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index medicus (1742) 1742
animals (1277) 1277
humans (1005) 1005
mice (692) 692
dystroglycan (631) 631
dystroglycans - metabolism (594) 594
alpha-dystroglycan (569) 569
biochemistry & molecular biology (466) 466
dystroglycans (449) 449
neurosciences (403) 403
glycosylation (385) 385
membrane glycoproteins - metabolism (357) 357
cell biology (352) 352
male (350) 350
cytoskeletal proteins - metabolism (348) 348
muscular dystrophy (326) 326
skeletal-muscle (320) 320
dystrophin (316) 316
muscle, skeletal - metabolism (316) 316
female (302) 302
laminin - metabolism (298) 298
proteins (294) 294
beta-dystroglycan (293) 293
dystrophin - metabolism (293) 293
laminin (285) 285
extracellular-matrix (278) 278
mutation (270) 270
expression (262) 262
muscular dystrophies - genetics (244) 244
muscular dystrophies - metabolism (240) 240
immunohistochemistry (228) 228
glycoprotein complex (225) 225
molecular sequence data (220) 220
utrophin (201) 201
rats (200) 200
amino acid sequence (191) 191
cells, cultured (191) 191
clinical neurology (190) 190
congenital muscular-dystrophy (190) 190
dystroglycans - genetics (189) 189
protein binding (188) 188
muscle, skeletal - pathology (178) 178
duchenne muscular-dystrophy (169) 169
article (166) 166
mutations (166) 166
cell line (163) 163
phenotype (157) 157
walker-warburg-syndrome (157) 157
genetics & heredity (156) 156
membrane proteins - metabolism (154) 154
dystrophin-glycoprotein complex (152) 152
gene (151) 151
mice, inbred c57bl (151) 151
dystrophin - genetics (147) 147
cytoskeletal proteins - genetics (145) 145
muscular-dystrophy (144) 144
disease models, animal (140) 140
membrane glycoproteins - genetics (137) 137
mice, knockout (134) 134
research (133) 133
analysis (125) 125
muscle (125) 125
blotting, western (124) 124
cells (124) 124
protein (122) 122
extracellular matrix (121) 121
muscular dystrophies - pathology (120) 120
pathology (119) 119
musculoskeletal system (116) 116
complex (115) 115
adult (114) 114
gene expression (112) 112
physiological aspects (112) 112
genetic aspects (111) 111
protein structure, tertiary (110) 110
brain (109) 109
musculoskeletal diseases (108) 108
child (107) 107
neurology (107) 107
rodents (107) 107
research article (105) 105
multidisciplinary sciences (104) 104
identification (99) 99
basement membrane - metabolism (98) 98
agrin (97) 97
extracellular matrix - metabolism (97) 97
binding (96) 96
localization (95) 95
biophysics (94) 94
muscle proteins - metabolism (94) 94
neuromuscular-junction (94) 94
mice, transgenic (93) 93
sarcoglycans (93) 93
signal transduction (93) 93
binding sites (92) 92
biology (92) 92
child, preschool (92) 92
abnormal glycosylation (90) 90
receptor (90) 90
membrane (88) 88
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Journal Article
Acta Neuropathologica, ISSN 0001-6322, 9/2011, Volume 122, Issue 3, pp. 293 - 311
Cerebrovascular lesions related to congophilic amyloid angiopathy (CAA) often accompany deposition of β-amyloid (Aβ) in Alzheimer’s disease (AD), leading to... 
