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1. Full Text An objective approach to dry eye disease severity
by Sullivan, Benjamin D and Whitmer, Diane and Nichols, Kelly K and Tomlinson, Alan and Foulks, Gary N and Geerling, Gerd and Pepose, Jay S and Kosheleff, Valerie and Porreco, Allison and Lemp, Michael A
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 12/2010, Volume 51, Issue 12, pp. 6125 - 6130
PURPOSE. A prospective, multisite clinical study (10 sites in the European Union and the United States) evaluated the clinical utility of commonly used tests... 
OCULAR SURFACE | CORNEAL | DIAGNOSIS | SECRETIONS | ANDROGEN DEFICIENCY | OPHTHALMOLOGY | HUMAN MEIBOMIAN GLAND | TEAR FILM | INDEX | OSMOLARITY | Severity of Illness Index | Prospective Studies | Dry Eye Syndromes - physiopathology | Tears - chemistry | Humans | Middle Aged | Male | Dry Eye Syndromes - diagnosis | Disease Progression | Young Adult | Osmolar Concentration | Adolescent | Aged, 80 and over | Biomarkers | Adult | Female | Aged | Dry Eye Syndromes - classification | Index Medicus
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2. Full Text Corneal nerve structure and function in patients with non-sjögren dry eye: Clinical correlations
by Labbé, Antoine and Liang, Qingfeng and Wang, Zhiqun and Zhang, Yang and Xu, Liang and Baudouin, Christophe and Sun, Xuguang
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 2013, Volume 54, Issue 8, pp. 5144 - 5150
PURPOSE. To evaluate the relationship between the in vivo confocal microscopic (IVCM) morphology of subbasal corneal nerves, corneal sensitivity, and clinical... 
Sensitivity | Non-sjögren dry eye | Dry eye | In vivo confocal microscopy | OCULAR SURFACE | non-Sjogren dry eye | VIVO CONFOCAL MICROSCOPY | LASER-SCANNING MICROSCOPY | INNERVATION | in vivo confocal microscopy | dry eye | WORKSHOP 2007 | SUBCOMMITTEE | DISEASE | OPHTHALMOLOGY | sensitivity | SUBSTANCE-P | MORPHOLOGY | Ophthalmic Nerve - physiopathology | Sensation - physiology | Dry Eye Syndromes - physiopathology | Follow-Up Studies | Humans | Middle Aged | Male | Sjogren's Syndrome | Dry Eye Syndromes - pathology | Microscopy, Confocal | Nerve Fibers - physiology | Ophthalmic Nerve - pathology | Adult | Cornea - innervation | Female | Aged | Cornea - physiopathology | Retrospective Studies | Index Medicus
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3. Full Text Impact of Dry Eye Syndrome on Vision-Related Quality of Life
by Miljanović, Biljana, MD, MPH, MSc|Dana, Reza, MD, MPH, MSc|Sullivan, David A., PhD|Schaumberg, Debra A., ScD, OD, MPH
American Journal of Ophthalmology, ISSN 0002-9394, 2007, Volume 143, Issue 3, pp. 409 - 415.e2
Purpose To evaluate the impact of dry eye syndrome (DES) on vision-associated quality of life. Design Cross-sectional study. Methods We identified 450... 
Ophthalmology | SAMPLE | CONTRAST SENSITIVITY | REPEATABILITY | LOW-DOSE ASPIRIN | CARDIOVASCULAR-DISEASE | OPHTHALMOLOGY | FUNCTIONAL VISUAL-ACUITY | PREVALENCE | BURDEN | PRIMARY PREVENTION | WOMENS HEALTH | Disability Evaluation | Women's Health | Cross-Sectional Studies | Double-Blind Method | Dry Eye Syndromes - physiopathology | Sickness Impact Profile | Humans | Middle Aged | Activities of Daily Living | Vision Disorders - physiopathology | Health Personnel | Aged, 80 and over | Quality of Life | Adult | Female | Surveys and Questionnaires | Aged | Odds Ratio | Dry Eye Syndromes - complications | Vision Disorders - etiology | Hypertension | Confidence intervals | Mens health | Health Insurance Portability & Accountability Act 1996-US | Family income | Womens health | Cardiovascular disease | Standard deviation | Diabetes | Health risk assessment | Eyes & eyesight | Age | Index Medicus | Abridged Index Medicus
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4. Full Text Neuropathic Ocular Pain due to Dry Eye Is Associated With Multiple Comorbid Chronic Pain Syndromes
by Galor, Anat|Covington, Derek|Levitt, Alexandra E.|McManus, Katherine T.|Seiden, Benjamin|Felix, Elizabeth R.|Kalangara, Jerry|Feuer, William|Patin, Dennis J.|Martin, Eden R.|Sarantopoulos, Konstantinos D.|Levitt, Roy C
Journal of Pain, ISSN 1526-5900, 2016, Volume 17, Issue 3, pp. 310 - 318
Abstract Recent data show that dry eye (DE) susceptibility and other chronic pain syndromes (CPS) such as chronic widespread pain, irritable bowel syndrome,... 
