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Journal Article
BMC genomics, ISSN 1471-2164, 2015, Volume 16, Issue 1, p. 964
Journal Article
Nature (London), ISSN 1476-4687, 2014, Volume 517, Issue 7536, pp. 583 - 588
.... We also synthesized a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes that, upon activation, confer resistance to a BRAF inhibitor... 
RAF INHIBITION | MELANOMA | RNA | PATHWAY | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | RESISTANCE | PROTEIN-COUPLED RECEPTORS | TARGET DNA | CAS9 | CANCER | Transcriptional Activation - genetics | Genetic Testing | RNA, Untranslated - metabolism | Humans | DNA, Complementary - genetics | Genetic Loci - genetics | RNA, Untranslated - genetics | Melanoma - genetics | DNA, Complementary - biosynthesis | Indoles - pharmacology | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Gene Expression Regulation, Neoplastic - genetics | Genetic Engineering - methods | Reproducibility of Results | Gene Library | CRISPR-Associated Proteins - genetics | Up-Regulation - genetics | Sulfonamides - pharmacology | CRISPR-Cas Systems - genetics | Genome, Human - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | RNA, Untranslated - biosynthesis | CRISPR-Associated Proteins - metabolism | Melanoma - drug therapy | Cell Line, Tumor | Drug Resistance, Neoplasm - drug effects | Enzymes | Nucleotide sequence | Genetic research | Genomes | Genetic aspects | Genetic engineering | Genetic transcription | Research | Proteins | Transcription factors | Genomics | Melanoma | Epigenetics | Drug resistance | Gene expression | Crystal structure
Journal Article
PLoS genetics, ISSN 1553-7404, 2013, Volume 9, Issue 1, pp. e1003144 - e1003144
High levels of antibiotic tolerance are a hallmark of bacterial biofilms. In contrast to well-characterized inherited antibiotic resistance, molecular... 
HETEROGENEITY | CHROMOSOME | REPLICATION | PSEUDOMONAS-AERUGINOSA | ESCHERICHIA-COLI | SUSCEPTIBILITY | GENETICS & HEREDITY | GENE-EXPRESSION | RESISTANCE | BETA-LACTAM ANTIBIOTICS | INDUCTION | Biofilms - drug effects | Plankton - drug effects | Starvation | Drug Tolerance - genetics | Biofilms - growth & development | Amino Acids - genetics | Ofloxacin - pharmacology | Mutagenesis | Escherichia coli - genetics | Fluoroquinolones - pharmacology | SOS Response (Genetics) | DNA Transposable Elements - genetics | Plankton - genetics | Anti-Bacterial Agents - pharmacology | Drug Resistance, Bacterial - drug effects | Escherichia coli - growth & development | Drug Resistance, Bacterial - genetics | Transposons | Antibiotics | Gene mutations | Physiological aspects | Genetic aspects | Dosage and administration | Research | Drug resistance | Health aspects | Biofilms | Microbiology | E coli | Bacteria | Mutation | Carbon | Index Medicus | Ofloxacin/pharmacology | DNA Transposable Elements/genetics | Bacterial/drug effects/genetics | Anti-Bacterial Agents/pharmacology | Plankton/drug effects/genetics | Escherichia coli/genetics/growth & development | Bacteriology | Fluoroquinolones/pharmacology | Life Sciences | Microbiology and Parasitology | Biofilms/drug effects/growth & development | Drug Tolerance/genetics | Amino Acids/genetics | Drug Resistance
Journal Article
PLoS genetics, ISSN 1553-7404, 2010, Volume 6, Issue 10, pp. e1001165 - 10
Conjugation is one mechanism for intra- and inter-species horizontal gene transfer among bacteria. Conjugative elements have been instrumental in many... 
