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1. Full Text The Neural Basis of Addiction: A Pathology of Motivation and Choice
by Kalivas, Peter W and Volkow, Nora D
American Journal of Psychiatry, ISSN 0002-953X, 08/2005, Volume 162, Issue 8, pp. 1403 - 1413
OBJECTIVE: A primary behavioral pathology in drug addiction is the overpowering motivational strength and decreased ability to control the desire to obtain... 
CONDITIONED REWARD | COCAINE-SEEKING BEHAVIOR | INDUCED REINSTATEMENT | NUCLEUS-ACCUMBENS CORE | PSYCHIATRY | BASOLATERAL AMYGDALA | PREFRONTAL CORTEX NEURONS | ANTERIOR CINGULATE | DRUG-SEEKING | SYNAPTIC PLASTICITY | GLUTAMATE TRANSMISSION | Recurrence | Substance-Related Disorders - etiology | Brain - physiopathology | Humans | Globus Pallidus - physiology | Rodentia | Behavior, Addictive - etiology | Positron-Emission Tomography | Nucleus Accumbens - physiology | Brain - physiology | Neural Pathways - physiology | Substance-Related Disorders - physiopathology | Animals | Motivation | Dopamine - physiology | Substance-Related Disorders - psychology | Choice Behavior - physiology | Behavior, Addictive - psychology | Models, Neurological | Behavior, Addictive - physiopathology | Prefrontal Cortex - physiology | Compulsive behavior | Motivation (Psychology) | Research | Addiction
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2. Full Text Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD
by Ma, Tengfei and Cheng, Yifeng and Roltsch Hellard, Emily and Wang, Xuehua and Lu, Jiayi and Gao, Xinsheng and Huang, Cathy C. Y and Wei, Xiao-Yan and Ji, Jun-Yuan and Wang, Jun
Nature Neuroscience, ISSN 1097-6256, 03/2018, Volume 21, Issue 3, pp. 373 - 383
Addiction is proposed to arise from alterations in synaptic strength via mechanisms of long-term potentiation (LTP) and depression (LTD). However, the... 
DORSOMEDIAL STRIATUM | NEURONAL-ACTIVITY | TERM DEPRESSION | DORSAL STRIATUM | SILENT SYNAPSES | SYNAPTIC PLASTICITY | COCAINE EXPOSURE | NEUROSCIENCES | DOPAMINERGIC CONTROL | NUCLEUS-ACCUMBENS | DRINKING BEHAVIOR | Long-Term Synaptic Depression - physiology | Receptors, Presynaptic - physiology | Drug-Seeking Behavior - physiology | Rats, Long-Evans | Rats | Evoked Potentials - physiology | Male | Optogenetics | Alcohol Drinking | Receptors, N-Methyl-D-Aspartate - physiology | Neostriatum - physiology | Self Administration | Animals | Receptors, Dopamine D1 - physiology | Long-Term Potentiation - physiology | Cerebral Cortex - physiology | Glutamates - physiology | Research | Addiction | Health aspects | Long-term potentiation | Depression, Mental | Potentiation | Drug addiction | Brain | Drug abuse | Operant conditioning | Dopamine | Synaptic strength | Glutamic acid receptors (ionotropic) | Cortex | N-Methyl-D-aspartic acid receptors | Alcohol | Alcohols | Depolarization | Plasticity (behavioral) | Drug self-administration | Plasticity (synaptic) | Dopamine D1 receptors | Neostriatum | Plasticity | Addictive behaviors | Alcoholic beverages | Glutamatergic transmission
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3. Full Text Emotions and motivated behavior converge on an amygdala‐like structure in the zebrafish
by Trotha, Jakob William and Vernier, Philippe and Bally‐Cuif, Laure
European Journal of Neuroscience, ISSN 0953-816X, 11/2014, Volume 40, Issue 9, pp. 3302 - 3315
The brain reward circuitry plays a key role in emotional and motivational behaviors, and its dysfunction underlies neuropsychiatric disorders such as... 
