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1. Full Text Rikkunshito, an Herbal Medicine, Suppresses Cisplatin-Induced Anorexia in Rats Via 5-HT2 Receptor Antagonism
by Takeda, Hiroshi and Sadakane, Chiharu and Hattori, Tomohisa and Katsurada, Takehiko and Ohkawara, Tatsuya and Nagai, Koichi and Asaka, Masahiro
Gastroenterology, ISSN 0016-5085, 2008, Volume 134, Issue 7, pp. 2004 - 2013
Background & Aims: Chemotherapy with an anticancer agent generally causes gastrointestinal tract disorders such as vomiting and anorexia, but the mechanism... 
Gastroenterology and Hepatology | SEROTONIN RECEPTOR | GHRELIN LEVELS | SYMPTOMS | MICE | EMESIS | GASTROENTEROLOGY & HEPATOLOGY | STOMACH | Receptor, Serotonin, 5-HT2B - metabolism | Receptor, Serotonin, 5-HT2C - metabolism | Body Weight - drug effects | Drugs, Chinese Herbal - pharmacology | Male | Stomach - metabolism | Drugs, Chinese Herbal - metabolism | Anorexia - physiopathology | Quinolines - pharmacology | Serotonin Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Serotonin 5-HT2 Receptor Antagonists | Chalcones - pharmacology | Dopamine Antagonists - metabolism | Receptors, Ghrelin - metabolism | Indoles - pharmacology | Stomach - innervation | Stomach - drug effects | Drugs, Chinese Herbal - therapeutic use | Flavones - pharmacology | Acylation | Disease Models, Animal | Antineoplastic Agents | Rats | Thiophenes - pharmacology | Anorexia - metabolism | Dopamine Antagonists - therapeutic use | Receptors, Ghrelin - drug effects | Piperazines - pharmacology | Rats, Sprague-Dawley | Vagotomy | Cisplatin | Ghrelin - metabolism | Eating - drug effects | Gastrointestinal Agents - pharmacology | Ghrelin - blood | Animals | Dopamine Antagonists - pharmacology | Aminopyridines - pharmacology | Serotonin - metabolism | Gastrointestinal Agents - therapeutic use | Anorexia - prevention & control | Hesperidin - pharmacology | Protein Binding | Anorexia - chemically induced | Oligopeptides - pharmacology | Gastrointestinal Agents - metabolism | Medicine, Botanic | Medicine, Herbal
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2. Full Text A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights
by Gao, Wei and Hillwig, Matthew L and Huang, Luqi and Cui, Guanghong and Wang, Xueyong and Kong, Jianqiang and Yang, Bin and Peters, Reuben J
Organic Letters, ISSN 1523-7060, 11/2009, Volume 11, Issue 22, pp. 5170 - 5173
Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza... 
(+)-COPALYL DIPHOSPHATE | CHEMISTRY, ORGANIC | PLANTS | ABIETADIENE SYNTHASE | MECHANISM | ABIES-GRANDIS | Phenanthrenes - chemistry | Drugs, Chinese Herbal - chemistry | Stereoisomerism | Genomics | Biological Factors - chemistry | Molecular Structure | Biological Factors - metabolism | Drugs, Chinese Herbal - metabolism | Phenanthrenes - metabolism | Diterpenes, Abietane | Letter
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3. Full Text Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts
by Wang, Shanshan and Zheng, Zhengui and Weng, Yinqi and Yu, Yijun and Zhang, Daifu and Fan, Weihu and Dai, Ruihong and Hu, Zhibi
Life Sciences, ISSN 0024-3205, 2004, Volume 74, Issue 20, pp. 2467 - 2478
The aqueous extracts of 24 herbs traditionally used as curing ischemic heart disease in clinic in China were screened for their in vitro angiogenic activity,... 