Anesthesia & Perioperative Care | Pain Medicine | chronic overlapping pain syndromes | neuropathic pain | allodynia | chronic pain | neuropathic ocular pain | Dry eye symptoms | comorbid pain syndromes | hyperalgesia | central pain syndromes | OF-FUNCTION MUTATION | DEPRESSION | CENTRAL SENSITIZATION | STATES | DISORDERS | SYMPTOMS | NEUROSCIENCES | CLINICAL NEUROLOGY | CENTRAL SENSITIVITY SYNDROMES | FIBROMYALGIA | CORNEAL SENSITIVITY | OVERLAPPING CONDITIONS | Dry Eye Syndromes - physiopathology | Comorbidity | Humans | Middle Aged | Male | Dry Eye Syndromes - diagnosis | Syndrome | Chronic Pain - epidemiology | Dry Eye Syndromes - epidemiology | Female | Aged | Neuralgia - diagnosis | Chronic Pain - physiopathology | Neuralgia - physiopathology | Neuralgia - epidemiology | Pain Measurement | Cohort Studies | Care and treatment | Pain | Depression, Mental | Analysis | Irritable bowel syndrome | Post-traumatic stress disorder | Chronic pain | Medical research | Medicine, Experimental | Index Medicus | dry eye symptoms
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5. Full Text Role of Hyperosmolarity in the Pathogenesis and Management of Dry Eye Disease: Proceedings of the OCEAN Group Meeting
by Baudouin, Christophe, MD, PhD|Aragona, Pasquale, MD, PhD|Messmer, Elisabeth M., MD, PhD, FEBO|Tomlinson, Alan, PhD, DSc, FCOptom|Calonge, Margarita, MD, PhD|Boboridis, Kostas G., MD, PhD, FEBO|Akova, Yonca A., MD|Geerling, Gerd, MD, PhD, FEBO|Labetoulle, Marc, MD, PhD|Rolando, Maurizio, MD
Ocular Surface, The, ISSN 1542-0124, 2013, Volume 11, Issue 4, pp. 246 - 258
Abstract Dry eye disease (DED), a multifactorial disease of the tears and ocular surface, is common and has a significant impact on quality of life. Reduced... 
Ophthalmology | osmoregulation | osmoprotection | dry eye disease | L-carnitine | tear hyperosmolarity | compatible solutes | tear film instability | erythritol | Compatible solutes | Osmoprotection | Tear hyperosmolarity | Osmoregulation | Dry eye disease | Tear film instability | Erythritol | L-CARNITINE | ISOTONIC SOLUTIONS | KERATOCONJUNCTIVITIS SICCA | CORNEAL EPITHELIAL-CELLS | OCULAR SURFACE DISEASE | ELECTRICAL-IMPEDANCE | OPHTHALMOLOGY | SODIUM HYALURONATE | ORGANIC OSMOLYTES | TEAR FILM OSMOLARITY | TREHALOSE PROTECTS | Osmolar Concentration | Dry Eye Syndromes - physiopathology | Humans | Osmoregulation - physiology | Dry Eye Syndromes - therapy | Tears - physiology | Goblet Cells - pathology | Dry Eye Syndromes - etiology | Goblet Cells - metabolism | Index Medicus
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6. Full Text Lifitegrast ophthalmic solution 5.0% versus placebo for treatment of dry eye disease results of the randomized phase III OPUS-2 study
by Tauber, Joseph and Karpecki, Paul and Latkany, Robert and Luchs, Jodi and Martel, Joseph and Sall, Kenneth and Raychaudhuri, Aparna and Smith, Valerie and Semba, Charles P and OPUS- 2 Investigators and OPUS-2 Investigators
Ophthalmology, ISSN 0161-6420, 12/2015, Volume 122, Issue 12, pp. 2423 - 2431
Purpose Lifitegrast is an integrin antagonist that decreases T-cell-mediated inflammation associated with dry eye disease (DED). We report the results of... 