Pathology | Neurosciences | Congophilic amyloid angiopathy | Medicine & Public Health | Alzheimer’s disease | Astrocytes | Cerebral glucose metabolism | Alzheimer's disease | MICROVASCULAR PATHOLOGY | ALZHEIMERS-DISEASE | NEUROVASCULAR MECHANISMS | GLUCOSE-UTILIZATION | PATHOLOGY | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | CLINICAL NEUROLOGY | MOUSE MODEL | ENDOTHELIAL-CELLS | A-BETA | SMOOTH-MUSCLE-CELLS | RAT-BRAIN | Microdialysis - methods | Humans | Astrocytes - pathology | Dystroglycans - metabolism | Glucose Transporter Type 1 - metabolism | Muscle, Smooth - ultrastructure | Glial Fibrillary Acidic Protein - metabolism | Microscopy, Electron, Scanning - methods | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Cell Culture Techniques | Disease Models, Animal | Endothelium - pathology | Mice, Transgenic | Cerebral Arteries - ultrastructure | Basement Membrane - metabolism | Disease Progression | Symporters - metabolism | Astrocytes - ultrastructure | Blood-Brain Barrier - pathology | Cerebral Arteries - metabolism | Brain - pathology | Glucose - metabolism | Plaque, Amyloid - metabolism | Mice | Astrocytes - metabolism | Blood-Brain Barrier - physiopathology | Basement Membrane - pathology | Cerebral Amyloid Angiopathy - complications | Monocarboxylic Acid Transporters - metabolism | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Hemorrhage - etiology | Amyloid beta-Protein Precursor - metabolism | Lactase - metabolism | Cerebral Amyloid Angiopathy - genetics | Astrocytes - drug effects | Plaque, Amyloid - pathology | Gene Expression Regulation - genetics | Hemorrhage - metabolism | Muscle, Smooth - metabolism | Cerebrovascular Disorders - etiology | Cerebral Amyloid Angiopathy - pathology | Animals | Endothelium - metabolism | Glucose Transporter Type 1 - genetics | Symporters - genetics | Cerebral Arteries - pathology | Laminin - metabolism | Monocarboxylic Acid Transporters - genetics | Cerebrovascular Disorders - pathology | Hemorrhage - pathology | Muscle, Smooth - pathology | Index Medicus | Glucose transporter | Leakage | Brain | Neurodegenerative diseases | Cognitive ability | Transgenic mice | Blood vessels | Data processing | Smooth muscle | beta -Amyloid | Glucose transport | Metabolism | Amyloid precursor protein | Blood-brain barrier | Cerebral blood flow | Lactic acid | Mutation | Original Paper
Journal Article
Neuron, ISSN 0896-6273, 2003, Volume 40, Issue 3, pp. 501 - 514
Targeted deletion of focal adhesion kinase (fak) in the developing dorsal forebrain resulted in local disruptions of the cortical basement membrane located... 
NEURONAL MIGRATION | MATRIX METALLOPROTEINASES | TYROSINE PHOSPHORYLATION | ALPHA-6 INTEGRINS | ECTOPIC EXPRESSION | CENTRAL-NERVOUS-SYSTEM | BETA-DYSTROGLYCAN | FOCAL ADHESION KINASE | NEUROSCIENCES | MENINGEAL CELLS | BASEMENT-MEMBRANE | Immunohistochemistry | Membrane Glycoproteins - metabolism | Embryo, Mammalian | Protein-Tyrosine Kinases - metabolism | Homeodomain Proteins - metabolism | Astrocytes - pathology | Cerebral Cortex - pathology | Glial Fibrillary Acidic Protein - metabolism | Muscular Dystrophies - genetics | Protein-Tyrosine Kinases - deficiency | Focal Adhesion Kinase 1 | Calbindins | Neurons - metabolism | Serine Endopeptidases | Disease Models, Animal | Fibroblasts - metabolism | Muscular Dystrophies - metabolism | Muscular Dystrophies - congenital | Silver Staining | Nerve Tissue Proteins | Basement Membrane - metabolism | Blotting, Western | Precipitin Tests | Mice, Knockout | Infection | Staining and Labeling | Mice | Mutation | Dura Mater | Astrocytes - metabolism | Neurons - pathology | Microtubule-Associated Proteins - metabolism | Otx Transcription Factors | Phosphopyruvate Hydratase - metabolism | Basement Membrane - pathology | Dystroglycans | Cerebral Cortex - metabolism | Cerebral Cortex - ultrastructure | Phosphotyrosine - metabolism | DNA-Binding Proteins - metabolism | Protein-Tyrosine Kinases - genetics | Lamins - metabolism | src-Family Kinases - metabolism | Cytoskeletal Proteins - metabolism | Cell Adhesion Molecules, Neuronal - metabolism | Cerebral Cortex - abnormalities | Extracellular Matrix Proteins - metabolism | Fibroblasts - virology | Cells, Cultured | Focal Adhesion Protein-Tyrosine Kinases | Microscopy, Electron | Muscular Dystrophies - pathology | S100 Calcium Binding Protein G - metabolism | Transcription Factors - metabolism | Animals | Carrier Proteins - metabolism | Calbindin 2 | Bacterial Proteins - metabolism | Heterozygote | Proteins | Neurons | Rodents | Protein expression | Kinases | Embryos | Muscular dystrophy | Deoxyribonucleic acid--DNA | Cell adhesion & migration | Index Medicus
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 08/2009, Volume 85, Issue 2, pp. 155 - 167
We report the case of a congenital myasthenic syndrome due to a mutation in , the gene encoding agrin, an extracellular matrix molecule released by the nerve... 
