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Nature (London), ISSN 1476-4687, 2011, Volume 472, Issue 7343, pp. 361 - 365
TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other retroviruses immediately following virus... 
HIV-1 | CYCLOPHILIN-A | UNANCHORED POLYUBIQUITIN CHAINS | TRIM5-ALPHA PROTEIN | RECOGNITION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | RESISTANCE | INFECTION | RESTRICTION | Capsid - chemistry | Receptors, Pattern Recognition - immunology | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | Lipopolysaccharides - immunology | Transcription Factor AP-1 - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | HIV-1 - chemistry | HEK293 Cells | Carrier Proteins - immunology | Cell Line | Retroviridae - chemistry | Ubiquitin-Protein Ligases - metabolism | Retroviridae - immunology | MAP Kinase Kinase Kinases - metabolism | Transcription Factors - metabolism | Capsid - immunology | Carrier Proteins - genetics | Immunity, Innate - immunology | HIV-1 - immunology | Carrier Proteins - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Protein Binding | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Signal transduction | Efficiency | RNA polymerase | Pattern recognition | Kinases | Evacuations & rescues | Immune system | HIV-1/immunology | Capsid/immunology | Life Sciences | MAP Kinase Kinase Kinases/metabolism | Carrier Proteins/immunology | Immunology | Transcription Factors/metabolism | Capsid/chemistry | HIV-1/chemistry | Ubiquitin/metabolism | Receptors, Pattern Recognition/immunology | Retroviridae/chemistry | Ubiquitin-Protein Ligases/immunology | Ubiquitin-Conjugating Enzymes/metabolism | HumansImmunity, Innate/immunology | Lipopolysaccharides/pharmacology | Signal Transduction/drug effects | Retroviridae/immunology | Transcription Factor AP-1/metabolism | Lipopolysaccharides/immunology | Ubiquitin-Protein Ligases/metabolism | Carrier Proteins/genetics | Signal Transduction/immunology | NF-kappa B/metabolism | Ubiquitin-Protein Ligases/genetics | Carrier Proteins/metabolism | Receptors, Pattern Recognition/metabolism
Journal Article
Molecular biology of the cell, ISSN 1939-4586, 2009, Volume 20, Issue 3, pp. 870 - 881
Using a bioinformatic approach, we identified a TP53INP1-related gene encoding a protein with 30% identity with tumor protein 53-induced nuclear protein 1... 
GATE-16 | MOLECULAR MACHINERY | GENE | MEMBRANE-TRANSPORT MODULATOR | PANCREATITIS | INHIBITORS | EXPRESSION | CONJUGATION SYSTEM | GABARAP | SUBUNIT | CELL BIOLOGY | Gene Silencing - drug effects | Microtubule-Associated Proteins - metabolism | Humans | Molecular Sequence Data | Protein Transport - drug effects | Luminescent Measurements | Phylogeny | Autophagy - drug effects | Protein Binding - drug effects | Cloning, Molecular | Conserved Sequence | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Phagosomes - drug effects | Beclin-1 | Amino Acid Sequence | Cell Line | Heat-Shock Proteins - metabolism | Phagosomes - metabolism | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Sirolimus - pharmacology | Apoptosis Regulatory Proteins - metabolism | Animals | Carrier Proteins - metabolism | Mice | Adaptor Proteins, Signal Transducing - metabolism | Heat-Shock Proteins - chemistry | Heat-Shock Proteins: chemistry,metabolism | Membrane Proteins: metabolism | Protein Binding: drug effects | Gene Silencing: drug effects | Adaptor Proteins, Signal Transducing: metabolism | Life Sciences | Phagosomes: drug effects,metabolism | Apoptosis Regulatory Proteins: metabolism | Nuclear Proteins: chemistry,metabolism | Autophagy: drug effects | Protein Transport: drug effects | Microtubule-Associated Proteins: metabolism | Sirolimus: pharmacology | Carrier Proteins: chemistry,metabolism | Other
Journal Article
Journal Article
Journal of controlled release, ISSN 0168-3659, 09/2016, Volume 238, pp. 139 - 148
Therapeutic nanoparticles (NPs) approved for clinical use in solid tumor therapy provide only modest improvements in patient survival, in part due to... 
