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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2017, Volume 114, Issue 41, pp. E8603 - E8610
Journal Article
MOLECULAR CELL, ISSN 1097-2765, 07/2013, Volume 51, Issue 1, pp. 35 - 45
Translation factor elF5A, containing the unique amino acid hypusine, was originally shown to stimulate Met-puromycin synthesis, a model assay for peptide bond... 
EF-P | MESSENGER-RNA | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PEPTIDE-BOND FORMATION | SYNTHESIS INITIATION-FACTORS | TRANSFER-RNA | PROTEIN-SYNTHESIS | SACCHAROMYCES-CEREVISIAE | ELONGATION-FACTOR-P | 70S RIBOSOME | CELL BIOLOGY
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 10/2015, Volume 137, Issue 40, pp. 12997 - 13006
The peptide bond formation with the amino acid praline (Pro) on the ribosome is slow, resulting in translational stalling when several Pro have to be... 
FACTOR EF-P | ESCHERICHIA-COLI RIBOSOME | AMINOACYL-TRANSFER-RNA | COLLAGEN STABILITY | CIS-TRANS ISOMERIZATION | PEPTIDE-BOND FORMATION | TRANSLATION | PROTEINS | POLYPROLINE STRETCHES | CHEMISTRY, MULTIDISCIPLINARY | PROLINE RESIDUES
Journal Article
Science, ISSN 0036-8075, 04/2015, Volume 348, Issue 6233, pp. 457 - 460
Protein synthesis rates can affect gene expression and the folding and activity of the translation product. Interactions between the nascent polypeptide and... 
EXIT TUNNEL | TRANSLOCATION | PEPTIDES | EF-P | TRANSLATION | MULTIDISCIPLINARY SCIENCES | Protein research | Protein biosynthesis | Polypeptides | Research | Ribosomes | Proteins | Ribonucleic acid--RNA | Chemical synthesis | Synthesis | Tunnels (transportation) | Protein synthesis | Plugging | Mathematical models | Translations | Folding
Journal Article
by Li, X and Krafczyk, R and Macosek, J and Li, YL and Zou, Y and Simon, B and Pan, X and Wu, QY and Yan, F and Li, S and Hennig, J and Jung, K and Lassak, J and Hu, HG
CHEMICAL SCIENCE, ISSN 2041-6520, 2016, Volume 7, Issue 12, pp. 6995 - 7001
A previously discovered posttranslational modification strategy - arginine rhamnosylation - is essential for elongation factor P (EF-P) dependent rescue of... 
FACTOR EF-P | PROTEIN | GLCNACYLATION | PATHWAY | SYNTHETASE | GLYCOSYLATION | GLYCOPEPTIDES | GLYCOSYLTRANSFERASES | POLYPROLINE STRETCHES | CHEMISTRY, MULTIDISCIPLINARY | RIBOSOME
Journal Article
Nature Reviews Microbiology, ISSN 1740-1526, 05/2015, Volume 13, Issue 5, pp. 285 - 297
Journal Article
Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 08/2018, Volume 10, Issue 8
n this review, we highlight the current understanding of translation elongation and recoding in eukaryotes. In addition to providing an overview of the... 
MESSENGER-RNA TRANSLATION | EF-P | SITE TRANSFER-RNA | RIBOSOMAL FRAMESHIFT SIGNALS | IMMUNODEFICIENCY-VIRUS TYPE-1 | ALLOSTERIC 3-SITE MODEL | SACCHAROMYCES-CEREVISIAE | PROTEIN-SYNTHESIS | PEPTIDYL-TRANSFER-RNA | STEM-LOOP RNA | CELL BIOLOGY
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 12/2017, Volume 45, Issue 22, pp. 12601 - 12610
A bacterial translation factor EF-P alleviates ribosomal stalling caused by polyproline sequence by accelerating Pro-Pro formation. EF-P recognizes a specific... 
PEPTIDYL-TRANSFER | ELONGATION-FACTOR TU | GENETIC-CODE | PEPTIDOMIMETICS | EF-P | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIBOSOMAL SYNTHESIS | TRANSLATION | SELECTION | PROLINE RESIDUES | DISCOVERY | NAR Breakthrough
Journal Article
Biochemistry, ISSN 0006-2960, 07/2018, Volume 57, Issue 29, pp. 4241 - 4246
A complete understanding of the determinants that restrict d-amino acid incorporation by the ribosome, which is of interest to both basic biologists and the... 
CHLORAMPHENICOL | EF-P | ELONGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | ERYTHROMYCIN | MACROLIDE ANTIBIOTICS | SITE-SPECIFIC INCORPORATION | PROTEIN-SYNTHESIS | D-TYROSYL | RIBOSOME
Journal Article
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, ISSN 1943-0264, 05/2019, Volume 11, Issue 5
The translation of messenger RNA (mRNA) into protein and the folding of the resulting protein into an active form are prerequisites for virtually every... 
