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1. Full Text Tear Cytokine Profiles in Dysfunctional Tear Syndrome
by Lam, Helene|Bleiden, Lauren|de Paiva, Cintia S.|Farley, William|Stern, Michael E.|Pflugfelder, Stephen C
American Journal of Ophthalmology, ISSN 0002-9394, 2009, Volume 147, Issue 2, pp. 198 - 205.e1
Purpose To compare tear cytokine and chemokine concentrations in asymptomatic control and Dysfunctional Tear syndrome (DTS) patients and determine the... 
Ophthalmology | NEUROPATHIC PAIN | MULTICENTER | WORKSHOP 2007 | SUBCOMMITTEE | KERATOCONJUNCTIVITIS SICCA | CCR5 EXPRESSION | SJOGRENS-SYNDROME | GENE-EXPRESSION | OPHTHALMOLOGY | DRY EYE DISEASE | CONJUNCTIVAL EPITHELIUM | Severity of Illness Index | Tumor Necrosis Factor-alpha - metabolism | Prospective Studies | Cytokines - metabolism | Humans | Middle Aged | Tears - metabolism | Epidermal Growth Factor - metabolism | Male | Dry Eye Syndromes - diagnosis | Interferon-gamma - metabolism | Eyelid Diseases - metabolism | Immunoenzyme Techniques | Interleukins - metabolism | Eye Proteins - metabolism | Meibomian Glands - metabolism | Dry Eye Syndromes - metabolism | Chemokine CCL3 - metabolism | Female | Surveys and Questionnaires | Chemokine CCL5 - metabolism | Chemokines - metabolism | Dry Eye Syndromes - classification | Cytokines | Epidermal growth factor | Disease | Medical treatment | Rodents | Standard deviation | Chemokines | Index Medicus | Abridged Index Medicus
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2. Full Text Distribution of Aqueous-Deficient and Evaporative Dry Eye in a Clinic-Based Patient Cohort: A Retrospective Study
by Lemp, Michael A and Crews, Leslie A and Bron, Anthony J and Foulks, Gary N and Sullivan, Benjamin D
Cornea, ISSN 0277-3740, 05/2012, Volume 31, Issue 5, pp. 472 - 478
PURPOSE:To evaluate in a general clinic-based cohort of patients with dry eye disease (DED) the distribution of patients with aqueous-deficient or evaporative... 
dry eye disease | evaporative dry eye | TearLab | meibomian gland dysfunction | aqueous dry eye | POPULATION | DIAGNOSIS | OCULAR SURFACE DISEASE | TEAR FILM | PREVALENCE | WORKSHOP 2007 | SUBCOMMITTEE | OPHTHALMOLOGY | ASSOCIATION | EPIDEMIOLOGY | Humans | Middle Aged | Eyelid Diseases - classification | Tears - metabolism | Male | Dry Eye Syndromes - diagnosis | Meibomian Glands - pathology | Aqueous Humor - metabolism | Body Water - metabolism | Dry Eye Syndromes - metabolism | Eyelid Diseases - diagnosis | Female | Retrospective Studies | Dry Eye Syndromes - classification | Cohort Studies | Diagnostic Techniques, Ophthalmological | Index Medicus
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3. Full Text Dysfunctional Tear Syndrome: A Delphi Approach to Treatment Recommendations
by Behrens, Ashley and Doyle, John J and Stern, Lee and Chuck, Roy S and McDonnell, Peter J and Azar, Dimitri T and Dua, Harminder S and Hom, Milton and Karpecki, Paul M and Laibson, Peter R and Lemp, Michael A and Meisler, David M and Castillo, Juan Murube del and OʼBrien, Terrence P and Pflugfelder, Stephen C and Rolando, Maurizio and Schein, Oliver D and Seitz, Berthold and Tseng, Scheffer C and Setten, Gysbert van and Wilson, Steven E and Yiu, Samuel C and Dysfunctional Tear Syndrome Study and Dysfunctional tear syndrome study group
Cornea, ISSN 0277-3740, 09/2006, Volume 25, Issue 8, pp. 900 - 907
PURPOSE:To develop current treatment recommendations for dry eye disease from consensus of expert advice. METHODS:Of 25 preselected international specialists... 