Nanoparticles | Intravital microscopy | Multiple particle tracking (MPT) | PEG density | Surface plasmon resonance (SPR) | Tumor tissue penetration | SOLID TUMORS | DEEP PENETRATION | CHEMISTRY, MULTIDISCIPLINARY | PHASE-III TRIAL | BREAST-CANCER | DELIVERY-SYSTEM | IN-VIVO | PHARMACOLOGY & PHARMACY | EXTRACELLULAR-MATRIX | HUMAN MUCUS | Neoplasms - metabolism | Nanoparticles - analysis | Humans | Polyethylene Glycols - analysis | Drug Carriers - analysis | Albumin-Bound Paclitaxel - administration & dosage | Antineoplastic Agents - administration & dosage | Polyglycolic Acid - analysis | Breast - metabolism | Breast Neoplasms - metabolism | Antineoplastic Agents - metabolism | Nanoparticles - metabolism | Surface Properties | Doxorubicin - analogs & derivatives | Female | Doxorubicin - metabolism | Polyglycolic Acid - metabolism | Diffusion | Lactic Acid - analysis | Doxorubicin - administration & dosage | Albumin-Bound Paclitaxel - metabolism | Polyethylene Glycols - metabolism | Drug Carriers - metabolism | Lactic Acid - metabolism | Proteoglycans - metabolism | Breast Neoplasms - drug therapy | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Particle Size | Collagen - metabolism | Animals | Breast - drug effects | Mice, Nude | Cell Line, Tumor | Mice | Laminin - metabolism | Drug Combinations | Drugs | Ethylene glycol | Drug delivery systems | Drug therapy | Drug approval | Tumors | Vehicles | Medical colleges | Cancer | multiple particle tracking (MPT) | tumor tissue penetration | surface plasmon resonance (SPR) | nanoparticles | intravital microscopy
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 4/2013, Volume 110, Issue 14, pp. 5422 - 5427
Journal Article
PloS one, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, p. e82364
.... Mitochondria play a central role in coupling glucose metabolism to insulin secretion. However, little is known on mitochondrial responses to specific stresses; i.e... 
OXIDATIVE STRESS | STIMULATED INSULIN-SECRETION | PANCREATIC-ISLETS | METABOLIC HOMEOSTASIS | GLUTAMATE PATHWAYS | MULTIDISCIPLINARY SCIENCES | LONG-TERM EXPOSURE | CARBOXYLASE GENE-EXPRESSION | LINE INS-1 | ENDOPLASMIC-RETICULUM STRESS | DYSFUNCTION | Electron Transport - drug effects | Apoptosis - drug effects | Electron Transport - genetics | Cell Survival - genetics | Apoptosis - genetics | Carnitine - metabolism | Gene Expression Profiling | Mitochondrial Proteins - genetics | Protein Subunits - metabolism | Oxidative Phosphorylation - drug effects | Mitochondrial Proteins - metabolism | Lipid Metabolism - genetics | Biological Transport - drug effects | Biological Transport - genetics | Stress, Physiological - drug effects | Carnitine - analogs & derivatives | Energy Metabolism - genetics | Cell Line | Cell Survival - drug effects | Stress, Physiological - genetics | Rats | Glucose - pharmacology | Mitochondria - metabolism | Transcriptome - genetics | DNA - metabolism | Mitochondria - drug effects | Transcription Factors - metabolism | Insulin - metabolism | Animals | Lipid Metabolism - drug effects | Proteome - metabolism | Energy Metabolism - drug effects | Fatty Acids - pharmacology | Cell culture | Oxidative stress | Hydrogen peroxide | Genomics | Genes | Immunoblotting | Glucose | Palmitic acid | Caspase-3 | Chronic exposure | Glucose metabolism | Mitochondria | Energy | Metabolites | Rodents | Physiology | Sensors | Signatures | Bioinformatics | Deoxyribonucleic acid--DNA | Caspase | Exposure | Metabolism | Gene expression | Insulin | Fatty acids | SIRT1 protein | Citric acid | Carnitine | Carriers | Cell death | Diabetes | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
The Plant cell, ISSN 1532-298X, 2006, Volume 18, Issue 11, pp. 3171 - 3181
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 6, pp. e0130624 - e0130624
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia,... 
