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Journal Article
International Journal of Cancer, ISSN 0020-7136, 01/2012, Volume 130, Issue 1, pp. 83 - 95
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2017, Volume 12, Issue 9, pp. e0183488 - e0183488
Here, we aimed to investigate the potential role of DUSP6, a dual specificity phosphatase, that specifically inactivates extracellular signal-regulated kinase... 
HEPATIC GLUCONEOGENESIS | METABOLIC SYNDROME | ACTIVATION | CANCER CELLS | INTESTINAL MICROBIOTA | HOST GENETICS | GUT MICROBIOME | KINASE PHOSPHATASES | MULTIDISCIPLINARY SCIENCES | DIET-INDUCED OBESITY | EXPRESSION | Body Composition | Epididymis - metabolism | Dual Specificity Phosphatase 6 - genetics | Body Weight | Leptin - metabolism | Adipose Tissue, White - metabolism | Homeostasis | Nutritional Physiological Phenomena | Male | Gene Expression Profiling | Glucose Intolerance - pathology | RNA, Messenger - metabolism | Obesity - genetics | Diet, High-Fat | Glucose Intolerance - enzymology | Glucose Intolerance - genetics | Fasting | Obesity - complications | Mice, Inbred C57BL | RNA, Messenger - genetics | Lipid Metabolism | Glucose Intolerance - complications | Mice, Knockout | Dual Specificity Phosphatase 6 - metabolism | Animals | Dual Specificity Phosphatase 6 - deficiency | Adipose tissues | Obesity | Messenger RNA | Body weight | Leptin | Physiological aspects | Research | Health aspects | Mitogen-activated protein kinases | Brain | Energy metabolism | Neurosciences | Adipose tissue | Body fat | Neurobiology | Genomes | mRNA | Adipocytes | Glucose | Hypothalamus | Kinases | Metabolic syndrome | Phosphatase | High fat diet | Proteins | Glucose metabolism | Genotype & phenotype | Control | Rodents | Physiology | Lipid metabolism | Age | Extracellular signal-regulated kinase | Light emitting diodes | Exposure | Environmental factors | Gene expression | Metabolism | Cholesterol | Glucose tolerance | Intolerance | Weight control | Brain research | Diet | Weight reduction | Mice | Diabetes | Differentiation | In vitro methods and tests | Metabolic disorders | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2018, Volume 115, Issue 34, pp. E8027 - E8036
Activated T cells undergo metabolic reprogramming and effector-cell differentiation but the factors involved are unclear. Utilizing mice lacking DUSP6... 
Glycolysis | Follicular helper T cells | DUSP6 | IL-21 | T cell metabolism | ACTIVATION | follicular helper T cells | PROTEIN-KINASE PHOSPHATASE | MULTIDISCIPLINARY SCIENCES | glycolysis | IMMUNOGLOBULIN PRODUCTION | CXC CHEMOKINE RECEPTOR-5 | FOLLICULAR-HELPER-CELLS | GLUCOSE-METABOLISM | SIGNALING PATHWAY | GENERATION | DUAL-SPECIFICITY PHOSPHATASE | EXPRESSION | Dual Specificity Phosphatase 6 - genetics | MAP Kinase Kinase 4 - immunology | Mitochondria - immunology | Oxygen Consumption - physiology | Interleukins - metabolism | CD28 Antigens - metabolism | Glycolysis - physiology | Interleukins - genetics | MAP Kinase Kinase 4 - metabolism | CD28 Antigens - genetics | Mitochondria - genetics | Immunoglobulin G - immunology | T-Lymphocytes, Helper-Inducer - immunology | Interleukins - immunology | T-Lymphocytes, Helper-Inducer - cytology | Receptors, Antigen, T-Cell - immunology | p38 Mitogen-Activated Protein Kinases - metabolism | Cell Differentiation - physiology | T-Lymphocytes, Helper-Inducer - metabolism | Dual Specificity Phosphatase 6 - immunology | Receptors, Antigen, T-Cell - metabolism | p38 Mitogen-Activated Protein Kinases - genetics | CD28 Antigens - immunology | Mitochondria - metabolism | p38 Mitogen-Activated Protein Kinases - immunology | Antibody Formation - physiology | Mice, Knockout | Dual Specificity Phosphatase 6 - metabolism | Animals | MAP Kinase Kinase 4 - genetics | Signal Transduction - physiology | Mice | Receptors, Antigen, T-Cell - genetics | Immunoglobulin G - metabolism
Journal Article
Immunity, ISSN 1074-7613, 06/2013, Volume 38, Issue 6, pp. 1116 - 1128
Immune tolerance requires regulatory T (Treg) cells to prevent autoimmune disease, with the transcription factor Foxp3 functioning as the critical regulator of... 