REPAIR SYSTEMS | RECOMBINATION | PSIB GENES | EVOLUTION | ESCHERICHIA-COLI | GENETICS & HEREDITY | TRANSCRIPTION INITIATION | GENE-TRANSFER | ENTRY EXCLUSION | PLASMID R64 | VIBRIO-CHOLERAE | Conjugation, Genetic | Green Fluorescent Proteins - metabolism | Integrons - genetics | Bacteria - metabolism | Vibrio cholerae - genetics | Lac Operon - genetics | Gene Transfer, Horizontal | Green Fluorescent Proteins - genetics | Drug Resistance, Microbial - genetics | Bacteria - genetics | Recombinant Fusion Proteins - metabolism | SOS Response (Genetics) - genetics | Vibrio cholerae - metabolism | DNA, Single-Stranded - genetics | Time Factors | Adaptation, Physiological - genetics | Escherichia coli - genetics | Escherichia coli - metabolism | Plasmids - genetics | Recombinant Fusion Proteins - genetics | Integrases - metabolism | Gene Expression Regulation, Bacterial | Integrases - genetics | Adaptations | Integrase | Pathogens | Recombination | Gene transfer | Transcription | DNA damage | Data processing | Genomes | SOS response | Infection | Antibiotics | Mutagenesis | Bioreactors | Plasmids | Antibiotic resistance | Development | Host range | Conjugation | gene rearrangement | Adaptation, Physiological | Integrons | Green Fluorescent Proteins | Vibrio cholerae | Escherichia coli | Recombinant Fusion Proteins | Integrases | SOS Response, Genetics | Life Sciences | Drug Resistance, Microbial | Bacteria | Genetics | DNA, Single-Stranded | Lac Operon | Cholera | Microbiology | Gene expression | Bacteriology
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2017, Volume 355, Issue 6320, pp. 78 - 83
Prostate cancer relapsing from antiandrogen therapies can exhibit variant histology with altered lineage marker expression, suggesting that lineage plasticity facilitates therapeutic resistance... 
PATHWAY | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | SMALL-CELL CARCINOMA | PTEN | GENERATION | TUMORIGENESIS | EXPRESSION | DEFICIENCY | DELETION | EZH2 | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | Epigenesis, Genetic | Humans | SOXB1 Transcription Factors - antagonists & inhibitors | Male | Retinoblastoma-Like Protein p107 - genetics | Tumor Suppressor Protein p53 - genetics | Neoplasms, Experimental - pathology | Neoplasm Metastasis | Prostatic Neoplasms - genetics | SOXB1 Transcription Factors - genetics | Neoplasms, Experimental - genetics | Adenocarcinoma - genetics | Prostatic Neoplasms - drug therapy | Neuroendocrine Tumors - pathology | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Enhancer of Zeste Homolog 2 Protein - genetics | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Neuroendocrine Tumors - genetics | Cell Lineage | Drug Resistance, Neoplasm - genetics | Animals | Androgen Antagonists - therapeutic use | Cell Line, Tumor | Neuroendocrine Tumors - drug therapy | Cell Plasticity | Mice | Mutation | Neoplasms, Experimental - drug therapy | Prevention | Antimitotic agents | Epigenetic inheritance | Development and progression | Genetic aspects | Dosage and administration | Metastasis | Gene expression | Antineoplastic agents | Drug resistance | Health aspects | Prostate cancer | Drugs | Therapy | Deprivation | Histology | Hormones | Suppressors | Switching | Signal transduction | Sensitivity | Androgens | Inhibitors | Rodents | Plasticity | Epigenetics | Tumor suppressor genes | Plastic properties | Prostate | Cancer | Tumors | Mutations
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 546, Issue 7658, pp. 431 - 435
...). Resistance can result from secondary mutations(3,4), but in other cases there is no clear genetic cause, raising the possibility of non-genetic rare cell variability(5-11... 
METASTATIC MELANOMA | BRAF INHIBITOR | SUBPOPULATIONS | CHROMATIN | MULTIDISCIPLINARY SCIENCES | SINGLE MAMMALIAN-CELLS | STATE | MECHANISMS | MUTATIONS | VEMURAFENIB | PLASTICITY | Transcription, Genetic - drug effects | Humans | Male | Transcription Factor AP-1 - metabolism | DNA-Binding Proteins - metabolism | Melanoma - genetics | Female | Indoles - pharmacology | Epigenesis, Genetic - drug effects | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Single-Cell Analysis | Cellular Reprogramming - genetics | ErbB Receptors - metabolism | In Situ Hybridization, Fluorescence | Nuclear Proteins - metabolism | Signal Transduction - genetics | Melanoma - pathology | Sulfonamides - pharmacology | Cellular Reprogramming - drug effects | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Genetic Markers - drug effects | Vemurafenib | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Genetic Markers - genetics | Cell Line, Tumor | Oncogene Protein p65(gag-jun) - metabolism | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Antimitotic agents | Cell interaction | Dosage and administration | Antineoplastic agents | Drug resistance | Observations | Health aspects | Subpopulations | Transcription factors | Substance abuse treatment | Variability | Activator protein 1 | Melanoma | Genomes | Kinases | Gene expression | Sox10 protein | Signal transduction | Signaling | Converting | Population | Mutation | Differentiation | Deoxyribonucleic acid--DNA | Cancer
Journal Article