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Cancer Letters, ISSN 0304-3835, 2016, Volume 383, Issue 2, pp. 309 - 317
Abstract In previous studies we demonstrated that targeting the nuclear exporter protein exportin-1 (CRM1/XPO1) by a selective inhibitor of nuclear export... 
Hematology, Oncology and Palliative Medicine | NHL | XPO1 | Selective inhibitors of nuclear export | SINE | CRM1 | Exportin-1 | SURVIVAL | DRUG-RESISTANCE | MODEL | CANCER | STRATEGIES | ONCOLOGY | LINE | CHOP | PROTEINS | Vincristine - pharmacology | TOR Serine-Threonine Kinases - metabolism | Transcription Factor RelA - antagonists & inhibitors | Apoptosis - drug effects | Humans | Lymphoma, Non-Hodgkin - enzymology | Lymphoma, Non-Hodgkin - pathology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Dexamethasone - pharmacology | Time Factors | Oxadiazoles - pharmacology | Acrylamides - pharmacology | Lymphoma, Non-Hodgkin - drug therapy | Cell Survival - drug effects | Hydrazines - pharmacology | Everolimus - pharmacology | Mice, SCID | Mice, Inbred ICR | Drug Synergism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Karyopherins - metabolism | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Tumor Burden - drug effects | Active Transport, Cell Nucleus - drug effects | Cyclophosphamide - pharmacology | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Prednisone - pharmacology | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Karyopherins - antagonists & inhibitors | Doxorubicin - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | International trade | Cyclophosphamide | Care and treatment | Dexamethasone | Analysis | Lymphomas | Prednisone | Exports | Steroids | Cancer | Drugs
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2013, Volume 110, Issue 43, pp. 17253 - 17258
Phenotypic polarization of macrophages is regulated by a milieu of cues in the local tissue microenvironment. Although much is known about how soluble factors... 
Phenotypes | Cell growth | Cytokines | Stem cells | Cell lines | Actins | Physiological regulation | Macrophages | Endothelial cells | Cells | FIBER | MATRIX | ACTIVATION | ACTIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DIFFERENTIATION | SCAFFOLDS | CULTURE | MESENCHYMAL STEM-CELLS | Mannose-Binding Lectins - metabolism | Arginase - metabolism | Lectins, C-Type - immunology | Cell Shape - immunology | Myosin-Light-Chain Kinase - antagonists & inhibitors | Cytochalasin D - pharmacology | Lectins, C-Type - metabolism | Arginase - immunology | Interleukin-4 - pharmacology | Flow Cytometry | Doxorubicin - analogs & derivatives | Inflammation Mediators - metabolism | Female | Immunophenotyping - methods | Cell Polarity - drug effects | Doxorubicin - metabolism | Macrophages - immunology | Cytokines - immunology | Amides - pharmacology | Biomarkers - metabolism | Inflammation Mediators - immunology | Cell Polarity - immunology | Cytokines - metabolism | Myosin-Light-Chain Kinase - metabolism | Mice, Inbred C57BL | Biomarkers - analysis | Cells, Cultured | Receptors, Cell Surface - metabolism | Macrophages - cytology | Interleukin-13 - pharmacology | Receptors, Cell Surface - immunology | Azepines - pharmacology | Cell Shape - drug effects | Macrophages - metabolism | Animals | Mannose-Binding Lectins - immunology | Lipopolysaccharides - pharmacology | Mice | Pyridines - pharmacology | Doxorubicin - immunology | Interferon-gamma - pharmacology | Microscopy, Fluorescence | Physiological aspects | Microbial genetics | Phenotype | Genetic aspects | Research | Biological Sciences | Physical Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 33, pp. 14621 - 14626
.... Available methods are inefficient and are not able to support network pharmacology. We developed an automatic and robust approach that exploits similarity in gene... 