OPHTHALMOLOGY | SYMPTOMS | ANTAGONIST SAR 1118 | QUESTIONNAIRE | SIGNS | SEVERITY | Prospective Studies | Double-Blind Method | Dry Eye Syndromes - physiopathology | Phenylalanine - analogs & derivatives | Dry Eye Syndromes - drug therapy | Humans | Middle Aged | Visual Analog Scale | Male | Treatment Outcome | Lymphocyte Function-Associated Antigen-1 - drug effects | Young Adult | Cornea - drug effects | Aged, 80 and over | Ophthalmic Solutions | Adult | Female | Aged | Cornea - physiopathology | Tears - physiology | Phenylalanine - administration & dosage | Visual Acuity - physiology | Sulfones - administration & dosage | Index Medicus
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7. Full Text Corneal mechanical thresholds negatively associate with dry eye and ocular pain symptoms
by Spierer, Oriel and Felix, Elizabeth R and McClellan, Allison L and Parel, Jean Marie and Gonzalez, Alex and Feuer, William J and Sarantopoulos, Constantine D and Levitt, Roy C and Ehrmann, Klaus and Galor, Anat
Investigative Ophthalmology and Visual Science, ISSN 0146-0404, 02/2016, Volume 57, Issue 2, pp. 617 - 625
PURPOSE. To examine associations between corneal mechanical thresholds and metrics of dry eye. METHODS. This was a cross-sectional study of individuals seen in... 
Mechanical thresholds | Ocular pain | Dry eye | Aesthesiometer | mechanical thresholds | POSTTRAUMATIC-STRESS-DISORDER | CONFOCAL MICROSCOPY | STIMULATION | ocular pain | SJOGRENS-SYNDROME | SENSITIVITY | VALIDATION | dry eye | NERVE MORPHOLOGY | NEUROPATHIC PAIN | SURFACE DISEASE | OPHTHALMOLOGY | QUALITY-OF-LIFE | aesthesiometer | Eye Pain - metabolism | Eye Pain - physiopathology | Pain Threshold - physiology | Cross-Sectional Studies | Dry Eye Syndromes - physiopathology | Humans | Middle Aged | Tears - metabolism | Male | Biomechanical Phenomena | Dry Eye Syndromes - metabolism | Aged, 80 and over | Eye Pain - etiology | Adult | Female | Surveys and Questionnaires | Aged | Cornea - physiopathology | Retrospective Studies | Dry Eye Syndromes - complications | Index Medicus | Clinical and Epidemiologic Research
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8. Full Text Short-term Consumption of Oral Omega-3 and Dry Eye Syndrome
by Kangari, Haleh, OD, PhD|Eftekhari, Mohammad Hossein, MD|Sardari, Sara, MSc|Hashemi, Hassan, MD|Salamzadeh, Jamshid, PhD|Ghassemi-Broumand, Mohammad, MD|Khabazkhoob, Mehdi, MSc
Ophthalmology, ISSN 0161-6420, 2013, Volume 120, Issue 11, pp. 2191 - 2196
Purpose To assess the effect of oral omega-3 fatty acids on tear break-up time (TBUT), Schirmer’s score, and Ocular Surface Disease Index (OSDI) through a... 
