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Nature (London), ISSN 0028-0836, 07/2018, Volume 559, Issue 7713, pp. 259 - 263
The spread of antimicrobial resistance has become a serious public health concern, making once-treatable diseases deadly again and undermining the achievements of modern medicine(1,2... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Moths - microbiology | Species Specificity | Escherichia coli - drug effects | Phylogeny | Microbial Sensitivity Tests | Colistin - pharmacology | Drug Interactions | Larva - drug effects | Salmonella typhimurium - classification | Salmonella typhimurium - drug effects | Drug Resistance, Microbial - drug effects | Benzaldehydes - pharmacology | Pseudomonas aeruginosa - drug effects | Food Additives - pharmacology | Drug Synergism | Gram-Negative Bacteria - drug effects | Moths - growth & development | Animals | Anti-Bacterial Agents - pharmacology | Larva - microbiology | Pseudomonas aeruginosa - classification | Drug Resistance, Multiple, Bacterial - drug effects | Drug Combinations | Escherichia coli - classification | Gram-Negative Bacteria - classification | Pharmaceutical research | Drug resistance in microorganisms | Research | Antibiosis | Drug interactions | Drugs | Larvae | Salmonella | Additives | Colistin | Clinical isolates | Infections | Drug resistance | Experiments | Proteins | E coli | Food additives | Bacteria | Pseudomonas aeruginosa | Drug dosages | Species | Public health | Food | Integrated approach | Bacterial infections | Antimicrobial agents | Gene expression | Antibiotics | Antimicrobial resistance | Vanillin | Drug additives | Index Medicus | Life Sciences | Microbiology and Parasitology | Salmonella typhimurium/classification | Escherichia coli/drug effects | Anti-Bacterial Agents/pharmacology | Pseudomonas aeruginosa/drug effects | Pseudomonas aeruginosa/classification
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 05/2016, Volume 534, Issue 7605, pp. 129 - 132
Journal Article
PloS one, ISSN 1932-6203, 06/2011, Volume 6, Issue 6, pp. e21187 - e21187
.... In the present study we demonstrate how a single, simple dietary factor-leucine-can modify insulin resistance by acting on multiple tissues and at multiple levels of metabolism... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Inflammation - pathology | Metabolomics | Leucine - pharmacology | Liver - pathology | Liver - enzymology | Body Weight - drug effects | Leucine - therapeutic use | Liver - drug effects | Dietary Fats - pharmacology | Adenylate Kinase - metabolism | Dietary Fats - administration & dosage | Glucose Tolerance Test | Adiposity - drug effects | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Adipose Tissue - pathology | Insulin Resistance | Leucine - administration & dosage | Fatty Liver - drug therapy | Feeding Behavior - drug effects | Insulin - metabolism | Animals | Diet | Muscles - enzymology | Signal Transduction - drug effects | Muscles - drug effects | Mice | Adipose Tissue - drug effects | Dietary Supplements | Type 2 diabetes | Drinking water | Metabolites | RNA | Liver | Physiological aspects | Amino acids | Insulin resistance | Glucose | Fatty acids | Dextrose | Tricarboxylic acid cycle | Phosphorylation | Adipose tissue | Homeostasis | Environmental changes | mRNA | Leucine | Kinases | High fat diet | Fatty liver | Rodents | Animal tissues | Obesity | Abnormalities | Diabetes mellitus | Health risks | Environmental factors | Inflammation | Metabolism | Insulin | Body weight gain | Cholesterol | Intermediates | Ribosomal protein S6 kinase | Glucose tolerance | Signaling | Insulin receptor substrate 1 | Food intake | Metabolic disorders | Index Medicus
Journal Article
Frontiers in immunology, ISSN 1664-3224, 09/2018, Volume 9, Issue SEP, pp. 2134 - 2134
.... This expression profile, together with the role of CD38 in adhesion and as ectoenzyme, resulted in the development of CD38 antibodies for the treatment of multiple myeloma (MM... 
a_open_article_in_open_journal | MOR202 | Resistance | Isatuximab | Antibody | Daratumumab | CD38 | Mode of action | TAK-079 | Life Sciences & Biomedicine | Immunology | Science & Technology | Apoptosis - drug effects | Immunoglobulin Fc Fragments - metabolism | Humans | Antibody-Dependent Cell Cytotoxicity - immunology | Antibodies, Monoclonal - therapeutic use | Multiple Myeloma - immunology | Myeloid-Derived Suppressor Cells - drug effects | ADP-ribosyl Cyclase 1 - antagonists & inhibitors | T-Lymphocytes, Regulatory - immunology | Multiple Myeloma - drug therapy | Immunoglobulin Fc Fragments - immunology | Membrane Glycoproteins - antagonists & inhibitors | ADP-ribosyl Cyclase 1 - immunology | Gene Expression Regulation, Neoplastic - drug effects | Membrane Glycoproteins - immunology | Tumor Microenvironment - drug effects | Myeloid-Derived Suppressor Cells - immunology | Phagocytosis - drug effects | Antibodies, Monoclonal - pharmacology | Phagocytosis - immunology | Gene Expression Regulation, Neoplastic - immunology | Treatment Outcome | Drug Resistance, Neoplasm - immunology | B-Lymphocytes, Regulatory - immunology | Antineoplastic Agents, Immunological - pharmacology | Randomized Controlled Trials as Topic | Tumor Microenvironment - immunology | Drug Resistance, Neoplasm - genetics | Multiple Myeloma - pathology | T-Lymphocytes, Regulatory - drug effects | Apoptosis - immunology | Antineoplastic Agents, Immunological - therapeutic use | B-Lymphocytes, Regulatory - drug effects | Antibody-Dependent Cell Cytotoxicity - drug effects | Viral antibodies | Treatment outcome | Care and treatment | Analysis | Multiple myeloma | Antibodies | Research | B cells | Index Medicus | isatuximab | antibody | daratumumab
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, pp. e89064 - e89064
The anti-apoptotic protein Mcl-1 plays a major role in multiple myeloma (MM) cell survival as well as bortezomib- and microenvironmental forms of drug resistance in this disease... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Kinases - metabolism | Apoptosis - drug effects | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Multiple Myeloma - drug therapy | Benzamides - therapeutic use | Bcl-2-Like Protein 11 | Protein Binding - drug effects | Cytoprotection - drug effects | Benzamides - pharmacology | Membrane Proteins - metabolism | Multiple Myeloma - enzymology | Proto-Oncogene Proteins - metabolism | Mesenchymal Stromal Cells - drug effects | Bortezomib | Syndecan-1 - metabolism | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | bcl-2-Associated X Protein - metabolism | Mesenchymal Stromal Cells - metabolism | Down-Regulation - drug effects | Apoptosis Regulatory Proteins - metabolism | Up-Regulation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Protein Kinase Inhibitors - therapeutic use | Cell Line, Tumor | Checkpoint Kinase 1 | Protein Kinase Inhibitors - pharmacology | Mesenchymal Stromal Cells - pathology | Pyrazines - pharmacology | Boronic Acids - pharmacology | Drug Resistance, Neoplasm - drug effects | Drug resistance | Apoptosis | Cell culture | Regulations | Cell survival | Bax protein | Transcription | Insulin-like growth factor I | CHK1 protein | Gene regulation | Multiple myeloma | Insulin-like growth factors | Mcl-1 protein | Hemopoiesis | Interleukin 6 | Disease resistance | Stromal cells | Inhibition | BIM protein | Index Medicus
Journal Article