reward | amphetamine | adult neurogenesis | cfos | amygdala | addiction | Amphetamine | Reward | Addiction | Amygdala | Adult neurogenesis | CALCIUM-BINDING PROTEINS | CONDITIONED PLACE PREFERENCE | BASOLATERAL AMYGDALA | ADULT HIPPOCAMPAL NEUROGENESIS | NEUROSCIENCES | ENHANCED SYNAPTIC PLASTICITY | GOAL-DIRECTED BEHAVIOR | TELENCEPHALIC PALLIUM | MEDIAL PREFRONTAL CORTEX | GABAERGIC NEURONS | MOLECULAR-MECHANISMS | Emotions - physiology | Amygdala - drug effects | Age Factors | Drug-Seeking Behavior - physiology | Proto-Oncogene Proteins c-fos - metabolism | GABAergic Neurons - drug effects | GABAergic Neurons - physiology | Conditioning, Classical - physiology | Telencephalon - physiology | Animals | Motivation - physiology | Telencephalon - drug effects | Neurons - physiology | Zebrafish - physiology | Glutamic Acid - metabolism | Neurons - drug effects | Amygdala - physiology | Dextroamphetamine - administration & dosage | Nervous system diseases | Life Sciences | Neurons and Cognition | Behavioral Neuroscience
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4. Full Text HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors
by Taniguchi, Makoto and Carreira, Maria B and Cooper, Yonatan A and Bobadilla, Ana-Clara and Heinsbroek, Jasper A and Koike, Nobuya and Larson, Erin B and Balmuth, Evan A and Hughes, Brandon W and Penrod, Rachel D and Kumar, Jaswinder and Smith, Laura N and Guzman, Daniel and Takahashi, Joseph S and Kim, Tae-Kyung and Kalivas, Peter W and Self, David W and Lin, Yingxi and Cowan, Christopher W
Neuron, ISSN 0896-6273, 09/2017, Volume 96, Issue 1, pp. 130 - 144.e6
Individuals suffering from substance-use disorders develop strong associations between the drug’s rewarding effects and environmental cues, creating powerful,... 
NPAS4 | HDAC5 | cocaine addiction | reinstatement | conditioned place preference | ChIP-seq | nucleus accumbens | histone deacetylase | drug self-administration | chromatin immunoprecipitation | WEBGESTALT | DELTA-FOSB | PLACE PREFERENCE | REINSTATEMENT | ENSEMBLES | INCREASES | RECEPTOR | TRANSCRIPTION FACTOR | BINDING | EXPRESSION | NEUROSCIENCES | Basic Helix-Loop-Helix Transcription Factors - physiology | Conditioning (Psychology) - physiology | Drug-Seeking Behavior - physiology | Reinforcement (Psychology) | Conditioning, Operant - physiology | Gene Expression Regulation - physiology | Rats | Male | Mice, Transgenic | Fear - physiology | Nucleus Accumbens - physiology | Mice, Knockout | Dose-Response Relationship, Drug | Cocaine - pharmacology | Self Administration | Animals | Conditioning, Operant - drug effects | Extinction, Psychological | Fear - psychology | Mice | Histone Deacetylases - physiology | Primary Cell Culture | Nucleus Accumbens - drug effects | Genes | Analysis | Cocaine | Neurosciences | Chromatin | Cues | Histone deacetylase | Transcription factors | Neurons | Memory | Genomes | Gene expression | Addictions | Nuclei | Nucleus accumbens | Learning | Drug self-administration | Clonal deletion | Fos protein | Rodents | Reinstatement | Addictive behaviors | Reinforcement | Deletion | Behavior | Conditioning
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5. Full Text Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence
by Meinhardt, Marcus W and Hansson, Anita C and Perreau-Lenz, Stephanie and Bauder-Wenz, Christina and Stählin, Oliver and Heilig, Markus and Harper, Clive and Drescher, Karla U and Spanagel, Rainer and Sommer, Wolfgang H
Journal of Neuroscience, ISSN 0270-6474, 02/2013, Volume 33, Issue 7, pp. 2794 - 2806
A key deficit in alcohol dependence is disrupted prefrontal function leading to excessive alcohol seeking, but the molecular events underlying the emergence of... 
Immunohistochemistry | Rats, Wistar | Humans | Receptors, Metabotropic Glutamate - physiology | Male | RNA - genetics | Central Nervous System Depressants - pharmacology | In Situ Hybridization | Receptors, Metabotropic Glutamate - genetics | Microarray Analysis | Limbic System - physiology | Lentivirus - genetics | Alcoholism - physiopathology | Receptors, Metabotropic Glutamate - deficiency | Alcoholism - psychology | Real-Time Polymerase Chain Reaction | Diagnostic and Statistical Manual of Mental Disorders | Gene Expression | Drug-Seeking Behavior - physiology | Rats | Behavior, Animal - physiology | Down-Regulation - physiology | RNA - biosynthesis | Ethanol - pharmacology | Animals | Brain - pathology | Alcoholism - genetics | Genetic Vectors | Substance Withdrawal Syndrome - psychology
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6. Full Text Bidirectional Modulation of Incubation of Cocaine Craving by Silent Synapse-Based Remodeling of Prefrontal Cortex to Accumbens Projections
by Ma, Yao-Ying and Lee, Brian R and Wang, Xiusong and Guo, Changyong and Liu, Lei and Cui, Ranji and Lan, Yan and Balcita-Pedicino, Judith J and Wolf, Marina E and Sesack, Susan R and Shaham, Yavin and Schlüter, Oliver M and Huang, Yanhua H and Dong, Yan
Neuron, ISSN 0896-6273, 09/2014, Volume 83, Issue 6, pp. 1453 - 1467
Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens (NAc) contribute to cocaine relapse. Here we show that silent... 
