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Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/2017, Volume 141, Issue 6, pp. 1110 - 1119
E6 oncoprotein is a necessary agent of HPV driven oncogenic transformation. This study is aimed at evaluating the risk stratification potency of HPV 16/18 E6... 
risk predictor | screening cohort | E6 oncoprotein | triage | cervical cancer | HPV | POPULATION | HPV INFECTION | CERVICAL-CANCER | HUMAN-PAPILLOMAVIRUS | CYTOLOGY | STRATEGIES | POSITIVE WOMEN | RURAL CHINA | ONCOLOGY | NEOPLASIA | YOUNG-WOMEN | Predictive Value of Tests | Prospective Studies | Humans | Middle Aged | Uterine Cervical Neoplasms - epidemiology | DNA, Viral - analysis | DNA-Binding Proteins - analysis | Oncogene Proteins, Viral - analysis | Repressor Proteins - analysis | DNA-Binding Proteins - metabolism | Human papillomavirus 16 - isolation & purification | Uterine Cervical Neoplasms - metabolism | Human papillomavirus 18 - metabolism | Adult | Female | Papillomavirus Infections - virology | Cervical Intraepithelial Neoplasia - epidemiology | Human papillomavirus 18 - genetics | Repressor Proteins - metabolism | Oncogene Proteins, Viral - metabolism | Risk Assessment | Papillomavirus Infections - epidemiology | China - epidemiology | Human papillomavirus 16 - metabolism | Cervical Intraepithelial Neoplasia - virology | Human papillomavirus 18 - isolation & purification | Papillomavirus Infections - metabolism | Uterine Cervical Neoplasms - virology | Cervical Intraepithelial Neoplasia - metabolism | DNA, Viral - genetics | Human papillomavirus 16 - genetics | Cohort Studies | Diagnosis | Information management | Acetic acid | Papillomavirus infections | Cervical cancer | Organic acids | Cancer | Transformation | Colposcopy | Cytology | Health risks | Inspection | Risk | Infections | Cervix | Medical screening | Incidence | Studies | Proteins | Screening | Human papillomavirus | Biopsy | Quality | DNA testing | Genetic testing | Health risk assessment | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, pp. e103440 - e103440
Background and Objectives: Human papillomavirus (HPV)-16 infection may be related to non-smoking associated lung cancer. Our previous studies have found that... 
E6 ONCOPROTEIN | OVEREXPRESSION | HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA | MULTIDISCIPLINARY SCIENCES | NEVER-SMOKERS | HYPOXIA | HUMAN CERVICAL-CARCINOMA | TUMOR-GROWTH | ASSOCIATION | ENDOTHELIAL GROWTH-FACTOR | PROTEIN ACCUMULATION | Vascular Endothelial Growth Factor A | Carcinoma, Non-Small-Cell Lung - blood supply | Humans | Lung Neoplasms - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Morpholines - pharmacology | Repressor Proteins - genetics | Neovascularization, Pathologic - virology | Lung Neoplasms - virology | Hypoxia-Inducible Factor 1, alpha Subunit | Papillomavirus E7 Proteins - genetics | Genes, jun - drug effects | Papillomavirus E7 Proteins - metabolism | MAP Kinase Signaling System - drug effects | Cell Line, Tumor | Oncogene Proteins, Viral - genetics | Neovascularization, Pathologic - metabolism | Carcinoma, Non-Small-Cell Lung - virology | Interleukin-8 - metabolism | Chromones - pharmacology | In Vitro Techniques | Repressor Proteins - metabolism | Lung Neoplasms - blood supply | Oncogene Proteins, Viral - metabolism | TOR protein | Transcription factors | Immunoprecipitation | Laboratories | Lung | Interleukin | Lung cancer | AKT protein | Activation | mRNA | Kinases | Western blotting | Proteins | Angiogenesis | Signal transduction | Human papillomavirus | Pathways | Vascular endothelial growth factor | Interleukin 8 | Enzyme-linked immunosorbent assay | Hypoxia-inducible factors | Stability | Secretion | Non-small cell lung carcinoma | c-Jun protein | siRNA | Endothelial cells | 1-Phosphatidylinositol 3-kinase | Signaling | Plasmids | Cell lines | Hypoxia | Umbilical vein | Cancer | Smoking | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 10/2019, Volume 145, Issue 8, pp. 2042 - 2050
HPV testing is a better alternative for cervical cancer screening, but additional procedures are required for triage of HPV positive women. HPV encoded... 
Honduras | screening | E6 oncoproteins | ESTAMPA | HPV | ONCOLOGY | HUMAN-PAPILLOMAVIRUS | Immunohistochemistry | Medical tests | Diagnosis | Papillomavirus infections | Cervical cancer | Cancer | Colposcopy | Cervix | Medical screening | Screening | Sensitivity | Carcinogens | Human papillomavirus | Carcinogenicity | Lesions | Deoxyribonucleic acid--DNA
Journal Article
Genes and Development, ISSN 0890-9369, 07/1998, Volume 12, Issue 13, pp. 2061 - 2072
Interferon regulatory factor-3 (IRF-3) was found to specifically interact with HPV16 E6 in a yeast two-hybrid screen. IRF-3 is activated by the presence of... 
