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Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 09/1998, Volume 273, Issue 38, pp. 24770 - 24774
Tyrosine O-sulfation, a common post-translational modification in eukaryotes, is mediated by Gels enzymes that catalyze the transfer of the sulfuryl group from... 
HUMAN-COMPLEMENT | EFFICIENT THROMBIN CLEAVAGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TYROSINE SULFATION | FACTOR-VIII | P-SELECTIN | FACTOR-V | 4TH COMPONENT | IDENTIFICATION | VON-WILLEBRAND-FACTOR | RESIDUES
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 01/2004, Volume 279, Issue 4, pp. 3084 - 3095
There is strong evidence that a functionally important cluster of amino acids is located on the COOH-terminal portion of the heavy chain of factor Va, between... 
HEAVY-CHAIN | ANION-BINDING EXOSITE | EFFICIENT THROMBIN CLEAVAGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTHROMBINASE COMPLEX | HEPARIN COFACTOR-II | PROTEIN-C | COAGULATION FACTOR-V | FACTOR-XA | TISSUE FACTOR | MACROMOLECULAR SUBSTRATE
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 2005, Volume 579, Issue 1, pp. 53 - 58
Journal Article
Biochemistry, ISSN 0006-2960, 12/2002, Volume 41, Issue 52, pp. 15590 - 15600
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2016, Volume 11, Issue 5, pp. e0156106 - e0156106
Adenylate kinase (AK) from Escherichia coli was used as both solubility and affinity tag for recombinant protein production. When fused to the N-terminus of a... 
MUTANT | CLONING | MULTIDISCIPLINARY SCIENCES | AFFINITY TAGS | BINDING-PROTEIN | ADENYLATE-KINASE | TOXICITY | CLEAVAGE | EFFICIENT | VECTORS | FUSION PROTEINS | Tumor Necrosis Factor-alpha - metabolism | Recombinant Fusion Proteins - isolation & purification | Affinity Labels - chemistry | Tumor Necrosis Factor-alpha - genetics | Solubility | Expressed Sequence Tags - chemistry | Histidine - metabolism | Recombinant Fusion Proteins - metabolism | Chromatography, Affinity | Escherichia coli - genetics | Cloning, Molecular - methods | Escherichia coli - metabolism | Recombinant Fusion Proteins - genetics | Gene Expression Regulation, Bacterial | Genetic Vectors | Histidine - chemistry | Adenylate Kinase - genetics | Physiological aspects | Genetic aspects | Research | Recombinant proteins | Health aspects | Escherichia coli | Dehydrogenases | Enzyme activity | Protein purification | Thrombin | Biochemistry | Glucose | Kinases | Proteins | E coli | Enzymatic activity | Bacteria | Tumor necrosis factor-TNF | Life sciences | Fusion protein | Tags | Deoxyribonucleic acid--DNA | Recombinant | Enzymes | Adenosine | Elution | Purification | Cloning | Substrates | Adenylate kinase | Plasmids | N-Terminus | Homogeneity | Protein expression | Affinity | Molecular biology | Binding sites | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2003, Volume 13, Issue 8, pp. 1445 - 1449
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2005, Volume 46, Issue 25, pp. 4373 - 4376
The synthesis of 3,5-disubstituted prolines and 5-substituted diazabicycloalkanes from a common precursor is described and a model for the observed... 
Heterocycles | Peptide mimetics | Cyclization | Stereoselective synthesis | DESIGN | THROMBIN | MIMICS | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | BICYCLIC LACTAM INHIBITORS | cyclization | PEPTIDOMIMETICS | heterocycles | AMINO-ACIDS | stereoselective synthesis | CONFORMATIONAL-ANALYSIS | SCAFFOLDS | DIPEPTIDE MIMETICS | peptide mimetics | Hydrocarbons | Analysis
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 1997, Volume 7, Issue 18, pp. 2421 - 2426
SAR and molecular modeling investigations on the potent and selective thrombin inhibitor 1b (CVS 1578) and related serine protease inhibitors led to the design... 
K EE CHEMISTRY, ORGANIC | HUMAN ALPHA-THROMBIN | POTENT | CHEMISTRY, MEDICINAL | PEPTIDES | REAGENTS | CHEMISTRY, ORGANIC | EFFICIENT | K DX CHEMISTRY, MEDICINAL
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, pp. e106936 - e106936
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 1997, Volume 38, Issue 6, pp. 953 - 956
A convergent synthesis of the pentapeptide poststatin has been developed. The key step involves oxidative cleavage of an acyl cyanophosphorane. The resulting... 
PHYSICOCHEMICAL PROPERTIES | THROMBIN INHIBITORS | K EE CHEMISTRY, ORGANIC | STREPTOMYCES-VIRIDOCHROMOGENES MH534-30F3 | PORCINE PANCREATIC ELASTASE | PROLYL ENDOPEPTIDASE | SPONGE THEONELLA SP | ESTERS | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | BIOACTIVE MARINE METABOLITES | CYCLOTHEONAMIDE-B
Journal Article