Angiogenesis | Chinese medicinal herbs | Anti-angiogenesis | EMBRYO CHORIOALLANTOIC MEMBRANE | MEDICINE, RESEARCH & EXPERIMENTAL | METASTASIS | angiogenesis | TUMOR ANGIOGENESIS | IN-VITRO | SOLE THERAPY | anti-angiogenesis | ENDOTHELIAL-CELLS | GROWTH | PHARMACOLOGY & PHARMACY | GENE-THERAPY | MICE | CORONARY-ARTERY-DISEASE | Endothelium, Vascular - cytology | Medicine, Chinese Traditional | Cells, Cultured | Neovascularization, Pathologic | Chick Embryo | Drugs, Chinese Herbal - metabolism | Fibroblast Growth Factors - metabolism | Chorion - anatomy & histology | Plant Extracts - metabolism | Angiogenesis Inhibitors - metabolism | Animals | Allantois - metabolism | Cattle | Drugs, Chinese Herbal - chemistry | Endothelium, Vascular - metabolism | Glucocorticoids - metabolism | Angiogenesis Inducing Agents - metabolism | Allantois - anatomy & histology | Dexamethasone - metabolism | Chorion - metabolism | Neovascularization, Physiologic
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4. Full Text Assessment of chemical equivalence in herbal materials using chromatographic fingerprints by combination of three similarity indices and three-dimensional kernel density estimation
by Lee, Gwang Jin and Lee, Jeong Hee and Park, Jeong Hill and Kwon, Sung Won and Lim, Johan and Lee, Sungim and Lee, Jeongmi
Analytica Chimica Acta, ISSN 0003-2670, 12/2018, Volume 1037, pp. 220 - 229
An intuitive and practical way to control chemical equivalence of secondary metabolites in herbal materials based on chromatographic fingerprints deserves a... 
Similarity analysis | Herbal materials | Secondary metabolites | Chemical equivalence | Chromatographic fingerprints | CHEMISTRY, ANALYTICAL | HPLC-DAD | RADIX | QUALITY-CONTROL | ATRACTYLODES MACROCEPHALA | TANDEM MASS-SPECTROMETRY | IDENTIFICATION | PERFORMANCE LIQUID-CHROMATOGRAPHY | DIODE-ARRAY DETECTION | RHIZOMA | COMBINED CHEMOMETRICS METHODS | Atractylodes - metabolism | Chromatography, High Pressure Liquid | Models, Statistical | Drugs, Chinese Herbal - metabolism | Atractylodes - chemistry | Herbal Medicine | Drugs, Chinese Herbal - analysis | Usage | Analysis | Chromatography | Plant metabolites
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5. Full Text A metabolite of Danshen formulae attenuates cardiac fibrosis induced by isoprenaline, via a NOX2/ROS/p38 pathway
by Yin, Qian and Lu, Haiyan and Bai, Yajun and Tian, Aiju and Yang, Qiuxiang and Wu, Jimin and Yang, Chengzhi and Fan, Tai‐Ping and Zhang, Youyi and Zheng, Xiaohui and Zheng, Xiaopu and Li, Zijian
British Journal of Pharmacology, ISSN 0007-1188, 12/2015, Volume 172, Issue 23, pp. 5573 - 5585
Background and Purpose Cardiac fibrosis is a common feature of advanced coronary heart disease and is characteristic of heart disease. However, currently... 
AQUEOUS EXTRACT | OXIDATIVE STRESS | ACTIVATION | MYOCARDIAL FIBROSIS | CONCISE GUIDE | PHARMACOLOGY | PHARMACOLOGY & PHARMACY | CELL-PROLIFERATION | DYSFUNCTION | EXPRESSION | CONTRIBUTES | Propionates - pharmacology | Propionates - metabolism | Fibrosis - drug therapy | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | NADPH Oxidases - metabolism | Drugs, Chinese Herbal - pharmacology | Male | Propionates - administration & dosage | Structure-Activity Relationship | Fibrosis - metabolism | Drugs, Chinese Herbal - metabolism | Dose-Response Relationship, Drug | Salvia miltiorrhiza - metabolism | Injections, Subcutaneous | p38 Mitogen-Activated Protein Kinases - metabolism | Drugs, Chinese Herbal - administration & dosage | Phosphorylation - drug effects | Drugs, Chinese Herbal - therapeutic use | Fibroblasts - metabolism | Animals, Newborn | Fibrosis - chemically induced | Propionates - therapeutic use | Rats | Heart Failure - metabolism | NADPH Oxidase 2 | Rats, Sprague-Dawley | Heart Failure - drug therapy | Salvia miltiorrhiza - chemistry | Animals | Signal Transduction - drug effects | Fibroblasts - drug effects | Isoproterenol - pharmacology | Heart - drug effects | Cell Proliferation - drug effects | Heart Failure - chemically induced | Oxidases | Metabolites | RNA | Collagen | Fibrosis | Resveratrol | Superoxide | Mass spectrometry | Coronary heart disease | Cardiovascular agents | Cardiovascular disease | Rodents | Themed Section | Research Papers | Research Paper
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6. Research advance in metabolism of effective ingredients from traditional Chinese medicines by probiotics
by Dai, Cheng-En and Li, Hai-Long and He, Xiao-Ping and Zheng, Fen-Fen and Zhu, Hua-Liu and Liu, Liang-Feng and Du, Wei
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, ISSN 1001-5302, 01/2018, Volume 43, Issue 1, p. 31
The pharmacological activity of active ingredients from Chinese medicine depends greatly on the microecological environment of probiotics in the human body.... 
