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1. Full Text Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance
by Healey, Kelley R and Zhao, Yanan and Perez, Winder B and Lockhart, Shawn R and Sobel, Jack D and Farmakiotis, Dimitrios and Kontoyiannis, Dimitrios P and Sanglard, Dominique and Taj-Aldeen, Saad J and Alexander, Barbara D and Jimenez-Ortigosa, Cristina and Shor, Erika and Perlin, David S
Nature Communications, ISSN 2041-1723, 03/2016, Volume 7, Issue 1, pp. 11128 - 11128
The fungal pathogen Candida glabrata has emerged as a major health threat since it readily acquires resistance to multiple drug classes, including triazoles... 
PROPHYLAXIS | ANTIFUNGAL DRUG-RESISTANCE | REDUCED SUSCEPTIBILITY | MICAFUNGIN | MULTIDISCIPLINARY SCIENCES | AMPHOTERICIN-B | FKS MUTATIONS | CLINICAL ISOLATE | EPIDEMIOLOGY | ECHINOCANDIN RESISTANCE | ERG6 GENE | Kidney - pathology | Drug Resistance, Multiple - drug effects | Humans | Colony Count, Microbial | Candidiasis - microbiology | Antifungal Agents - therapeutic use | Candidiasis - drug therapy | Gene Deletion | Genes, Fungal | Echinocandins - pharmacology | Disease Models, Animal | Antifungal Agents - pharmacology | Drug Resistance, Multiple - genetics | Kidney - drug effects | Drug Resistance, Fungal - drug effects | Genotype | Drug Resistance, Fungal - genetics | Mutation - genetics | Kidney - microbiology | Phenotype | Animals | Candida glabrata - isolation & purification | Echinocandins - therapeutic use | Mice | Candida glabrata - genetics | Index Medicus
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2. Full Text Fungal echinocandin resistance
by Walker, Louise A and Gow, Neil A.R and Munro, Carol A
Fungal Genetics and Biology, ISSN 1087-1845, 02/2010, Volume 47, Issue 2, pp. 117 - 126
The echinocandins are the newest class of antifungal agents in the clinical armory. These secondary metabolites are non-competitive inhibitors of the synthesis... 
Candida albicans | Antifungals | Glucan | Chitin | Aspergillus fumigatus | Fungal cell wall | CELL-WALL INTEGRITY | REDUCED SUSCEPTIBILITY | PROSTHETIC VALVE ENDOCARDITIS | CANDIDA-ALBICANS BIOFILMS | IN-VITRO SUSCEPTIBILITY | AMPHOTERICIN-B | YEAST SACCHAROMYCES-CEREVISIAE | GENETICS & HEREDITY | MYCOLOGY | ANTIFUNGAL DRUG CASPOFUNGIN | PERSISTENTLY NEUTROPENIC RABBITS | EXPERIMENTAL PULMONARY ASPERGILLOSIS | Antifungal Agents - pharmacology | Aspergillus fumigatus - drug effects | Humans | Drug Resistance, Fungal - physiology | Candida albicans - metabolism | Drug Resistance, Fungal - genetics | Aspergillus fumigatus - genetics | Candida albicans - growth & development | Antifungal Agents - therapeutic use | Candida albicans - genetics | Biofilms | Candida albicans - drug effects | Cell Wall - drug effects | Genome, Fungal - genetics | Models, Biological | Cell Wall - metabolism | Mycoses - drug therapy | Echinocandins - therapeutic use | Aspergillus fumigatus - metabolism | Mycoses - immunology | Echinocandins - pharmacology | Enzymes | Polyketides | Enzyme inhibitors | Antifungal agents | Physiological aspects | Plant metabolites | Index Medicus
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3. Full Text Hsp90 governs dispersion and drug resistance of fungal biofilms
by Robbins, Nicole and Uppuluri, Priya and Nett, Jeniel and Rajendran, Ranjith and Ramage, Gordon and Lopez-Ribot, Jose L and Andes, David and Cowen, Leah E
PLoS Pathogens, ISSN 1553-7366, 09/2011, Volume 7, Issue 9, pp. e1002257 - e1002257
Fungal biofilms are a major cause of human mortality and are recalcitrant to most treatments due to intrinsic drug resistance. These complex communities of... 
