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Anti-Cancer Drugs, ISSN 0959-4973, 04/2002, Volume 13, Issue 4, pp. 381 - 393
Ecteinascidin 743 (ET-743) is an anticancer agent derived from the Caribbean tunicate Ecteinascidia turbinata. In the present article, the pharmacokinetics and... 
ecteinascidin-743
Journal Article
EUROPEAN JOURNAL OF CANCER, ISSN 0959-8049, 03/2012, Volume 48, Issue 4, pp. 579 - 585
Purpose: To determine the toxicity, efficacy and pharmacokinetics of trabectedin given over 24 h every 3 weeks to children with recurrent rhabdomyosarcoma,... 
Sarcoma | ONCOLOGY | Clinical trials | Phase 2 | Paediatrics | ECTEINASCIDIN-743 ET-743 | CHEMOTHERAPY
Journal Article
Journal Article
ONCOLOGY, ISSN 0030-2414, 2018, Volume 95, pp. 1 - 4
Journal Article
Organic Letters, ISSN 1523-7060, 11/2015, Volume 17, Issue 22, pp. 5650 - 5653
An efficient route to isoindolinones and isoquinolinones has been achieved via a domino Ni-catalyzed homoallylation/lactamization from in situ prepared imines,... 
ASYMMETRIC-SYNTHESIS | TETRAHYDROISOQUINOLINES | HYDROGENATION | 1,3-DIENES | ECTEINASCIDIN-743 | CARBON STEREOCENTERS | CHEMISTRY, ORGANIC | ALDEHYDES | NICKEL-CATALYZED HOMOALLYLATION | DERIVATIVES | CYCLIZATION
Journal Article
Organic Letters, ISSN 1523-7060, 02/2016, Volume 18, Issue 4, pp. 634 - 637
A one-pot, three-component synthesis of widely substituted isoindolinones and isoquinolinones, featuring a Lewis acid-catalyzed efficient Strecker reaction and... 
3-COMPONENT SYNTHESIS | ASYMMETRIC-SYNTHESIS | TETRAHYDROISOQUINOLINES | ECTEINASCIDIN-743 | CARBON STEREOCENTERS | CHEMISTRY, ORGANIC | CASCADE | PICTET-SPENGLER REACTIONS | INHIBITORS | DERIVATIVES | CYCLIZATION
Journal Article
GYNECOLOGIC ONCOLOGY, ISSN 0090-8258, 06/2008, Volume 109, Issue 3, pp. 329 - 334
Objectives. Fixed-dose rate gemcitabine plus docetaxel is active as second-line therapy for metastatic uterine leioinyosarcoma. We sought to determine the... 
SOFT-TISSUE SARCOMAS | PULMONARY TOXICITY | UTERUS | COMBINATION | IFOSFAMIDE | CHEMOTHERAPY | OBSTETRICS & GYNECOLOGY | LUNG-CANCER | ETOPOSIDE | ONCOLOGY | docetaxel | ECTEINASCIDIN-743 | gemcitabine | uterine leimnyosarconia | RECURRENT LEIOMYOSARCOMA
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2014, Volume 136, Issue 41, pp. 14583 - 14588
Asymmetric hydroformylation (AHF) of Z-enamides and Z-enol esters provides chiral, alpha-functionalized aldehydes with high selectivity and atom economy.... 
HYDROGENATION | ECTEINASCIDIN-743 | COMPLEXES | TERMINAL ALKYNES | OLEFINS | HIGHLY ENANTIOSELECTIVE HYDROFORMYLATION | QUATERNARY CARBON CENTERS | DIAZAPHOSPHOLANE LIGANDS | CHEMISTRY, MULTIDISCIPLINARY | BOUND DIRECTING GROUP | CARBOXYLIC-ACIDS | Chemical properties | Rhodium | Structure | Hydrogen
Journal Article
BRITISH JOURNAL OF CANCER, ISSN 0007-0920, 09/2019, Volume 121, Issue 6, pp. 464 - 473
BACKGROUND: Myxoid liposarcoma is a histological subtype of liposarcoma particularly sensitive to trabectedin. In clinical use this drug does not cause... 
SENSITIVITY | ONCOLOGY | ECTEINASCIDIN-743 | GENETICS | TUMORS | CELL-LINE | Transcription | Toxicity | Medical treatment | Xenotransplantation | Medical services | Nucleotide excision repair | Nucleotides | Patients | Morphology | Liposarcoma | Xenografts | Biocompatibility | In vivo methods and tests | Mutation | Adipogenesis | Tumors
Journal Article
Journal of Heterocyclic Chemistry, ISSN 0022-152X, 01/2010, Volume 47, Issue 1, pp. 50 - 53
Using L‐tyrosine as a chiral starting material, we developed an efficient synthetic route to (–)‐MY 336a. A key step in the sequence is a highly regio‐ and... 
CHEMISTRY, ORGANIC | MY336-A | ECTEINASCIDIN-743 | DERIVATIVES
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 03/2010, Volume 70, Issue 6, pp. 2235 - 2244
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 08/2018, Volume 188, pp. 118 - 123
Metastatic soft-tissue sarcoma (STS), a devastating disease, has a median overall survival of only 12–18 months. Until recently, therapeutic options were... 
Epigenetics | Metastatic disease | Chemotherapy | Sarcoma | Targeted therapy | Immunotherapy | UNIQUE MECHANISM | PHASE-II | OPEN-LABEL | NUCLEOTIDE-EXCISION | P53 PATHWAY | ET-743 | DEDIFFERENTIATED LIPOSARCOMA | ECTEINASCIDIN-743 | PHARMACOLOGY & PHARMACY | ERIBULIN MESYLATE | EXPRESSION | Epigenetic inheritance | Anthracyclines | Stem cells | Metastasis | Health aspects | Cancer
Journal Article
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