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Journal of Cancer Research and Therapeutics, ISSN 0973-1482, 03/2018, Volume 14, Issue 8, pp. S72 - S78
Journal Article
Mucosal Immunology, ISSN 1933-0219, 05/2015, Volume 8, Issue 3, pp. 505 - 515
Mitogen-activated protein kinase (MAPK) phosphatases are dual-specificity phosphatases (DUSPs) that dephosphorylate phosphothreonine and phosphotyrosine... 
INACTIVATION | RESPONSES | PROTEIN PHOSPHATASES | ACTIVATION | DIFFERENTIATION | IMMUNOLOGY | INTERLEUKIN-10-DEFICIENT MICE | MAPK PHOSPHATASES | EXPRESSION | ERK | ENTEROCOLITIS | Th1 Cells - pathology | Dual Specificity Phosphatase 6 - genetics | Cell Proliferation | Diphenylamine - pharmacology | Colitis - genetics | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Immunity, Mucosal | Interleukin-17 - immunology | Colitis - pathology | Colon - immunology | Th1 Cells - immunology | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Diphenylamine - analogs & derivatives | Mitogen-Activated Protein Kinase 1 - genetics | Receptors, Antigen, T-Cell - immunology | Benzamides - pharmacology | Cell Differentiation | Interferon-gamma - genetics | Colitis - immunology | Disease Models, Animal | Mitogen-Activated Protein Kinase 3 - immunology | Interleukin-10 - deficiency | Mitogen-Activated Protein Kinase 1 - immunology | Dual Specificity Phosphatase 6 - immunology | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Colon - pathology | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | Interleukin-17 - genetics | Mice, Knockout | Animals | Interferon-gamma - immunology | Interleukin-10 - genetics | Mice | Receptors, Antigen, T-Cell - genetics | Interleukin-10 - immunology | Dual Specificity Phosphatase 6 - deficiency | Index Medicus | CD4 | ERK1 | Inflammatory Bowel Disease | T cells | DUSP6
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 01/2012, Volume 130, Issue 1, pp. 83 - 95
Journal Article
Immunity, ISSN 1074-7613, 06/2013, Volume 38, Issue 6, pp. 1116 - 1128
Immune tolerance requires regulatory T (Treg) cells to prevent autoimmune disease, with the transcription factor Foxp3 functioning as the critical regulator of... 
APOPTOSIS | THYMUS | GENE | SPECIFICITY | AUTOIMMUNITY | BIM | NEGATIVE SELECTION | SELF | DIFFERENTIATION | IMMUNOLOGY | LINEAGE FATE | Dual Specificity Phosphatase 6 - genetics | Lymphopoiesis - genetics | Apoptosis - genetics | Male | Interleukin Receptor Common gamma Subunit - immunology | Proto-Oncogene Proteins c-bcl-2 - metabolism | MAP Kinase Kinase 4 - metabolism | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Cytokines - immunology | T-Lymphocytes, Regulatory - physiology | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Cell Survival | Membrane Proteins - genetics | Cells, Cultured | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Dual Specificity Phosphatase 6 - metabolism | Animals | MAP Kinase Kinase 4 - genetics | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Cytokines | T cells | Singers | Apoptosis | Proteins | Medical research | Transcription factors | Lymphocytes | Rodents | Bone marrow | Protein expression | T cell receptors | Gene expression | Chromosomes | Index Medicus
Journal Article
The FEBS Journal, ISSN 1742-464X, 05/2018, Volume 285, Issue 9, pp. 1593 - 1610
Tumor necrosis factor ( TNF )‐α activates a diverse array of signaling pathways in vascular endothelial cells ( EC s), leading to the inflammatory phenotype... 
κB | septic lung injury | DUSP | endothelial inflammation | ERK | NF-κB | DUSP6 | NEGATIVE-FEEDBACK-REGULATION | INTERCELLULAR-ADHESION MOLECULE-1 | MAP KINASE | TRANSENDOTHELIAL MIGRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NF-B | ACUTE LUNG INJURY | NEUTROPHIL RECRUITMENT | TUMOR-NECROSIS-FACTOR | BIOMECHANICAL PROPERTIES | VCAM-1 EXPRESSION | NF-KAPPA-B | Chemotaxis, Leukocyte | Human Umbilical Vein Endothelial Cells | Vena Cava, Inferior | Whole-Body Irradiation | Dual Specificity Phosphatase 6 - genetics | Humans | NF-kappa B - metabolism | Adoptive Transfer | Endothelium, Vascular - enzymology | Neutrophil Infiltration | Acute Lung Injury - prevention & control | U937 Cells | Intercellular Adhesion Molecule-1 - biosynthesis | Aorta | Extracellular Signal-Regulated MAP Kinases - physiology | Genes, Reporter | Acute Lung Injury - physiopathology | Dual Specificity Phosphatase 6 - physiology | Gene Expression Regulation - physiology | Inflammation | Cell Adhesion | Tumor Necrosis Factor-alpha - pharmacology | Animals | Intercellular Adhesion Molecule-1 - genetics | Lipopolysaccharides - pharmacology | Endothelium, Vascular - pathology | Mice | Dual Specificity Phosphatase 6 - deficiency | Phosphatases | Mitogens | Endothelium | Lung | Inflammatory response | Kinases | Phosphatase | Inflammatory diseases | Lipopolysaccharides | Signal transduction | Pathways | Clonal deletion | Rodents | Cell adhesion | Deletion | Tumor necrosis factor-TNF | Phenotypes | RNA-mediated interference | Medical treatment | Neutrophils | Emigration | Extracellular signal-regulated kinase | Molecular chains | Endothelial cells | White blood cells | Signaling | Tumor necrosis factor | Sepsis | Pulmonary circulation | Umbilical vein | Cell migration | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2017, Volume 12, Issue 9, pp. e0183488 - e0183488
Here, we aimed to investigate the potential role of DUSP6, a dual specificity phosphatase, that specifically inactivates extracellular signal-regulated kinase... 
