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1. Full Text Menopausal hormone therapy trends before versus after 2002: impact of the Womenʼs Health Initiative Study Results
by Crawford, Sybil L and Crandall, Carolyn J and Derby, Carol A and Khoudary, Samar R El and Waetjen, L Elaine and Fischer, Mary and Joffe, Hadine
Menopause, ISSN 1072-3714, 12/2018, Volume 26, Issue 6, pp. 588 - 597
OBJECTIVE:To better understand how to educate patients and providers about study findings relevant to treatment guidelines, we assessed pre- versus... 
STATEMENT | PUBLICATION | Hormone therapy | CLINICIAN | PRESCRIBING PATTERNS | SYMPTOMS | PREVALENCE | DISCONTINUATION | ATTITUDES | OBSTETRICS & GYNECOLOGY | Vasomotor symptoms | Women's Health Initiative | REPLACEMENT THERAPY | POSTMENOPAUSAL WOMEN | Hot Flashes - drug therapy | Prospective Studies | United States | Humans | Menopause | Middle Aged | Logistic Models | Estrogen Replacement Therapy - trends | Estrogen Replacement Therapy - statistics & numerical data | Women's Health - trends | Adult | Female | Surveys and Questionnaires | Patient Compliance | Longitudinal Studies | Cohort Studies | Women | Medical research | Care and treatment | Health promotion | Medicine, Experimental | Forecasts and trends | Research | Health aspects
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2. Full Text Immunostimulatory monoclonal antibodies for hepatocellular carcinoma therapy. Trends and perspectives
by Mazzolini, Guillermo D and Malvicini, Mariana
Medicina (Argentina), ISSN 0025-7680, 02/2018, Volume 78, Issue 1, pp. 29 - 32
Hepatocellular carcinoma (HCC) is the second cause of cancer-related death in the world and is the main cause of death in cirrhotic patients. Unfortunately,... 
Hepatocellular carcinoma | Immunostimulatory monoclonal antibodies | Programmed cell death 1 ligand (PD1-L) | Tumor-infiltrating lymphocytes | Cytotoxic T-lymphocyte antigen 4 (CTLA-4) | cytotoxic T-lymphocyte antigen 4 (CTLA-4) | MEDICINE, GENERAL & INTERNAL | IMMUNOTHERAPY | LIVER | programmed cell death 1 ligand (PD1-L) | tumor-infiltrating lymphocytes | immunostimulatory monoclonal antibodies | SORAFENIB | hepatocellular carcinoma | Immunotherapy - methods | Carcinoma, Hepatocellular - drug therapy | Antineoplastic Agents, Immunological - therapeutic use | Humans | Liver Neoplasms - drug therapy | Phenylurea Compounds - therapeutic use | Antibodies, Monoclonal - therapeutic use | Nivolumab - therapeutic use | Clinical Trials as Topic | Sorafenib - therapeutic use | Pyridines - therapeutic use
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3. Full Text Surgery and hormone therapy trends in octogenarians with invasive breast cancer
by Kantor, Olga, M.D and Pesce, Catherine, M.D and Liederbach, Erik, B.S and Wang, Chi-Hsiung, Ph.D and Winchester, David J., M.D and Yao, Katharine, M.D
American Journal of Surgery, The, ISSN 0002-9610, 2016, Volume 211, Issue 3, pp. 541 - 545
Abstract Background There has been a trend toward minimizing surgery in elderly women with estrogen receptor-positive (ER+) breast cancer. Methods Using the... 
Surgery | Breast cancer | Hormone therapy | Elderly | Primary endocrine therapy | SURGERY | WOMEN | OLDER | AGE | Breast Neoplasms - surgery | Receptors, Estrogen | Neoplasm Invasiveness | Antineoplastic Agents, Hormonal - therapeutic use | Humans | Aged, 80 and over | Female | Treatment Outcome | Combined Modality Therapy | Breast Neoplasms - drug therapy | Estrogen | Biopsy | Womens health | Patients | Older people | Mortality
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4. Full Text National Use of Postmenopausal Hormone Therapy: Annual Trends and Response to Recent Evidence
by Hersh, Adam L and Stefanick, Marcia L and Stafford, Randall S
JAMA, ISSN 0098-7484, 01/2004, Volume 291, Issue 1, pp. 47 - 53
CONTEXT Postmenopausal hormone therapy use increased dramatically during the past 2 decades because of a prevailing belief in its health benefits. Recent... 