INTERLEUKIN-1 | ACTIVATION | MOLECULAR PLATFORM | INHIBITION | DISTINCT PATHWAYS | NEUROINFLAMMATION | MULTIDISCIPLINARY SCIENCES | IL-1-BETA | MECHANISMS | RECEPTORS | NALP3 INFLAMMASOME | Microglia - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Peptide Fragments - toxicity | Caspase 1 - metabolism | Interleukin-1alpha - metabolism | alpha-Synuclein - pharmacology | Interleukin-1beta - metabolism | Interleukin-1beta - secretion | Microglia - cytology | Brain - cytology | Interleukin-1beta - analysis | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Caspase 1 - deficiency | Receptors, Purinergic P2X7 - metabolism | Mice | Interleukin-18 - metabolism | Astrocytes - metabolism | Cytokines | Health aspects | Nervous system diseases | Brain | Cell culture | Traumatic brain injury | Peptides | Aluminum sulfate | Homeostasis | Nervous system | Activation | Macrophages | Synuclein | Proteins | Rodents | Amyloid | Life sciences | Communication | Immune system | Neurodegenerative diseases | Astrocytes | Inflammation | Trauma | Molecular chains | Microglia | Interleukin 18 | Mode of action | Neurological diseases | Nigericin | Brain research | Ligands | Alum | Laboratory animals | Alzheimers disease | Chemokines | Index Medicus
Journal Article
Journal of controlled release, ISSN 0168-3659, 10/2014, Volume 191, pp. 24 - 33
...+ cytotoxic T cell response. Here, a neutral, pH-responsive polymer micelle carrier that alters intracellular antigen trafficking was shown to enhance CD8... 
Nanoparticles | Polymer micelles | Subunit vaccine | pH-responsive | CD8+ T cell response | Ph-responsive | FRAGMENTATION CHAIN TRANSFER | VACCINE | FREE-RADICAL POLYMERIZATION | POPULATIONS | CHEMISTRY, MULTIDISCIPLINARY | NODE DENDRITIC CELLS | CDS+ T cell response | INTRACELLULAR DELIVERY | PHARMACOLOGY & PHARMACY | RAFT | STERICALLY HINDERED MONOMERS | CROSS-PRESENTATION | Endosomes - immunology | Ovalbumin - immunology | Dendritic Cells - immunology | Endosomes - metabolism | Drug Carriers | T-Lymphocytes, Cytotoxic - drug effects | Time Factors | Micelles | Endosomes - drug effects | Dendritic Cells - drug effects | Female | Lymph Nodes - drug effects | Ovalbumin - chemistry | Dendritic Cells - metabolism | Macrophages - immunology | T-Lymphocytes, Cytotoxic - immunology | Antigens | Cell Line | Immunization | Mice, Inbred C57BL | Lymph Nodes - metabolism | Technology, Pharmaceutical - methods | Lymph Nodes - immunology | Ovalbumin - pharmacology | Chemistry, Pharmaceutical | Protein Transport | Particle Size | Macrophages - metabolism | Animals | Vaccines, Subunit - pharmacology | T-Lymphocytes, Cytotoxic - metabolism | Lymphocyte Activation - drug effects | Macrophages - drug effects | Polymers - chemistry | Delayed-Action Preparations | Hydrogen-Ion Concentration | nanoparticles | subunit vaccine | CD8 T cell response | polymer micelles
Journal Article