Community structure | Datasets | Communities | Genes | Cell lines | Antineoplastics | Signatures | Dosage | Gene expression | Mode of action | Drug repurposing | Chemotherapy | Systems biology | Computational drug discovery | systems biology | TARGET | APOPTOSIS | computational drug discovery | MULTIDISCIPLINARY SCIENCES | CONNECTIVITY MAP | KAPPA-B | AUTOPHAGY | chemotherapy | drug repurposing | INHIBITION | CAMPTOTHECIN | PROTEASOME | BIOLOGY | Neoplasms - metabolism | Oligonucleotide Array Sequence Analysis | Humans | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Drug Discovery - methods | Gene Expression Profiling | RNA Polymerase II - metabolism | Autophagy - drug effects | Neoplasms - genetics | Piperidines - pharmacology | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Antineoplastic Agents - classification | Fuzzy Logic | Camptothecin - analogs & derivatives | Pyrazoles - pharmacology | Drug Screening Assays, Antitumor - methods | Blotting, Western | Pyrroles - pharmacology | Algorithms | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Cell Line, Tumor | HeLa Cells | Neoplasms - pathology | Camptothecin - pharmacology | Doxorubicin - pharmacology | Dose-response relationship (Biochemistry) | Physiological aspects | Research | Observations | Methods | Cancer | Cyclin-dependent kinase 2 | Drugs | Enhancers | Neurodegenerative diseases | Transcription | Pharmacology | Drug discovery | Nodes | Phagocytosis | Rho-associated kinase | Biological Sciences
Journal Article
Nature communications, ISSN 2041-1723, 2019, Volume 10, Issue 1, pp. 5065 - 15
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 12/2001, Volume 276, Issue 50, pp. 47107 - 47115
Journal Article
JNCI : Journal of the National Cancer Institute, ISSN 1460-2105, 2004, Volume 96, Issue 10, pp. 739 - 749
Background. Trastuzumab, a humanized anti-HER2 antibody, increases the clinical benefit of first-line chemotherapy in patients with metastatic breast cancers... 
TUMOR-CELL LINES | GROWTH-FACTOR RECEPTOR | PHASE-II TRIAL | IN-VITRO | PACLITAXEL TAXOL(R) | ONCOLOGY | 1ST-LINE CHEMOTHERAPY | RANDOMIZED-TRIAL | MONOCLONAL-ANTIBODY | CLINICAL PHARMACOKINETICS | DOCETAXEL TAXOTERE(R) | Up-Regulation | Cyclophosphamide - analogs & derivatives | Paclitaxel - pharmacology | Taxoids - pharmacology | Neoplastic Stem Cells - drug effects | Humans | Receptor, ErbB-2 - metabolism | Deoxycytidine - pharmacology | Transplantation, Heterologous | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Breast Neoplasms - metabolism | Antibodies, Monoclonal, Humanized | Vinblastine - analogs & derivatives | Female | Gene Expression Regulation, Neoplastic - drug effects | Receptor, ErbB-2 - drug effects | Disease Models, Animal | Floxuridine - pharmacology | Cell Survival - drug effects | Tumor Stem Cell Assay | Proto-Oncogene Proteins - drug effects | Enzyme-Linked Immunosorbent Assay | Antibodies, Monoclonal - pharmacology | Docetaxel | Breast Neoplasms - drug therapy | DNA, Neoplasm - drug effects | Guanine Nucleotide Exchange Factors | Drug Synergism | Animals | Mice, Nude | Cyclophosphamide - pharmacology | Cell Line, Tumor | Mice | Vinblastine - pharmacology | Carboplatin - pharmacology | Deoxycytidine - analogs & derivatives | Doxorubicin - pharmacology | Trastuzumab | Vinorelbine | Epirubicin - pharmacology | Chemotherapy | Care and treatment | Breast cancer | Research | Health aspects
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 12, p. e111840
... transduction and chromatin modification has been facilitated by interfacing the sciences of chemical biology and pharmacology [5], [6]. For example, the availability... 
PROTEIN METHYLTRANSFERASES | SELECTIVE-INHIBITION | MOLECULAR SUBTYPES | APOPTOSIS | B-CELL LYMPHOMA | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | RESISTANCE | MECHANISMS | CANCER | SOMATIC MUTATIONS | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | Neoplasm Transplantation | Vincristine - pharmacology | Humans | Receptors, Glucocorticoid - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Receptors, Glucocorticoid - agonists | Dexamethasone - pharmacology | Female | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Drug Evaluation, Preclinical | Lymphoma, Non-Hodgkin - drug therapy | Enhancer of Zeste Homolog 2 Protein - metabolism | Random Allocation | Mice, SCID | Prednisolone - pharmacology | Animals | Cyclophosphamide - pharmacology | Lymphoma, Non-Hodgkin - metabolism | Cell Line, Tumor | Glucocorticoids - pharmacology | Prednisone - pharmacology | Doxorubicin - pharmacology | Pyridones - pharmacology | Care and treatment | Corticosteroids | Fluocinolone acetonide | Central nervous system depressants | Analysis | Histones | Models | Non-Hodgkin's lymphomas | Immunosuppressive agents | Steroids | Cancer | Enzymes | Dexamethasone | Glucocorticoids | Research & development--R&D | Gene expression | Lymphoma | Anticancer properties | Signal transduction | Cell growth | Inhibitors | Lymphomas | Mutation | Prednisolone | Apoptosis | Research & development | R&D
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 12/2008, Volume 105, Issue 49, pp. 19306 - 19311
Journal Article