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Nature (London), ISSN 1476-4687, 2009, Volume 462, Issue 7275, pp. 930 - 934
In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions to restrict cells from entering S phase by binding and... 
TRANSCRIPTION FACTORS | INTESTINAL EPITHELIUM | ROLES | MULTIDISCIPLINARY SCIENCES | S-PHASE | E2F3 | MICE | BINDING PROTEIN | EXPRESSION | CELLULAR PROLIFERATION | CYCLE | E2F Transcription Factors - deficiency | Cell Cycle - genetics | Embryonic Stem Cells - metabolism | E2F2 Transcription Factor - genetics | Cell Proliferation | Embryonic Stem Cells - cytology | E2F2 Transcription Factor - deficiency | E2F2 Transcription Factor - metabolism | E2F Transcription Factors - metabolism | Embryo, Mammalian - metabolism | E2F1 Transcription Factor - deficiency | Repressor Proteins - deficiency | Female | Cell Differentiation | Repressor Proteins - metabolism | Retinoblastoma Protein - metabolism | Gene Expression Regulation | Repressor Proteins - genetics | E2F3 Transcription Factor - genetics | Mice, Transgenic | Retinoblastoma Protein - deficiency | E2F1 Transcription Factor - metabolism | E2F3 Transcription Factor - deficiency | Animals | Intestine, Small - cytology | Embryo, Mammalian - cytology | Alleles | E2F3 Transcription Factor - metabolism | Cell Cycle - physiology | Mice | Intestine, Small - metabolism | E2F1 Transcription Factor - genetics | E2F Transcription Factors - genetics | Apoptosis | Physiological aspects | Transcription factors | Genetic aspects | Research | Embryonic stem cells | Cell cycle | Rodents | Stem cells | Cell division | Gene expression | Independent sample | E2F | tumor suppressor | cell cycle | retinoblastoma | Small intestine
Journal Article
Nature cell biology, ISSN 1476-4679, 2012, Volume 14, Issue 11, pp. 1192 - 1202
Journal Article
Nature cell biology, ISSN 1476-4679, 2011, Volume 13, Issue 9, pp. 1146 - 1152
Journal Article
Oncogene, ISSN 1476-5594, 2007, Volume 27, Issue 3, pp. 366 - 377
The activating protein-1 (AP-1) transcription factor transduces growth signals through signal transduction pathways to the nucleus, leading to the expression of genes involved in growth and malignant transformation in many cell types... 
Gene expression regulation | Proliferation arrest | Cyclin D1 | AP-1 factor | Breast cancer cells | E2F factors | TRANSFORMATION | proliferation arrest | breast cancer cells | KINASE-ACTIVITY | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOS | CELL BIOLOGY | gene expression regulation | OVEREXPRESSION | GENE | ONCOLOGY | GENETICS & HEREDITY | BINDING-SITE | cyclin D1 | DIFFERENTIATION | C-JUN | EXPRESSION | Cyclin D1 - metabolism | E2F2 Transcription Factor - genetics | Cell Proliferation | Transcription Factor DP1 - metabolism | Humans | Cyclins - genetics | Gene Expression Regulation, Neoplastic | RNA, Messenger - metabolism | E2F2 Transcription Factor - metabolism | Transcription Factor AP-1 - metabolism | E2F Transcription Factors - metabolism | Cyclin D1 - antagonists & inhibitors | Chromatin Immunoprecipitation | Cyclins - metabolism | RNA, Messenger - antagonists & inhibitors | Female | E2F4 Transcription Factor - metabolism | Promoter Regions, Genetic | Peptide Fragments - metabolism | Down-Regulation | E2F1 Transcription Factor - metabolism | E2F4 Transcription Factor - genetics | Transcription Factor AP-1 - antagonists & inhibitors | Breast Neoplasms - genetics | Cyclin D1 - genetics | Breast Neoplasms - pathology | Proto-Oncogene Proteins c-jun - metabolism | Cell Line, Tumor | E2F1 Transcription Factor - genetics | E2F Transcription Factors - genetics | Care and treatment | Cellular signal transduction | Genetic aspects | Breast cancer | Research | DNA binding proteins | Health aspects | Proteins | Signal transduction | Cell growth | Cyclin-dependent kinases | Oncology | Gene expression | Cells
Journal Article
Nature cell biology, ISSN 1476-4679, 2015, Volume 17, Issue 8, pp. 1036 - 1048
Robust mechanisms to control cell proliferation have evolved to maintain the integrity of organ architecture. Here, we investigated how two critical... 
RNA-POLYMERASE-I | TRANSCRIPTIONAL NETWORK | C-MYC | GENE-EXPRESSION | MURINE DEVELOPMENT | INTESTINAL CRYPTS | RIBOSOMAL DNA | CONDITIONAL DELETION | BETA-CATENIN | DNA-REPLICATION | CELL BIOLOGY | E2F Transcription Factors - deficiency | E2F2 Transcription Factor - genetics | Cell Proliferation | Epithelial Cells - metabolism | Intestine, Small - pathology | Male | Mice, 129 Strain | E2F2 Transcription Factor - metabolism | E2F Transcription Factors - metabolism | S Phase Cell Cycle Checkpoints | Time Factors | G1 Phase Cell Cycle Checkpoints | Female | Transcription, Genetic | Binding Sites | Promoter Regions, Genetic | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Chromatin Assembly and Disassembly | E2F3 Transcription Factor - genetics | Epithelial Cells - pathology | Genotype | Retinoblastoma Protein - deficiency | E2F1 Transcription Factor - metabolism | Proto-Oncogene Proteins c-myc - metabolism | G2 Phase Cell Cycle Checkpoints | Mice, Knockout | Cell Cycle Checkpoints | Phenotype | Animals | Retinoblastoma Protein - genetics | Proto-Oncogene Proteins c-myc - deficiency | E2F3 Transcription Factor - metabolism | Proto-Oncogene Proteins c-myc - genetics | Intestine, Small - metabolism | E2F1 Transcription Factor - genetics | E2F Transcription Factors - genetics | Cell proliferation | Transcription factors | Genetic aspects | Genetic transcription | Properties | Health aspects | Life Sciences | Animal genetics | Genetics | Molecular biology | Biochemistry, Molecular Biology | Cancer
Journal Article
Nature (London), ISSN 0028-0836, 2008, Volume 454, Issue 7208, pp. 1137 - 1141
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2014, Volume 289, Issue 49, pp. 34205 - 34213
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2017, Volume 292, Issue 38, pp. 15952 - 15963
Journal Article
Gene, ISSN 0378-1119, 01/2017, Volume 599, pp. 36 - 52
.... E2F1 is the transcription factor most closely associated with genes down-regulated by ageing and is down-regulated at the protein level in osteocytes... 
