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1. Full Text Drug-Induced Liver Injury
by Leise, Michael D., MD and Poterucha, John J., MD and Talwalkar, Jayant A., MD
Mayo Clinic Proceedings, ISSN 0025-6196, 2014, Volume 89, Issue 1, pp. 95 - 106
Abstract Drug hepatoxicity can be nonidiosyncratic (predictable), as in the case of acetaminophen, or idiosyncratic (unpredictable). This review article... 
Internal Medicine | POPULATION | MEDICINE, GENERAL & INTERNAL | HEPATITIS-E VIRUS | SUSCEPTIBILITY | RESISTANCE | RISK | DYSFUNCTION | ACETAMINOPHEN HEPATOTOXICITY | FAILURE | EPIDEMIOLOGY | ORAL MEDICATIONS | Democratic People's Republic of Korea - epidemiology | Iceland - epidemiology | United States - epidemiology | Protein-Tyrosine Kinases - metabolism | Humans | Isoniazid - adverse effects | Male | Adult | Female | Dietary Supplements - adverse effects | Republic of Korea - epidemiology | Enzyme Inhibitors - adverse effects | France - epidemiology | Comorbidity | Chemical and Drug Induced Liver Injury - epidemiology | China - epidemiology | Liver Diseases - epidemiology | Clavulanic Acid - adverse effects | Fluoroquinolones - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Tumor Necrosis Factor-alpha - adverse effects | Spain - epidemiology | Amoxicillin - adverse effects | Causality | Drugs | Adverse and side effects | Hepatitis | Care and treatment | Diagnosis | Risk factors
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2. Full Text Drug-induced liver injury
by Fisher, Kurt and Vuppalanchi, Raj and Saxena, Romil
Archives of Pathology and Laboratory Medicine, ISSN 0003-9985, 07/2015, Volume 139, Issue 7, pp. 876 - 887
Context.-Drug-induced liver injury (DILI) represents a diverse set of responses following exposure to any manufactured or naturally occurring chemical... 
AMOXICILLIN-CLAVULANIC ACID | MEDICINE, RESEARCH & EXPERIMENTAL | CLINICAL-FEATURES | PATHOLOGY | CLASS-II GENOTYPE | ORAL MEDICATIONS | HISTOLOGICAL FEATURES | POLYMERASE GAMMA | HYPERSENSITIVITY REACTIONS | CAUSALITY ASSESSMENT | MEDICAL LABORATORY TECHNOLOGY | FULMINANT HEPATIC-FAILURE | IMATINIB MESYLATE | Liver - pathology | Prevalence | Prognosis | Humans | Risk Factors | Chemical and Drug Induced Liver Injury - epidemiology | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - classification | Medicine, Herbal | Liver diseases | Drug therapy | Liver | Medicine, Botanic
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3. Full Text Liver injury from herbals and dietary supplements in the U.S. Drug‐Induced Liver Injury Network
by Navarro, Victor J and Barnhart, Huiman and Bonkovsky, Herbert L and Davern, Timothy and Fontana, Robert J and Grant, Lafaine and Reddy, K. Rajender and Seeff, Leonard B and Serrano, Jose and Sherker, Averell H and Stolz, Andrew and Talwalkar, Jayant and Vega, Maricruz and Vuppalanchi, Raj
Hepatology, ISSN 0270-9139, 10/2014, Volume 60, Issue 4, pp. 1399 - 1408
The Drug‐Induced Liver Injury Network (DILIN) studies hepatotoxicity caused by conventional medications as well as herbals and dietary supplements (HDS). To... 
UNITED-STATES | HEAVY-METALS | ADULTS | PATTERNS | MEDICINES | OUTCOMES | HEALTH | GASTROENTEROLOGY & HEPATOLOGY | United States - epidemiology | Liver Transplantation | Prospective Studies | Humans | Middle Aged | Chemical and Drug Induced Liver Injury - mortality | Chemical and Drug Induced Liver Injury - epidemiology | Male | Incidence | Adult | Female | Aged | Retrospective Studies | Dietary Supplements - adverse effects | Chemical and Drug Induced Liver Injury - surgery | Drugs, Chinese Herbal - adverse effects | Fatalities | Liver | Rodents | Hepatology | Dietary supplements | Index Medicus | hepatotoxicity | causality assessment | transplantation | herbs
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4. Full Text Drug-Induced Liver Injury
by Neil Kaplowitz
Clinical Infectious Diseases, ISSN 1058-4838, 3/2004, Volume 38, Issue 2, pp. S44 - S48
Drug-induced hepatotoxicity is a frequent cause of liver injury. The predominant clinical presentation is acute hepatitis and/or cholestasis, although almost... 
