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Cell, ISSN 0092-8674, 2007, Volume 130, Issue 6, pp. 1120 - 1133
Coordination of cell proliferation and cell death is essential to attain proper organ size during development and for maintaining tissue homeostasis throughout... 
DEVBIO | SIGNALING | YES-ASSOCIATED PROTEIN | APOPTOSIS | DOMAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | TUMOR-SUPPRESSOR | YAP | MICE | CELL | CANCER | CELL BIOLOGY | Protein Kinases - metabolism | Phosphorylation | Cell Proliferation | Large Neutral Amino Acid-Transporter 1 - metabolism | Humans | Liver Neoplasms, Experimental - chemically induced | Homeostasis | Cytoplasm - metabolism | Drosophila Proteins - metabolism | Doxorubicin | Drosophila - enzymology | Liver Neoplasms, Experimental - metabolism | Cell Nucleus - metabolism | Transfection | Trans-Activators - genetics | Active Transport, Cell Nucleus | Liver Neoplasms, Experimental - pathology | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Drosophila - genetics | Cell Line | Mammals - metabolism | Mammals - growth & development | Signal Transduction | Mice, Inbred C57BL | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Intracellular Signaling Peptides and Proteins | Organ Size | Drosophila - cytology | Mice, Transgenic | Nuclear Proteins - metabolism | Transcription Factors - genetics | Serine - metabolism | Transcription Factors - metabolism | Animals | Liver Neoplasms, Experimental - enzymology | Trans-Activators - metabolism | Drosophila - growth & development | Mice | Drosophila - metabolism | Drosophila Proteins - genetics | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Apoptosis | Drosophila | Knowledge-based systems | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2010, Volume 335, Issue 3, pp. 533 - 545
Doxorubicin (DOX) and daunorubicin (DAUN) are effective anticancer drugs; however, considerable interpatient variability exists in their pharmacokinetics. This... 
DIHYDRODIOL DEHYDROGENASE ISOFORMS | QUINONE REDUCTASE | HUMAN CARBONYL REDUCTASE | ENZYMES | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | SUPERFAMILY | PHARMACOLOGY & PHARMACY | HUMAN LIVER | ALDEHYDE REDUCTASE | SINGLE NUCLEOTIDE POLYMORPHISMS | PROSTAGLANDIN-F SYNTHASE | Aldehyde Reductase - genetics | Humans | Polymorphism, Single Nucleotide - physiology | Mitochondrial Proteins - genetics | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Alcohol Oxidoreductases - genetics | Recombinant Proteins - isolation & purification | Mitochondrial Proteins - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Aldehyde Reductase - metabolism | Hydroxysteroid Dehydrogenases - metabolism | Doxorubicin - metabolism | Daunorubicin - metabolism | Glyceraldehyde - metabolism | Phenanthrenes - metabolism | Recombinant Proteins - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Biocatalysis | Oxidoreductases - metabolism | Oxidoreductases - genetics | Gene Frequency | Indans - metabolism | Models, Molecular | Alcohol Oxidoreductases - metabolism | Recombinant Proteins - genetics | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductases | Vitamin K 3 - metabolism | Aldo-Keto Reductase Family 1 Member C3 | NAD(P)H Dehydrogenase (Quinone) - metabolism | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 43, pp. 17253 - 17258
Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue microenvironment. Although much is known about how soluble factors... 