Bone | Proliferation | Mechanical loading | Ageing | OSTEOBLAST | SCLEROSTIN ANTIBODY | RNA | CYTOSCAPE | RECEPTOR | CANCELLOUS BONE | PATHWAY | GENETICS & HEREDITY | GENE-EXPRESSION | MICE | ADAPTIVE RESPONSE | Adaptation, Physiological | Cell Cycle - genetics | Cell Proliferation - genetics | Osteocytes - metabolism | Humans | Mice, Inbred C57BL | Transcriptome | Carbohydrate Metabolism - genetics | Signal Transduction - genetics | Gene Regulatory Networks | Tibia - pathology | Aging - pathology | Weight-Bearing - physiology | Extracellular Matrix - genetics | Animals | Aging - genetics | Aging - physiology | Female | Osteocytes - pathology | Mice | E2F1 Transcription Factor - genetics | Energy Metabolism - genetics | Tibia - physiopathology | DNA microarrays | Analysis | Cell cycle | Physiological aspects | Carbohydrate metabolism | Genetic transcription | DNA binding proteins | Transforming growth factors | NADH, Nicotinamide adenine dinucleotide | EGF, epidermal growth factor | Sp7, Sp7 transcription factor 7 | Ezh2, enhancer of zeste 2 polycomb repressive complex 2 subunit | Gtse, G2 and S-phase expressed 1 | Cdk6, cyclin dependent kinase 6 | Cdca3, cell division cycle associated 3 | RNA, Ribonucleic acid | BMD, bone mineral density | Research Paper | E2F1, E2F transcription factor 1 | CO2, Carbon dioxide | BMP, bone morphogenetic protein | Ttn, titin | DAVID, Database for Annotation, Visualization and Integrated Discovery | Bcl212, Bcl-2-like protein 2 | Itgb1, integrin subunit beta 1 | Bcl11a, B-cell CLL | Sox9, SRY-box 9 | Gnas, GNAS complex locus | Grb10, growth factor receptor bound protein 10 | ATP, Adenosine triphosphate | EGR2, early growth response 2 | Wnt16, Wnt family member 16 | Vcam1, vascular cell adhesion molecule 1 | Mark3, microtubule affinity regulating kinase 3 | Fzd7, frizzled class receptor 7 | b2MG, Beta-2-microglobulin | KEGG, Kyoto Encyclopaedia of Genes and Genomes | Phex, phosphate regulating endopeptidase homolog, X-linked | RarB, retinoic acid receptor beta | SPEED, Signalling Pathway Enrichment using Experimental Datasets | BiNGO, A Biological Network Gene Ontology tool | PASTAA, Predicted Association of Transcription factors from Annotated Affinities | lymphoma 11A | TGFb, transforming growth factor beta 1 | Tcf15, transcription factor 15 | Igf1, insulin like growth factor 1 | Dkk1, dickkopf WNT signalling pathway inhibitor 1 | Des, desmin | MAPK, mitogen-activated protein kinase | Dab2IP, disabled 2 interacting protein | Mmp25, matrix metallopeptidase 25 | Actn2, actinin alpha 2 | qRT-PCR, quantitative real time polymerase chain reaction | Mef2c, myocyte enhancer factor 2C | Mki67, marker of proliferation Ki-67 | Pitx2, paired-like homeodomain transcription factor 2 | MCM, Minichromosome maintenance protein complex | Cdc20, cell division cycle 20 | MEPE, matrix extracellular phosphoglycoprotein | QTC, Quality Threshold Clustering | TNFa, tumor necrosis factor a | Fgf7, fibroblast growth factor 7 | Igf2, insulin like growth factor 2 | Ccna2, cyclin A2 | Fgfr1, fibroblast growth factor receptor 1 | Pkia, protein kinase (cAMP-dependent, catalytic) inhibitor alpha | Ccnd3, cyclin D3 | Myf6, myogenic factor 6 | Sost, sclerostin | Sox6, SRY-box 6 | Atf3, activating transcription factor 3 | MMP13, matrix metallopeptidase 13 | AMPK, adenosine monophosphate-activated protein kinase | Mapt, microtubule associated protein tau | Scyl1, SCY1 like pseudokinase 1 | Insig2, insulin induced gene 2 | PBS, Phosphate buffered saline | Kcnma1, potassium calcium-activated channel subfamily M alpha 1 | FDR, false discovery rate | VegfA, vascular endothelial growth factor A | Nusap1, nucleolar and spindle associated protein 1 | ECM, Extracellular matrix | PdgfA, platelet derived growth factor, alpha
Journal Article
Molecular Endocrinology, ISSN 1944-9917, 2012, Volume 26, Issue 8, pp. 1268 - 1277
Journal Article