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Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2018, Volume 38, Issue 1, pp. 218 - 231
Journal Article
Circulation Research, ISSN 0009-7330, 11/2008, Volume 103, Issue 10, pp. 1173 - 1180
Obstructive sleep apnea leads to chronic intermittent hypoxia (CIH) and is associated with atherosclerosis. We have previously shown that C57BL/6J mice exposed... 
Hypoxia | Lipoproteins | Hypercholesterolemia | Obstructive sleep apnea | Atherosclerosis | atherosclerosis | obstructive sleep apnea | hypoxia | OBSTRUCTIVE SLEEP-APNEA | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | LIPID-PEROXIDATION | CLEAVAGE-ACTIVATING PROTEIN | FATTY-ACIDS | hypercholesterolemia | EARLY SIGNS | COA DESATURASE-1 | INSULIN-RESISTANCE | PERIPHERAL VASCULAR DISEASE | POSITIVE AIRWAY PRESSURE | INDUCIBLE FACTOR-1 | HEMATOLOGY | lipoproteins | Liver - pathology | Liver - enzymology | Humans | Male | Dyslipidemias - pathology | RNA, Messenger - metabolism | Dyslipidemias - enzymology | Atherosclerosis - enzymology | RNA, Messenger - antagonists & inhibitors | Enzyme Induction - drug effects | Obesity Hypoventilation Syndrome - pathology | Aorta - enzymology | Atherosclerosis - pathology | Hypoxia - enzymology | Oligonucleotides, Antisense - pharmacology | Oxyhemoglobins - metabolism | Atherosclerosis - chemically induced | Stearoyl-CoA Desaturase - antagonists & inhibitors | Cholesterol, VLDL - blood | Aorta - pathology | Up-Regulation - drug effects | Diet, Atherogenic | Stearoyl-CoA Desaturase - biosynthesis | Animals | Hypoxia - pathology | Dyslipidemias - chemically induced | Triglycerides - blood | Cholesterol - pharmacology | Mice | Hypoxia - chemically induced | Obesity Hypoventilation Syndrome - enzymology | Chronic Disease | Cholesterol - adverse effects | Index Medicus
Journal Article
Kidney International, ISSN 0085-2538, 01/2018, Volume 93, Issue 1, pp. 69 - 80
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2017, Volume 37, Issue 4, pp. 647 - 656
OBJECTIVE—Bempedoic acid (ETC-1002, 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid) is a novel low-density lipoprotein cholesterol–lowering compound. In... 
Lipids | Inflammation | Adenosine triphosphate citrate lyase | Atherosclerosis | atherosclerosis | lipids | ACTIVATED PROTEIN-KINASE | CHOLESTEROL | LOWERING THERAPY | LOW-DENSITY-LIPOPROTEIN | ENDOPLASMIC-RETICULUM STRESS | RECEPTOR-DEFICIENT MICE | adenosine triphosphate citrate lyase | inflammation | STATIN THERAPY | INSULIN-RESISTANCE | ETC-1002 | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | HEPATIC STEATOSIS | Dyslipidemias - genetics | ATP Citrate (pro-S)-Lyase - antagonists & inhibitors | Liver - enzymology | Atherosclerosis - genetics | Male | Dicarboxylic Acids - pharmacology | Insulin - blood | Obesity - blood | Obesity - genetics | Inflammation - blood | Dyslipidemias - enzymology | Atherosclerosis - enzymology | Dyslipidemias - blood | Liver - drug effects | Time Factors | Diet, High-Fat | Lipids - blood | Receptors, LDL - deficiency | Dyslipidemias - prevention & control | ATP Citrate (pro-S)-Lyase - metabolism | Disease Models, Animal | Receptors, LDL - genetics | Genetic Predisposition to Disease | Enzyme Inhibitors - pharmacology | Gene Expression Regulation | Inflammation Mediators - blood | Biomarkers - blood | Mice, Knockout | Atherosclerosis - blood | Blood Glucose - drug effects | Phenotype | Animals | Obesity - prevention & control | Inflammation - genetics | Inflammation - prevention & control | Obesity - enzymology | Blood Glucose - metabolism | Inflammation - enzymology | Atherosclerosis - prevention & control | Fatty Acids - pharmacology
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 383, Issue 1, pp. 125 - 134
Journal Article
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 11/2013, Volume 170, Issue 5, pp. 1064 - 1077
Background and Purpose Systemic oxidative stress associated with dietary calorie overload plays an important role in the deterioration of vascular function in... 