Drug induced liver injury | Hepatitis | Liver diseases | Cellular metabolism | Liver | Predisposing factors | Metabolic diseases | Physical trauma | Signatures | Hepatotoxicity | DANGER | INFECTIOUS DISEASES | MICROBIOLOGY | MECHANISMS | IMMUNOLOGY | BILIARY-CIRRHOSIS | Drug-Related Side Effects and Adverse Reactions | Humans | Risk Factors | Chemical and Drug Induced Liver Injury - epidemiology | Liver Diseases - epidemiology | Liver Diseases - physiopathology | Chemical and Drug Induced Liver Injury - physiopathology | Chemical and Drug Induced Liver Injury - etiology
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5. Full Text Liver injury from herbal and dietary supplements
by Navarro, Victor J and Khan, Ikhlas and Björnsson, Einar and Seeff, Leonard B and Serrano, Jose and Hoofnagle, Jay H
Hepatology, ISSN 0270-9139, 01/2017, Volume 65, Issue 1, pp. 363 - 373
Herbal and dietary supplements (HDS) are used increasingly both in the United States and worldwide, and HDS‐induced liver injury in the United States has... 
GREEN TEA | PLANT-MATERIAL | STEROIDS | SAFETY | EXPERIENCE | HEPATOTOXICITY | GASTROENTEROLOGY & HEPATOLOGY | OXYELITE PRO | TRENDS | United States | Humans | Tea - adverse effects | Chemical and Drug Induced Liver Injury - epidemiology | Forecasting | Chemical and Drug Induced Liver Injury - diagnosis | Biomedical Research - legislation & jurisprudence | Phytotherapy - adverse effects | Jaundice - chemically induced | Decision Trees | Dietary Supplements - adverse effects | Chemical and Drug Induced Liver Injury - etiology | United States Food and Drug Administration | Liver | Rodents | Dietary supplements | Bile | Hepatitis | Liver diseases | Toxicity | Tetraethylammonium | Green tea | Hepatotoxicity | Steroid hormones | Index Medicus
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6. Full Text Deep Learning for Drug-Induced Liver Injury
by Xu, Youjun and Dai, Ziwei and Chen, Fangjin and Gao, Shuaishi and Pei, Jianfeng and Lai, Luhua
Journal of Chemical Information and Modeling, ISSN 1549-9596, 10/2015, Volume 55, Issue 10, pp. 2085 - 2093
Drug-induced liver injury (DILI) has been the single most frequent cause of safety-related drug marketing withdrawals for the past 50 years. Recently, deep... 
CHEMISTRY, MEDICINAL | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS | NEURAL-NETWORKS | CHEMOINFORMATICS | ALGORITHM | COMPUTER SCIENCE, INFORMATION SYSTEMS | PREDICTIONS | HEPATOTOXICITY | CHEMISTRY, MULTIDISCIPLINARY | ARCHITECTURES | Algorithms | Glycine - chemistry | Models, Biological | Humans | Risk Factors | ROC Curve | Chemical and Drug Induced Liver Injury | Safety-Based Drug Withdrawals | Software - standards
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7. Full Text Central role of mitochondria in drug-induced liver injury
by Pessayre, Dominique and Fromenty, Bernard and Berson, Alain and Robin, Marie-Anne and Lettéron, Philippe and Moreau, Richard and Mansouri, Abdellah
Drug Metabolism Reviews, ISSN 0360-2532, 2/2012, Volume 44, Issue 1, pp. 34 - 87
A frequent mechanism for drug-induced liver injury (DILI) is the formation of reactive metabolites that trigger hepatitis through direct toxicity or immune... 
drug-induced liver injury | susceptibility | idiosyncrasy | liver | hepatotoxicity | mitochondria | mitochondrial DNA | mitochondrial permeability transition | mitochondrial dysfunction | Adverse drug reactions | hepatitis | steatosis | adverse drug reactions | PERMEABILITY TRANSITION PORE | COA DEHYDROGENASE-DEFICIENCY | ENDOPLASMIC-RETICULUM STRESS | HUMAN-IMMUNODEFICIENCY-VIRUS | ISOLATED RAT HEPATOCYTES | REVERSE-TRANSCRIPTASE INHIBITORS | HEPATITIS-C VIRUS | HEPATOCYTE PLASMA-MEMBRANE | FATTY-ACID OXIDATION | MANGANESE SUPEROXIDE-DISMUTASE | PHARMACOLOGY & PHARMACY | Liver - pathology | Fatty Liver - metabolism | Mitochondria, Liver - pathology | Reactive Oxygen Species - metabolism | Oxidation-Reduction | DNA, Mitochondrial - drug effects | Fatty Liver - pathology | Mitochondria, Liver - metabolism | Humans | Liver - metabolism | Mitochondrial Proteins - biosynthesis | Mitochondria, Liver - drug effects | Mitochondrial Proteins - drug effects | Pharmaceutical Preparations - metabolism | Chemical and Drug Induced Liver Injury - metabolism | Immune System - metabolism | Drug-Related Side Effects and Adverse Reactions | Mitochondria, Liver - ultrastructure | Cell Respiration - drug effects | Chemical and Drug Induced Liver Injury - pathology | DNA, Mitochondrial - biosynthesis | Fatty Liver - etiology | Index Medicus | Hépatology and Gastroenterology | Reactive Oxygen Species | Liver | DNA, Mitochondrial | Drug-Induced Liver Injury | Mitochondrial Proteins | Fatty Liver | Mitochondria, Liver | Life Sciences | Human health and pathology | Cell Respiration | Immune System | Pharmaceutical Preparations
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8. Full Text Mechanisms of immune-mediated liver injury
by Adams, David H and Ju, Cynthia and Ramaiah, Shashi K and Uetrecht, Jack and Jaeschke, Hartmut
Toxicological Sciences, ISSN 1096-6080, 01/2010, Volume 115, Issue 2, pp. 307 - 321
Hepatic inflammation is a common finding during a variety of liver diseases including drug-induced liver toxicity. The inflammatory phenotype can be attributed... 
