology | Mesenteric Arteries - physiopathology | Doxazosin - pharmacology | Rats, Wistar | Stereoisomerism | Urinary Bladder Neck Obstruction - physiopathology | Adrenergic alpha-1 Receptor Antagonists - chemistry | Adrenergic beta-Agonists - pharmacology | Male | Mesenteric Arteries - drug effects | Carbachol - pharmacology | Muscle, Smooth - drug effects | Animals | Doxazosin - chemistry | Adrenergic alpha-1 Receptor Antagonists - pharmacology | Muscle Contraction - drug effects | Isoproterenol - pharmacology | Muscle, Smooth - physiopathology | Urinary Bladder - physiopathology | Urinary Bladder - drug effects | Muscle Relaxation - drug effects | Cholinergic Agonists - pharmacology | Physiological aspects | Bladder | Doxazosin | Muscle contraction | Health aspects
Journal Article
Journal Article