UNITED-STATES | MEDICINE, GENERAL & INTERNAL | NONCONTRACEPTIVE ESTROGENS | HEALTH INITIATIVE MEMORY | REPLACEMENT THERAPY | CARDIOVASCULAR-DISEASE | RANDOMIZED CONTROLLED-TRIAL | ESTROGEN PLUS PROGESTIN | CORONARY-HEART-DISEASE | CALCIUM-CHANNEL BLOCKERS | PRIMARY PREVENTION | Office Visits - statistics & numerical data | United States - epidemiology | Drug Utilization - trends | Progestins - therapeutic use | Humans | Risk | Estrogen Replacement Therapy - trends | Office Visits - trends | Estrogen Replacement Therapy - utilization | Evidence-Based Medicine | Estrogen Replacement Therapy - adverse effects | Estrogens - therapeutic use | Practice Patterns, Physicians' - trends | Practice Patterns, Physicians' - statistics & numerical data | Drug Prescriptions - statistics & numerical data | Female | Drug Utilization - statistics & numerical data | Drugs | Prescribing | Hormone therapy | Statistics
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5. Full Text Nanomedicine in cancer therapy: Innovative trends and prospects
by Blanco, Elvin and Hsiao, Angela and Mann, Aman P and Landry, Matthew G and Meric‐Bernstam, Funda and Ferrari, Mauro
Cancer Science, ISSN 1347-9032, 07/2011, Volume 102, Issue 7, pp. 1247 - 1252
Cancer is a leading cause of morbidity and mortality worldwide, with recent advancements resulting in modest impacts on patient survival. Nanomedicine... 
ONCOLOGY | DRUG-DELIVERY | METASTATIC BREAST-CANCER | DENDRIMERS | MICELLES | PEGYLATED-LIPOSOMAL DOXORUBICIN | MESOPOROUS SILICON PARTICLES | TUMOR VASCULATURE | BLOCK-COPOLYMER | PHASE-I | CHEMOTHERAPY | Nanoparticles | Dendrimers | Animals | Humans | Micelles | Antineoplastic Agents - administration & dosage | Liposomes | Delayed-Action Preparations | Nanomedicine | Drug Carriers | Drug Delivery Systems | Neoplasms - drug therapy | Antimitotic agents | Drugs | Drug delivery systems | Care and treatment | Oncology, Experimental | Research | Antineoplastic agents | Health aspects | Cancer | Vehicles
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6. Full Text Natural products in cancer prevention and therapy, trends in methods and modelling, 3rd edition, Phytochemical Society of Europe (PSE) symposium (Naples, Italy, 4–7 September 2018)
by Lanzotti, Virginia and Grauso, Laura
Phytochemical Analysis, ISSN 0958-0344, 09/2019, Volume 30, Issue 5, pp. 496 - 497
CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | PLANT SCIENCES | Models, Theoretical | Humans | Italy | Neoplasms - prevention & control | Antineoplastic Agents - therapeutic use | Drug Discovery | Biological Products - therapeutic use | Neoplasms - drug therapy | Prevention | Care and treatment | Conferences, meetings and seminars | Health aspects | Conferences and conventions | Trade and professional associations | Methods | Cancer | Natural products
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7. Full Text Acute Stroke Reperfusion Therapy Trends in the Expanded Treatment Window Era
by Asaithambi, Ganesh, MD and Tong, Xin, MPH and George, Mary G., MD, MSPH, FACS and Tsai, Albert W., PhD, MPH and Peacock, James M., PhD, MPH and Luepker, Russell V., MD, MS and Lakshminarayan, Kamakshi, MD, PhD
Journal of Stroke and Cerebrovascular Diseases, ISSN 1052-3057, 2014, Volume 23, Issue 9, pp. 2316 - 2321
Background The American Heart Association/American Stroke Association (AHA/ASA) recommended an expansion of the time window for acute ischemic stroke (AIS)... 
Neurology | Cardiovascular | Expanded time window | thrombolysis—trend analysis | ischemic stroke | Thrombolysis-trend analysis | Ischemic stroke | thrombolysis | trend analysis | POPULATION | STATES | TIME WINDOW | NEUROSCIENCES | TRIAL | PLASMINOGEN-ACTIVATOR | ALTEPLASE | ACUTE ISCHEMIC-STROKE | ENDOVASCULAR TREATMENT | PERIPHERAL VASCULAR DISEASE | REGISTRY | Guidelines as Topic | Hospital Mortality | Time-to-Treatment | Humans | Middle Aged | Male | Treatment Outcome | Stroke - drug therapy | Tissue Plasminogen Activator - therapeutic use | Socioeconomic Factors | Young Adult | Reperfusion - trends | Fibrinolytic Agents - therapeutic use | Thrombolytic Therapy | Adolescent | Aged, 80 and over | Adult | Female | Aged | Stroke - mortality | Stroke - therapy | Infusions, Intra-Arterial | Stroke (Disease) | Sects | Tissue plasminogen activator | Public health
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8. Full Text Antithrombotic therapy trends in non-valvular atrial fibrillation patients undergoing percutaneous coronary stent implantation: Results from a survey among fellows at the Japanese College of Cardiology
by Fukamachi, Daisuke and Hirayama, Atsushi and Miyauchi, Katsumi and Yasuda, Satoshi and Ogawa, Hisao and Ito, Hiroshi and Daida, Hiroyuki
Journal of Cardiology, ISSN 0914-5087, 08/2018, Volume 72, Issue 2, pp. 113 - 119
Antithrombotic therapy with oral anticoagulants (OAC) in patients with atrial fibrillation (AF) after stent implantation, where dual antiplatelet therapy... 
