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1. Full Text Macrophages and Therapeutic Resistance in Cancer
by Ruffell, Brian and Coussens, Lisa M
Cancer cell, ISSN 1535-6108, 04/2015, Volume 27, Issue 4, pp. 462 - 472
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasm Metastasis - therapy | Humans | Tumor Microenvironment | Drug Resistance, Neoplasm | Models, Immunological | Neoplasms - therapy | Animals | Neoplasm Metastasis - immunology | Neoplasms - immunology | Immunotherapy | Macrophages - drug effects | Mice | Neovascularization, Pathologic - immunology | Neoplasms - pathology | Immunity, Cellular | Macrophages - immunology | Neovascularization, Pathologic - therapy | Macrophages | Health aspects | Analysis | Cancer | Index Medicus | macrophages | metastasis | tumor | immunotherapy | cancer | chemotherapy | resistance
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2. Full Text TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
by Mariathasan, Sanjeev and Turley, Shannon J and Nickles, Dorothee and Castiglioni, Alessandra and Yuen, Kobe and Wang, Yulei and Kadel, Edward E and Koeppen, Hartmut and Astarita, Jillian L and Cubas, Rafael and Jhunjhunwala, Suchit and Banchereau, Romain and Yang, Yagai and Guan, Yinghui and Chalouni, Cecile and Ziai, James and Şenbabaoǧlu, Yasin and Santoro, Stephen and Sheinson, Daniel and Hung, Jeffrey and Giltnane, Jennifer M and Pierce, Andrew A and Mesh, Kathryn and Lianoglou, Steve and Riegler, Johannes and Carano, Richard A. D and Eriksson, Pontus and Höglund, Mattias and Somarriba, Loan and Halligan, Daniel L and Van Der Heijden, Michiel S and Loriot, Yohann and Rosenberg, Jonathan E and Fong, Lawrence and Mellman, Ira and Chen, Daniel S and Green, Marjorie and Derleth, Christina and Fine, Gregg D and Hegde, Priti S and Bourgon, Richard and Powles, Thomas
Nature (London), ISSN 0028-0836, 02/2018, Volume 554, Issue 7693, pp. 544 - 548
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | CD8-Positive T-Lymphocytes - cytology | Humans | Antibodies, Monoclonal - therapeutic use | Urothelium - pathology | Antibodies, Monoclonal, Humanized | Urologic Neoplasms - pathology | Neoplasm Metastasis | Urologic Neoplasms - drug therapy | Urologic Neoplasms - genetics | Immunotherapy | Antibodies - immunology | Antigens, Neoplasm - metabolism | Transforming Growth Factor beta - antagonists & inhibitors | Antigens, Neoplasm - analysis | Disease Models, Animal | Fibroblasts - metabolism | Antibodies - therapeutic use | Antigens, Neoplasm - immunology | Antibodies, Monoclonal - pharmacology | Treatment Outcome | B7-H1 Antigen - immunology | Urologic Neoplasms - immunology | Antibodies - pharmacology | Tumor Microenvironment - immunology | Collagen - metabolism | Phenotype | Animals | B7-H1 Antigen - antagonists & inhibitors | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | CD8-Positive T-Lymphocytes - drug effects | Urothelium - immunology | Mice | Mutation | CD8-Positive T-Lymphocytes - immunology | Urothelium - drug effects | Transforming Growth Factor beta - metabolism | Cohort Studies | Drug Resistance, Neoplasm - drug effects | PD-1 protein | CD8 antigen | Transforming growth factor-a | Antibodies | Parenchyma | Lymphocytes T | Metastasis | Immunity | Metastases | Genotype & phenotype | Signal transduction | Lymphocytes | Cell cycle | Fibroblasts | Growth factors | Urothelial cancer | Phenotypes | Cytokines | Melanoma | Blocking | Gene expression | Patients | Generalized linear models | Signaling | Stromal cells | Medical prognosis | Collagen | PD-L1 protein | Ligands | Determinants | Infiltration | Cancer | Tumors | Apoptosis | Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
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3. Full Text Acquired IFN gamma resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
by Sucker, Antje and Zhao, Fang and Pieper, Natalia and Heeke, Christina and Maltaner, Raffaela and Stadtler, Nadine and Real, Birgit and Bielefeld, Nicola and Howe, Sebastian and Weide, Benjamin and Gutzmer, Ralf and Utikal, Jochen and Loquai, Carmen and Gogas, Helen and Klein-Hitpass, Ludger and Zeschnigk, Michael and Westendorf, Astrid M and Trilling, Mirko and Horn, Susanne and Schilling, Bastian and Schadendorf, Dirk and Griewank, Klaus G and Paschen, Annette