APOPTOSIS | THYMUS | GENE | SPECIFICITY | AUTOIMMUNITY | BIM | NEGATIVE SELECTION | SELF | DIFFERENTIATION | IMMUNOLOGY | LINEAGE FATE | Dual Specificity Phosphatase 6 - genetics | Lymphopoiesis - genetics | Apoptosis - genetics | Male | Interleukin Receptor Common gamma Subunit - immunology | Proto-Oncogene Proteins c-bcl-2 - metabolism | MAP Kinase Kinase 4 - metabolism | Bcl-2-Like Protein 11 | Forkhead Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Cytokines - immunology | T-Lymphocytes, Regulatory - physiology | Proto-Oncogene Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Cell Survival | Membrane Proteins - genetics | Cells, Cultured | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Dual Specificity Phosphatase 6 - metabolism | Animals | MAP Kinase Kinase 4 - genetics | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Cytokines | T cells | Singers | Apoptosis | Proteins | Medical research | Transcription factors | Lymphocytes | Rodents | Bone marrow | Protein expression | T cell receptors | Gene expression | Chromosomes | Index Medicus
Journal Article
Journal Article
ChemBioChem, ISSN 1439-4227, 07/2014, Volume 15, Issue 10, pp. 1436 - 1445
Journal Article
Biochemical Journal, ISSN 0264-6021, 06/2008, Volume 412, Issue 2, pp. 287 - 298
DUSP6 (dual-specificity phosphatase 6), also known as MKP-3 [MAPK (mitogen-activated protein kinase) phosphatase-3] specifically inactivates ERK1/2... 
Fibroblast growth factor (FGF) | Transcription | Phosphatase | Mitogen-activated protein kinase phosphatase-3 (MKP-3) | Mitogen-activated protein kinase (MAPK) | Dual-specificity phosphatase 6 (DUSP6) | ACTIVATED PROTEIN-KINASE | transcription | MKP3 | MAP-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | mitogen-activated protein kinase phosphatase-3 (MKP-3) | FAMILY | EMBRYO | IN-VIVO | fibroblast growth factor (FGF) | phosphatase | dual-specificity phosphatase 6 (DUSP6) | EXPRESSION | DUAL-SPECIFICITY PHOSPHATASES | CATALYTIC ACTIVATION | VERTEBRATE LIMB | Dual Specificity Phosphatase 6 - genetics | Proto-Oncogene Proteins c-ets - genetics | Humans | Molecular Sequence Data | Phosphatidylinositol 3-Kinases - metabolism | Fibroblast Growth Factors - metabolism | Base Sequence | Mitogen-Activated Protein Kinase 1 - genetics | Proto-Oncogene Proteins c-ets - metabolism | Transgenes | Binding Sites | Cell Line | Promoter Regions, Genetic | Mitogen-Activated Protein Kinase 3 - genetics | Gene Expression Regulation | Phosphatidylinositol 3-Kinases - genetics | Dual Specificity Phosphatase 6 - metabolism | Sequence Alignment | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - physiology | Mice | Enzyme Activation | Feedback, Physiological - physiology | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | MEK, MAPK | SRF, serum-response factor | SRY, sex-determining region Y | PI3K, phosphoinositide 3-kinase | FGFR, FGF receptor | MKP, MAPK phosphatase | βGal, β-galactosidase | Ets, E twenty-six | JNK, c-Jun N-terminal kinase | ERK kinase | DUSP, dual-specificity phosphatase | ChIP, chromatin immunoprecipitation | HH10, Hamburger and Hamilton stage 10 | ERK, extracellular-signal-regulated kinase | DMEM, Dulbecco's modified Eagle's medium | 4-HT, 4-hydroxytamoxifen | mRFP, monomeric red fluorescent protein | TNFα, tumour necrosis factor α | IκBα, inhibitor of nuclear factor κB α | EGFP, enhanced green fluorescent protein | NF-κB, nuclear factor κB | PBX1, pre-B-cell leukaemia transcription factor 1 | Elk1, Ets-like kinase 1 | FBS, fetal bovine serum | FKHD, Forkhead mutant | FGF, fibroblast growth factor | RSV, rous sarcoma virus | MKK, MAPK kinase | HA, haemagglutinin | EMSA, electrophoretic mobility-shift assay | ER, oestrogen receptor | AER, apical ectodermal ridge | ConA, concanavalin A | MKKK, MAPK kinase kinase | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2015, Volume 467, Issue 2, pp. 254 - 260
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2011, Volume 286, Issue 29, pp. 25663 - 25674
Journal Article
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