Non-valvu atrial fibrillation | Direct oral anticoagulant | Oral anticoagulant | Dual antiplatelet therapy | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | METAANALYSIS | LOW-DOSE ASPIRIN | ORAL ANTICOAGULANTS | INTERVENTION | ASSOCIATION | ELEVATION MYOCARDIAL-INFARCTION | DRUG-ELUTING STENTS | FOCUSED UPDATE | Medical equipment | Usage | Atrial fibrillation | Practice | Cardiologists | Thrombolytic drugs | Drug therapy | Physiological apparatus
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9. Full Text Prospects for combining targeted and conventional cancer therapy with immunotherapy
by Gotwals, Philip and Cameron, Scott and Cipolletta, Daniela and Cremasco, Viviana and Crystal, Adam and Hewes, Becker and Mueller, Britta and Quaratino, Sonia and Sabatos-Peyton, Catherine and Petruzzelli, Lilli and Engelman, Jeffrey A and Dranoff, Glenn
Nature Reviews Cancer, ISSN 1474-175X, 05/2017, Volume 17, Issue 5, pp. 286 - 301
Over the past 25 years, research in cancer therapeutics has largely focused on two distinct lines of enquiry. In one approach, efforts to understand the... 
CELL LUNG-CANCER | CHEMOKINE LIGAND 2 | PARACASPASE MALT1 | TGF-BETA | ONCOLOGY | IMMUNE CHECKPOINT BLOCKADE | HUMAN MONOCLONAL-ANTIBODY | REGULATORY T-CELLS | CARLUMAB CNTO 888 | NF-KAPPA-B | TUMOR MICROENVIRONMENT | Neoplasms - therapy | Animals | Molecular Targeted Therapy - trends | Neoplasms - genetics | Neoplasms - immunology | Humans | Immunotherapy - trends | Combined Modality Therapy | Neoplasms - drug therapy | Chemotherapy | Care and treatment | Immunotherapy | Drug therapy, Combination | Research | Health aspects | Cancer
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10. Full Text Cornerstones of CRISPR-Cas in drug discovery and therapy
by Fellmann, Christof and Gowen, Benjamin G and Lin, Pei-Chun and Doudna, Jennifer A and Corn, Jacob E
Nature Reviews Drug Discovery, ISSN 1474-1776, 02/2017, Volume 16, Issue 2, pp. 89 - 100
The recent development of CRISPR-Cas systems as easily accessible and programmable tools for genome editing and regulation is spurring a revolution in biology.... 
HEMATOPOIETIC STEM/PROGENITOR CELLS | OFF-TARGET SITES | GENOME-EDITING SPECIFICITY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | VIRUS ENTRY REQUIRES | EMBRYONIC STEM-CELLS | IN-VIVO | DOUBLE-STRAND BREAKS | PHARMACOLOGY & PHARMACY | HUMAN CANCER-CELLS | ZINC-FINGER NUCLEASES | T-CELLS | Animals | Genetic Engineering | CRISPR-Associated Proteins - drug effects | Humans | CRISPR-Cas Systems | Drug Discovery - trends | Biomarkers | Genetic Therapy - trends | Clustered Regularly Interspaced Short Palindromic Repeats - drug effects | Drug Therapy - trends | Drug discovery | Research | Drug therapy | Prokaryotes
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11. Full Text Targeting Apoptosis Pathways in Cancer Therapy
by Ghobrial, Irene M and Witzig, Thomas E and Adjei, Alex A
CA: A Cancer Journal for Clinicians, ISSN 0007-9235, 05/2005, Volume 55, Issue 3, pp. 178 - 194
Apoptosis, or programmed cell death, is a mechanism by which cells undergo death to control cell proliferation or in response to DNA damage. The understanding... 
PROGRAMMED CELL-DEATH | MULTIPLE-MYELOMA | PHASE-II TRIAL | SURVIVIN EXPRESSION | ONCOLOGY | PROTE