Probiotics | Medicine, Chinese Traditional | Humans | Drugs, Chinese Herbal - metabolism
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7. Full Text An integrated view of aristolochic acid nephropathy: Update of the literature
by Jadot, Inès and Declèves, Anne-Emilie and Nortier, Joëlle and Caron, Nathalie
International Journal of Molecular Sciences, ISSN 1661-6596, 02/2017, Volume 18, Issue 2, pp. 297 - 297
The term aristolochic acid nephropathy (AAN) is used to include any form of toxic interstitial nephropathy that is caused either by ingestion of plants... 
Aristolochic acids | Renal interstitial fibrosis | Balkan endemic nephropathy | Urothelial carcinoma | Herbal remedies | ACUTE KIDNEY INJURY | UROTHELIAL CANCER | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARISTOLACTAM-DNA ADDUCTS | ORGANIC ANION TRANSPORTERS | ACUTE TUBULAR-NECROSIS | CHEMISTRY, MULTIDISCIPLINARY | renal interstitial fibrosis | CHINESE HERBS NEPHROPATHY | herbal remedies | urothelial carcinoma | RISK-FACTOR | INTERSTITIAL RENAL FIBROSIS | ENVIRONMENTAL CARCINOGEN | aristolochic acids | Balkan Nephropathy - epidemiology | Oxidative Stress | Nephritis, Interstitial - diagnosis | Humans | Cell Transformation, Neoplastic - chemically induced | Drugs, Chinese Herbal - metabolism | Aristolochic Acids - adverse effects | Nephritis, Interstitial - epidemiology | Animals | Aristolochic Acids - metabolism | Biopsy | Drugs, Chinese Herbal - chemistry | Kidney Neoplasms - etiology | Fibrosis | Nephritis, Interstitial - etiology | Aristolochic Acids - chemistry | Balkan Nephropathy - diagnosis | Balkan Nephropathy - etiology | Drugs, Chinese Herbal - adverse effects
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8. Full Text Increased ghrelin signaling prolongs survival in mouse models of human aging through activation of sirtuin1
by Fujitsuka, N and Asakawa, A and Morinaga, A and Amitani, M.S and Amitani, H and Katsuura, G and Sawada, Y and Sudo, Y and Uezono, Y and Mochiki, E and Sakata, I and Sakai, T and Hanazaki, K and Yada, T and Yakabi, K and Sakuma, E and Ueki, T and Niijima, A and Nakagawa, K and Okubo, N and Takeda, H and Asaka, M and Inui, A
Molecular Psychiatry, ISSN 1359-4184, 11/2016, Volume 21, Issue 11, pp. 1613 - 1623
Caloric restriction (CR) is known to retard aging and delay functional decline as well as the onset of diseases in most organisms. Ghrelin is secreted from the... 
