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Journal of Cell Science, ISSN 0021-9533, 04/2013, Volume 126, Issue 8, pp. 1744 - 1752
The tumor suppressor protein p16INK4a is a member of the INK4 family of cyclin-dependent kinase (Cdk) inhibitors, which are involved in the regulation of the... 
eEF1A2 | Anti-proliferative effects | p16 | Translational activity | Ovarian cancer | p16INK4a
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 11/2019, Volume 176, p. 112814
The two isoforms of the eukaryotic Elongation Factor 1A (eEF1A1 and eEF1A2), sustain the progression/aggressiveness of cancer cells. Thus, they are considered... 
Immunohistochemistry | In Cell Western | eEF1A2 | LoVo DX | siRNA | PC-3 | PZHPV-7 | LoVo109 | Drug resistance | eEF1A1
Journal Article
by McRae, Jeremy F and Clayton, Stephen and Fitzgerald, Tomas W and Kaplanis, Joanna and Prigmore, Elena and Rajan, Diana and Sifrim, Alejandro and Aitken, Stuart and Akawi, Nadia and Alvi, Mohsan and Ambridge, Kirsty and Barrett, Daniel M and Bayzetinova, Tanya and Jones, Philip and Jones, Wendy D and King, Daniel and Krishnappa, Netravathi and Mason, Laura E and Singh, Tarjinder and Tivey, Adrian R and Ahmed, Munaza and Anjum, Uruj and Archer, Hayley and Armstrong, Ruth and Awada, Jana and Balasubramanian, Meena and Banka, Siddharth and Baralle, Diana and Barnicoat, Angela and Batstone, Paul and Baty, David and Bennett, Chris and Berg, Jonathan and Bernhard, Birgitta and Bevan, A. Paul and Bitner-Glindzicz, Maria and Blair, Edward and Blyth, Moira and Bohanna, David and Bourdon, Louise and Bourn, David and Bradley, Lisa and Brady, Angela and Brent, Simon and Brewer, Carole and Brunstrom, Kate and Bunyan, David J and Burn, John and Canham, Natalie and Castle, Bruce and Chandler, Kate and Chatzimichali, Elena and Cilliers, Deirdre and Clarke, Angus and Clasper, Susan and Clayton-Smith, Jill and Clowes, Virginia and Coates, Andrea and Cole, Trevor and Colgiu, Irina and Collins, Amanda and Collinson, Morag N and Connell, Fiona and Cooper, Nicola and Cox, Helen and Cresswell, Lara and Cross, Gareth and Crow, Yanick and D'Alessandro, Mariella and Dabir, Tabib and Davidson, Rosemarie and Davies, Sally and De Vries, Dylan and Dean, John and Deshpande, Charu and Devlin, Gemma and Dixit, Abhijit and Dobbie, Angus and Donaldson, Alan and Donnai, Dian and Donnelly, Deirdre and Donnelly, Carina and Douglas, Angela and Douzgou, Sofia and Duncan, Alexis and Eason, Jacqueline and Ellard, Sian and Ellis, Ian and Elmslie, Frances and Evans, Karenza and Everest, Sarah and Fendick, Tina and Fisher, Richard and Flinter, Frances and Foulds, Nicola and Fry, Andrew and Fryer, Alan and Gardiner, Carol and Gaunt, Lorraine and Ghali, Neeti and ... and Deciphering Developmental Disorders Study
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 433 - 438
The genomes of individuals with severe, undiagnosed developmental disorders are enriched in damaging de novo mutations (DNMs) in developmentally important... 
INTELLECTUAL DISABILITY | METAANALYSIS | VARIANTS | GENETICS | HEART-DEFECTS | MULTIDISCIPLINARY SCIENCES | GENES | SEQUENCE | FRAMEWORK | DISCOVERY | GENOME | Prevalence | Humans | Middle Aged | Parents | Male | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Developmental Disabilities - genetics | Casein Kinase II - genetics | Autoantigens - genetics | Young Adult | ras GTPase-Activating Proteins - genetics | Adult | Female | Child | CDC2 Protein Kinase - genetics | Histone-Lysine N-Methyltransferase - genetics | Repressor Proteins - genetics | Sex Characteristics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nerve Tissue Proteins - genetics | Sequence Analysis, DNA | Homeodomain Proteins - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Phenotype | Myeloid-Lymphoid Leukemia Protein - genetics | Adolescent | Heredity - genetics | Protein Phosphatase 2C - genetics | Cohort Studies | Child development deviations | Genetic aspects | Genetic disorders | Developmental disabilities | Distribution | Genes | Families & family life | Births | Genomes | Mutation | Causality | Estimates | Age | TRIO | MYT1L | EHMT1 | HNRNPU | SUV420H1 | COL4A3BP | SYNGAP1 | PPP2R1A | POGZ | EP300 | KCNH1 | SCN1A | MEF2C | CDKL5 | CSNK2A1 | DYRK1A | CASK | ALG13 | FOXP1 | KAT6B | TBL1XR1 | KAT6A | SCN8A | KCNQ2 | EEF1A2 | KCNQ3 | ADNP | PhenIcons | SET | KMT2A | ANKRD11 | STXBP1 | FOXG1 | ZC4H2 | ITPR1 | De novo mutation | Seizures | ZBTB18 | CREBBP | SMAD4 | PDHA1 | IQSEC2 | AUTS2 | BCL11A | BRAF | SMARCA2 | GRIN2B | MED13L | GNAO1 | CNOT3 | TCF4 | SCN2A | CDK13 | GABRB3 | SETD5 | KDM5B | Developmental Disease | DDX3X | CHD8 | PTEN | CHD4 | TCF20 | CTCF | CHD2 | WDR45 | SLC6A1 | MECP2 | CHAMP1 | KIF1A | Average Faces | MSL3 | PPP2R5D | SMC1A | ARID1B | DNM1 | CNKSR2 | PACS1 | WAC | ZMYND11 | AHDC1 | NFIX | SATB2 | HDAC8 | PPM1D | GNAI1 | PURA | PUF60 | NSD1 | Intellectual Disability | SLC35A2 | DYNC1H1 | NAA10 | USP9X | PTPN11 | GATAD2B | ASXL1 | KANSL1 | ASXL3 | CTNNB1 | QRICH1
Journal Article
Brain & development, ISSN 0387-7604, 08/2019
Mutations in the elongation factor 1 alpha 2 (EEF1A2) gene have been recently shown to cause epileptic encephalopathy (MIM # 616409 EIEE33) associated with... 
