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Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2004, Volume 384, Issue 2, pp. 201 - 232
The death morphology commonly known as apoptosis results from a post-translational pathway driven largely by specific limited proteolysis. In the last decade... 
Zymogen | Caspase | Inhibitor | Protease | Inhibitor of apoptosis protein (IAP) | Apoptosis | INDUCED-PROXIMITY MODEL | VIRAL SERPIN CRMA | X-LINKED INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | inhibitor of apoptosis protein (IAP) | apoptosis | zymogen | caspase | INTERLEUKIN-1-BETA CONVERTING-ENZYME | protease | PROGRAMMED CELL-DEATH | TOLL-LIKE RECEPTOR-2 | inhibitor | ANTI-APOPTOTIC ACTIVITY | CYTOCHROME-C RELEASE | DEATH-EFFECTOR DOMAIN | SIGNALING COMPLEX DISC | Caspases - physiology | Enzyme Precursors - chemistry | Humans | Models, Molecular | Molecular Sequence Data | Substrate Specificity | Amino Acid Sequence - physiology | Structure-Activity Relationship | Caspase Inhibitors | Enzyme Precursors - metabolism | Animals | Caspases - metabolism | Protein Conformation | Molecular Structure | Caspases - chemistry | Enzyme Activation - physiology | CAD, caspase-activated DNase | FLICE, FADD-like ICE | TNF, tumour necrosis factor | CARD, LRR and NACHT-containing protein | Rip, receptor-interacting protein | DRONC, Drosophila Nedd2-like caspase | CARD-containing ICE-associated kinase | Ipaf | ICAD, inhibitor of CAD | CED, cell death-defective | DFF, DNA fragmentation factor | CARD, caspase-recruitment domain | APAF-1, apoptotic protease activating factor-1 | CLARP, caspase-like apoptosis-regulatory protein | DIABLO, direct IAP-binding protein with low pI | CLAN, ICE-protease-activating factor | RAIDD, caspase-2 and RipK1 domain-containing adaptor with death domain | ICE, interleukin-1β-converting enzyme | NALP1, NACHT, LRR and Pyrin domain containing 1 | ALPS, autoimmune lymphoproliferative syndrome | LRR, leucine-rich repeat | PYD- and CARD-containing molecule | NOD, nucleotide-binding and oligomerization domain-containing protein | NACHT, NTPase-domain named after NAIP, CIITA, HET-E and TP1 | S1, S2, …Sn and S1′, S2′, …Sm′ refer to the cognate pockets on the protease that accept these side chains | PYCARD, apoptosis-associated speck-like protein containing a CARD | PARP, poly(ADP-ribose) polymerase | P1, P2, …Pn and P1′, P2′, …Pm′ designate the side chains in substrates and inhibitors in the N- and C-terminal direction respectively from the P1–P1′ scissile peptide bond | TFPI, tissue factor pathway inhibitor | TLR, Toll-like receptor | serpin, serine protease inhibitor | RING, really interesting new gene | XIAP | DED, death effector domain | Review | PIDD, p53-induced protein with a death domain | TRAIL, TNF-related apoptosis-inducing ligand | IAP, inhibitor of apoptosis protein | NBD, nucleotide-binding domain | ASC | TRAF, TNF receptor-associated factor | BIRC4, X-linked IAP | DD, death domain | Smac, second mitochondrial activator of caspases | DIAP1, Drosophila inhibitor of apoptosis 1 | BIR, baculoviral IAP repeat | IBM, IAP binding motif | TRADD, TNFRSF1A-associated via death domain | CRADD | DISC, death-inducing signalling complex | FADD, Fas (TNFRSF6)-associated via death domain | FLIP, FLICE inhibitory protein | NF-κB, nuclear factor-κB | CARP, caspase-associated RING protein | CrmA, cytokine response modifier A | CARDIAK, Rip-like interacting CLARP kinase | RICK | Rip-associated protein with a death domain | baculoviral IAP repeat-containing 4
Journal Article
Current Opinion in Structural Biology, ISSN 0959-440X, 04/2012, Volume 22, Issue 2, pp. 241 - 247
► Death domain oligomerization is facilitated by conserved interaction surfaces. ► Known death domain oligomers possess helical symmetry. ► Helical... 