Dry eye therapy | Punctal plugs | Dysfunctional tear syndrome | Dry eye | Eye lubricants | Cyclosporine A | Delphi panel | Concensus | Algorithm | Steroids | cyclosporine A | CONSENSUS METHODS | dry eye therapy | SIGNS | GUIDELINES | eye lubricants | SYMPTOMS | RELIABILITY | PREVALENCE | dry eye | WOMEN | EXPERT PANELS | dysfunctional tear syndrome | punctal plugs | OPHTHALMOLOGY | steroids | concensus | SEVERITY | algorithm | DRY EYE SYNDROME | Algorithms | Delphi Technique | Dry Eye Syndromes - metabolism | Humans | Tears - metabolism | Terminology as Topic | Dry Eye Syndromes - therapy | Dry Eye Syndromes - diagnosis | Dry Eye Syndromes - classification | Diagnostic Techniques, Ophthalmological | Practice Guidelines as Topic | Index Medicus
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4. Full Text Clinical and Molecular Inflammatory Response in Sjögren Syndrome–Associated Dry Eye Patients Under Desiccating Stress
by López-Miguel, Alberto|Tesón, Marisa|Martín-Montañez, Vicente|Enríquez-de-Salamanca, Amalia|Stern, Michael E.|González-García, María J.|Calonge, Margarita
American Journal of Ophthalmology, ISSN 0002-9394, 2016, Volume 161, pp. 133 - 141.e2
Purpose To evaluate the response of the lacrimal function unit in Sjögren syndrome (SS)-associated dry eye patients exposed to 2 simulated daily life... 
Ophthalmology | INTERLEUKIN-1 | REPEATABILITY | RISK-FACTORS | SUBCOMMITTEE | MANAGEMENT | DISEASE | MATRIX-METALLOPROTEINASE-9 | OPHTHALMOLOGY | CONJUNCTIVA | PREVALENCE | TEAR CYTOKINES | Staining and Labeling - methods | Prospective Studies | Humans | Middle Aged | Stress, Physiological | Tears - metabolism | Sjogren's Syndrome - metabolism | Fluorophotometry | Environment, Controlled | Matrix Metalloproteinase 9 - metabolism | Osmolar Concentration | Interleukin 1 Receptor Antagonist Protein - metabolism | Humidity | Lacrimal Apparatus Diseases - physiopathology | Adult | Female | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Dry Eye Syndromes - physiopathology | Tears - chemistry | Sjogren's Syndrome - physiopathology | Cross-Over Studies | Lacrimal Apparatus Diseases - metabolism | Pilot Projects | Eye Proteins - metabolism | Dry Eye Syndromes - metabolism | Aged | Biological products | Air flow | Epidermal growth factor | Cytokines | Colleges & universities | Questionnaires | Eye diseases | Ligands | Automobiles | Vascular endothelial growth factor | Eye care products | Chemokines | Index Medicus | Abridged Index Medicus
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5. Full Text Analysis of Inflammatory Cytokines in the Tears of Dry Eye Patients
by Massingale, Morgan L and Li, Xiaohong and Vallabhajosyula, Maithreyi and Chen, Dongmei and Wei, Yi and Asbell, Penny A
Cornea, ISSN 0277-3740, 10/2009, Volume 28, Issue 9, pp. 1023 - 1027
PURPOSE:To determine the levels of 8 important cytokines and 1 chemokine in tears of patients with dry eye disease. METHODS:Tear samples were collected from 7... 
Inflammation | Cytokines | Dry eye disease | Real time RT-PCR | Multiplex bead immunoassays | CYCLOSPORINE OPHTHALMIC EMULSION | OCULAR SURFACE | INTERLEUKIN-6 LEVELS | SJOGRENS-SYNDROME | dry eye disease | real time RT-PCR | BEHCETS-DISEASE | WORKSHOP 2007 | SUBCOMMITTEE | KERATOCONJUNCTIVITIS SICCA | inflammation | GENE-EXPRESSION | OPHTHALMOLOGY | cytokines | CONJUNCTIVAL EPITHELIUM | Tumor Necrosis Factor-alpha - metabolism | Immunoassay | Interleukin-8 - genetics | Gene Expression | Humans | Middle Aged | Tumor Necrosis Factor-alpha - genetics | Tears - metabolism | Interferon-gamma - metabolism | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Interleukins - metabolism | Interleukins - genetics | Eye Proteins - metabolism | Dry Eye Syndromes - metabolism | Adult | Aged | Eye Proteins - genetics | Interleukin-8 - metabolism | Dry Eye Syndromes - classification | Index Medicus
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6. Full Text Lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease: Results of the OPUS-1 phase 3 study
by Sheppard, John D and Torkildsen, Gail L and Lonsdale, John D and D'Ambrosio Jr, Francis A and McLaurin, Eugene B and Eiferman, Richard A and Kennedy, Kathryn S and Semba, Charles P and OPUS 1 Study Grp and OPUS-1 Study Group
Ophthalmology, ISSN 0161-6420, 02/2014, Volume 121, Issue 2, pp. 475 - 483
Purpose To assess the efficacy and safety of lifitegrast ophthalmic solution 5.0% compared with placebo in subjects with dry eye disease. Design Prospective,... 