Nature communications, ISSN 2041-1723, 05/2017, Volume 8, Issue 1, pp. 15440 - 15440
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Immunotherapy - methods | Skin Neoplasms - drug therapy | Tumor Escape - genetics | Humans | Interferon-gamma - metabolism | Janus Kinase 1 - metabolism | Signal Transduction - immunology | DNA Mutational Analysis | Melanoma - genetics | Janus Kinase 1 - genetics | Janus Kinase 2 - metabolism | Skin - pathology | Skin Neoplasms - pathology | Datasets as Topic | T-Lymphocytes - secretion | Skin Neoplasms - immunology | Antigens, Neoplasm - immunology | Interferon-gamma - secretion | Histocompatibility Antigens Class I - immunology | Janus Kinase 2 - genetics | Antigen Presentation - genetics | Mutation Rate | Treatment Outcome | Drug Resistance, Neoplasm - immunology | Signal Transduction - genetics | Melanoma - pathology | Patient-Specific Modeling | Antineoplastic Agents, Immunological - pharmacology | Whole Genome Sequencing | Drug Resistance, Neoplasm - genetics | Antineoplastic Agents, Immunological - therapeutic use | Biopsy | Melanoma - immunology | Interferon-gamma - immunology | Melanoma - drug therapy | Skin Neoplasms - genetics | Cell Line, Tumor | T-Lymphocytes - immunology | Mutation | Precision Medicine - methods | Index Medicus
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4. Full Text An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy
by Chung, Alicia S and Wu, Xiumin and Zhuang, Guanglei and Ngu, Hai and Kasman, Ian and Zhang, Jianhuan and Vernes, Jean-Michel and Jiang, Zhaoshi and Meng, Y Gloria and Peale, Franklin V and Ouyang, Wenjun and Ferrara, Napoleone
Nature medicine, ISSN 1078-8956, 09/2013, Volume 19, Issue 9, pp. 1114 - 1123
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Neoplasms - metabolism | Humans | Lung Neoplasms - metabolism | Drug Resistance, Neoplasm | Male | NF-kappa B - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Lymphoma - metabolism | Myeloid Cells - immunology | Gastrointestinal Hormones - metabolism | Antibodies - immunology | Female | Neovascularization, Pathologic - immunology | Granulocytes - metabolism | Colorectal Neoplasms - metabolism | Fibroblasts - metabolism | Paracrine Communication | Mice, Inbred C57BL | Angiogenesis Inhibitors - pharmacology | Neuropeptides - metabolism | Vascular Endothelial Growth Factor A - immunology | Mice, Knockout | Neoplasms - drug therapy | Tumor Microenvironment - immunology | Interleukin-17 - metabolism | Animals | Granulocyte Colony-Stimulating Factor - biosynthesis | Neoplasms - immunology | Th17 Cells - immunology | Mice | CD11b Antigen - metabolism | Immunohistochemistry | Physiological aspects | Angiogenesis inhibitors | Research | Interleukins | Health aspects | Angiogenesis | Inhibitor drugs | Cytokines | Pharmacology | Vascular endothelial growth factor | Immune system | Cancer | Index Medicus
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5. Full Text Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases
by Frentzas, Sophia and Simoneau, Eve and Bridgeman, Victoria L and Vermeulen, Peter B and Foo, Shane and Kostaras, Eleftherios and Nathan, Mark R and Wotherspoon, Anew and Gao, Zu-Hua and Shi, Yu and Van den Eynden, Gert and Daley, Frances and Peckitt, Clare and Tan, Xianming and Salman, Ayat and Lazaris, Anthoula and Gazinska, Patrycja and Berg, Tracy J and Eltahir, Zak and Ritsma, Laila and van Rheenen, Jacco and Khashper, Alla and Brown, Gina and Nyström, Hanna and Sund, Malin and Van Laere, Steven and Loyer, Evelyne and Dirix, Luc and Cunningham, David and Metrakos, Peter and Reynolds, Anew R
Nature medicine, ISSN 1078-8956, 11/2016, Volume 22, Issue 11, pp. 1294 - 1302