Idiosyncratic liver toxicity | Immunemediated liver injury | Lymphocytes | Neutrophils | Innate immunity | Adverse drug reactions | Macrophages | Hepatotoxicity | DRUG-INDUCED HEPATOTOXICITY | SYSTEMIC-LUPUS-ERYTHEMATOSUS | VASCULAR ADHESION PROTEIN-1 | lymphocytes | immune-mediated liver injury | idiosyncratic liver toxicity | MURINE ACETAMINOPHEN HEPATOTOXICITY | NEUTROPHIL DEPLETION PROTECTS | adverse drug reactions | macrophages | innate immunity | HEPATIC ISCHEMIA-REPERFUSION | hepatotoxicity | C-INFECTED LIVER | REGULATORY T-CELLS | TOXICOLOGY | PARENCHYMAL-CELL INJURY | INFLAMMATORY RESPONSE | neutrophils | Liver - pathology | Immunity, Innate - drug effects | Humans | Neutrophils - drug effects | Neutrophils - immunology | Xenobiotics - toxicity | Chemical and Drug Induced Liver Injury - immunology | Liver - immunology | Lymphocyte Activation - immunology | Animals | Lymphocytes - immunology | Liver - drug effects | Lymphocyte Activation - drug effects | Drug-Related Side Effects and Adverse Reactions | Lymphocytes - drug effects | Macrophages - drug effects | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Macrophages - immunology | Disease Models, Animal | Index Medicus | Review
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9. Full Text Circulating MicroRNAs, Potential Biomarkers for Drug-Induced Liver Injury
by Kai Wang and Shile Zhang and Bruz Marzolf and Pamela Troisch and Amy Brightman and Zhiyuan Hu and Leroy E. Hood and David J. Galas
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2009, Volume 106, Issue 11, pp. 4402 - 4407
Drug-induced liver injury is a frequent side effect of many drugs, constitutes a significant threat to patient health and has an enormous economic impact on... 
MicroRNA | Animals | Tissue samples | RNA | Liver | Overdose | Physical trauma | Biological markers | Species | Blood plasma | Plasma | ALT | Acetaminophen overdose | Toxicity | MiRNA | toxicity | DIAGNOSIS | TESTS | acetaminophen overdose | MULTIDISCIPLINARY SCIENCES | N-ACETYLCYSTEINE | CANCER | PARACETAMOL OVERDOSE | miRNA | SERUM BIOMARKERS | HEPATOTOXICITY | TISSUES | plasma | Acetaminophen - adverse effects | Liver Circulation | Drug Overdose | Humans | Biomarkers - blood | Liver - injuries | Tissue Distribution | MicroRNAs - analysis | Drug-Related Side Effects and Adverse Reactions | Liver Diseases - diagnosis | Chemical and Drug Induced Liver Injury | Mice | MicroRNAs - blood | Liver diseases | Genetic aspects | Diagnosis | Research | Health aspects | Index Medicus | Biological Sciences
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10. Full Text Pathogenesis of Idiosyncratic Drug-Induced Liver Injury and Clinical Perspectives
by Fontana, Robert J
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 4, pp. 914 - 928.e1
Idiosyncratic drug-induced liver injury (DILI) is a rare disease that develops independently of drug dose, route, or duration of administration. Furthermore,... 
Gastroenterology and Hepatology | Side Effect | Liver Failure | Acetaminophen | Epidemiology | ACETAMINOPHEN-INDUCED HEPATOTOXICITY | GENETIC-BASIS | T-CELLS PROVIDES | ORAL MEDICATIONS | GENERAL-POPULATION | CLASS-I | TERM-FOLLOW-UP | GENOME-WIDE | GASTROENTEROLOGY & HEPATOLOGY | PHENOTYPE STANDARDIZATION | PROTEIN ADDUCTS | Predictive Value of Tests | Genetic Predisposition to Disease | Liver - pathology | Pharmacogenetics | Prognosis | Humans | Liver - metabolism | Risk Factors | Terminology as Topic | Chemical and Drug Induced Liver Injury - epidemiology | Biomarkers - blood | Chemical and Drug Induced Liver Injury - genetics | Chemical and Drug Induced Liver Injury - diagnosis | Animals | Liver - drug effects | Registries | Chemical and Drug Induced Liver Injury - blood | Chemical and Drug Induced Liver Injury - classification | Liver diseases | Metabolites | Glutamate | Liver | Genomics | Amoxicillin | Index Medicus | Abridged Index Medicus | side effect | epidemiology | liver failure
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