ANTAGONIST SAR 1118 | LFA-1 | EFFICACY | SAFETY | SIGNS | OCULAR SURFACE DISEASE | OPHTHALMOLOGY | SYMPTOMS | ICAM-1 | SJOGRENS | Prospective Studies | Phenylalanine - adverse effects | Phenylalanine - analogs & derivatives | Humans | Middle Aged | Sulfones - adverse effects | Male | Fluorometry | Lissamine Green Dyes - metabolism | Conjunctiva - metabolism | Young Adult | Aged, 80 and over | Ophthalmic Solutions | Adult | Female | Double-Blind Method | Dry Eye Syndromes - physiopathology | Dry Eye Syndromes - drug therapy | Treatment Outcome | Lymphocyte Function-Associated Antigen-1 - drug effects | Cornea - metabolism | Dry Eye Syndromes - metabolism | Staining and Labeling | Aged | Phenylalanine - administration & dosage | Administration, Topical | Fluorescein - metabolism | Sulfones - administration & dosage | Index Medicus
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7. Full Text Tear Cathepsin S as a Candidate Biomarker for Sjögren's Syndrome
by Hamm‐Alvarez, Sarah F and Janga, Srikanth R and Edman, Maria C and Madrigal, Sara and Shah, Mihir and Frousiakis, Starleen E and Renduchintala, Kavita and Zhu, Jay and Bricel, Seth and Silka, Kimberly and Bach, Dianne and Heur, Martin and Christianakis, Stratos and Arkfeld, Daniel G and Irvine, John and Mack, Wendy J and Stohl, William
Arthritis & Rheumatology, ISSN 2326-5191, 07/2014, Volume 66, Issue 7, pp. 1872 - 1881
Objective. The diagnosis of Sjogren's syndrome (SS) in routine practice is largely a clinical one and requires a high index of suspicion by the treating... 
MALE NOD MOUSE | AUTOANTIBODIES | LACRIMAL GLANDS | AUTOIMMUNITY | DRY EYE | DISEASE | INVARIANT CHAIN | RHEUMATOLOGY | CLASSIFICATION CRITERIA | MHC CLASS-II | CLINICAL-SIGNIFICANCE | Dry Eye Syndromes - immunology | Antibodies, Antinuclear - immunology | Humans | Middle Aged | Lupus Erythematosus, Systemic - metabolism | Sjogren's Syndrome - immunology | Tears - metabolism | Dry Eye Syndromes - diagnosis | Sjogren's Syndrome - metabolism | Blepharitis - diagnosis | Lupus Erythematosus, Systemic - immunology | Adult | Female | Biomarkers - metabolism | Blepharitis - immunology | Diagnosis, Differential | Blepharitis - metabolism | Lupus Erythematosus, Systemic - diagnosis | Animals | Cathepsins - metabolism | Sjogren's Syndrome - diagnosis | Dry Eye Syndromes - metabolism | Mice, Inbred NOD | Aged | Mice | Index Medicus | Abridged Index Medicus
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8. Full Text IL-17 disrupts corneal barrier following desiccating stress
by De Paiva, C.S and Chotikavanich, S and Pangelinan, S.B and Pitcher, J.D and Fang, B and Zheng, X and Ma, P and Farley, W.J and Siemasko, K.F and Niederkorn, J.Y and Stern, M.E and Li, D.-Q and Pflugfelder, S.C
Mucosal Immunology, ISSN 1933-0219, 05/2009, Volume 2, Issue 3, pp. 243 - 253
T helper (Th)-17 is a recently identified subtype of Th response that has been implicated in host defense and autoimmunity. We investigated whether there is... 
