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1. Full Text Identification of an Acinetobacter baumannii Zinc Acquisition System that Facilitates Resistance to Calprotectin-mediated Zinc Sequestration
by Hood, M. Indriati and Mortensen, Brittany L and Moore, Jessica L and Zhang, Yaofang and Kehl-Fie, Thomas E and Sugitani, Norie and Chazin, Walter J and Caprioli, Richard M and Skaar, Eric P
PLoS Pathogens, ISSN 1553-7366, 12/2012, Volume 8, Issue 12, pp. e1003068 - e1003068
Acinetobacter baumannii is an important nosocomial pathogen that accounts for up to 20 percent of infections in intensive care units worldwide. Furthermore, A.... 
PROTEIN | ENVIRONMENTS | MICROBIOLOGY | IRON | TRANSPORT | GRAM-NEGATIVE BACTERIA | VIROLOGY | ZUR | GROWTH | GENES | INFECTION | MULTIDRUG-RESISTANCE | PARASITOLOGY | Manganese - immunology | Humans | Leukocyte L1 Antigen Complex - immunology | Acinetobacter Infections - genetics | Biological Transport, Active | Carbapenems - pharmacology | Zinc - immunology | Acinetobacter Infections - immunology | Pneumonia, Bacterial - genetics | Pneumonia, Bacterial - pathology | Disease Models, Animal | Neutrophil Infiltration - immunology | Neutrophils - pathology | Lung - pathology | Acinetobacter Infections - drug therapy | Neutrophils - immunology | Acinetobacter baumannii - pathogenicity | Neutrophil Infiltration - genetics | Mice, Knockout | Animals | Acinetobacter baumannii - immunology | Pneumonia, Bacterial - immunology | Mice | Acinetobacter baumannii - genetics | Drug Resistance, Multiple, Bacterial - genetics | Drug Resistance, Multiple, Bacterial - immunology | Drug Resistance, Multiple, Bacterial - drug effects | Lung - immunology | Medical research | Intensive care | Disease | Pathogenesis | Metals | Infections | Experiments | Zinc | Training | Lungs | Antibiotics | Bacteria | Public health | Index Medicus
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2. Full Text Whole-genome sequencing for detecting antimicrobial resistance in nontyphoidal Salmonella
by McDermott, Patrick F and Tyson, Gregory H and Kabera, Claudine and Chen, Yuansha and Li, Cong and Folster, Jason P and Ayers, Sherry L and Lam, Claudia and Tate, Heather P and Zhao, Shaohua
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2016, Volume 60, Issue 9, pp. 5515 - 5520
Laboratory-based in vitro antimicrobial susceptibility testing is the foundation for guiding anti-infective therapy and monitoring antimicrobial resistance... 
UNITED-STATES | ANIMALS | BETA-LACTAMASE | QUINOLONE RESISTANCE | ESCHERICHIA-COLI | SURVEILLANCE | HUMANS | PARC GENES | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | ENTERICA | FOOD | United States | Humans | Salmonella - genetics | Genotype | Salmonella - drug effects | Mutation - genetics | Phenotype | beta-Lactams - pharmacology | beta-Lactamases - genetics | Anti-Bacterial Agents - pharmacology | Drug Resistance, Multiple, Bacterial - genetics | Drug Resistance, Multiple, Bacterial - drug effects | Microbial Sensitivity Tests - methods | Meat - microbiology | Index Medicus
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3. Full Text Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis
by Kohanski, Michael A and DePristo, Mark A and Collins, James J
Molecular Cell, ISSN 1097-2765, 2010, Volume 37, Issue 3, pp. 311 - 320
Antibiotic resistance arises through mechanisms such as selection of naturally occurring resistant mutants and horizontal gene transfer. Recently, oxidative... 
DNA | MICROBIO | HUMDISEASE | MUTATION-RATES | BACTERIA | EVOLUTION | OXIDATIVE DAMAGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | HYDROGEN-PEROXIDE | STAPHYLOCOCCUS-AUREUS | SUPEROXIDE-DISMUTASE | CIPROFLOXACIN | CELL BIOLOGY | Amino Acid Sequence | Reactive Oxygen Species - metabolism | Escherichia coli - drug effects | Molecular Sequence Data | Gene Transfer, Horizontal - drug effects | Microbial Sensitivity Tests | Sequence Analysis, Protein | Sequence Alignment | Mutagenesis | Escherichia coli - genetics | Base Sequence | Escherichia coli - metabolism | Anti-Bacterial Agents - pharmacology | Drug Resistance, Multiple, Bacterial - genetics | Drug Resistance, Multiple, Bacterial - drug effects | Evolutionary biology | Drug resistance in microorganisms | Index Medicus
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4. Full Text A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset
by Chin, Willy and Zhong, Guansheng and Pu, Qinqin and Yang, Chuan and Lou, Weiyang and De Sessions, Paola Florez and Periaswamy, Balamurugan and Lee, Ashlynn and Liang, Zhen Chang and Ding, Xin and Gao, Shujun and Chu, Collins Wenhan and Bianco, Simone and Bao, Chang and Tong, Yen Wah and Fan, Weimin and Wu, Min and Hedrick, James L and Yang, Yi Yan
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 917 - 14
Polymyxins remain the last line treatment for multidrug-resistant (MDR) infections. As polymyxins resistance emerges, there is an urgent need to develop... 
