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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2018, Volume 115, Issue 12, pp. E2734 - E2741
Eukaryotic gene regulation is a complex process, often coordinated by the action of tens to hundreds of proteins. Although previous biochemical studies have... 
Reverse ChIP | CRISPR/Cas9 | Gene expression | Histone regulation | histone regulation | CHROMATIN | DROSOPHILA-MELANOGASTER | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | RNA-BINDING PROTEIN | MESSENGER-RNA | reverse ChIP | EMBRYONIC STEM-CELLS | NUCLEOPROTEIN HYBRIDIZATION | SINGLE GENOMIC LOCUS | POLYMERASE-II | PROTEOMIC ANALYSIS | gene expression | RNA-Binding Proteins - genetics | Endonucleases - genetics | RNA, Guide - genetics | RNA, Guide - metabolism | Humans | CRISPR-Associated Protein 9 | Endonucleases - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Genes, Regulator - genetics | Chromatin Immunoprecipitation | 3' Untranslated Regions | Recombinant Proteins - metabolism | Promoter Regions, Genetic | Gene Expression | Chromosomal Proteins, Non-Histone - metabolism | Bacterial Proteins - genetics | Recombinant Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Chromatin - isolation & purification | Animals | Histones - genetics | Bacterial Proteins - metabolism | Drosophila Proteins - genetics | Histones - metabolism | Chromatin - genetics | RNA-Binding Proteins - metabolism | Proteins | Histones | Genetic research | Genetic aspects | Research | Genetic regulation | CRISPR | Regulators | Chromatin | Histone H2A | Drosophila | Gene regulation | Mass spectroscopy | Loci | Screens | Proteomics | Gene loci | Nuclease | Mass spectrometry | Index Medicus | Biological Sciences | PNAS Plus | Cas9
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2006, Volume 103, Issue 27, pp. 10236 - 10241
Journal Article
Nature, ISSN 0028-0836, 10/2004, Volume 431, Issue 7010, pp. 873 - 878
Covalent modification of histones is important in regulating chromatin dynamics and transcription. One example of such modification is ubiquitination, which... 
CORE | RECRUITMENT | TRANSCRIPTIONAL ACTIVATION | COMPLEX | LIGASE ACTIVITY | MULTIDISCIPLINARY SCIENCES | RAD6 | H3 LYSINE-27 METHYLATION | UBIQUITYLATION | RING FINGER PROTEINS | DROSOPHILA | Nuclear Proteins - isolation & purification | Nucleosomes - chemistry | Humans | Multiprotein Complexes | Ubiquitin - metabolism | Molecular Sequence Data | Drosophila melanogaster - genetics | Promoter Regions, Genetic - genetics | Protein Subunits - metabolism | DNA-Binding Proteins - metabolism | Protein Subunits - isolation & purification | Repressor Proteins - isolation & purification | Response Elements - genetics | Nuclear Proteins - genetics | Proto-Oncogene Proteins - isolation & purification | Repressor Proteins - metabolism | Protein Subunits - genetics | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Catalytic Domain | Repressor Proteins - chemistry | Gene Silencing | Ubiquitin-Protein Ligases - metabolism | Nucleosomes - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Polycomb-Group Proteins | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - isolation & purification | Ubiquitin-Protein Ligases - chemistry | DNA-Binding Proteins - chemistry | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Polycomb Repressive Complex 2 | Animals | Polycomb Repressive Complex 1 | Transcription Factors - isolation & purification | Ubiquitin-Protein Ligases - isolation & purification | Protein Subunits - chemistry | Drosophila Proteins - genetics | HeLa Cells | Histones - metabolism | Ubiquitin-Protein Ligases - genetics | Proteins | Enzymes | Cell culture | Chromatin | Biochemistry | Index Medicus
Journal Article
Science, ISSN 0036-8075, 11/2002, Volume 298, Issue 5595, pp. 1039 - 1043
Polycomb group (PcG) proteins play important roles in maintaining the silent state of HOX genes. Recent studies have implicated histone methylation in... 