OCULAR SURFACE | KERATOCONJUNCTIVITIS SICCA | EPITHELIAL-CELLS | EXPERIMENTAL DRY EYE | SJOGRENS-SYNDROME | HOST-DEFENSE | IL-17-DEFICIENT MICE | IMMUNOLOGY | INFLAMMATORY CYTOKINES | T-CELLS | TH17 CELLS | Eye - pathology | Humans | Middle Aged | Cornea - immunology | Interleukin-17 - immunology | Interleukin-17 - physiology | Male | Epithelium, Corneal - pathology | Conjunctiva - metabolism | Young Adult | Dry Eye Syndromes - pathology | Conjunctiva - pathology | Matrix Metalloproteinase 9 - metabolism | Eye - immunology | T-Lymphocytes, Helper-Inducer - immunology | Scopolamine Hydrobromide | Aged, 80 and over | Adult | Female | Cornea - pathology | Epithelium, Corneal - immunology | Cytokines - immunology | Eye - metabolism | Promoter Regions, Genetic | T-Lymphocytes, Helper-Inducer - metabolism | Conjunctiva - immunology | Cytokines - metabolism | Mice, Inbred C57BL | Matrix Metalloproteinase 3 - metabolism | Mice, Knockout | Cornea - metabolism | Animals | Dry Eye Syndromes - metabolism | Dry Eye Syndromes - chemically induced | Epithelium, Corneal - metabolism | Aged | Mice | Index Medicus
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9. Full Text Analysis of Th17-associated cytokines and clinical correlations in patients with dry eye disease
by Liu, Rongjun and Gao, Caifeng and Chen, Huijin and Li, Yaxin and Jin, Ying and Qi, Hong
PLoS ONE, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0173301 - e0173301
We aimed to investigate the expressions of three Th17-associated cytokines, interleukin (IL)-17A, IL-6 and IL-23, in protein and mRNA levels and their... 
TEARS | INTERLEUKIN-17 | SIGNS | MULTIDISCIPLINARY SCIENCES | PATHOGENIC T(H)17 CELLS | SYMPTOMS | DIAGNOSTIC-TESTS | DIFFERENTIATION | SJOGREN-SYNDROME | Biomarkers - metabolism | Cytokines - metabolism | Humans | Middle Aged | Tears - metabolism | Sjogren's Syndrome - metabolism | RNA, Messenger - metabolism | Case-Control Studies | Conjunctiva - metabolism | Cornea - metabolism | Interleukin-17 - metabolism | Interleukin-23 - metabolism | Th17 Cells - metabolism | Dry Eye Syndromes - metabolism | Female | Aged | Interleukin-6 - metabolism | Fluorescein - metabolism | Eye diseases | Care and treatment | Genetic aspects | Research | Interleukins | Gene expression | Pathogenesis | Chains (polymeric) | Assaying | Metastases | Eye | Proteins | Signal transduction | Histopathology | Surgery | Classification | Tubes | Eye (anatomy) | Breakup | Bioindicators | Diagnosis | Public health | Antigens | Bovine serum albumin | Evaluation | Cytokines | Interleukin 12 | Time measurement | Epithelium | Patients | Interleukin 17 | Studies | Hospitals | Biomarkers | Collection | Infiltration | Colitis | Cornea | Sjogren's syndrome | Conferences | Transforming growth factor-b | Glands | Antibodies | Staining | Clinical trials | Scoring | mRNA | Infections | Tissues | Inflammatory diseases | Interleukin 6 | Biomedical materials | Lymphocytes | Rodents | Quality | Interleukin 1 | Tumor necrosis factor-TNF | Children | Rubber | Interleukin 8 | Hypertension | Desiccants | Diabetes mellitus | Inflammation | Evaporation | Chronic fatigue syndrome | CD4 antigen | Blindness | In vivo methods and tests | Differentiation | Index Medicus
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10. Full Text Dry Eye Exacerbation in Patients Exposed to Desiccating Stress under Controlled Environmental Conditions
by López-Miguel, Alberto|Tesón, Marisa|Martín-Montañez, Vicente|Enríquez-de-Salamanca, Amalia|Stern, Michael E.|Calonge, Margarita|González-García, María J
American Journal of Ophthalmology, ISSN 0002-9394, 2014, Volume 157, Issue 4, pp. 788 - 798.e2
Purpose To determine if controlled environmental conditions can induce acute exacerbations of signs and symptoms in dry eye and asymptomatic subjects. Design... 