HEPATIC GLUCONEOGENESIS | METABOLIC SYNDROME | ACTIVATION | CANCER CELLS | INTESTINAL MICROBIOTA | HOST GENETICS | GUT MICROBIOME | KINASE PHOSPHATASES | MULTIDISCIPLINARY SCIENCES | DIET-INDUCED OBESITY | EXPRESSION | Body Composition | Epididymis - metabolism | Dual Specificity Phosphatase 6 - genetics | Body Weight | Leptin - metabolism | Adipose Tissue, White - metabolism | Homeostasis | Nutritional Physiological Phenomena | Male | Gene Expression Profiling | Glucose Intolerance - pathology | RNA, Messenger - metabolism | Obesity - genetics | Diet, High-Fat | Glucose Intolerance - enzymology | Glucose Intolerance - genetics | Fasting | Obesity - complications | Mice, Inbred C57BL | RNA, Messenger - genetics | Lipid Metabolism | Glucose Intolerance - complications | Mice, Knockout | Dual Specificity Phosphatase 6 - metabolism | Animals | Dual Specificity Phosphatase 6 - deficiency | Adipose tissues | Obesity | Messenger RNA | Body weight | Leptin | Physiological aspects | Research | Health aspects | Mitogen-activated protein kinases | Brain | Energy metabolism | Neurosciences | Adipose tissue | Body fat | Neurobiology | Genomes | mRNA | Adipocytes | Glucose | Hypothalamus | Kinases | Metabolic syndrome | Phosphatase | High fat diet | Proteins | Glucose metabolism | Genotype & phenotype | Control | Rodents | Physiology | Lipid metabolism | Age | Extracellular signal-regulated kinase | Light emitting diodes | Exposure | Environmental factors | Gene expression | Metabolism | Cholesterol | Glucose tolerance | Intolerance | Weight control | Brain research | Diet | Weight reduction | Mice | Diabetes | Differentiation | In vitro methods and tests | Metabolic disorders | Index Medicus
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 05/2013, Volume 92, Issue 5, pp. 725 - 743
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2018, Volume 115, Issue 34, pp. E8027 - E8036
Activated T cells undergo metabolic reprogramming and effector-cell differentiation but the factors involved are unclear. Utilizing mice lacking DUSP6... 
Glycolysis | Follicular helper T cells | DUSP6 | IL-21 | T cell metabolism | ACTIVATION | follicular helper T cells | PROTEIN-KINASE PHOSPHATASE | MULTIDISCIPLINARY SCIENCES | glycolysis | IMMUNOGLOBULIN PRODUCTION | CXC CHEMOKINE RECEPTOR-5 | FOLLICULAR-HELPER-CELLS | GLUCOSE-METABOLISM | SIGNALING PATHWAY | GENERATION | DUAL-SPECIFICITY PHOSPHATASE | EXPRESSION | Dual Specificity Phosphatase 6 - genetics | MAP Kinase Kinase 4 - immunology | Mitochondria - immunology | Oxygen Consumption - physiology | Interleukins - metabolism | CD28 Antigens - metabolism | Glycolysis - physiology | Interleukins - genetics | MAP Kinase Kinase 4 - metabolism | CD28 Antigens - genetics | Mitochondria - genetics | Immunoglobulin G - immunology | T-Lymphocytes, Helper-Inducer - immunology | Interleukins - immunology | T-Lymphocytes, Helper-Inducer - cytology | Receptors, Antigen, T-Cell - immunology | p38 Mitogen-Activated Protein Kinases - metabolism | Cell Differentiation - physiology | T-Lymphocytes, Helper-Inducer - metabolism | Dual Specificity Phosphatase 6 - immunology | Receptors, Antigen, T-Cell - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | CD28 Antigens - immunology | Mitochondria - metabolism | p38 Mitogen-Activated Protein Kinases - immunology | Antibody Formation - physiology | Mice, Knockout | Dual Specificity Phosphatase 6 - metabolism | Animals | MAP Kinase Kinase 4 - genetics | Signal Transduction - physiology | Mice | Receptors, Antigen, T-Cell - genetics | Immunoglobulin G - metabolism
Journal Article
BMC Developmental Biology, ISSN 1471-213X, 03/2018, Volume 18, Issue 1, pp. 6 - 6
Journal Article