Ophthalmology | POPULATION | RISK-FACTORS | DISEASE | SJOGRENS-SYNDROME | OPHTHALMOLOGY | FATTY-ACIDS | CHINESE | PREVALENCE | Double-Blind Method | Dry Eye Syndromes - physiopathology | Administration, Oral | Dry Eye Syndromes - drug therapy | Humans | Middle Aged | Male | Eicosapentaenoic Acid - administration & dosage | Docosahexaenoic Acids - administration & dosage | Capsules | Aged, 80 and over | Female | Surveys and Questionnaires | Aged | Tears - physiology | Fatty Acids, Omega-3 - administration & dosage | Eye diseases | Consumption data | Fatty acids | Index Medicus
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9. Full Text Clinical and Molecular Inflammatory Response in Sjögren Syndrome–Associated Dry Eye Patients Under Desiccating Stress
by López-Miguel, Alberto|Tesón, Marisa|Martín-Montañez, Vicente|Enríquez-de-Salamanca, Amalia|Stern, Michael E.|González-García, María J.|Calonge, Margarita
American Journal of Ophthalmology, ISSN 0002-9394, 2016, Volume 161, pp. 133 - 141.e2
Purpose To evaluate the response of the lacrimal function unit in Sjögren syndrome (SS)-associated dry eye patients exposed to 2 simulated daily life... 
Ophthalmology | INTERLEUKIN-1 | REPEATABILITY | RISK-FACTORS | SUBCOMMITTEE | MANAGEMENT | DISEASE | MATRIX-METALLOPROTEINASE-9 | OPHTHALMOLOGY | CONJUNCTIVA | PREVALENCE | TEAR CYTOKINES | Staining and Labeling - methods | Prospective Studies | Humans | Middle Aged | Stress, Physiological | Tears - metabolism | Sjogren's Syndrome - metabolism | Fluorophotometry | Environment, Controlled | Matrix Metalloproteinase 9 - metabolism | Osmolar Concentration | Interleukin 1 Receptor Antagonist Protein - metabolism | Humidity | Lacrimal Apparatus Diseases - physiopathology | Adult | Female | Interleukin-8 - metabolism | Interleukin-6 - metabolism | Dry Eye Syndromes - physiopathology | Tears - chemistry | Sjogren's Syndrome - physiopathology | Cross-Over Studies | Lacrimal Apparatus Diseases - metabolism | Pilot Projects | Eye Proteins - metabolism | Dry Eye Syndromes - metabolism | Aged | Biological products | Air flow | Epidermal growth factor | Cytokines | Colleges & universities | Questionnaires | Eye diseases | Ligands | Automobiles | Vascular endothelial growth factor | Eye care products | Chemokines | Index Medicus | Abridged Index Medicus
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10. Full Text Comparison of dry eye and corneal sensitivity between small incision lenticule extraction and femtosecond LASIK for myopia
by Li, Meiyan and Zhao, Jing and Shen, Yang and Li, Tao and He, L and Xu, Hailin and Yu, Yongfu and Zhou, Xingtao
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 10, pp. e77797 - e77797
Purpose: To investigate the changes in dry eye symptoms and clinical signs and corneal sensitivity after small incision lenticule extraction (SMILE) and... 
OCULAR SURFACE | IN-SITU KERATOMILEUSIS | HINGE POSITION | NEUROTROPHIC EPITHELIOPATHY | LASER | MULTIDISCIPLINARY SCIENCES | DISEASE | REFRACTIVE SURGERY | SENSATION | SMILE | Surgical Flaps | Prognosis | Prospective Studies | Sensation - physiology | Dry Eye Syndromes - physiopathology | Follow-Up Studies | Humans | Male | Case-Control Studies | Lasers, Excimer | Myopia - physiopathology | Fluorescein | Adult | Female | Cornea - physiopathology | Myopia - surgery | Keratomileusis, Laser In Situ | Medicine, Experimental | Medical research | Eye diseases | Comparative analysis | Femtosecond | Cataracts | Cornea | Stability | Myopia | Staining | Epidemiology | Patients | Eye | Confidence intervals | Tearing | Sensitivity | Hospitals | Lasers | Surgery | Anesthesia | Eye (anatomy) | Index Medicus
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11. Full Text Relationship Between Dry Eye Symptoms and Pain Sensitivity
by Vehof, Jelle and Kozareva, Diana and Hysi, Pirro G and Harris, Juliette and Nessa, Ayrun and Williams, Frances K and Bennett, David L. H and McMahon, Steve B and Fahy, Samantha J and Direk, Kenan and Spector, Tim D and Hammond, Christopher J
JAMA Ophthalmology, ISSN 2168-6165, 10/2013, Volume 131, Issue 10, pp. 1304 - 1308
IMPORTANCE Dry eye disease (DED) is common, but little is known about factors contributing to symptoms of dry eye, given the poor correlation between these... 