UNITED-STATES | ASPERGILLUS-FUMIGATUS | INFECTIONS | PROTEIN | SUSCEPTIBILITY | CANDIDA-ALBICANS BIOFILMS | MICROBIOLOGY | FLUCONAZOLE RESISTANCE | VIROLOGY | EFFLUX PUMPS | ANTIFUNGAL AGENTS | EPIDEMIOLOGY | PARASITOLOGY | Antifungal Agents - pharmacology | Aspergillus fumigatus - drug effects | Biofilms - drug effects | Gene Expression Regulation, Fungal | Fluconazole - pharmacology | Microscopy, Electron, Scanning | Biofilms - growth & development | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Aspergillus fumigatus - genetics | Azoles - pharmacology | Candida albicans - growth & development | Candida albicans - genetics | Microscopy, Confocal | Calcineurin - genetics | Candida albicans - drug effects | Echinocandins - metabolism | HSP90 Heat-Shock Proteins - metabolism | Aspergillus fumigatus - growth & development | HSP90 Heat-Shock Proteins - genetics | Calcineurin - metabolism | Fungal Proteins - metabolism | Fungi | Drug resistance in microorganisms | Heat shock proteins | Physiological aspects | Research | Microbial mats | Health aspects | Medical equipment | Medical research | Microbiology | Drug resistance | Mortality | Index Medicus
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4. Full Text A nuclear receptor-like pathway regulating multidrug resistance in fungi
by Pan, Shih-Jung and Frueh, Dominique P and Moye-Rowley, W. Scott and Yang, Fajun and Struhl, Kevin and Breger, Julia and Wagner, Gerhard and Thakur, Jitendra K and Gulshan, Kailash and Li, Darrick K and Arthanari, Haribabu and Fan, Xiaochun and Mylonakis, Eleftherios and Näär, Anders M and Cormack, Brendan P
Nature, ISSN 0028-0836, 04/2008, Volume 452, Issue 7187, pp. 604 - 609
Multidrug resistance ( MDR) is a serious complication during treatment of opportunistic fungal infections that frequently afflict immunocompromised... 
CANDIDA-GLABRATA | NMR-SPECTROSCOPY | MULTIDISCIPLINARY SCIENCES | KIX DOMAIN | COACTIVATOR COMPLEXES | CASSETTE TRANSPORTER | TRANSACTIVATION DOMAIN | SECONDARY STRUCTURE | DRUG-RESISTANCE | SACCHAROMYCES-CEREVISIAE | TRANSCRIPTION-FACTOR-BINDING | Fungal Proteins - chemistry | Multigene Family | Receptors, Steroid - metabolism | Saccharomyces cerevisiae - genetics | Saccharomyces cerevisiae - drug effects | Trans-Activators - chemistry | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Antifungal Agents - metabolism | Trans-Activators - genetics | Gene Expression Regulation, Fungal - genetics | Xenobiotics - metabolism | Mediator Complex | Genes, Fungal - genetics | Antifungal Agents - pharmacology | Protein Structure, Tertiary | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | Candida glabrata - metabolism | DNA-Binding Proteins - chemistry | Transcription Factors - metabolism | Animals | Saccharomyces cerevisiae Proteins - metabolism | Trans-Activators - metabolism | Transcription, Genetic - genetics | Candida glabrata - genetics | Candida glabrata - drug effects | Fungal Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Biomedical research | Fungal infections | Drug resistance | Molecular biology | Binding sites | Index Medicus
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5. Full Text High-frequency Triazole Resistance Found in Nonculturable Aspergillus fumigatus from Lungs of Patients With Chronic Fungal Disease
by David W. Denning and Steven Park and Cornelia Lass-Florl and Marcin G. Fraczek and Marie Kirwan and Robin Gore and Jaclyn Smith and Ahmed Bueid and Caroline B. Moore and Paul Bowyer and David S. Perlin
Clinical Infectious Diseases, ISSN 1058-4838, 5/2011, Volume 52, Issue 9, pp. 1123 - 1129
Background. Oral triazole therapy is well established for the treatment of invasive (IPA), allergic (ABPA), and chronic pulmonary (CPA) aspergillosis and is... 