RELAPSE | AMPA RECEPTORS | INDUCED REINSTATEMENT | RAT | SENSITIZATION | SEEKING BEHAVIOR | NEURONS | DRUG-SEEKING | NEUROSCIENCES | ADDICTION | NUCLEUS-ACCUMBENS | Nucleus Accumbens - physiopathology | Synapses - drug effects | Neural Pathways - drug effects | Synapses - physiology | Drug-Seeking Behavior - physiology | Prefrontal Cortex - physiopathology | Electrophysiology | Rats | Male | Optogenetics | Cocaine-Related Disorders - physiopathology | Rats, Sprague-Dawley | Animals | Neuronal Plasticity - physiology | Prefrontal Cortex - drug effects | Craving - physiology | Neural Pathways - physiopathology | Nucleus Accumbens - drug effects | Cocaine | Neurophysiology | Studies | Extinction | Neurons | Rodents | Optics | Behavior | Experiments
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7. Full Text Role of TAAR1 within the subregions of the mesocorticolimbic dopaminergic system in cocaine-seeking behavior
by Liu, Jian-Feng and Siemian, Justin N and Seaman, Robert and Zhang, Yanan and Li, Jun-Xu
Journal of Neuroscience, ISSN 0270-6474, 01/2017, Volume 37, Issue 4, pp. 882 - 892
A novel G-protein coupled receptor, trace amine-associated receptor 1 (TAAR1), has been shown to be a promising target to prevent stimulant relapse. Our recent... 
Self-administration | Cocaine | Mesocorticolimbic regions | TAAR1 | Reinstatement | AMINE-ASSOCIATED RECEPTOR-1 | cocaine | DRUG RELAPSE | CUE-INDUCED REINSTATEMENT | BASOLATERAL AMYGDALA | TRACE AMINES | NEUROSCIENCES | PREFRONTAL CORTEX | MONOAMINERGIC NEUROTRANSMISSION | mesocorticolimbic regions | DORSAL HIPPOCAMPUS | reinstatement | self-administration | NUCLEUS-ACCUMBENS CORE | MODULATION | Amygdala - drug effects | Conditioning, Operant - physiology | Male | Receptors, G-Protein-Coupled - agonists | Ventral Tegmental Area - physiology | Nucleus Accumbens - physiology | Phenethylamines - administration & dosage | Self Administration | Prefrontal Cortex - drug effects | Conditioning, Operant - drug effects | Dopamine - physiology | Dopaminergic Neurons - drug effects | Dopaminergic Neurons - physiology | Limbic System - physiology | Limbic System - drug effects | Receptors, G-Protein-Coupled - physiology | Microinjections | Drug-Seeking Behavior - physiology | Rats | Rats, Sprague-Dawley | Drug-Seeking Behavior - drug effects | Cocaine - administration & dosage | Animals | Oxazoles - administration & dosage | Nucleus Accumbens - drug effects | Amygdala - physiology | Prefrontal Cortex - physiology
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8. Full Text Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On
by Everitt, Barry J and Robbins, Trevor W
Annual Review of Psychology, ISSN 0066-4308, 1/2016, Volume 67, Issue 1, pp. 23 - 50
A decade ago, we hypothesized that drug addiction can be viewed as a transition from voluntary, recreational drug use to compulsive drug-seeking habits,... 
endophenotype | vulnerability | striatum | insula | prefrontal cortex | inhibitory control | Striatum | Insula | Inhibitory control | Vulnerability | Prefrontal cortex | Endophenotype | COCAINE-SEEKING BEHAVIOR | BETA-ADRENERGIC-RECEPTORS | DORSOLATERAL STRIATUM | REACTION-TIME-TASK | PSYCHOLOGY | PSYCHOLOGY, MULTIDISCIPLINARY | VENTROMEDIAL PREFRONTAL CORTEX | DECISION-MAKING | NUCLEUS-ACCUMBENS CORE | DORSAL STRIATUM | MEMORY RECONSOLIDATION | DEPENDENT INDIVIDUALS | Animals | Compulsive Behavior - psychology | Conditioning (Psychology) - physiology | Brain - physiopathology | Drug-Seeking Behavior - physiology | Humans | Compulsive Behavior - physiopathology | Substance-Related Disorders - psychology | Substance-Related Disorders - therapy | Substance-Related Disorders - physiopathology | Habits | Drug abuse | Public health administration | Forecasts and trends | Health behavior | Care and treatment | Substance abuse
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