POPULATION | REPEATABILITY | WORKSHOP 2007 | STIMULATION | DISEASE | SJOGRENS-SYNDROME | BREAK-UP | OPHTHALMOLOGY | DRYNESS SENSATIONS | CORNEAL SENSITIVITY | TWIN | Pain Threshold - physiology | Diseases in Twins - diagnosis | Diseases in Twins - genetics | Cross-Sectional Studies | Dry Eye Syndromes - physiopathology | Humans | Hyperesthesia - genetics | Middle Aged | Dry Eye Syndromes - genetics | Dry Eye Syndromes - diagnosis | Hot Temperature | Hyperesthesia - physiopathology | Young Adult | Diseases in Twins - physiopathology | Pain - genetics | Pain - physiopathology | Aged, 80 and over | Adult | Female | Surveys and Questionnaires | Aged | Hyperesthesia - diagnosis | Twins | Pain - diagnosis | Sensory stimulation | Dry eye syndromes | Care and treatment | Usage | Diagnosis | Index Medicus | Abridged Index Medicus
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12. Full Text Dry eye symptoms align more closely to non-ocular conditions than to tear film parameters
by Galor, Anat and Felix, Elizabeth R and Feuer, William and Shalabi, Nabeel and Martin, Eden R and Margolis, Todd P and Sarantopoulos, Constantine D and Levitt, Roy C
British Journal of Ophthalmology, ISSN 0007-1161, 08/2015, Volume 99, Issue 8, pp. 1126 - 1129
ObjectiveTo evaluate the relationship between dry eye symptoms, non-ocular conditions and tear film parameters.MethodsDesign: Cross-sectional study.... 
POSTTRAUMATIC-STRESS-DISORDER | CONTROLLED-TRIAL | DEPRESSION | POPULATION | RISK-FACTORS | PAIN | DISEASE | VETERANS | OPHTHALMOLOGY | PHOTOREFRACTIVE KERATECTOMY | GABAPENTIN | Prospective Studies | Cross-Sectional Studies | Dry Eye Syndromes - physiopathology | Outcome Assessment (Health Care) | Tears - chemistry | Humans | Middle Aged | Depressive Disorder - diagnosis | Male | Dry Eye Syndromes - diagnosis | Stress Disorders, Post-Traumatic - physiopathology | Pain - physiopathology | Depressive Disorder - physiopathology | Stress Disorders, Post-Traumatic - diagnosis | Quality of Life | Female | Surveys and Questionnaires | Aged | Pain Measurement | Pain - diagnosis | Dry eye syndromes | Diagnosis | Depression, Mental | Post-traumatic stress disorder | Studies | Pain | Post traumatic stress disorder | Questionnaires | Mental depression | Automobiles | Patients | Eye care products | Index Medicus
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13. Full Text Fluctuations of corneal sensitivity in dry eye syndromes - A longitudinal pilot study
by Nepp, Johannes and Wirth, Magdalena
Cornea, ISSN 0277-3740, 07/2015, Volume 34, Issue 10, pp. 1221 - 1226
Purpose:The aim of this study was to observe corneal sensitivity (CoS) longitudinally in patients with dry eye and to evaluate the correlation between CoS,... 
longitudinal observation | dry eye syndromes | corneal sensitivity | etiology | CLASSIFICATION | SYMPTOMS | PREVALENCE | LASIK | CONJUNCTIVAL | DISEASE | OPHTHALMOLOGY | RETINOPATHY | SENSATION | Staining and Labeling - methods | Hypesthesia - physiopathology | Prospective Studies | Dry Eye Syndromes - physiopathology | Follow-Up Studies | Tears - chemistry | Humans | Middle Aged | Male | Corneal Diseases - physiopathology | Pilot Projects | Female | Cornea - physiopathology | Dry Eye Syndromes - etiology | Corneal Diseases - complications | Diagnostic Techniques, Ophthalmological | Hypesthesia - complications | Index Medicus
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