RHESUS-MONKEYS | PSYCHIATRY | PROTEIN-KINASE | OLDER-ADULTS | FOOD-INTAKE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HERBAL MEDICINE | ENDOGENOUS GHRELIN | NEUROSCIENCES | GROWTH-HORMONE | CALORIC RESTRICTION | IN-VIVO | NF-KAPPA-B | Sirtuin 1 - metabolism | Ghrelin - physiology | Signal Transduction | Caloric Restriction | Hypothalamus | Drugs, Chinese Herbal - metabolism | Receptors, Ghrelin - genetics | Mice, Inbred ICR | Ghrelin - metabolism | Animals | Aging - physiology | Sirtuin 1 - physiology | Mice | Drugs, Chinese Herbal - therapeutic use | Disease Models, Animal | Aging | Ghrelin | Health aspects | Original
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9. Full Text Optimization of enzyme assisted extraction of Fructus Mori polysaccharides and its activities on antioxidant and alcohol dehydrogenase
by Deng, Qingfang and Zhou, Xin and Chen, Huaguo
Carbohydrate Polymers, ISSN 0144-8617, 10/2014, Volume 111, pp. 775 - 782
In the present study, enzyme assisted extraction of polysaccharides ( ) from using four kinds of enzymes and three compound enzymes were examined. Research... 
Fructus Mori polysaccharides | Activate alcohol dehydrogenase activity | Response surface methodology | Enzyme assisted extraction | Antioxidant activity | POLYMER SCIENCE | CHEMISTRY, ORGANIC | RESPONSE-SURFACE METHODOLOGY | COMMUNITIES | CHEMISTRY, APPLIED | MULBERRY FRUIT | Alcohol Dehydrogenase - metabolism | Glucose Oxidase - metabolism | Antioxidants - chemistry | Antioxidants - metabolism | Drugs, Chinese Herbal - pharmacology | Antioxidants - pharmacology | Enzyme Activation - drug effects | Drugs, Chinese Herbal - metabolism | Polysaccharides - pharmacology | Polysaccharides - metabolism | Antioxidants - isolation & purification | Drugs, Chinese Herbal - chemistry | Polysaccharides - isolation & purification | Polysaccharides - chemistry | Drugs, Chinese Herbal - isolation & purification | Oxidases | Antioxidants | Glucose metabolism | Polysaccharides | Analysis | Glucose | Dextrose
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10. Full Text An Integrated Approach for Studying Exposure, Metabolism, and Disposition of Multiple Component Herbal Medicines Using High-Resolution Mass Spectrometry and Multiple Data Processing Tools
by Wu, CS and Zhang, HY and Wang, CH and Qin, HL and Zhu, MS and Zhang, JL
DRUG METABOLISM AND DISPOSITION, ISSN 0090-9556, 06/2016, Volume 44, Issue 6, pp. 800 - 808
A typical prescription of traditional Chinese medicine (TCM) contains up to a few hundred prototype components. Studying their absorption, metabolism,... 
PERFORMANCE LIQUID-CHROMATOGRAPHY | IN-VITRO | MING DECOCTION XXMD | ARISTOLOCHIA-MANSHURIENSIS | THOROUGH BACKGROUND SUBTRACTION | LC/MS DATA APPLICATION | PHARMACOLOGY & PHARMACY | CHEN-HAO-TANG | DRUG METABOLITES | RAT PLASMA | INTESTINAL BACTERIA | Herbal Medicine - methods | Kidney - metabolism | Animals | Rats, Wistar | Drugs, Chinese Herbal - chemistry | Liver - metabolism | Plasma - chemistry | Rats | Medicine, Chinese Traditional - methods | Drugs, Chinese Herbal - metabolism | Mass Spectrometry - methods
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11. Full Text Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects
by Li, Yannan and Ning, Jing and Wang, Yan and Wang, Chao and Sun, Chengpeng and Huo, Xiaokui and Yu, Zhenlong and Feng, Lei and Zhang, Baojing and Tian, Xiangge and Ma, Xiaochi
Toxicology Letters, ISSN 0378-4274, 09/2018, Volume 294, pp. 27 - 36
The high risk of herb-drug interactions (HDIs) mediated by the herbal medicines and dietary supplements which containing abundant flavonoids had become more... 