Phenotypes | Cell growth | Cytokines | Stem cells | Cell lines | Actins | Physiological regulation | Macrophages | Endothelial cells | Cells | FIBER | MATRIX | ACTIVATION | ACTIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DIFFERENTIATION | SCAFFOLDS | CULTURE | MESENCHYMAL STEM-CELLS | Mannose-Binding Lectins - metabolism | Arginase - metabolism | Lectins, C-Type - immunology | Cell Shape - immunology | Myosin-Light-Chain Kinase - antagonists & inhibitors | Cytochalasin D - pharmacology | Lectins, C-Type - metabolism | Arginase - immunology | Interleukin-4 - pharmacology | Flow Cytometry | Doxorubicin - analogs & derivatives | Inflammation Mediators - metabolism | Female | Immunophenotyping - methods | Cell Polarity - drug effects | Doxorubicin - metabolism | Macrophages - immunology | Cytokines - immunology | Amides - pharmacology | Biomarkers - metabolism | Inflammation Mediators - immunology | Cell Polarity - immunology | Cytokines - metabolism | Myosin-Light-Chain Kinase - metabolism | Mice, Inbred C57BL | Biomarkers - analysis | Cells, Cultured | Receptors, Cell Surface - metabolism | Macrophages - cytology | Interleukin-13 - pharmacology | Receptors, Cell Surface - immunology | Azepines - pharmacology | Cell Shape - drug effects | Macrophages - metabolism | Animals | Mannose-Binding Lectins - immunology | Lipopolysaccharides - pharmacology | Mice | Pyridines - pharmacology | Doxorubicin - immunology | Interferon-gamma - pharmacology | Microscopy, Fluorescence | Physiological aspects | Microbial genetics | Phenotype | Genetic aspects | Research | Geometry | Genotype & phenotype | Morphology | Index Medicus | Biological Sciences | Physical Sciences
Journal Article
Nature, ISSN 0028-0836, 02/2011, Volume 470, Issue 7334, pp. 359 - 365
Telomere dysfunction activates p53-mediated cellular growth arrest, senescence and apoptosis to drive progressive atrophy and functional decline in... 
STEM-CELLS | HEPATOCELLULAR-CARCINOMA | BIOGENESIS | PGC-1-ALPHA | MULTIDISCIPLINARY SCIENCES | HEART-FAILURE | LEADS | MICE | DAMAGE | P53 | COACTIVATORS | Cell Proliferation | Reactive Oxygen Species - metabolism | Hematopoietic Stem Cells - pathology | DNA, Mitochondrial - analysis | Adenosine Triphosphate - biosynthesis | Tumor Suppressor Protein p53 - genetics | RNA - genetics | Telomerase - deficiency | Cardiomyopathies - physiopathology | Telomerase - genetics | Myocardium - metabolism | Telomere - metabolism | Gluconeogenesis | Telomere - genetics | Liver - metabolism | Tumor Suppressor Protein p53 - metabolism | Cardiomyopathies - pathology | Transcription Factors - antagonists & inhibitors | Hematopoietic Stem Cells - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Tumor Suppressor Protein p53 - deficiency | Doxorubicin - toxicity | Aging - pathology | Myocardium - cytology | Transcription Factors - metabolism | Telomere - pathology | Animals | Cardiomyopathies - metabolism | Telomere - enzymology | Liver - cytology | Mice | Aging - metabolism | Cardiomyopathies - chemically induced | Telomeres | Mitochondria | Genetic aspects | Chemical properties | Abnormalities | Liver | Cell division | Mitochondrial DNA | Biosynthesis | Biology | DNA repair | Proteins | Studies | Aging | Telomerase | Binding sites | Apoptosis | Index Medicus
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2016, Volume 60, Issue 9, pp. 5400 - 5411
Nosocomial infections with Enterococcus faecalis are an emerging health problem. However, drug efflux pumps contributing to intrinsic drug resistance are... 