COMPLEX | CRYSTAL-STRUCTURE | DIGITAL ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NMR STRUCTURE | RECEPTOR | FADD | NF-KAPPA-B | SIGNALING PLATFORM | EFFECTOR DOMAIN | PYRIN DOMAIN | CELL BIOLOGY | Protein Structure, Tertiary | Animals | Proteins - metabolism | Signal Transduction | Humans | Protein Binding | Ligands | Proteins - chemistry | Oligomers
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 06/2016, Volume 41, Issue 6, pp. 478 - 490
Two types of sequences, proline-rich domains (PRDs) and the WASP-homology 2 (WH2) domain, are found in most actin filament nucleation and elongation factors... 
PROMOTING FACTOR | ATP-ACTIN | CORDON-BLEU | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RICKETTSIA SCA2 | ARP2/3 COMPLEX | SYNDAPIN I | MUSCLE-CELLS | BACTERIAL EFFECTOR VOPL | FILAMENT NUCLEATION | Autoantigens - metabolism | Cytoskeletal Proteins - genetics | Actin-Related Protein 2-3 Complex - ultrastructure | Humans | Actins - metabolism | Fetal Proteins - metabolism | Autoantigens - genetics | Drosophila melanogaster - genetics | Actins - genetics | Drosophila melanogaster - metabolism | Actin-Related Protein 2-3 Complex - metabolism | Cell Nucleus - metabolism | Actins - chemistry | Cytoskeletal Proteins - metabolism | Microfilament Proteins - metabolism | Protein Interaction Domains and Motifs | Nuclear Proteins - genetics | Microfilament Proteins - genetics | Amino Acid Sequence | Microfilament Proteins - chemistry | Bacteria - metabolism | Actin Cytoskeleton - metabolism | Protein Structure, Secondary | Polymerization | Nuclear Proteins - metabolism | Autoantigens - chemistry | Cytoskeletal Proteins - chemistry | Nuclear Proteins - chemistry | Bacteria - genetics | Sequence Homology, Amino Acid | Sequence Alignment | Animals | Cell Nucleus - genetics | Fetal Proteins - genetics | Actin Cytoskeleton - ultrastructure | Fetal Proteins - chemistry | Physiological aspects | Muscle proteins | Actin | Protein-protein interactions | Protein binding
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 236 - 250
Caspase-8 activation can be triggered by death receptor-mediated formation of the death-inducing signaling complex (DISC) and by the inflammasome adaptor ASC.... 
caspase-8 | DED | MC159 | cFLIP | DISC | Fas | death domain | FADD | vFLIP | filament | APOPTOSIS | ACTIVATION | IMMUNE-SYSTEM | INHIBITION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | UNIFIED MODEL | EFFECTOR DOMAIN | CELL-DEATH | CELL BIOLOGY | Death Domain Receptor Signaling Adaptor Proteins - chemistry | Apoptosis - drug effects | Cytoskeletal Proteins - genetics | Humans | Caspase 8 - metabolism | Caspase 8 - chemistry | CASP8 and FADD-Like Apoptosis Regulating Protein - chemistry | Death Domain Receptor Signaling Adaptor Proteins - genetics | Recombinant Fusion Proteins - metabolism | Viral Proteins - metabolism | Caspase 8 - genetics | Transfection | Cytoskeletal Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism | Death Effector Domain | Fas-Associated Death Domain Protein - genetics | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | CASP8 and FADD-Like Apoptosis Regulating Protein - genetics | Jurkat Cells | Viral Proteins - chemistry | Fas-Associated Death Domain Protein - metabolism | Viral Proteins - genetics | fas Receptor - pharmacology | Cytoskeletal Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Plasmids - metabolism | Fas-Associated Death Domain Protein - chemistry | Cryoelectron Microscopy | Sequence Homology, Amino Acid | Sequence Alignment | Protein Conformation, beta-Strand | CARD Signaling Adaptor Proteins | Plasmids - chemistry | Protein Binding | Recombinant Fusion Proteins - genetics | Death Domain Receptor Signaling Adaptor Proteins - metabolism | Autoimmunity | Medical colleges | Skin diseases | Molecular biology | Analysis | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2015, Volume 125, Issue 11, pp. 4160 - 4170
IgG molecules exert both pro- and antiinflammatory effector functions based on the composition of the fragment crystallizable (Fc) domain glycan. Sialylated... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | ANTIINFLAMMATORY ACTIVITY | EFFECTOR FUNCTIONS | IN-VIVO | BINDING-SITE | ANTIBODY | GLYCOSYLATION | GAMMA-RIV | RECEPTORS | IMMUNOGLOBULIN-G | Antigen-antibody reactions | Genetic aspects | Regulation | Immune response | Properties | Immunoglobulin G | Antigens | Acids | Colleges & universities | Lectins | Cytotoxicity | Software | Autoimmune diseases
Journal Article