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Seminars in Oncology, ISSN 0093-7754, 2015, Volume 42, Issue 6, pp. 801 - 819
.... Most of these molecular alterations promote multiple steps of carcinogenesis in FGFR oncogene-addicted cells, increasing cell proliferation, angiogenesis, and drug resistance... 
BREAST-CANCER | LUNG-CANCER | IN-VITRO | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | RESISTANCE | GENE AMPLIFICATION | POTENTIAL THERAPEUTIC TARGET | PROGNOSTIC-SIGNIFICANCE | ANTITUMOR-ACTIVITY | EXPRESSION | Neoplasms - metabolism | Gastrointestinal Neoplasms - genetics | Gastrointestinal Neoplasms - drug therapy | Humans | Brain Neoplasms - pathology | Fibroblast Growth Factors - genetics | Brain Neoplasms - metabolism | Head and Neck Neoplasms - metabolism | Breast Neoplasms - metabolism | Fibroblast Growth Factors - metabolism | Gastrointestinal Neoplasms - pathology | Glioblastoma - genetics | Receptors, Fibroblast Growth Factor - genetics | Female | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Molecular Targeted Therapy - methods | Gastrointestinal Neoplasms - metabolism | Biomarkers, Tumor - analysis | Head and Neck Neoplasms - drug therapy | Receptors, Fibroblast Growth Factor - antagonists & inhibitors | Thoracic Neoplasms - pathology | Brain Neoplasms - genetics | Brain Neoplasms - drug therapy | Breast Neoplasms - drug therapy | Thoracic Neoplasms - metabolism | Head and Neck Neoplasms - pathology | Neoplasms - drug therapy | Breast Neoplasms - genetics | Thoracic Neoplasms - genetics | Breast Neoplasms - pathology | Glioblastoma - pathology | Receptors, Fibroblast Growth Factor - metabolism | Head and Neck Neoplasms - genetics | Fibroblast Growth Factors - antagonists & inhibitors | Thoracic Neoplasms - drug therapy | Glioblastoma - drug therapy | Neoplasms - pathology | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2015, Volume 125, Issue 4, pp. 1591 - 1602
... that the compensatory upregulation of glutamine metabolism promotes resistance to mTOR kinase inhibitors... 
RAPAMYCIN | MEDICINE, RESEARCH & EXPERIMENTAL | PATHWAY | MUTATION | KINASE INHIBITORS | PROLIFERATION | CELL-GROWTH | PTEN-DEFICIENT | CANCER | CONTRIBUTES | Gas Chromatography-Mass Spectrometry | Humans | Glutamine - metabolism | Male | Neoplasm Proteins - antagonists & inhibitors | Purines - administration & dosage | Indoles - administration & dosage | Benzophenanthridines - therapeutic use | Glioblastoma - metabolism | Purines - therapeutic use | Neoplasm Proteins - genetics | Glutaminase - biosynthesis | Magnetic Resonance Spectroscopy | Benzophenanthridines - administration & dosage | Brain Neoplasms - drug therapy | Benzophenanthridines - pharmacology | Drug Synergism | Energy Metabolism | Signal Transduction - drug effects | Mice, Nude | Glioblastoma - pathology | Cell Line, Tumor | Indoles - therapeutic use | Mice | Mice, Inbred BALB C | Glioblastoma - drug therapy | Glutaminase - physiology | Neoplasm Proteins - physiology | Brain Neoplasms - pathology | Molecular Targeted Therapy | Brain Neoplasms - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Ketoglutaric Acids - metabolism | Neoplasm Proteins - biosynthesis | Purines - pharmacology | RNA, Small Interfering - pharmacology | Temporal Lobe - metabolism | Glutaminase - antagonists & inhibitors | Citric Acid Cycle | Xenograft Model Antitumor Assays | Rotarod Performance Test | Animals | Metabolome - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Glycolysis | Signal Transduction - physiology | Aged | Glutamic Acid - metabolism | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - physiology | Glutaminase - genetics | Pharmacology, Experimental | Oncology, Experimental | Glutamine metabolism | Research | Drug therapy | Drug resistance | Health aspects | Glioblastoma multiforme | Cancer | Medical research | Enzymes | Brain cancer | Neurosurgery | Glucose | Kinases | Metabolism | Carbon | Cancer therapies | Medicine | Cell growth | Brain research | Laboratory animals | Tumors | University graduates | Oncology
Journal Article
Oncogene, ISSN 1476-5594, 2012, Volume 32, Issue 39, pp. 4634 - 4645
FOXM1 is implicated in genotoxic drug resistance but its role and mechanism of action remain unclear... 