BINDING CASSETTE TRANSPORTER | TRANSITION | ATP HYDROLYSIS | STREPTOCOCCUS-PNEUMONIAE | STRUCTURAL BASIS | FLEXIBILITY | RESISTANCE | SITES | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | HIGH-THROUGHPUT CLONING | LACTOCOCCUS-LACTIS | Fluoroquinolones - chemistry | Sequence Deletion | Ethidium - chemistry | Protein Multimerization | Proteolipids - metabolism | Bacterial Proteins - chemistry | Ethidium - metabolism | Lactococcus lactis - metabolism | Doxorubicin - chemistry | Genetic Loci | Benzimidazoles - chemistry | ATP-Binding Cassette Transporters - chemistry | Chromosomes, Bacterial - metabolism | Fluoroquinolones - metabolism | ATP-Binding Cassette Transporters - genetics | Biological Transport | Adenosine Triphosphate - metabolism | Anti-Bacterial Agents - chemistry | Base Sequence | ATP-Binding Cassette Transporters - metabolism | Doxorubicin - metabolism | Protein Interaction Domains and Motifs | Daunorubicin - metabolism | Transgenes | Lactococcus lactis - genetics | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Chromosomes, Bacterial - chemistry | Enterococcus faecalis - genetics | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Anti-Bacterial Agents - metabolism | Recombinant Proteins - genetics | Daunorubicin - chemistry | Enterococcus faecalis - metabolism | Protein Conformation, beta-Strand | Benzimidazoles - metabolism | Protein Binding | Bacterial Proteins - metabolism | Adenosine Triphosphate - chemistry | Proteolipids - chemistry | Index Medicus
Journal Article
Journal Article
Pharmacological Research, ISSN 1043-6618, 09/2016, Volume 111, pp. 757 - 766
G protein-coupled receptor 55 (GPR55) possesses pro-oncogenic activity and its function can be competitively inhibited with ( )-4⿲-methoxy-1-naphthylfenoterol... 
Cancer biomarkers | β-Catenin | Hypoxia-inducible factor 1α (HIF-1α) | Pyruvate kinase M2 (PKM2) | Multidrug resistance (MDR) | GPR55 | PKM2 | PHOSPHORYLATION | INVOLVEMENT | P-GLYCOPROTEIN EXPRESSION | GROWTH-FACTOR RECEPTOR | INHIBITION | Hypoxia-inducible factor 1 alpha (HIF-1 alpha) | beta-Catenin | PHARMACOLOGY & PHARMACY | MULTIDRUG-RESISTANCE | LYSOPHOSPHATIDYLINOSITOL | PROMOTES | AGONIST | Phosphorylation | Pancreatic Neoplasms - metabolism | Antibiotics, Antineoplastic - pharmacology | Humans | Deoxycytidine - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Mitogen-Activated Protein Kinase Kinases - metabolism | Deoxycytidine - metabolism | MCF-7 Cells | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Biomarkers, Tumor - metabolism | Antimetabolites, Antineoplastic - pharmacology | Doxorubicin - metabolism | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Antimetabolites, Antineoplastic - metabolism | Fenoterol - pharmacology | Pancreatic Neoplasms - pathology | Fenoterol - analogs & derivatives | beta Catenin - metabolism | Carrier Proteins - metabolism | Signal Transduction - drug effects | Thyroid Hormones - metabolism | Receptors, G-Protein-Coupled - antagonists & inhibitors | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Cell Proliferation - drug effects | Antibiotics, Antineoplastic - metabolism | Deoxycytidine - analogs & derivatives | Doxorubicin - pharmacology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Gerontology | Cancer | Benzoic acid | Drug resistance in microorganisms | Anthracyclines | Epidermal growth factor | Pancreatic cancer | Cancer cells | G proteins | Membrane proteins | Index Medicus | hypoxia-inducible factor 1α (HIF-1α) | β-catenin
Journal Article
Nature medicine, ISSN 1078-8956, 11/2014, Volume 20, Issue 11, pp. 1301 - 1309
Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of innate and T cell-mediated anticancer immune responses. Here we... 
MEDICINE, RESEARCH & EXPERIMENTAL | DOUBLE-STRANDED-RNA | DENDRITIC CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE | RIG-I | TUMORS | CELL BIOLOGY | TOLL-LIKE RECEPTOR-3 | BREAST-CANCER | ANTICANCER CHEMOTHERAPY | GENE | IMMUNE-RESPONSES | Doxorubicin - therapeutic use | Breast Neoplasms - immunology | Humans | RNA, Messenger - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Interferon Type I - biosynthesis | Receptors, Pattern Recognition - metabolism | Neoplasm Metastasis | Anthracyclines - pharmacology | Interferon Type I - metabolism | Female | Neoadjuvant Therapy | Gene Expression Regulation, Neoplastic - drug effects | RNA - metabolism | Receptor, Interferon alpha-beta - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Treatment Outcome | Toll-Like Receptor 3 - metabolism | Breast Neoplasms - drug therapy | Animals | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Immunocompetence - drug effects | Anthracyclines - therapeutic use | Chemokine CXCL10 - metabolism | Myxovirus Resistance Proteins - metabolism | Doxorubicin - pharmacology | Anthracyclines | Care and treatment | Analysis | Physiological aspects | Interferon | Research | Cancer | Signal transduction | Chemotherapy | Breast cancer | Chemokines | Index Medicus | Life Sciences | Immunology | Immunotherapy
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 09/2016, Volume 238, pp. 139 - 148
Therapeutic nanoparticles (NPs) approved for clinical use in solid tumor therapy provide only modest improvements in patient survival, in part due to... 