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Bevacizumab - therapeutic use | Humans | Middle Aged | Actin-Related Protein 2-3 Complex - genetics | Drug Resistance, Neoplasm | Male | Cell Movement - genetics | Gene Knockdown Techniques | Neoplasm Grading | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Angiogenesis Inhibitors - therapeutic use | Adult | Female | Liver Neoplasms - secondary | Carcinoma, Ductal, Breast - secondary | Carcinoma - secondary | Carcinoma, Lobular - secondary | Carcinoma - drug therapy | Liver Neoplasms - drug therapy | HT29 Cells | Liver Neoplasms - blood supply | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Neovascularization, Pathologic - drug therapy | Aged | Carcinoma - blood supply | Colorectal Neoplasms - pathology | Liver cancer | Metastasis | Angiogenesis inhibitors | Drug therapy | Patient outcomes | Angiogenesis | Coronary vessels | Index Medicus
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6. Full Text Resistance to checkpoint blockade therapy through inactivation of antigen presentation
by Sade-Feldman, Moshe and Jiao, Yunxin J and Chen, Jonathan H and Rooney, Michael S and Barzily-Rokni, Michal and Eliane, Jean-Pierre and Bjorgaard, Stacey L and Hammond, Marc R and Vitzthum, Hans and Blackmon, Shauna M and Frederick, Dennie T and Hazar-Rethinam, Mehlika and Nadres, Brandon A and Van Seventer, Emily E and Shukla, Sachet A and Yizhak, Keren and Ray, John P and Rosebrock, Daniel and Livitz, Dimitri and Adalsteinsson, Viktor and Getz, Gad and Duncan, Lyn M and Li, Bo and Corcoran, Ryan B and Lawrence, Donald P and Stemmer-Rachamimov, Anat and Boland, Genevieve M and Landau, Dan A and Flaherty, Keith T and Sullivan, Ryan J and Hacohen, Nir
Nature communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1136 - 11
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Mice, Inbred C57BL | Antibodies, Monoclonal - therapeutic use | Antigen Presentation - genetics | Melanoma - pathology | CTLA-4 Antigen - immunology | Loss of Heterozygosity | Mice, Knockout | Neoplasms, Experimental - pathology | Point Mutation | Drug Resistance, Neoplasm - genetics | Neoplasm Metastasis | Animals | Melanoma - genetics | Melanoma - drug therapy | Neoplasms, Experimental - genetics | Female | Antigen Presentation - drug effects | Programmed Cell Death 1 Receptor - immunology | Neoplasms, Experimental - drug therapy | Antibodies, Monoclonal - immunology | beta 2-Microglobulin - genetics | Drug Resistance, Neoplasm - drug effects | Antigen presentation | Deactivation | PD-1 protein | Melanoma | Metastasis | Inactivation | Patients | Metastases | Heterozygosity | CTLA-4 protein | Major histocompatibility complex | Immune checkpoint | Loss of heterozygosity | Mutation | Target acquisition | Index Medicus
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7. Full Text Drug resistance and new therapies in colorectal cancer
by Van Der Jeught, Kevin and Xu, Han-Chen and Li, Yu-Jing and Lu, Xiong-Bin and Ji, Guang
World journal of gastroenterology : WJG, ISSN 1007-9327, 09/2018, Volume 24, Issue 34, pp. 3834 - 3848
Checkpoint inhibitors | Therapy resistance | Tumor microenvironment | Immunotherapy | Colorectal cancer | Α-amanitin | Antibody-drug conjugates | Microbiome | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Tumor Escape - drug effects | Immunotherapy - methods | Nucleic Acid Synthesis Inhibitors - pharmacology | Tumor Escape - genetics | Colorectal Neoplasms - genetics | Humans | Tumor Suppressor Protein p53 - genetics | Immunoconjugates - pharmacology | Colorectal Neoplasms - drug therapy | Immunoconjugates - therapeutic use | Costimulatory and Inhibitory T-Cell Receptors - antagonists & inhibitors | Costimulatory and Inhibitory T-Cell Receptors - immunology | Tumor Escape - immunology | Colorectal Neoplasms - mortality | Tumor Microenvironment - drug effects | Nucleic Acid Synthesis Inhibitors - therapeutic use | RNA Polymerase II - antagonists & inhibitors | Alpha-Amanitin - pharmacology | Microsatellite Instability - drug effects | Treatment Outcome | Drug Resistance, Neoplasm - immunology | Antineoplastic Agents, Immunological - pharmacology | Alpha-Amanitin - therapeutic use | Tumor Microenvironment - immunology | Drug Resistance, Neoplasm - genetics | Colorectal Neoplasms - immunology | Antineoplastic Agents, Immunological - therapeutic use | Drug Resistance, Neoplasm - drug effects | Index Medicus | α-amanitin | Review
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