ageing | Nox2 inhibitor | NADPH oxidase | insulin resistance | endothelial dysfunction | obesity | oxidative stress | P47(PHOX) PHOSPHORYLATION | CELLS | HIGH-FAT DIET | NITRIC-OXIDE SYNTHASE | NECROSIS-FACTOR-ALPHA | ANGIOTENSIN-II | ARRIVE GUIDELINES | NAD(P)H OXIDASES | ANIMAL-MODELS | PHARMACOLOGY & PHARMACY | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | NADPH Oxidases - metabolism | Endothelium, Vascular - drug effects | Obesity - blood | Vasodilation | Dyslipidemias - enzymology | NADPH Oxidases - deficiency | Membrane Glycoproteins - antagonists & inhibitors | Time Factors | Diet, High-Fat | NADPH Oxidases - genetics | Hypertension - enzymology | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Obesity - physiopathology | Mice, Knockout | Mitogen-Activated Protein Kinase 3 - metabolism | Mice | Oxidative Stress - drug effects | Blood Glucose - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Blood Pressure | Phosphorylation | Age Factors | Endothelium, Vascular - enzymology | Insulin - blood | Obesity - genetics | Dose-Response Relationship, Drug | Dyslipidemias - blood | Aorta - physiopathology | Nitric Oxide Synthase Type III - metabolism | Aorta - enzymology | Vasodilator Agents - pharmacology | Tissue Culture Techniques | Aorta - drug effects | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Insulin Resistance | Antioxidants - pharmacology | NADPH Oxidase 2 | Hypertension - physiopathology | Membrane Glycoproteins - genetics | Animals | Receptor, Insulin - metabolism | Obesity - enzymology | Membrane Glycoproteins - deficiency | Oxidases | Hypertension | Oxidative stress | Obesity | Analysis | Insulin resistance | Acetylcholine | Insulin | Endothelium | Middle age | Rodents | Research Papers
Journal Article
Circulation Research, ISSN 0009-7330, 11/2009, Volume 105, Issue 10, pp. 1013 - 1022
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 10/2018, Volume 106, pp. 733 - 737
Previous clinical studies have demonstrated that tangganjian (TGJ), a modern Chinese prescribed medicine, has a clinical effect in the treatment of type 2... 
Wistar rats | Nonalcoholic fatty liver disease | Type 2 diabetes mellitus | IRS/PI3K/AKT signaling pathway | Tangganjian | MEDICINE, RESEARCH & EXPERIMENTAL | OBESITY | INSULIN-RESISTANCE | PHARMACOLOGY & PHARMACY | MODEL | GLUCOSE-UPTAKE | Diabetes Mellitus, Experimental - drug therapy | Liver - pathology | Liver - enzymology | Rats, Wistar | Diabetes Mellitus, Experimental - enzymology | Streptozocin | Drugs, Chinese Herbal - pharmacology | Non-alcoholic Fatty Liver Disease - etiology | Male | Insulin Receptor Substrate Proteins - metabolism | Insulin - blood | Dietary Sugars | Dyslipidemias - enzymology | Diabetes Mellitus, Experimental - blood | Dose-Response Relationship, Drug | Non-alcoholic Fatty Liver Disease - blood | Dyslipidemias - blood | Liver - drug effects | Diet, High-Fat | Lipids - blood | Non-alcoholic Fatty Liver Disease - enzymology | Diabetes Mellitus, Type 2 - etiology | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Dyslipidemias - drug therapy | Diabetes Mellitus, Type 2 - enzymology | Biomarkers - blood | Hypolipidemic Agents - pharmacology | Hypoglycemic Agents - pharmacology | Non-alcoholic Fatty Liver Disease - drug therapy | Blood Glucose - drug effects | Diabetes Mellitus, Type 2 - blood | Animals | Diabetes Mellitus, Experimental - etiology | Signal Transduction - drug effects | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Glucose metabolism | Medical research | Fatty liver | Blood sugar | Low density lipoproteins | Medicine, Experimental | Triglycerides
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, p. e0155994
Journal Article
eLife, ISSN 2050-084X, 04/2013, Volume 2013, Issue 2, p. e00444
The secretory pathway of eukaryotic cells packages cargo proteins into COPII-coated vesicles for transport from the endoplasmic reticulum (ER) to the Golgi. We... 
ANEMIA TYPE-II | COPII-COATED VESICLES | BIOLOGY | RETICULUM EXIT SITES | ENDOPLASMIC-RETICULUM | TRANSPORT VESICLES | SELECTIVE EXPORT | MEMBRANE-PROTEINS | KNOCKOUT MICE | BULK FLOW | APOLIPOPROTEIN-E | Dyslipidemias - genetics | Liver - enzymology | Vesicular Transport Proteins - metabolism | Cholesterol - blood | Humans | Mice, 129 Strain | Apolipoproteins E - metabolism | Endoplasmic Reticulum - secretion | Dyslipidemias - enzymology | Dyslipidemias - blood | Transfection | HEK293 Cells | Proprotein Convertases - secretion | Proprotein Convertases - blood | Serine Endopeptidases - secretion | Endoplasmic Reticulum - enzymology | Receptors, LDL - genetics | Down-Regulation | Mice, Inbred C57BL | Vesicular Transport Proteins - genetics | Receptors, LDL - metabolism | Genotype | Liver - secretion | Mice, Knockout | Protein Transport | Phenotype | Animals | COP-Coated Vesicles - enzymology | Vesicular Transport Proteins - deficiency | COP-Coated Vesicles - secretion | Epistasis, Genetic | Apolipoproteins E - genetics | Serine Endopeptidases - blood | Cell Line, Tumor | Mutation | Proprotein Convertase 9 | Yeast | Secretion | Epistasis | Biology | Mammals | Cholesterol | Golgi apparatus | Proteins | Apolipoprotein E | Rodents | Lipoprotein (low density) receptors | Coated vesicles | Endoplasmic reticulum | Pharmaceutical sciences
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2013, Volume 33, Issue 1, pp. 139 - 146
Journal Article