Herb-drug interactions (HDIs) | Flavonoids | CYP3A4 | QSAR | SOPHORA-TONKINENSIS | ANTIBACTERIAL | RISK | PIE | HERBS | IN-VITRO | INHIBITION | CYTOCHROME-P450 ENZYMES | GRAPEFRUIT JUICE | TOXICOLOGY | PROBE | Anti-Anxiety Agents - metabolism | Cytochrome P-450 CYP3A Inhibitors - pharmacology | Diazepam - metabolism | Humans | Microsomes, Liver - metabolism | Drugs, Chinese Herbal - pharmacology | Hydroxylation - drug effects | Hepatocytes - metabolism | Drugs, Chinese Herbal - metabolism | Dietary Supplements - analysis | Diazepam - pharmacology | Hepatocytes - cytology | Diazepam - chemistry | Bufanolides - metabolism | Microsomes, Liver - drug effects | Cytochrome P-450 CYP3A Inhibitors - chemistry | Cytochrome P-450 CYP3A - chemistry | Anti-Anxiety Agents - chemistry | Microsomes, Liver - enzymology | Molecular Structure | Hepatocytes - drug effects | Quantitative Structure-Activity Relationship | Food-Drug Interactions | Cells, Cultured | Computational Biology | Anti-Anxiety Agents - pharmacology | Models, Molecular | Cytochrome P-450 CYP3A Inhibitors - metabolism | Cytochrome P-450 CYP3A - metabolism | Drugs, Chinese Herbal - chemistry | Flavonoids - metabolism | Herb-Drug Interactions | Bufanolides - chemistry | Kinetics | Flavonoids - chemistry | Analysis | Drug interactions | Cytochrome P-450 | Dietary supplements | Isoflavones | Index Medicus
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12. Full Text The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice
by Prasain, Jeevan K and Peng, Ning and Rajbhandari, Rajani and Wyss, J. Michael
Phytomedicine, ISSN 0944-7113, 12/2012, Volume 20, Issue 1, pp. 17 - 23
The incidence of type 2 diabetes and metabolic disease is rapidly increasing, but effective therapies for their prevention and treatment have been poorly... 
Glucose metabolism | Lipids | Kudzu | Pueraria lobata | Puerarin | Glucose Intolerance - metabolism | Hypolipidemic Agents - metabolism | Obesity - drug therapy | Hypoglycemic Agents - metabolism | Isoflavones - pharmacology | Drugs, Chinese Herbal - pharmacology | Isoflavones - metabolism | Male | Reference Values | Drugs, Chinese Herbal - metabolism | Adipose Tissue - metabolism | Glucose Intolerance - drug therapy | Plant Roots | Phytotherapy | Drugs, Chinese Herbal - therapeutic use | Hypoglycemic Agents - therapeutic use | Mice, Inbred C57BL | Insulin Resistance | Hypolipidemic Agents - pharmacology | Hypoglycemic Agents - pharmacology | Mice, Knockout | Obesity - metabolism | Animals | Lipid Metabolism - drug effects | Mice, Obese | Hypolipidemic Agents - therapeutic use | Isoflavones - therapeutic use | Mice | Pueraria - chemistry | Blood Glucose - metabolism | Adipose Tissue - drug effects | Dietary Supplements | Index Medicus | puerarin | lipids | glucose metabolism
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13. Full Text A systems biology approach to understanding the mechanisms of action of chinese herbs for treatment of cardiovascular disease
by Li, Bohui and Xu, Xue and Wang, Xia and Yu, Hua and Li, Xiuxiu and Tao, Weiyang and Wang, Yonghua and Yang, Ling
International Journal of Molecular Sciences, ISSN 1661-6596, 2012, Volume 13, Issue 10, pp. 13501 - 13520
Traditional Chinese Medicine (TCM) involves a broad range of empirical testing and refinement and plays an important role in the health maintenance for people... 
Adme | Cardiovascular diseases | Systems pharmacology | Traditional chinese medicine | RHIZOMA-CHUANXIONG | ADME | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | cardiovascular diseases | CORYDALIS-YANHUSUO | CHEMISTRY, MULTIDISCIPLINARY | BIOAVAILABILITY | Traditional Chinese Medicine | INHIBITION | FERULIC ACID | INFLAMMATION | THERAPEUTIC TARGET | systems pharmacology | LIGUSTICUM-CHUANXIONG | EXPRESSION | Cardiovascular Diseases - metabolism | Corydalis - metabolism | Cardiovascular Diseases - drug therapy | Humans | Drugs, Chinese Herbal - metabolism | Systems Biology | Corydalis - chemistry | Drugs, Chinese Herbal - pharmacokinetics | Metabolic Networks and Pathways | Drugs, Chinese Herbal - chemistry | Dalbergia - chemistry | Dalbergia - metabolism | Drugs, Chinese Herbal - therapeutic use
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