Polymerase chain reaction | Gels | Drosophila | Genes | Histones | Antibodies | Amino acids | Reports | Biochemistry | Repression | Methylation | BITHORAX COMPLEX | SITE | REPRESSION | DROSOPHILA-MELANOGASTER | GROUP GENE | MULTIDISCIPLINARY SCIENCES | GROUP PROTEINS | ENHANCER | HP1 | CHROMO DOMAIN | ZESTE | Protein Methyltransferases | Chromatin - metabolism | Temperature | Methyltransferases - isolation & purification | Humans | Methyltransferases - metabolism | Drosophila Proteins - metabolism | Proteins - isolation & purification | DNA-Binding Proteins - metabolism | Peptide Mapping | RNA Interference | Repressor Proteins - isolation & purification | Lysine - metabolism | Genes, Homeobox | Repressor Proteins - metabolism | Response Elements | Histone-Lysine N-Methyltransferase | Cell Cycle Proteins - metabolism | Gene Silencing | Nucleosomes - metabolism | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Enhancer of Zeste Homolog 2 Protein | Precipitin Tests | Polycomb Repressive Complex 2 | Animals | Carrier Proteins - metabolism | Histone Methyltransferases | Polycomb Repressive Complex 1 | Proteins - metabolism | Homeodomain Proteins | Carrier Proteins - isolation & purification | Transcription Factors | Drosophila Proteins - genetics | HeLa Cells | Histones - metabolism | Protein engineering | Research | Lysine | Proteins | Insects | Index Medicus
Journal Article
Journal Article
Cell, ISSN 0092-8674, 05/2006, Volume 125, Issue 3, pp. 509 - 522
Cell-cell communication via Wnt signals represents a fundamental means by which animal development and homeostasis are controlled. The identification of... 
ENCODES | MORPHOGENESIS | CAENORHABDITIS-ELEGANS | POLARITY | PATHWAY | WINGLESS SIGNAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | ENDOPLASMIC-RETICULUM | DROSOPHILA | LONG-RANGE ACTION | CELL BIOLOGY | Drosophila melanogaster - embryology | Humans | DNA, Complementary - genetics | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Cell Communication - physiology | Male | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Wnt Proteins - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Blastomeres - metabolism | Wnt Proteins - genetics | Base Sequence | Conserved Sequence | Female | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | DNA, Complementary - analysis | Amino Acid Sequence | Membrane Proteins - isolation & purification | Caenorhabditis elegans - metabolism | Membrane Proteins - genetics | Blastomeres - cytology | Caenorhabditis elegans - embryology | Drosophila Proteins - isolation & purification | Body Patterning - physiology | Animals | Caenorhabditis elegans - cytology | Intracellular Signaling Peptides and Proteins - isolation & purification | Cell Polarity - physiology | Signal Transduction - physiology | Wnt3 Protein | Drosophila Proteins - genetics | Wnt3A Protein | Evolution, Molecular | Genetic research | Genetic aspects | Research | Drosophila | Membrane proteins | Proteins | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 2002, Volume 111, Issue 2, pp. 197 - 208
Journal Article
Science, ISSN 0036-8075, 9/2003, Volume 301, Issue 5641, pp. 1921 - 1925
The RNA interference (RNAi) pathway is initiated by processing long double-stranded RNA into small interfering RNA (siRNA). The siRNA-generating enzyme was... 
Molecules | Double stranded RNA | Messenger RNA | Gels | Drosophila | Small interfering RNA | Actins | Antibodies | Reports | Embryos | Recombinant proteins | REQUIREMENTS | DOUBLE-STRANDED-RNA | CAENORHABDITIS-ELEGANS | GENETIC INTERFERENCE | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | C-ELEGANS | RNA Helicases - metabolism | RNA-Binding Proteins - genetics | Endoribonucleases - genetics | Endoribonucleases - isolation & purification | Caenorhabditis elegans Proteins - chemistry | Molecular Sequence Data | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | RNA-Binding Proteins - isolation & purification | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | RNA Interference | RNA Helicases - genetics | Electrophoretic Mobility Shift Assay | RNA, Double-Stranded - metabolism | RNA Helicases - isolation & purification | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Biotinylation | Caenorhabditis elegans - metabolism | Endoribonucleases - metabolism | Caenorhabditis elegans - genetics | Chemical Precipitation | RNA-Binding Proteins - chemistry | Drosophila Proteins - chemistry | Drosophila Proteins - isolation & purification | RNA-Induced Silencing Complex - isolation & purification | Animals | Ribonuclease III | RNA-Induced Silencing Complex - metabolism | Argonaute Proteins | Drosophila Proteins - genetics | Kinetics | Mutation | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Physiological aspects | Genetic aspects | Research | RNA | Proteins | Enzymes | Biochemistry | Ribonucleic acid--RNA | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 02/2004, Volume 6, Issue 2, pp. 97 - 105
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2019, Volume 10, Issue 1, pp. 1659 - 16
Journal Article
Journal Article