IRF-3 | Transcription | Protein-protein interactions | Oncoprotein | HPV16 | CARCINOMA CELL-LINES | FACTOR FAMILY | PROTEIN | transcription | DNA-DAMAGE | HPV-16 E6 | DEVELOPMENTAL BIOLOGY | HUMAN KERATINOCYTES | protein-protein interactions | FULL-LENGTH E6 | IFN-BETA | EPITHELIAL-CELLS | GENETICS & HEREDITY | GENE-EXPRESSION | oncoprotein | Protein Binding - genetics | Keratinocytes - virology | Humans | Repressor Proteins | Trans-Activators - physiology | DNA-Binding Proteins - metabolism | Interferon Regulatory Factor-3 | RNA, Messenger - biosynthesis | RNA, Messenger - antagonists & inhibitors | Interferon-beta - genetics | Transcription, Genetic | Oncogene Proteins, Viral - metabolism | Oncogene Proteins, Viral - physiology | Oncogene Proteins, Viral - isolation & purification | DNA-Binding Proteins - antagonists & inhibitors | Interferon-beta - biosynthesis | Transcription Factors - antagonists & inhibitors | Binding Sites - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Interferon-beta - antagonists & inhibitors | Transcription Factors - metabolism | Animals | Keratinocytes - metabolism | Respirovirus - physiology | Mice | HeLa Cells | Trans-Activators - antagonists & inhibitors | Papillomaviruses | Antiviral agents | Interferon | Research | Structure-activity relationships | Index Medicus | protein–protein interactions | Research Paper
Journal Article
International Journal of Cancer, ISSN 0020-7136, 04/2018, Volume 142, Issue 7, pp. 1467 - 1479
Recent advances in immunotherapy against cancer underscore the importance of T lymphocytes and tumor microenvironment, but few vaccines targeting cancer have... 
E6 | tissue resident memory | CD4 | E7 | vaccine | CD8 | adenovirus | human papillomavirus | neoplasia | female reproductive tract | REGRESSION | IMMUNITY | CARRAGEENAN | SAFETY | CERVICAL INTRAEPITHELIAL NEOPLASIA | IMMUNIZATION | IMMUNOGENICITY | ONCOLOGY | DOUBLE-BLIND | INFECTION | EXPRESSION | Immunotherapy - methods | Papillomavirus Infections - complications | Adenoviridae | Transduction, Genetic | Mice, Inbred C57BL | Vaccination | Papillomavirus E7 Proteins - immunology | Cancer Vaccines - immunology | Animals | Repressor Proteins - immunology | Papillomavirus Infections - immunology | Uterine Cervical Neoplasms - virology | Female | Papillomavirus Vaccines - immunology | Mice | Mice, Inbred BALB C | Oncogene Proteins, Viral - immunology | CD8-Positive T-Lymphocytes - immunology | Genetic Vectors | Evolutionary biology | Tumor antigens | Adenoviruses | Development and progression | T cells | Health aspects | Cervical cancer | CD8 antigen | Mucosa | Trafficking | Immune clearance | Viruses | Lymphocytes T | Infections | Malignancy | Vaccines | Proteins | Cancer vaccines | CD69 antigen | Human papillomavirus | CD103 antigen | Lymphocytes | Etiology | Immunotherapy | Lesions | Expression vectors | Antigens | Immunization | Immunological memory | Memory cells | Tumor necrosis factor-α | Epithelium | Immunogenicity | Antigen (tumor-associated) | Persistent infection | γ-Interferon | Cancer | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2015, Volume 112, Issue 32, pp. 9872 - 9877
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 06/2015, Volume 54, Issue 27, pp. 7958 - 7962
The E6 oncoproteins of high‐risk mucosal (hrm) human papillomaviruses (HPVs) contain a pocket that captures LxxLL motifs and a C‐terminal motif that recruits... 
inhibitors | peptides | protein engineering | human papillomavirus | antitumor agents | Protein engineering | Human papillomavirus | Antitumor agents | Inhibitors | Peptides | RESIDENCE TIME | MECHANISM | HUMAN-PAPILLOMAVIRUS E6 | CERVICAL-CANCER | CELL-GROWTH | CHEMISTRY, MULTIDISCIPLINARY | MULTIVALENCY | PROTEINS | BINDING | ASSOCIATION | Neoplasms - metabolism | Oncogene Proteins, Viral - chemistry | Recombinant Fusion Proteins - pharmacology | Humans | Recombinant Fusion Proteins - metabolism | Papillomavirus Infections - therapy | DNA-Binding Proteins - metabolism | Neoplasms - virology | Neoplasms - therapy | Cell Death | Human papillomavirus 18 - metabolism | Adenoviridae - genetics | Papillomavirus Infections - virology | Human papillomavirus 16 - chemistry | Binding Sites | Repressor Proteins - metabolism | Oncogene Proteins, Viral - metabolism | Cell Line | Gene Expression | Repressor Proteins - chemistry | Tumor Suppressor Protein p53 - metabolism | Models, Molecular | Human papillomavirus 18 - chemistry | Recombinant Fusion Proteins - chemistry | DNA-Binding Proteins - chemistry | Human papillomavirus 16 - metabolism | Amino Acid Motifs | Papillomavirus Infections - metabolism | PDZ Domains | Protein Binding | Recombinant Fusion Proteins - genetics | Ligands | HeLa Cells | Nuclear magnetic resonance spectroscopy | Tumor proteins | Papillomavirus infections | Rodents | Index Medicus | Human | Proteins | Cellular | Death | Calorimetry | Nanostructure | Binders | Communications
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 11/2015, Volume 7, Issue 11, pp. 1426 - 1449
Journal Article