MUTANT MICE | PROTEIN | DEFICIENT | GENETICS & HEREDITY | MUSCULAR-DYSTROPHY | SKELETAL-MUSCLE FIBERS | DIFFERENTIATION | NEUROMUSCULAR-JUNCTION | DYSTROGLYCAN | BINDING | ACETYLCHOLINE-RECEPTOR | Agrin - chemistry | Models, Chemical | Neuromuscular Junction - metabolism | Humans | Dystroglycans - metabolism | Male | Muscle, Skeletal - metabolism | Muscle Fibers, Skeletal - metabolism | Mutation, Missense | Agrin - metabolism | Muscle, Skeletal - surgery | Synapses - metabolism | DNA Mutational Analysis | Neuromuscular Junction - genetics | Adult | Female | Myasthenic Syndromes, Congenital - genetics | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Agrin - genetics | Cell Line | Receptors, Cholinergic - metabolism | Muscle, Skeletal - ultrastructure | Rats | Recombinant Proteins - chemistry | Neuromuscular Junction - ultrastructure | Receptors, Cholinergic - physiology | Animals | Biopsy | Pedigree | Muscle Fibers, Skeletal - cytology | Muscle, Skeletal - pathology | Neuromuscular Junction - physiology | Receptors, Cholinergic - genetics | Myasthenia gravis | Gene mutations | Analysis | Physiological aspects | Genetic aspects | Research | Neuromuscular junction | Synapses | Cell culture | Glycoproteins | Genetic disorders | Mutation | Muscular system | Rodents | Index Medicus | Life Sciences | Genetics | Neurons and Cognition
Journal Article
Journal Article
Neuron, ISSN 0896-6273, 12/2012, Volume 76, Issue 5, pp. 931 - 944
Precise patterning of axon guidance cue distribution is critical for nervous system development. Using a murine forward genetic screen for novel determinants... 
ALPHA-DYSTROGLYCAN | CONGENITAL MUSCULAR-DYSTROPHY | SLIT | DEFECTIVE GLYCOSYLATION | WALKER-WARBURG-SYNDROME | RECEPTOR | HEPARAN-SULFATE | EXTRACELLULAR-MATRIX | NEUROSCIENCES | BRAIN | MIDLINE | Protein Binding - genetics | Embryo, Mammalian | Alkaline Phosphatase - metabolism | Glycoproteins - metabolism | Cercopithecus aethiops | Gene Expression Regulation, Developmental - genetics | N-Acetylglucosaminyltransferases - genetics | Neurons - cytology | Central Nervous System - embryology | Amino Acids - metabolism | Transfection | N-Acetylglucosaminyltransferases - deficiency | Neural Cell Adhesion Molecule L1 - metabolism | Nucleotidyltransferases - metabolism | Dystroglycans - physiology | Glycoproteins - genetics | Alkaline Phosphatase - genetics | Mice, Inbred C57BL | Axons - metabolism | Models, Molecular | Mice, Transgenic | Glycosylation | Mutation - genetics | Nerve Tissue Proteins - genetics | Body Patterning - physiology | Nerve Tissue Proteins - metabolism | Animals | Central Nervous System - cytology | Nucleotidyltransferases - genetics | Dystroglycans - genetics | Mice | Laminin - metabolism | Neurofilament Proteins - metabolism | Receptors, Immunologic - genetics | Body Patterning - genetics | COS Cells | Receptors, Immunologic - metabolism | Neurosciences | Analysis | Proteins | Ligands | Spinal cord | Mutation | Insects | Defects | Index Medicus | Dystroglycan | Alternation learning | Floor plate | Slit protein | Nervous system | Robo protein | Basement membranes | Axon guidance | Genetic screening
Journal Article
PLoS Pathogens, ISSN 1553-7366, 09/2011, Volume 7, Issue 9, pp. e1002232 - e1002232
The highly pathogenic Old World arenavirus Lassa virus (LASV) and the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) use a-dystroglycan as a... 
ENDOCYTIC PATHWAY | DENDRITIC CELLS | MICROBIOLOGY | LYMPHOCYTIC CHORIOMENINGITIS VIRUS | COATED VESICLE FORMATION | GROWTH-FACTOR RECEPTOR | RECEPTOR ALPHA-DYSTROGLYCAN | VIROLOGY | MEDIATED ENDOCYTOSIS | LASSA FEVER VIRUS | VESICULAR STOMATITIS-VIRUS | MONOCLONAL-ANTIBODIES | PARASITOLOGY | Lysophospholipids - metabolism | Vacuolar Proton-Translocating ATPases - genetics | Phosphatidylinositol Phosphates - metabolism | Receptors, Virus - metabolism | Humans | Cercopithecus aethiops | Dystroglycans - metabolism | Endosomal Sorting Complexes Required for Transport - genetics | Immunoblotting | Vacuolar Proton-Translocating ATPases - metabolism | Viral Proteins - metabolism | Endosomes - metabolism | Virus Internalization | DNA-Binding Proteins - metabolism | Endocytosis | Multivesicular Bodies - virology | Biological Transport | RNA Interference | Lymphocytic choriomeningitis virus - pathogenicity | HEK293 Cells | Real-Time Polymerase Chain Reaction | Cell Line | ATPases Associated with Diverse Cellular Activities | Cricetinae | Endosomal Sorting Complexes Required for Transport - metabolism | Viral Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Monoglycerides - metabolism | Lassa virus - pathogenicity | Transcription Factors - metabolism | Animals | Mutation | Transferrin - metabolism | Physiological aspects | Glycoproteins | Arenaviruses | Research | Health aspects | Cells | Biomedical research | Plasmids | Colleges & universities | Viruses | Grants | Experiments | Index Medicus
Journal Article
Journal Article
NATURE, ISSN 0028-0836, 07/2017, Volume 547, Issue 7662, pp. 179 - 179
Journal Article
Nature, ISSN 0028-0836, 07/2017, Volume 547, Issue 7662, pp. 227 - 231
The regenerative capacity of the adult mammalian heart is limited, because of the reduced ability of cardiomyocytes to progress through mitosis(1). Endogenous... 