Ophthalmology | SICK BUILDING SYNDROME | DESIGN | HUMIDITY | DYSFUNCTIONAL TEAR SYNDROME | OCULAR SURFACE DISEASE | BREAK-UP | MATRIX-METALLOPROTEINASE-9 | SCALES | OPHTHALMOLOGY | CYTOKINE | RELIABILITY | Phenolsulfonphthalein | Prospective Studies | Cross-Sectional Studies | Tears - chemistry | Coloring Agents | Humans | Middle Aged | Stress, Physiological | Fluorescent Dyes - metabolism | Tears - metabolism | Male | Dry Eye Syndromes - diagnosis | Environment, Controlled | Conjunctiva - metabolism | Cornea - metabolism | Osmolar Concentration | Eye Proteins - metabolism | Dry Eye Syndromes - metabolism | Humidity | Female | Surveys and Questionnaires | Dry Eye Syndromes - etiology | Fluorescein - metabolism | Environmental quality | Epidermal growth factor | Cytokines | Colleges & universities | Questionnaires | Eye diseases | Ligands | Vascular endothelial growth factor | Patients | Chemokines | Index Medicus | Abridged Index Medicus
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11. Full Text Proinflammatory cytokine profiling of tears from dry eye patients by means of antibody microarrays
by Boehm, Nils and Riechardt, Aline I and Wiegand, Michaela and Pfeiffer, Norbert and Grus, Franz H
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 09/2011, Volume 52, Issue 10, pp. 7725 - 7730
PURPOSE. In the pathogenesis of keratoconjunctivitis sicca, immune processes are thought to play an important role. However, the exact details of the... 
OCULAR SURFACE | LIPID LAYER | DESICCATING STRESS | WORKSHOP 2007 | FILM | DISEASE | SJOGRENS-SYNDROME | OPHTHALMOLOGY | PROTEIN-PATTERNS | CONJUNCTIVA | INFLAMMATORY CYTOKINES | Tumor Necrosis Factor-alpha - metabolism | Tears - chemistry | Humans | Middle Aged | Child, Preschool | Tears - metabolism | Infant | Male | Interferon-gamma - metabolism | Young Adult | Eye Proteins - metabolism | Interleukin-1beta - metabolism | Dry Eye Syndromes - metabolism | Adolescent | Protein Array Analysis | Adult | Female | Aged | Child | Dry Eye Syndromes - classification | Interleukin-6 - metabolism | Index Medicus
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12. Full Text Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome
by Lam, SM and Tong, L and Reux, B and Duan, XR and Petznick, A and Yong, SS and Khee, CBS and Lear, MJ and Wenk, MR and Shui, GH
JOURNAL OF LIPID RESEARCH, ISSN 0022-2275, 02/2014, Volume 55, Issue 2, pp. 299 - 306
As current diagnostic markers for dry eye syndrome (DES) are lacking in both sensitivity and specificity, a pressing concern exists to develop activity markers... 
TESTS | PROTEIN | PRINCIPAL COMPONENT ANALYSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEIBOMIAN GLAND DYSFUNCTION | meibum | WAX | WORKSHOP 2007 | SUBCOMMITTEE | SPECTROSCOPY | tear lipidome | CHRONIC BLEPHARITIS | DISEASE | wax esters | mass spectrometry | Meibomian Glands - physiopathology | Lipids - chemistry | Fatty Acids - chemistry | Molecular Weight | Dry Eye Syndromes - physiopathology | Meibomian Glands - metabolism | Dry Eye Syndromes - metabolism | Humans | Tears - metabolism | Lipid Metabolism | Index Medicus
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13. Full Text Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics
by Zhou, Lei and Beuerman, Roger W and Choi, Mun Chan and Shao, Zhen Zhao and Xiao, Rong Li and Yang, He and Tong, Louis and Liu, Shouping and Stern, Michael E and Tan, Donald
Journal of Proteome Research, ISSN 1535-3893, 11/2009, Volume 8, Issue 11, pp. 4889 - 4905
The proteins found in tears have an important role in the maintenance of the ocular surface and changes in the quality and quantity of tear components reflect... 
iTRAQ | Biomarker | Quantitative proteomics | Tear proteomics | Dry eye | OCULAR SURFACE | tear proteomics | BIOCHEMICAL RESEARCH METHODS | PATTERNS | PREVALENCE | biomarker | MASS-SPECTROMETRY | WORKSHOP 2007 | ELECTROPHORESIS | DISEASE | S100A4 | EXPRESSION | quantitative proteomics | CALCIUM-BINDING PROTEIN | Amino Acid Sequence | Tears - chemistry | Humans | Middle Aged | Biomarkers - analysis | Molecular Sequence Data | Male | Chromatography, High Pressure Liquid | Dry Eye Syndromes - diagnosis | Eye Proteins - analysis | Young Adult | Tandem Mass Spectrometry | Dry Eye Syndromes - metabolism | Adolescent | Aged, 80 and over | Adult | Female | ROC Curve | Aged | Eye Proteins - genetics | Proteomics - methods | Index Medicus
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