HOST-DEFENSE PEPTIDES | FORMING PEPTIDE AMPHIPHILES | ACINETOBACTER-BAUMANNII | POLYMERS | DE-NOVO DESIGN | ANTIMICROBIAL POLYCARBONATES | CHEMICAL-STRUCTURE | TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | RANDOM COPOLYMERS | IN-VITRO ACTIVITY | Hemolysis - drug effects | Anti-Infective Agents - pharmacology | Bacteria - drug effects | Male | Microbial Sensitivity Tests | Polymers - therapeutic use | Ligation | Cecum - surgery | Female | Bacterial Infections - microbiology | Disease Models, Animal | Macromolecular Substances - therapeutic use | Tissue Distribution - drug effects | Polymers - chemical synthesis | Bacterial Infections - drug therapy | Mice, Inbred C57BL | Punctures | Mice, Inbred ICR | Bacteria - isolation & purification | Animals | Sequence Analysis, RNA | Macromolecular Substances - pharmacokinetics | Polymers - pharmacokinetics | Polymers - chemistry | Kinetics | Drug Resistance, Multiple, Bacterial - drug effects | Biodegradation | Animal models | Antimicrobial activity | Bacterial infections | Biodegradability | Lung | Macromolecules | Multidrug resistance | Escherichia coli | Cecum | Antimicrobial agents | Infections | Drug resistance | Antiinfectives and antibacterials | Methicillin | Antibiotics | Polycarbonates | Biocompatibility | Polymers | Peritonitis | Polymyxins | Index Medicus
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5. Full Text Antibacterial Activity of Eravacycline (TP-434), a Novel Fluorocycline, against Hospital and Community Pathogens
by J. A. Sutcliffe and W. O'Brien and C. Fyfe and T. H. Grossman
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2013, Volume 57, Issue 11, pp. 5548 - 5558
Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
CARBAPENEM-RESISTANT ENTEROBACTERIACEAE | ACINETOBACTER-BAUMANNII | TIGECYCLINE | INFECTIOUS-DISEASES | MULTIPLEX PCR | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | OUTCOMES | MULTIDRUG-RESISTANCE | ANTIMICROBIAL RESISTANCE | KLEBSIELLA-PNEUMONIAE | Tetracyclines - chemistry | Gram-Positive Bacteria - drug effects | Humans | Tetracyclines - pharmacology | Gram-Negative Bacteria - isolation & purification | Gram-Negative Bacterial Infections - microbiology | Gram-Positive Bacteria - genetics | Microbial Sensitivity Tests | beta-Lactamases - genetics | ATP-Binding Cassette Transporters - genetics | Community-Acquired Infections - drug therapy | Anti-Bacterial Agents - chemistry | Gram-Positive Bacterial Infections - microbiology | ATP-Binding Cassette Transporters - metabolism | Gram-Negative Bacteria - genetics | beta-Lactamases - metabolism | Gene Expression | Gram-Negative Bacterial Infections - drug therapy | Cross Infection - drug therapy | Gram-Negative Bacteria - drug effects | Cross Infection - microbiology | Gram-Positive Bacteria - isolation & purification | Anti-Bacterial Agents - pharmacology | Drug Resistance, Multiple, Bacterial - genetics | Gram-Positive Bacterial Infections - drug therapy | Community-Acquired Infections - microbiology | Drug Resistance, Multiple, Bacterial - drug effects | Index Medicus | Antibacterial activity | Susceptibility
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6. Full Text An international multicenter retrospective study of Pseudomonas aeruginosa nosocomial pneumonia: Impact of multidrug resistance
by Micek, Scott T and Wunderink, Richard G and Kollef, Marin H and Chen, Catherine and Rello, Jordi and Chastre, Jean and Antonelli, Massimo and Welte, Tobias and Clair, Bernard and Ostermann, Helmut and Calbo, Esther and Torres, Antoni and Menichetti, Francesco and Schramm, Garrett E and Menon, Vandana
Critical Care, ISSN 1364-8535, 05/2015, Volume 19, Issue 1, pp. 219 - 219
Introduction: Pseudomonas aeruginosa nosocomial pneumonia (Pa-NP) is associated with considerable morbidity, prolonged hospitalization, increased costs, and... 