Polymerase chain reaction | Antifungals | Aspergillus | Azoles | Triazoles | Aspergillosis | Sputum | ARTICLES AND COMMENTARIES | Allergic bronchopulmonary aspergillosis | Aspergillus fumigatus | Genetic mutation | DIAGNOSIS | INFECTIOUS DISEASES | SEVERE ASTHMA | METAANALYSIS | MICROBIOLOGY | ITRACONAZOLE | IMMUNOLOGY | INVASIVE ASPERGILLOSIS | PULMONARY ASPERGILLOSIS | SENSITIZATION | AZOLE RESISTANCE | ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS | PCR | Aspergillus fumigatus - drug effects | Sputum - microbiology | Lung - microbiology | Aspergillosis, Allergic Bronchopulmonary - microbiology | Humans | Aspergillosis, Allergic Bronchopulmonary - drug therapy | Antifungal Agents - therapeutic use | Bronchoalveolar Lavage Fluid - microbiology | Aspergillus fumigatus - isolation & purification | Culture Media | Polymerase Chain Reaction | Aspergillosis, Allergic Bronchopulmonary - epidemiology | Invasive Pulmonary Aspergillosis - epidemiology | Triazoles - therapeutic use | Antifungal Agents - pharmacology | Invasive Pulmonary Aspergillosis - drug therapy | Pulmonary Aspergillosis - drug therapy | DNA, Fungal - analysis | Drug Resistance, Fungal - genetics | Aspergillus fumigatus - genetics | Pulmonary Aspergillosis - microbiology | Triazoles - pharmacology | Pulmonary Aspergillosis - epidemiology | Invasive Pulmonary Aspergillosis - microbiology | Mutation | Chronic Disease | Drug resistance in microorganisms | Usage | Physiological aspects | Causes of | Lung diseases, Fungal | Research | Drug therapy | Health aspects | Fungi | Infectious diseases | Medical diagnosis | Deoxyribonucleic acid--DNA | Nonnative species | Polymorphism | Index Medicus | and Commentaries
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6. Full Text PKC signaling regulates drug resistance of the fungal pathogen candida albicans via circuitry comprised of mkc1, calcineurin, and hsp90
by Lafayette, Shantelle L and Collins, Cathy and Zaas, Aimee K and Schell, Wiley A and Betancourt-Quiroz, Marisol and Leslie Gunatilaka, A.A and Perfect, John R and Cowen, Leah E
PLoS Pathogens, ISSN 1553-7366, 08/2010, Volume 6, Issue 8, pp. 79 - 80
Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful... 
UNITED-STATES | PROTEIN-KINASE-C | CELL INTEGRITY PATHWAY | NATURAL-PRODUCTS | MICROBIOLOGY | ENDOPLASMIC-RETICULUM STRESS | VIRULENCE | SACCHAROMYCES-CEREVISIAE | YEAST | EVOLUTION | VIROLOGY | CHAPERONE MACHINERY | PARASITOLOGY | Antifungal Agents - pharmacology | Saccharomyces cerevisiae - genetics | Immunoblotting | Candida albicans - metabolism | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Candida albicans - genetics | Microbial Sensitivity Tests | Saccharomyces cerevisiae - metabolism | Animals | Calcineurin - genetics | Protein Kinase C - metabolism | HSP90 Heat-Shock Proteins - metabolism | Mitogen-Activated Protein Kinases - genetics | Signal Transduction - physiology | HSP90 Heat-Shock Proteins - genetics | Mice | Calcineurin - metabolism | Fungal Proteins - metabolism | Mitogen-Activated Protein Kinases - metabolism | Candida albicans | Drug resistance in microorganisms | Calcineurin | Physiological aspects | Heat shock proteins | Research | Protein kinases | Index Medicus | Proteins | Fungi | Medical research | Kinases | Mortality
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7. Full Text Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata
by Singh-Babak, Sheena D and Babak, Tomas and Diezmann, Stephanie and Hill, Jessica A and Xie, Jinglin Lucy and Chen, Ying-Lien and Poutanen, Susan M and Rennie, Robert P and Heitman, Joseph and Cowen, Leah E
PLoS Pathogens, ISSN 1553-7366, 05/2012, Volume 8, Issue 5, pp. e1002718 - e1002718
The evolution of drug resistance has a profound impact on human health. Candida glabrata is a leading human fungal pathogen that can rapidly evolve resistance... 
CELL-WALL INTEGRITY | HSP90 MOLECULAR CHAPERONE | BUDDING YEAST | ANTIBIOTIC-RESISTANCE | MICROBIOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | SACCHAROMYCES-CEREVISIAE | EXPERIMENTAL POPULATIONS | VIROLOGY | FUNGAL DRUG-RESISTANCE | AZOLE RESISTANCE | 1,3-BETA-D-GLUCAN SYNTHASE | PARASITOLOGY | Humans | Middle Aged | Antifungal Agents - therapeutic use | Microbial Sensitivity Tests | Calcineurin - genetics | Genome, Fungal | Base Sequence | Female | HSP90 Heat-Shock Proteins - genetics | Echinocandins - pharmacology | Glucosyltransferases - genetics | Antifungal Agents - pharmacology | Candidemia - microbiology | Drug Resistance, Fungal - genetics | Fungal Proteins - genetics | Candida glabrata - metabolism | Sequence Analysis, DNA | Polymorphism, Genetic | Candidemia - drug therapy | HSP90 Heat-Shock Proteins - metabolism | Candida glabrata - genetics | Lipopeptides | Calcineurin - metabolism | Candida glabrata - drug effects | Evolution, Molecular | Fungal Proteins - metabolism | Drug resistance in microorganisms | Candida | Antifungal agents | Physiological aspects | Virulence (Microbiology) | Research | Health aspects | Medical research | Plasmids | Mortality | Evolution | Genomes | Mutation | Fungal infections | Drug resistance | Experiments | Drug dosages | Index Medicus
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