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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2017, Volume 114, Issue 12, pp. 3151 - 3156
Journal Article
Nature Medicine, ISSN 1078-8956, 01/2017, Volume 23, Issue 1, pp. 60 - 68
Forward genetic screens with CRISPR-Cas9 genome editing enable high-resolution detection of genetic vulnerabilities in cancer cells. We conducted genome-wide... 
Medicine(all) | Biochemistry, Genetics and Molecular Biology(all) | Journal Article | MEDICINE, RESEARCH & EXPERIMENTAL | RNF43 | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | CANCER | CELL BIOLOGY | ESSENTIAL GENES | INHIBITION | GROWTH | MUTATIONAL LANDSCAPE | WNT | RECEPTORS | Frizzled Receptors - antagonists & inhibitors | Neoplasm Transplantation | Oncogene Proteins - genetics | Pancreatic Neoplasms - metabolism | Colorectal Neoplasms - genetics | Humans | Carcinoma, Pancreatic Ductal - metabolism | Molecular Targeted Therapy | RNA, Messenger - metabolism | Carcinoma, Pancreatic Ductal - genetics | Adenocarcinoma - metabolism | Flow Cytometry | Organoids - metabolism | Clustered Regularly Interspaced Short Palindromic Repeats | Adenocarcinoma - genetics | Real-Time Polymerase Chain Reaction | Colorectal Neoplasms - metabolism | Frizzled Receptors - metabolism | Pancreatic Neoplasms - genetics | DNA-Binding Proteins - genetics | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Antibodies - pharmacology | Animals | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Cell Cycle Checkpoints - drug effects | Fluorescent Antibody Technique | Organoids - drug effects | Cell Line, Tumor | Mice | Care and treatment | Pancreatic cancer | Innovations | Development and progression | Genotype | Genetic engineering | Cellular signal transduction | Genetic aspects | Health aspects | Proteins | Viral antibodies | Genomics | Colorectal cancer | Antibodies | Genomes | Genetic screening | Cell proliferation | Adenocarcinoma | CRISPR | Therapy | Immunoglobulins | Wnt protein | Frizzled protein | Xenotransplantation | Colorectal carcinoma | Cell surface | Signaling | Receptors | Organoids | Xenografts | Inhibition | Mutation | Pancreas | Tumors | Recombinant
Journal Article
NATURE, ISSN 0028-0836, 04/2019, Volume 568, Issue 7753, pp. 511 - 511
Journal Article
Drug Discovery Today, ISSN 1359-6446, 11/2013, Volume 18, Issue 21-22, pp. 1067 - 1073
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2009, Volume 52, Issue 18, pp. 5712 - 5720
Journal Article
2013, 1st Vintage International edition., ISBN 9780394711829, 184
Book
British Journal of Pharmacology, ISSN 0007-1188, 01/2018, Volume 175, Issue 2, pp. 181 - 191
Journal Article
Journal Article