HOSPITALIZED-PATIENTS | INFECTIONS | RISK-FACTORS | VENTILATOR-ASSOCIATED PNEUMONIA | ACQUIRED PNEUMONIA | CARE-ASSOCIATED PNEUMONIA | BACTEREMIA | CARBAPENEMASE | PREVALENCE | PATHOGENS | CRITICAL CARE MEDICINE | Pseudomonas aeruginosa - isolation & purification | Humans | Middle Aged | Cross Infection - mortality | Male | Pseudomonas Infections - mortality | Hospital Mortality - trends | Anti-Bacterial Agents - therapeutic use | Pneumonia, Bacterial - mortality | Adult | Female | Retrospective Studies | Pseudomonas Infections - drug therapy | Pseudomonas Infections - diagnosis | Mortality - trends | Pneumonia, Bacterial - diagnosis | Pseudomonas aeruginosa - drug effects | Cross Infection - drug therapy | Internationality | Hospitalization - trends | Cross Infection - diagnosis | Pneumonia, Bacterial - drug therapy | Aged | Anti-Bacterial Agents - pharmacology | Drug Resistance, Multiple, Bacterial - drug effects | Medical research | Drug resistance in microorganisms | Pneumonia | Bacterial pneumonia | Mortality | Medicine, Experimental | Diabetes | Comparative analysis | France | Health aspects | Risk factors | Patient safety | Multidrug resistant organisms | Drug resistance | Index Medicus | Research
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7. Full Text A broad-spectrum antibiofilm peptide enhances antibiotic action against bacterial biofilms
by Reffuveille, Fany and De La Fuente-Nú̃nez, César and Mansour, Sarah and Hancock, Robert E. W
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 2014, Volume 58, Issue 9, pp. 5363 - 5371
Biofilm-related infections account for at least 65% of all human infections, but there are no available antimicrobials that specifically target biofilms. Their... 
INFECTIONS | INHIBITION | PSEUDOMONAS-AERUGINOSA | STRINGENT RESPONSE | PENICILLIN-BINDING PROTEINS | SWARMING MOTILITY | RESISTANCE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | STRATEGIES | Biofilms - drug effects | Anti-Bacterial Agents - pharmacology | Drug Resistance, Multiple, Bacterial - drug effects | Microbial Sensitivity Tests - methods | Bacteria - drug effects | Peptides - pharmacology | Index Medicus | Experimental Therapeutics
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8. Full Text Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: A retrospective cohort study
by Zilberberg, Marya D and Shorr, Andrew F and Micek, Scott T and Vazquez-Guillamet, Cristina and Kollef, Marin H
Critical Care, ISSN 1364-8535, 11/2014, Volume 18, Issue 6, pp. 596 - 596
Introduction: The impact of in vitro resistance on initially appropriate antibiotic therapy (IAAT) remains unclear. We elucidated the relationship between... 
HOSPITAL MORTALITY | SINGLE-CENTER EXPERIENCE | INFECTIONS | INTENSIVE-CARE-UNIT | VENTILATOR-ASSOCIATED PNEUMONIA | ANTIMICROBIAL THERAPY | PSEUDOMONAS-AERUGINOSA | GUIDELINES | INTRAVENOUS COLISTIN | CRITICALLY-ILL PATIENTS | CRITICAL CARE MEDICINE | Drug Resistance, Multiple, Bacterial - physiology | Humans | Middle Aged | Sepsis - diagnosis | Gram-Negative Bacterial Infections - drug therapy | Male | Shock, Septic - diagnosis | Shock, Septic - mortality | Sepsis - mortality | Hospital Mortality - trends | Anti-Bacterial Agents - therapeutic use | Sepsis - drug therapy | Shock, Septic - drug therapy | Female | Aged | Anti-Bacterial Agents - pharmacology | Gram-Negative Bacterial Infections - diagnosis | Retrospective Studies | Drug Resistance, Multiple, Bacterial - drug effects | Cohort Studies | Gram-Negative Bacterial Infections - mortality | Medical research | Drug resistance in microorganisms | Analysis | Medicine, Experimental | Beta lactamases | Pharmaceutical industry | Health aspects | Index Medicus | Research
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9. Full Text A novel in vitro multiple-stress dormancy model for mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen
by Deb, Chirajyoti and Lee, Chang-Muk and Dubey, Vinod S and Daniel, Jaiyanth and Abomoelak, Bassam and Sirakova, Tatiana D and Pawar, Santosh and Rogers, Linda and Kolattukudy, Pappachan E
PLoS ONE, ISSN 1932-6203, 06/2009, Volume 4, Issue 6, pp. e6077 - e6077
Background: Mycobacterium tuberculosis (Mtb) becomes dormant and phenotypically drug resistant when it encounters multiple stresses within the host. Inability... 
