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Journal Article
Nature Chemical Biology, ISSN 1552-4450, 02/2018, Volume 14, Issue 2, pp. 118 - 125
Given the importance of ubiquitin-specific protease 7 (USP7) in oncogenic pathways, identification of USP7 inhibitors has attracted considerable interest.... 
INACTIVATION | DUBS | STABILIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HAUSP | ACTIVATES P53 | PROTEASES | Ubiquitin | Cell culture | MDM2 protein | Ubiquitin-specific proteinase | Antagonists | Tumor cell lines | Optimization | Allosteric properties | Inhibitors | Cell lines | Binding sites | Crystal structure | Cancer
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 32, pp. 33623 - 33635
Members of the bromodomain and extra-C terminal (BET) domain protein family and the histone deacetylase (HDAC) enzyme family regulate the expression of... 
BET | Epigenetics | Breast cancer | Combined treatment | HDAC | TARGET | TRANSCRIPTION | breast cancer | IDENTIFICATION | epigenetics | FAMILY | CELL BIOLOGY | MYC | combined treatment | HISTONE DEACETYLASE INHIBITORS | DUB/USP17 DEUBIQUITINATING ENZYMES
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 03/2019, Volume 431, Issue 6, pp. 1160 - 1171
We applied a yeast-two-hybrid (Y2H) analysis to screen for ubiquitin variant (UbV) inhibitors of a human deubiquitinase (DUB), ubiquitin-specific protease 2... 
Mdm2 | yeast two-hybrid | ubiquitin | ubiquitin variants | Ubiquitin Proteasome System | ANTIBODIES | DUBS | STRATEGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PEPTIDE APTAMERS | USP2A | ENZYMES | RESISTANCE | TARGETS | SELECTION | REVEALS | Ubiquitin | Molecular genetics | Proteases | Analysis | Tryptophan | Fluorescence | Cells
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 02/2008, Volume 376, Issue 2, pp. 526 - 540
Nuclear factor κB (NF-κB) activation in tumor necrosis factor, interleukin-1, and Toll-like receptor pathways requires Lys63-linked nondegradative... 
DUB | crystal structure | deubiquitination | TRAF6 | A20 | CRYSTAL-STRUCTURE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT GENE-EXPRESSION | SIGNAL-TRANSDUCTION | ENDOTHELIAL-CELL ACTIVATION | UBIQUITIN-ALDEHYDE | KINASE TAK1 | STRUCTURAL BASIS | ZINC-FINGER PROTEIN | INTERLEUKIN-1 RECEPTOR
Journal Article
Drug Resistance Updates, ISSN 1368-7646, 2015, Volume 21, pp. 20 - 29
Journal Article
Current Cancer Drug Targets, ISSN 1568-0096, 2014, Volume 14, Issue 6, pp. 506 - 516
Journal Article