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Blood, ISSN 0006-4971, 08/2014, Volume 124, Issue 7, pp. 1047 - 1055
Journal Article
Journal of Clinical Pharmacology, ISSN 0091-2700, 08/2011, Volume 51, Issue 8, pp. 1152 - 1162
To increase our understanding of important subject characteristics and design variables affecting the performance of oral moxifloxacin in thorough QT studies,... 
Population pharmacokinetics | QT prolongation | exposure-response modeling | thorough QT studies | ICH E14 | moxifloxacin | WOMEN | INTERVAL PROLONGATION | TRAFFICKING | PHARMACOLOGY & PHARMACY | QT/QTC | QUINIDINE | Fluoroquinolones | Aza Compounds - pharmacokinetics | Quinolines - blood | Drugs, Investigational - adverse effects | Anti-Infective Agents - blood | United States | Humans | Middle Aged | Drugs, Investigational - pharmacokinetics | Aza Compounds - adverse effects | Male | Metabolic Clearance Rate | Quinolines - administration & dosage | Drugs, Investigational - analysis | Intestinal Absorption | Delayed-Action Preparations - administration & dosage | Quinolines - pharmacokinetics | Young Adult | Delayed-Action Preparations - pharmacokinetics | Adult | Aza Compounds - blood | Female | United States Food and Drug Administration | Aza Compounds - administration & dosage | Anti-Infective Agents - adverse effects | Administration, Oral | Electrocardiography - drug effects | Clinical Trials as Topic | Animals | Anti-Infective Agents - administration & dosage | Delayed-Action Preparations - adverse effects | Models, Biological | Anti-Infective Agents - pharmacokinetics | Adolescent | Drugs, Investigational - administration & dosage | Aged | Quinolines - adverse effects | Physiological aspects | Moxifloxacin | Research | Demographic aspects | Pharmacokinetics | Index Medicus
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 12/2002, Volume 94, Issue 24, pp. 1883 - 1888
The prescribed dose of anticancer agents is most commonly calculated using body surface area as the only independent variable, and it has been shown that this... 
TOPOISOMERASE-I INHIBITOR | INTRAVENOUS CISPLATIN | DOSE-ESCALATION | ADVANCED SOLID TUMORS | ONCOLOGY | ORAL TOPOTECAN | MATRIX-METALLOPROTEINASE INHIBITOR | SCHEDULE | CLINICAL PHARMACOKINETICS | PHASE-I | CREMOPHOR EL | Cytosine - analogs & derivatives | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Drugs, Investigational - pharmacokinetics | Cytosine - administration & dosage | Male | Paclitaxel - pharmacokinetics | Antineoplastic Agents - administration & dosage | Dose-Response Relationship, Drug | Fluorouracil - administration & dosage | Uracil - administration & dosage | Dacarbazine - analogs & derivatives | Adult | Dacarbazine - pharmacokinetics | Dioxolanes - pharmacokinetics | Female | Antineoplastic Agents - pharmacokinetics | Retrospective Studies | Body Surface Area | Paclitaxel - administration & dosage | Dacarbazine - administration & dosage | Cytosine - pharmacokinetics | Drug Administration Schedule | Docosahexaenoic Acids - administration & dosage | Docosahexaenoic Acids - pharmacokinetics | Drugs, Investigational - administration & dosage | Dioxolanes - administration & dosage | Infusions, Intravenous | Temozolomide | Fluorouracil - pharmacokinetics | Uracil - pharmacokinetics | Clinical Trials, Phase I as Topic | Uracil - analogs & derivatives | Antimitotic agents | Drug metabolism | Dosage and administration | Testolactone | Antineoplastic agents | Analysis | Studies | Medical research | Adults | History | Cancer | Index Medicus
Journal Article
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 10/2011, Volume 50, Issue 10, pp. 627 - 635
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 07/2014, Volume 54, Issue 7, pp. 792 - 799
ABSTRACTLY2605541 is a novel basal insulin analog with a prolonged duration of action. Two Phase I studies assessed LY2605541 pharmacokinetics (PK),... 
pharmacokinetics | glucodynamics | long‐acting basal insulin | long-acting basal insulin | DETEMIR | MANAGEMENT | EFFICACY | TO-TARGET TRIAL | NPH INSULIN | GLARGINE | THERAPY | PHARMACOLOGY & PHARMACY | ENDOGENOUS INSULIN | SECRETION | TYPE-1 | Drugs, Investigational - adverse effects | Humans | Middle Aged | Drugs, Investigational - pharmacokinetics | Half-Life | Insulin Lispro - pharmacokinetics | Polyethylene Glycols - adverse effects | Biological Availability | Male | Metabolic Clearance Rate | Drugs, Investigational - analysis | Insulin, Long-Acting - blood | Dose-Response Relationship, Drug | Young Adult | Hypoglycemic Agents - blood | Hypoglycemic Agents - administration & dosage | Injections, Subcutaneous | Insulin Lispro - blood | Adult | Female | Hypoglycemic Agents - pharmacokinetics | Reproducibility of Results | Blood Glucose - analysis | Insulin, Long-Acting - pharmacokinetics | Polyethylene Glycols - pharmacokinetics | Insulin Lispro - administration & dosage | Polyethylene Glycols - administration & dosage | Cross-Over Studies | Insulin, Long-Acting - adverse effects | Insulin, Long-Acting - administration & dosage | Insulin Glargine | Drugs, Investigational - administration & dosage | Insulin Lispro - adverse effects | Glucose Clamp Technique | Infusions, Intravenous | Hypoglycemic Agents - adverse effects | Cohort Studies | Usage | Half-life (Nuclear physics) | Analysis | Clinical trials | Dosage and administration | Research | Pharmacokinetics | Insulin | Index Medicus
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 01/2015, Volume 104, Issue 1, pp. 191 - 206
Transfer of knowledge along the different phases of drug development is a fundamental process in pharmaceutical research. In particular, cross-species... 
Simulations | Cross-species extrapolation | CYP enzymes | Virtual liver | Pharmacokinetic/pharmacodynamic models | First-in-man | physiologically based pharmacokinetic (PBPK) modeling | Systems pharmacology | Bioinformatics | Computational biology | First‐in‐man | Cross‐species extrapolation | Physiologically based pharmacokinetic (PBPK) modeling | ORGANIC ANION TRANSPORTER | CHEMISTRY, MEDICINAL | TRANSPLANT PATIENTS | CLINICAL PHARMACOKINETICS | CHEMISTRY, MULTIDISCIPLINARY | Pharmacokinetic | P-GLYCOPROTEIN | HEPATIC BIOTRANSFORMATION | CYCLOSPORINE-A | PRECLINICAL PHARMACOKINETICS | VITRO-IN-VIVO | TISSUE DISTRIBUTION | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | pharmacodynamic models | Gene Expression Regulation, Enzymologic - drug effects | Drugs, Investigational - pharmacology | Liver - enzymology | Species Specificity | Humans | Drugs, Investigational - pharmacokinetics | Cytochrome P-450 Enzyme System - metabolism | Drugs, Investigational - metabolism | Gene Expression Profiling | Liver - drug effects | Drug Evaluation, Preclinical - methods | Specific Pathogen-Free Organisms | Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Computational Biology | Pharmacology, Clinical - methods | Physiology, Comparative - methods | Organ Specificity | Gene Expression Regulation - drug effects | Animals | Models, Biological | Cytochrome P-450 Enzyme System - genetics | Liver - cytology | Germany | Physiological aspects | Pharmacists | Gene expression | Analysis | Cytochrome P-450 | Protein binding | Index Medicus
Journal Article