breast cancer | epirubicin | BRIP1 | FOXM1 | DNA damage | resistance | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR FOXM1 | BINDING DOMAIN | DOUBLE-STRAND BREAKS | MAMMALIAN-CELLS | BACH1 | CELL BIOLOGY | BREAST-CANCER CELLS | GENE | ONCOLOGY | GENETICS & HEREDITY | HOMOLOGOUS RECOMBINATION | PROGRESSION | Gamma Rays | MCF-7 Cells - radiation effects | Antibiotics, Antineoplastic - pharmacology | Humans | Neoplasm Proteins - physiology | Radiation Tolerance | Recombinant Fusion Proteins - physiology | Neoplasm Proteins - antagonists & inhibitors | Forkhead Transcription Factors - physiology | DNA Breaks, Double-Stranded | RNA, Messenger - biosynthesis | RNA Helicases - physiology | RNA Interference | RNA Helicases - biosynthesis | Fibroblasts | Female | RNA Helicases - genetics | Forkhead Transcription Factors - antagonists & inhibitors | Neoplasm Proteins - genetics | DNA-Binding Proteins - physiology | Neoplasm Proteins - biosynthesis | RNA, Small Interfering - pharmacology | DNA-Binding Proteins - genetics | MCF-7 Cells - drug effects | DNA, Neoplasm - drug effects | Fanconi Anemia Complementation Group Proteins | Animals | RNA, Neoplasm - biosynthesis | Histones - analysis | Recombinational DNA Repair - physiology | Mice | DNA Damage | DNA, Neoplasm - genetics | Forkhead Box Protein M1 | DNA-Binding Proteins - biosynthesis | Drug Resistance, Neoplasm - physiology | MCF-7 Cells - metabolism | Epirubicin - pharmacology | Care and treatment | Protein biosynthesis | Genetic aspects | Dosage and administration | Epirubicin | Research | Observations | Drug resistance | Cancer | Proteins | Chemotherapy | Breast cancer | Gene expression | DNA repair
Journal Article
Neoplasia, ISSN 1476-5586, 2011, Volume 13, Issue 11, pp. 1069 - IN35
Abstract Clinical resistance to chemotherapy is a frequent event in cancer treatment and is closely linked to poor outcome. High-grade serous (HGS... 
Oncology | INSULIN | IN-VITRO | PROTEIN | EVOLUTION | PKB/AKT | ONCOLOGY | PHOSPHORYLATION | KINASE | OVARIAN-CANCER | MUTATIONS | RECEPTOR INHIBITOR | DNA-Activated Protein Kinase - antagonists & inhibitors | Prostatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Ovarian Neoplasms - pathology | Apoptosis - genetics | Male | Antineoplastic Agents - therapeutic use | Ovarian Neoplasms - genetics | Platinum Compounds - therapeutic use | Prostatic Neoplasms - genetics | DNA-Activated Protein Kinase - genetics | DNA-Activated Protein Kinase - metabolism | Female | Ovarian Neoplasms - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Carcinoma - pathology | Nuclear Proteins - genetics | Oncogene Protein v-akt - metabolism | Ovarian Neoplasms - drug therapy | Prostatic Neoplasms - drug therapy | Carcinoma - drug therapy | Prostatic Neoplasms - pathology | RNA, Small Interfering - pharmacology | DNA-Activated Protein Kinase - physiology | Nuclear Proteins - metabolism | Down-Regulation - drug effects | Down-Regulation - genetics | Down-Regulation - physiology | Drug Resistance, Neoplasm - genetics | Nuclear Proteins - antagonists & inhibitors | Carcinoma - genetics | Nuclear Proteins - physiology | Apoptosis - physiology | Carcinoma - metabolism | Enzyme Activation - genetics | Drug Resistance, Neoplasm - physiology | Drug Resistance, Neoplasm - drug effects
Journal Article
Journal Article
British journal of cancer, ISSN 1532-1827, 2016, Volume 115, Issue 6, pp. 674 - 681
...). However, resistance to taxanes is common. Our objective was to investigate mechanisms of taxane resistance in prostate cancer. Methods... 
drug transporters | mCRPC | prostate cancer | SLCO1B3 | cabazitaxel | docetaxel resistance | patient-derived xenografts | MITOXANTRONE | CROSS-RESISTANCE | DOCETAXEL | PREDNISONE | TRANSPORT | THERAPY | ONCOLOGY | ENZALUTAMIDE | Neoplasms, Hormone-Dependent - metabolism | Organic Anion Transporters, Sodium-Independent - genetics | Prostatic Neoplasms - metabolism | Adenocarcinoma - pathology | Taxoids - pharmacology | Humans | Neoplasm Proteins - physiology | Male | Androstenes - pharmacology | Organic Anion Transporters, Sodium-Independent - biosynthesis | Gene Knockdown Techniques | Taxoids - therapeutic use | Adenocarcinoma - metabolism | Heterografts | Biological Transport | RNA Interference | Gene Expression Regulation, Neoplastic - drug effects | Antineoplastic Agents, Phytogenic - therapeutic use | Neoplasm Proteins - genetics | Antineoplastic Agents, Phytogenic - pharmacokinetics | Drug Resistance, Multiple - physiology | Prostatic Neoplasms - drug therapy | Solute Carrier Organic Anion Transporter Family Member 1B3 | Organic Anion Transporters, Sodium-Independent - physiology | Phenylthiohydantoin - pharmacology | Prostatic Neoplasms - pathology | Drug Resistance, Multiple - genetics | Neoplasm Proteins - biosynthesis | RNA, Small Interfering - pharmacology | Adenocarcinoma - drug therapy | Phenylthiohydantoin - analogs & derivatives | Taxoids - pharmacokinetics | Androgens | Drug Resistance, Neoplasm - genetics | Animals | Mice, Nude | Neoplasms, Hormone-Dependent - pathology | Cell Line, Tumor | Neoplasms, Hormone-Dependent - drug therapy | Antineoplastic Agents, Phytogenic - pharmacology | Drug Resistance, Neoplasm - physiology | Translational Therapeutics
Journal Article
Biochemical pharmacology, ISSN 0006-2952, 2012, Volume 83, Issue 8, pp. 1084 - 1103
Journal Article
Journal Article