MULTIDISCIPLINARY SCIENCES | Coloring Agents - pharmacology | Down-Regulation | Gene Expression Regulation | Reverse Transcriptase Polymerase Chain Reaction | Gene Expression Regulation, Bacterial - drug effects | Lipids - chemistry | Phenotype | Transcription, Genetic | Drug Resistance, Multiple, Bacterial - drug effects | Genes, Bacterial - drug effects | Microbial Sensitivity Tests - methods | Mycobacterium tuberculosis - metabolism | Xanthenes - pharmacology | Cluster Analysis | Hydrogen-Ion Concentration | Oxazines - pharmacology | Drugs | Drug resistance in microorganisms | Tuberculosis | Analysis | Antitubercular agents | Triglycerides | Genetic transcription | Target recognition | Genes | Carbon dioxide | High-throughput screening | Lipids | Biosynthesis | Genomes | Infections | Drug resistance | Drug development | pH effects | Drug screening | Deletion mutant | Dormancy | Replicating | Clonal deletion | Deletion | Complementation | Stresses | Pathogens | Metabolism | Gene expression | Carbon | Fatty acids | Stress | Medicine | Gene silencing | Screening | DNA microarrays | Storage | Antibiotics | Antibiotic tolerance | Hypoxia | Index Medicus
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10. Full Text Insights into a multidrug resistant Escherichia coli pathogen of the globally disseminated ST131 lineage: Genome analysis and virulence mechanisms
by Totsika, Makrina and Beatson, Scott A and Sarkar, Sohinee and Phan, Minh-Duy and Petty, Nicola K and Bachmann, Nathan and Szubert, Marek and Sidjabat, Hanna E and Paterson, David L and Upton, Mathew and Schembri, Mark A
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 10, pp. e26578 - e26578
Escherichia coli strains causing urinary tract infection (UTI) are increasingly recognized as belonging to specific clones. E. coli clone O25b:H4-ST131 has... 
URINARY-TRACT-INFECTIONS | BETA-LACTAMASE | TYPE-1 FIMBRIATION | SEQUENCE | BIOLOGY | CTX-M-15 | FIMB | CLONAL GROUPS | EPIDEMIC | STRAIN | EMERGENCE | Virulence - drug effects | Virulence Factors - genetics | Genes, Bacterial - genetics | Escherichia coli - drug effects | Humans | Mutagenesis, Insertional - drug effects | Colony Count, Microbial | Phylogeny | Fimbriae, Bacterial - genetics | Fimbriae, Bacterial - drug effects | Virulence - genetics | Base Sequence | Escherichia coli - pathogenicity | Plasmids - genetics | Urinary Bladder - microbiology | Urine - microbiology | Disease Models, Animal | Escherichia coli Infections - microbiology | United Kingdom | Mutation - genetics | Operon - genetics | Sequence Analysis, DNA | Mutagenesis, Insertional - genetics | Genome, Bacterial - genetics | Animals | Escherichia coli - genetics | Escherichia coli - isolation & purification | Internationality | Urinary Bladder - drug effects | Anti-Bacterial Agents - pharmacology | Mice | Australia | Drug Resistance, Multiple, Bacterial - genetics | Drug Resistance, Multiple, Bacterial - drug effects | Drug resistance in microorganisms | Transposons | Genes | Genomics | Genomes | Analysis | Genetic research | Urinary tract infections | Beta lactamases | Cross infection | Virulence (Microbiology) | Nosocomial infections | Health aspects | Colonization factor | Escherichia coli | Virulence | Clinical isolates | Insertion | Bladder | Infections | Urinary tract | Drug resistance | Inactivation | E coli | Urinary bladder | Virulence factors | Antibiotic resistance | Phylogenetics | Bioinformatics | Pathogens | Deactivation | Nucleotide sequence | Multidrug resistance | Cloning | Infectious diseases | Biofilms | Hospitals | Pili | Antibiotics | Womens health | Cephalosporinase | Ciprofloxacin | Colonization | Index Medicus
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11. Full Text Policy: An intergovernmental panel on antimicrobial resistance
by Woolhouse, Mark and Farrar, Jeremy
Nature, ISSN 0028-0836, 2014, Volume 509, Issue 7502, pp. 555 - 557
Leadership | United States | Humans | Inappropriate Prescribing - prevention & control | Methicillin-Resistant Staphylococcus aureus | Anti-Bacterial Agents - therapeutic use |