PRESSURE-OVERLOAD | GENE | ADULT HEART REGENERATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MOUSE MODEL | MUSCLE | DUCHENNE MUSCULAR-DYSTROPHY | MICE | Protein-Serine-Threonine Kinases - deficiency | Phosphorylation | Cell Proliferation | Glycoproteins - metabolism | Dystroglycans - metabolism | Male | Phosphoproteins - metabolism | Heart Failure - prevention & control | Multiprotein Complexes - metabolism | Dystrophin - deficiency | Mice, Inbred mdx | Cardiomyopathies | Glycoproteins - deficiency | Multiprotein Complexes - deficiency | Dystrophin - metabolism | Protein-Serine-Threonine Kinases - metabolism | Myocytes, Cardiac - cytology | Mice, Inbred C57BL | Organ Size | Heart Failure - genetics | Pressure | Multiprotein Complexes - chemistry | Animals | Dystrophin - genetics | Myocytes, Cardiac - metabolism | Protein Binding | Mice | Muscular Dystrophy, Duchenne - metabolism | Muscular Dystrophy, Duchenne - genetics | Adaptor Proteins, Signal Transducing - metabolism | Heart | Genes | Homeostasis | Genomes | Kinases | Muscular dystrophy | Cell growth | Actin | Duchenne's muscular dystrophy | Cell cycle | Extracellular matrix | Heart diseases | Dystrophin | Deoxyribonucleic acid--DNA | Heart failure | Dystroglycan | Glycoprotein | Cardiomyocytes | Studies | Yes-associated protein | Regeneration | Point mutation | Cytoskeleton | Dystrophy | Mutation | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 2004, Volume 117, Issue 7, pp. 953 - 964
Reduced ligand binding activity of α-dystroglycan is associated with muscle and central nervous system pathogenesis in a growing number of muscular... 
PERIPHERAL-NERVE | HUMAN LARGE GENE | ALPHA-DYSTROGLYCAN | CONGENITAL MUSCULAR-DYSTROPHY | LAMININ | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCOPROTEIN COMPLEX | BETA-SARCOGLYCAN | EXTRACELLULAR-MATRIX | SARCOGLYCAN COMPLEX | DEFICIENCY | CELL BIOLOGY | Protein Structure, Tertiary | Receptors, Laminin - metabolism | Rabbits | Recombinant Fusion Proteins - isolation & purification | Membrane Glycoproteins - metabolism | Cytoskeletal Proteins - genetics | Membrane Glycoproteins - chemistry | Cells, Cultured | Muscle, Skeletal - metabolism | Glycosylation | Stem Cells - cytology | Cytoskeletal Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Dystroglycans | Recombinant Fusion Proteins - metabolism | Blotting, Western | Membrane Glycoproteins - genetics | Mice, Knockout | Glycosyltransferases - metabolism | Animals | Adenoviridae - genetics | Cytoskeletal Proteins - metabolism | Mice | Protein Processing, Post-Translational | Laminin | Research | Gene expression | Mucins | Index Medicus | Muscle; Skeletal/metabolism | Protein Processing; Post-Translational | Blotting; Western | Research Support; U.S. Gov't; P.H.S | Receptors; Laminin/metabolism | Cells; Cultured | Glycosyltransferases/metabolism | Protein Structure; Tertiary | Mice; Knockout | Membrane Glycoproteins/chemistry/genetics/metabolism | Adenoviridae/genetics | Research Support; Non-U.S. Gov't | Cytoskeletal Proteins/chemistry/genetics/metabolism | Stem Cells/cytology | Recombinant Fusion Proteins/chemistry/isolation & purification/metabolism
Journal Article