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Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, pp. e44071 - e44071
Mortality in head and neck squamous cell carcinoma (HNSCC) is high due to emergence of therapy resistance which results in local and regional recurrences that... 
Gamma Rays | Receptor, Epidermal Growth Factor - genetics | Drug Resistance, Neoplasm - radiation effects | Gene Expression - drug effects | Oligonucleotide Array Sequence Analysis | Neoplastic Stem Cells - drug effects | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Carcinoma, Squamous Cell - radiotherapy | Epithelial-Mesenchymal Transition - genetics | Cell Lineage - drug effects | Head and Neck Neoplasms - metabolism | Cell Shape - radiation effects | Antibodies, Monoclonal, Humanized | Flow Cytometry | Neoplastic Stem Cells - metabolism | Antineoplastic Agents - pharmacology | Cetuximab | Cell Lineage - genetics | Neoplastic Stem Cells - radiation effects | Receptor, Epidermal Growth Factor - immunology | Antibodies, Monoclonal - pharmacology | Cell Cycle - radiation effects | Head and Neck Neoplasms - drug therapy | Cisplatin - pharmacology | Organ Specificity | Gene Expression - radiation effects | Hyaluronan Receptors - genetics | Cell Lineage - radiation effects | Cell Shape - drug effects | Head and Neck Neoplasms - radiotherapy | Carcinoma, Squamous Cell - drug therapy | Epithelial-Mesenchymal Transition - immunology | Cell Line, Tumor | Head and Neck Neoplasms - genetics | Cell Proliferation - drug effects | Hyaluronan Receptors - immunology | Cell Cycle - drug effects | Quinazolines - pharmacology | Cell Proliferation - radiation effects | Drug Resistance, Neoplasm - drug effects | Cell proliferation | Health sciences | Flow cytometry | Biotechnology | Laryngeal cancer | Mesenchyme | Cytology | Radiation | Fluorescence | Metastasis | Drug resistance | Cancer therapies | Cell surface | Genotype & phenotype | Epidermal growth factor | CD44 antigen | Surgery | Larynx | Neck | Gefitinib | Subpopulations | Squamous cell carcinoma | Epidermal growth factor receptors | Mortality | Breast cancer | Tumor cell lines | Cisplatin | Sensitivity | Antibiotics | Pancreatic cancer | Cell lines | Stem cells | Head and neck cancer | Head & neck cancer | Cancer | Tumors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2015, Volume 112, Issue 11, pp. 3421 - 3426
Akt is a robust oncogene that plays key roles in the development and progression of many cancers, including glioma. We evaluated the differential propensities... 
Akt | Glioma | RCAS/tv-a mouse model | DNA repair | PROTEIN | MULTIDISCIPLINARY SCIENCES | PHASE-II | BREAST-CANCER | GLIOBLASTOMA | MELANOMA | PROSTATE-CANCER | IN-VIVO | GROWTH | glioma | HIGH-GRADE GLIOMAS | NF-KAPPA-B | Drug Resistance, Neoplasm - radiation effects | Gene Amplification - radiation effects | Dacarbazine - therapeutic use | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | DNA Repair - radiation effects | Isoenzymes - chemistry | DNA Repair - genetics | Proto-Oncogene Proteins c-akt - genetics | Glioma - genetics | Dacarbazine - pharmacology | Isoenzymes - metabolism | Glioma - pathology | Dacarbazine - analogs & derivatives | DNA Damage - genetics | Transcription, Genetic | Signal Transduction - radiation effects | Proto-Oncogene Proteins c-akt - metabolism | Protein Structure, Tertiary | Brain Neoplasms - enzymology | DNA Repair - drug effects | Glioma - enzymology | Proto-Oncogene Proteins c-akt - chemistry | Isoenzymes - genetics | Brain Neoplasms - genetics | Radiation Tolerance - genetics | Signal Transduction - genetics | Disease Progression | Gene Amplification - drug effects | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Mice | Genome, Human | Drug Resistance, Neoplasm - drug effects | Development and progression | Care and treatment | Genetic aspects | Research | Gliomas | Gene amplification | Gene expression | Genomics | Deoxyribonucleic acid--DNA | Tumors | Index Medicus | tv-a mouse model | Biological Sciences | RCAS
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2016, Volume 96, Issue 3, pp. 556 - 565
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2018, Volume 24, Issue 12, pp. 1845 - 1851
Focal radiation therapy enhances systemic responses to anti-CTLA-4 antibodies in preclinical studies and in some patients with melanoma(1-3), but its efficacy... 
SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | REPERTOIRE | SOLID TUMORS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUPPRESSION | RADIATION | CELL BIOLOGY | NEURAL-NETWORKS | MUTATION | CELL | SEQ | IPILIMUMAB | Drug Resistance, Neoplasm - radiation effects | Humans | Middle Aged | Lung Neoplasms - radiotherapy | Lung Neoplasms - pathology | Male | Combined Modality Therapy | Lung Neoplasms - therapy | CTLA-4 Antigen - immunology | Radiotherapy | CD8-Positive T-Lymphocytes - radiation effects | Lung Neoplasms - immunology | Antibodies, Monoclonal - administration & dosage | Aged, 80 and over | Cell Line, Tumor | Female | Aged | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | Ipilimumab - administration & dosage | Treatment outcome | Usage | Care and treatment | Analysis | Genetic aspects | Research | Lung cancer, Non-small cell | T cells | Medical research | Radiation | Antibodies | Metastasis | Biological response modifiers | Viral antibodies | Chemotherapy | Tumor antigens | Medicine, Experimental | Interferon | Cancer | Radiation effects | CD8 antigen | Lung cancer | Data processing | Lymphocytes T | Functional analysis | Radiation therapy | Disease control | Patients | Metastases | Anticancer properties | CTLA-4 protein | Cell activation | Immunogenicity | Lymphocytes | Mutation | Tumors | Immune system | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 51, pp. 42502 - 42515
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2010, Volume 78, Issue 4, pp. 1184 - 1192
Purpose The standard treatment of patients with locally advanced rectal cancers comprises preoperative 5-fluorouracil–based chemoradiotherapy followed by... 
Radiology | Hematology, Oncology and Palliative Medicine | chemoradiotherapy | gene expression profiling | response | resistance | Colorectal cancer | RADIORESISTANCE FACTOR | CARCINOMA CELLS | SURVIVIN | RADIATION | LINES | PREDICTION | RECTAL-CANCER | INHIBITION | ONCOLOGY | CHEMORADIATION | RADIOSENSITIVITY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Colonic Neoplasms - radiotherapy | Colonic Neoplasms - genetics | Drug Resistance, Neoplasm - radiation effects | Colonic Neoplasms - drug therapy | Humans | Cell Survival - genetics | Gene Expression Profiling | Fluorouracil - therapeutic use | Rectal Neoplasms - genetics | Tumor Suppressor Proteins - genetics | Rectal Neoplasms - drug therapy | STAT3 Transcription Factor - genetics | Cell Survival - drug effects | Radiation Tolerance - genetics | Linear Models | Cell Survival - radiation effects | Rectal Neoplasms - radiotherapy | Antimetabolites, Antineoplastic - therapeutic use | Drug Resistance, Neoplasm - genetics | Genes, erbB-2 | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Combined Modality Therapy - methods | Genes, cdc | Drug Resistance, Neoplasm - drug effects | Care and treatment | Genetic aspects | Gene expression | Cancer | Index Medicus | 5-Fluorouracil | GASTROINTESTINAL TRACT | LARGE INTESTINE | DIGESTIVE SYSTEM | SENSITIVITY | HETEROCYCLIC COMPOUNDS | MEDICINE | AZINES | POLYMERASE CHAIN REACTION | HYDROXY COMPOUNDS | THERAPY | GENES | RADIOLOGY AND NUCLEAR MEDICINE | GENE AMPLIFICATION | CELL CYCLE | ORGANIC NITROGEN COMPOUNDS | COMBINED THERAPY | URACILS | NEOPLASMS | RECTUM | ORGANIC COMPOUNDS | PYRIMIDINES | INTESTINES | ORGANS | DISEASES | BODY
Journal Article
Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, 03/2016, Volume 139, pp. 180 - 189
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 04/2015, Volume 91, pp. 103 - 110
Cisplatin resistance is a challenge in the treatment of ovarian cancer. The aim of this study was to explore if ultrasound can overcome chemoresistance and... 
Cisplatin resistance | Cyclosporin A | Chemosensitization | Ultrasound | Survival | Ovarian cancer | DRUG | APOPTOSIS | ASSAY | CARCINOMA CELLS | TOXICITY | CHEMOTHERAPY | GLUTATHIONE | PHARMACOLOGY & PHARMACY | ADRIAMYCIN-RESISTANT | MULTIDRUG-RESISTANCE | IMMUNOSUPPRESSORS | Drug Resistance, Neoplasm - radiation effects | Cyclosporine - pharmacology | Tumor Burden - radiation effects | Humans | Immunosuppressive Agents - therapeutic use | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - metabolism | Biological Transport - radiation effects | Ultrasonic Therapy | Immunosuppressive Agents - metabolism | Female | Antineoplastic Agents - pharmacology | Biological Transport - drug effects | Ovarian Neoplasms - metabolism | Cyclosporine - metabolism | Immunosuppressive Agents - pharmacology | Ovarian Neoplasms - drug therapy | DNA Damage - drug effects | Ultrasonic Waves | Cell Survival - drug effects | Combined Modality Therapy | Cisplatin - pharmacology | Random Allocation | Cell Survival - radiation effects | Cisplatin - metabolism | Xenograft Model Antitumor Assays | Cyclosporine - therapeutic use | Animals | Cisplatin - therapeutic use | Tumor Burden - drug effects | Biotransformation - radiation effects | Mice, Nude | Biotransformation - drug effects | Survival Analysis | Cell Line, Tumor | Ovarian Neoplasms - therapy | Mice, Inbred BALB C | DNA Damage - radiation effects | Antimitotic agents | Cyclosporine | Antineoplastic agents | Index Medicus
Journal Article