Journal Article
PLOS ONE, ISSN 1932-6203, 01/2018, Volume 13, Issue 1
Eukaryotic translation factors, especially initiation factors have garnered much attention with regards to their role in the onset and progression of different... 
OVEREXPRESSION | GAMMA-RELATED SEQUENCE | FACTOR 1 ALPHA-2 | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | FACTOR EEF2 | FACTOR-I | PROTEIN-SYNTHESIS | UP-REGULATION | FACTOR EEF1A2 | TRANSFER-RNA-SYNTHETASE
Journal Article
INTERNATIONAL JOURNAL OF PHARMACEUTICS, ISSN 0378-5173, 06/2017, Volume 525, Issue 2, pp. 367 - 376
Eukaryotic elongation factor 1A (eEF1A), a protein involved in protein synthesis, has two major isoforms, eEF1A1 and eEF1A2. Despite the evidences of their... 
APOPTOSIS | CANCER CELLS | DOWN-REGULATION | HCC | siRNA | PROLIFERATION | BORTEZOMIB | Liposome delivery | GENES | E2F1 | E2F | PHARMACOLOGY & PHARMACY | eEF1A2 | EEF1A | FACTOR 1A | eEF1A1 | EXPRESSION
Journal Article
World Chinese Journal of Digestology, ISSN 1009-3079, 2014, Volume 22, Issue 14, pp. 2049 - 2054
Journal Article
International Journal of Clinical and Experimental Pathology, ISSN 1936-2625, 2016, Volume 9, Issue 6, pp. 6371 - 6377
Myeloid neoplasms are broadly divided into acute myeloid leukemia (AML) and chronic myeloid disorders. Understanding the molecular mechanisms of myeloid... 
Doxorubicin-tolerant | eEF1A2 | CML | K562 | RNA-Seq | MECHANISMS | PATHOLOGY | FACTOR-XII | CANCER | CHRONIC MYELOID-LEUKEMIA | ELONGATION-FACTOR EEF1A2 | ONCOLOGY | INTERACTS | RESISTANCE | doxorubicin-tolerant
Journal Article
CANCER CHEMOTHERAPY AND PHARMACOLOGY, ISSN 0344-5704, 12/2018, Volume 82, Issue 6, pp. 1067 - 1080
PurposeMetarrestin is a first-in-class small molecule clinical candidate capable of disrupting the perinucleolar compartment, a subnuclear structure unique to... 
SURVIVAL | PERINUCLEOLAR COMPARTMENT PREVALENCE | Pharmacodynamics | Peri-nucleolar compartment (PNC) | Metarrestin | CHEMOTHERAPY | BREAST-CANCER | ONCOLOGY | KPC mice | EEF1A2 | ENHANCEMENT | MICRONIZATION | IMPROVEMENT | PHARMACOLOGY & PHARMACY | Pharmacokinetics | EXPRESSION | DISSOLUTION RATE
Journal Article
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 06/2017, Volume 525, Issue 2, pp. 367 - 376
Eukaryotic elongation factor 1A (eEF1A), a protein involved in protein synthesis, has two major isoforms, eEF1A1 and eEF1A2. Despite the evidences of their... 
E2F1 | HCC | siRNA | eEF1A2 | eEF1A1 | Liposome delivery | Liposomes - chemistry | Humans | Protein Isoforms | Liver Neoplasms - metabolism | Cell Line, Tumor | RNA, Small Interfering - administration & dosage | Peptide Elongation Factor 1 - metabolism | Carcinoma, Hepatocellular - metabolism | Protein biosynthesis | Hepatoma
Journal Article