REVEALS DISTINCT | MESSENGER-RNA TRANSLATION | OPEN READING FRAMES | EF-P | ELONGATION | IN-VIVO | GENOME-WIDE ANALYSIS | GENE-EXPRESSION | PROTEIN-SYNTHESIS | REGULATORY VARIATION | CELL BIOLOGY | Proteins | Translation | Profiling | Protein synthesis | Protein folding | rRNA | Protein biosynthesis | mRNA | Genomes | Folding
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 09/2018, Volume 140, Issue 38, pp. 12159 - 12167
Due to their unique characteristics, which are not shared by canonical α-peptides, peptides that contain stretches of consecutive β-amino acids are attractive... 
ELONGATION-FACTOR TU | PEPTIDES | EF-P | TRANSFER-RNA SYNTHETASE | AFFINITY | TRANSLATION | SELECTION | PROTEIN-SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 48, pp. 18710 - 18718
The natural amino acid hypusine (N-is an element of-4-amino-2-hydroxybutyl( lysine)) is derived from the polyamine spermidine, and occurs only in a single... 
EF-P | CELL VIABILITY | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INITIATION-FACTOR 5A | HUMAN DEOXYHYPUSINE SYNTHASE | FACTOR EIF5A | PROTEIN-SYNTHESIS | SACCHAROMYCES-CEREVISIAE | ELONGATION-FACTOR-P | POSTTRANSLATIONAL MODIFICATION
Journal Article
by Nam, D and Choi, E and Shin, D and Lee, EJ
MOLECULAR MICROBIOLOGY, ISSN 0950-382X, 10/2016, Volume 102, Issue 2, pp. 221 - 232
Bacterial ribosome requires elongation factor P to translate fragments harbouring consecutive proline codons. Given the abundance of ORFs with potential EF-P... 
MYCOBACTERIUM-TUBERCULOSIS | FACTOR EF-P | MESSENGER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRAMACROPHAGE SURVIVAL | BACTERIAL VIRULENCE | TYPHIMURIUM | MICROBIOLOGY | TRANSLATION | IDENTIFICATION | POLYPROLINE STRETCHES | PROTEIN-SYNTHESIS
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2019, Volume 76, Issue 1, pp. 110 - 125.e9
Failure to make adaptive immune responses is a hallmark of aging. Reduced B cell function leads to poor vaccination efficacy and a high prevalence of... 
spermidine | TFEB | B cell | autophagy | aging | eIF5A | LIFE-SPAN EXTENSION | INHIBITION | EF-P | MECHANISM | INITIATION | ELONGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION | MAMMALIAN-CELLS | SPERMIDINE | REVEALS | CELL BIOLOGY
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2017, Volume 66, Issue 2, pp. 194 - 205.e5
Journal Article
Nature Communications, ISSN 2041-1723, 06/2016, Volume 7, Issue 1, p. 11952
Xpo4 is a bidirectional nuclear transport receptor that mediates nuclear export of eIF5A and Smad3 as well as import of Sox2 and SRY. How Xpo4 recognizes such... 
CELL VIABILITY | EF-P | DEOXYHYPUSINE HYDROXYLASE | STRUCTURE REFINEMENT | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | NUCLEAR-PORE COMPLEX | INITIATION-FACTOR 5A | MOLECULAR-CLONING | TRANSFER-RNA | CONTAINING PROTEIN
Journal Article
New Journal of Chemistry, ISSN 1144-0546, 2016, Volume 40, Issue 6, pp. 5209 - 5220
The acidity of N-acyl amino acids is dependent upon the rotameric state of the amide bond. In this work we systematically investigated the acidity difference... 
BOND ISOMERIZATION | PI-ASTERISK INTERACTION | FACTOR EF-P | CARBONYL GROUPS | AMINO-ACIDS | PROTEIN-STRUCTURE | NUCLEAR-MAGNETIC-RESONANCE | POLYPROLINE-II HELIX | PROLINE-CONTAINING PEPTIDES | AZETIDINE-2-CARBOXYLIC ACID | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Molecular Biology and Evolution, ISSN 0737-4038, 2019, Volume 36, Issue 4, pp. 650 - 662
The modification of adenosine to inosine at the first position of transfer RNA (tRNA) anticodons (I34) is widespread among bacteria and eukaryotes. In... 
Translation | CDS | tRNA | Transcriptome | ADAT | Evolution | mRNA | TadA | Speciation | SILK GLAND | ADENOSINE-DEAMINASE | EF-P | transcriptome | PHYLOGENETIC ANALYSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | STRESS-RESPONSE | evolution | IDENTIFICATION | speciation | EVOLUTIONARY BIOLOGY | SEQUENCE | GENES | GENETICS & HEREDITY | translation | POSTTRANSCRIPTIONAL MODIFICATIONS | ANTICODON
Journal Article