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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 10/2017, Volume 140, Issue 4, pp. 1191 - 1191
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2009, Volume 182, Issue 9, pp. 5306 - 5316
Most T cell progenitors develop into the αβ T cell lineage with an exception of a small fraction contributing to the γδ lineage throughout postnatal life. T... 
DN3 | TCR | VDJ recombination | E2A | Thymus
Journal Article
Clinical Immunology, ISSN 1521-6616, 08/2018, Volume 193, pp. 80 - 87
Individuals over the age of 65 comprise a substantial portion of the world population and become more susceptible to vaccine-preventable infections with age as... 
REPERTOIRE | ACTIVATION | ROLES | E2A | IMMUNOLOGY | T-BET | EXPRESSION
Journal Article
Current Biology, ISSN 0960-9822, 09/2019, Volume 29, Issue 18, pp. 3094 - 3100.e4
Stochastic mechanisms diversify cell fate in organisms ranging from bacteria to humans [ ]. In the anchor cell/ventral uterine precursor cell (AC/VU) fate... 
HLH-2 | LIN-12 | E2A | cell lineage | gonad | cell fate | Notch | C. elegans | stochastic
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 04/2019, Volume 25, Issue 8, pp. 2633 - 2643
Purpose: Little is known about the function of histone arginine methylation in acute lymphoblastic leukemia (ALL). The objective was to evaluate whether... 
PRMT5 | COMPLEX | PROTEIN | METHYLTRANSFERASE | ONCOLOGY | E2A ACTIVITY | SUPPRESSES | EXPRESSION | HISTONE ARGININE METHYLATION
Journal Article
Genes, ISSN 2073-4425, 12/2016, Volume 7, Issue 12, p. 116
Our understanding of the highly specialized functions for small non-coding single-stranded RNA (ssRNA) in the transcriptome of the human central nervous system... 
Alzheimer’s disease (AD) | Genetic control | Proteolysis | MiRNA-7 | Ubiquitin conjugating enzyme E2A (UBE2A) | Circular RNA (circRNA) | Proteasome | proteasome | circular RNA (circRNA) | genetic control | ubiquitin conjugating enzyme E2A (UBE2A) | proteolysis | miRNA-7
Journal Article
Immunity, ISSN 1074-7613, 05/2017, Volume 46, Issue 5, pp. 818 - 834.e4
Innate and adaptive lymphoid development is orchestrated by the activities of E proteins and their antagonist Id proteins, but how these factors regulate early... 
T cell development | innate lymphoid cell | basic helix-loop-helix transcription factor | HEB | E2A | Notch signaling | E-ID protein axis | early T cell progenitor | regulome | TRANSCRIPTION FACTORS | E2A PROTEINS | PROGENITORS | B-CELL | GENE REARRANGEMENTS | DNA-BINDING PROTEINS | LINEAGE SPECIFICATION | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | T-CELLS | Thymocytes - metabolism | Transcriptome | Gene Expression Profiling | Gene Regulatory Networks | Lymphocyte Subsets - immunology | Lymphocyte Subsets - metabolism | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Lymphocyte Subsets - cytology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Inhibitor of Differentiation Protein 2 - genetics | T-Cell Antigen Receptor Specificity - immunology | Adaptive Immunity | Gene Expression | Basic Helix-Loop-Helix Transcription Factors - genetics | Immunomodulation | Lymphoid Progenitor Cells - metabolism | Gene Expression Regulation | Immunophenotyping | Mice, Transgenic | Immunity, Innate | Inhibitor of Differentiation Protein 2 - metabolism | Mice, Knockout | Thymocytes - immunology | Cell Differentiation - immunology | Phenotype | Animals | Thymocytes - cytology | Mice | Cluster Analysis | Proteins | Genetic transcription | Research institutes | T cells | Molecular biology | Antigens | Transcription factors | Cytokines | Envelope protein | Gene expression | T-cell receptor | Receptors | Cell fate | Lymphocytes | Rodents | Bone marrow | Notch protein | Aberration | Deoxyribonucleic acid--DNA
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 03/2017, Volume 35, Issue 9, pp. 975 - 983
Journal Article
IMMUNITY, ISSN 1074-7613, 10/2009, Volume 31, Issue 4, pp. 565 - 575
alpha beta and gamma delta T cells arise from a common thymocyte progenitor during development in the thymus. Emerging evidence suggests that the pre-T cell... 
E2A PROTEINS | THYMOCYTE DEVELOPMENT | LYMPHOCYTE DEVELOPMENT | GENE | ALPHA-BETA | IGE PRODUCTION | IN-VIVO | PRE-TCR | IMMUNOLOGY | LINEAGE FATE | TRANSGENIC MICE
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 04/2019, Volume 216, Issue 4, pp. 884 - 899
Current models propose that group 2 innate lymphoid cells (ILC2s) are generated in the bone marrow. Here, we demonstrate that subsets of these cells can... 
E2A PROTEINS | MEDICINE, RESEARCH & EXPERIMENTAL | LOOP-HELIX PROTEINS | PROGENITORS | THYMOCYTE DEVELOPMENT | FACTOR GATA3 | ID1 | RECEPTOR-BETA | INNATE LYMPHOID-CELLS | INDUCTION | IMMUNOLOGY | EXPRESSION
Journal Article
EPIGENOMICS, ISSN 1750-1911, 02/2018, Volume 10, Issue 2, pp. 133 - 147
Aim: To determine whether methylation differences between mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes can be... 
E2A-HLF | ALL | leukemia | EXPRESSION ANALYSIS | FUSION | next-generation sequencing | epigenomics | EPIGENOMIC CHANGES | CHILDHOOD | epigenetics | CHROMOSOMAL TRANSLOCATIONS | RNA-Seq | E2A GENE | RRBS | HUMAN COLON-CANCER | GENETICS & HEREDITY | DNA methylation | transcriptomics | INTERACTION NETWORKS | NGS
Journal Article
Genes and Development, ISSN 0890-9369, 09/2018, Volume 32, Issue 17-18, pp. 1103 - 1104
Alternative splicing (AS) of pre-mRNAs is a ubiquitous process in mammals that is tightly regulated in a cell type-and cell state-dependent manner. However,... 
Alternative splicing | Human embryonic stem cell | T-cell factor 3 | E2A | Heterogeneous nuclear ribonucleoprotein | STEM-CELLS | alternative splicing | heterogeneous nuclear ribonucleoprotein | GENETICS & HEREDITY | DEVELOPMENTAL BIOLOGY | human embryonic stem cell | TCF3 | CELL BIOLOGY | Outlook
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 12/2017, Volume 8
IL-17-producing gamma delta T (gamma delta T17) cells are critical components of the innate immune system. However, the gene networks that control their... 
TCR SIGNAL STRENGTH | TRANSCRIPTION FACTORS | LINEAGE COMMITMENT | LOOP-HELIX PROTEIN | NKT CELLS | INTERFERON-GAMMA | E2A | ALPHA-BETA | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | PRECURSORS
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 306 - 13
Glucocorticoids (GCs) are effective drugs, but their clinical use is compromised by severe side effects including hyperglycemia, hyperlipidemia and obesity.... 
TRANSCRIPTION FACTORS | METABOLIC SYNDROME | READ ALIGNMENT | GENE | E2A | MEDIATOR | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | LIVER | RECEPTOR | FOXO1 | Piezomagnetism | Uranium | Nuclear fuels | Glucocorticoids | Magnetic structure | Industrial applications | Magnetism | Uranium dioxide | Magnetic properties
Journal Article
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