Nanoparticles | Intravital microscopy | Multiple particle tracking (MPT) | PEG density | Surface plasmon resonance (SPR) | Tumor tissue penetration | SOLID TUMORS | DEEP PENETRATION | CHEMISTRY, MULTIDISCIPLINARY | PHASE-III TRIAL | BREAST-CANCER | DELIVERY-SYSTEM | IN-VIVO | PHARMACOLOGY & PHARMACY | EXTRACELLULAR-MATRIX | HUMAN MUCUS | Neoplasms - metabolism | Nanoparticles - analysis | Humans | Polyethylene Glycols - analysis | Drug Carriers - analysis | Albumin-Bound Paclitaxel - administration & dosage | Antineoplastic Agents - administration & dosage | Polyglycolic Acid - analysis | Breast - metabolism | Breast Neoplasms - metabolism | Antineoplastic Agents - metabolism | Nanoparticles - metabolism | Surface Properties | Doxorubicin - analogs & derivatives | Female | Doxorubicin - metabolism | Polyglycolic Acid - metabolism | Diffusion | Lactic Acid - analysis | Doxorubicin - administration & dosage | Albumin-Bound Paclitaxel - metabolism | Polyethylene Glycols - metabolism | Drug Carriers - metabolism | Lactic Acid - metabolism | Proteoglycans - metabolism | Breast Neoplasms - drug therapy | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Particle Size | Collagen - metabolism | Animals | Breast - drug effects | Mice, Nude | Cell Line, Tumor | Mice | Laminin - metabolism | Drug Combinations | Drugs | Ethylene glycol | Drug delivery systems | Drug therapy | Drug approval | Tumors | Vehicles | Medical colleges | Cancer | Index Medicus | multiple particle tracking (MPT) | tumor tissue penetration | surface plasmon resonance (SPR) | nanoparticles | intravital microscopy
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 03/2006, Volume 20, Issue 5, pp. 601 - 612
Activation of the p53 pathway mediates cellular responses to diverse forms of stress. Here we report that the p53 target gene p21(CIP1) is regulated by stress... 
p53 tumor suppressor protein | Transcription elongation | p21 gene | RNA polymerase II | Apoptosis | P-TEFb | RECRUITMENT | ACTIVATION | TERMINAL DOMAIN KINASES | PHOSPHATASE | DNA-DAMAGE | apoptosis | DEVELOPMENTAL BIOLOGY | PROCESSING FACTORS | CELL BIOLOGY | transcription elongation | COUPLES | IN-VITRO | MESSENGER-RNA | ELONGATION | GENETICS & HEREDITY | Phosphorylation | Humans | Positive Transcriptional Elongation Factor B - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p21 - chemistry | Positive Transcriptional Elongation Factor B - metabolism | RNA Polymerase II - metabolism | Positive Transcriptional Elongation Factor B - genetics | Tumor Suppressor Protein p53 - genetics | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Flow Cytometry | Protein Isoforms - metabolism | Chromatin Immunoprecipitation | DNA - analysis | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Transcription, Genetic | RNA Polymerase II - chemistry | Protein Structure, Tertiary | High Mobility Group Proteins - metabolism | HCT116 Cells | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | DNA - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Serine - chemistry | Transcription Factors - metabolism | Transcriptional Elongation Factors - metabolism | Transcription Factor TFIIH - metabolism | Transcription Factors, TFII - metabolism | Kinetics | Doxorubicin - pharmacology | Research | Analysis | RNA polymerases | Index Medicus | Research Paper
Journal Article